488 results match your criteria tsh variance

Genetically determined TSH level within reference range is inversely associated with Alzheimer's disease.

J Clin Endocrinol Metab 2021 Jul 17. Epub 2021 Jul 17.

Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Context: Contradictory findings were reported in observational studies on the association of thyroid function [thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels] with Alzheimer's disease (AD).

Objective: To determine whether genetically determined TSH/FT4 levels within reference range are causally associated with AD.

Design: Bi-directional two-sample Mendelian randomization (MR) study. Read More

View Article and Full-Text PDF

Patterns of Bodyweight Changes in Patients With Hypothyroidism, a Retrospective Study From Basrah, Southern Iraq.

Cureus 2021 Jun 2;13(6):e15408. Epub 2021 Jun 2.

Diabetes and Endocrinology, Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah, IRQ.

Background Weight gain is one of the most important hypothyroidism-related concerns in patients with hypothyroidism. However, unexpectedly, levothyroxine replacement does not necessarily result in body weight (BWT) reduction among those patients. The study aimed to assess the patterns of BWT changes through time in patients with hypothyroidism. Read More

View Article and Full-Text PDF

Effects of thyroid function on hemostasis, coagulation, and fibrinolysis: a Mendelian Randomization study.

Thyroid 2021 Jul 1. Epub 2021 Jul 1.

Aarhus University Hospital, 11297, Steno Diabetes Center Aarhus, Hedeager 3, Aarhus, Aarhus, Denmark, 8000;

Background: Untreated hypothyroidism is associated with acquired von Willebrand syndrome, and hyperthyroidism is associated with increased thrombosis risk. However, the causal effects of thyroid function on hemostasis, coagulation, and fibrinolysis are unknown.

Methods: In a two sample Mendelian Randomization (MR) study with genome-wide association variants, we assessed causality of genetically predicted hypothyroidism (N=134,641), normal-range TSH (N=54,288) and fT4 (N=49,269), hyperthyroidism (N=51,823), and thyroid peroxidase antibody positivity (TPOAb) (N=25,821) on coagulation (APTT, VWF, factor VIII, PT, factor VII, fibrinogen) and fibrinolysis (D-dimer, TPA, PAI1) from the CHARGE Hemostasis Consortium (N=2,583-120,246). Read More

View Article and Full-Text PDF

Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study.

Chin Med J (Engl) 2021 Apr 13;134(9):1064-1069. Epub 2021 Apr 13.

Department of Cardiology, Peking University Third Hospital, Beijing 100191, China.

Background: Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate the causal association between thyroid function and serum lipid metabolism via a genetic analysis termed Mendelian randomization (MR). Read More

View Article and Full-Text PDF

Hypothyroidism and levothyroxine therapy following bariatric surgery: a systematic review, meta-analysis, network meta-analysis, and meta-regression.

Surg Obes Relat Dis 2021 Jun 6;17(6):1206-1217. Epub 2021 Mar 6.

Division of Clinical Pharmacy, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address:

Background: Many health benefits of bariatric surgery are known and well-studied, but there is scarce data on the benefits of bariatric surgery on the thyroid function.

Objective: We aimed to make a meta-analysis regarding the impact of bariatric surgery on thyroid-stimulating hormone (TSH) levels, levothyroxine dose, and the status of subclinical hypothyroidism.

Setting: Systematic review and meta-analysis. Read More

View Article and Full-Text PDF

Causal Association between Serum Thyroid-Stimulating Hormone and Obesity: A Bidirectional Mendelian Randomization Study.

J Clin Endocrinol Metab 2021 Mar 23. Epub 2021 Mar 23.

Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.

Context: The association between serum thyroid-stimulating hormone (TSH) and obesity traits has been investigated previously in several epidemiological studies. However, the underlying causal association has not been established.

Objective: To determine and analyze the causal association between serum TSH level and obesity-related traits (BMI and obesity). Read More

View Article and Full-Text PDF

Mendelian Randomization Highlights the Causal Role of Normal Thyroid Function on Blood Lipid Profiles.

Endocrinology 2021 May;162(5)

Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

The association between thyroid function and dyslipidemia has been well documented in observational studies. However, observational studies are prone to confounding, making it difficult to conduct causal inference. We performed a 2-sample bidirectional Mendelian randomization (MR) using summary statistics from large-scale genome-wide association studies of thyroid stimulating hormone (TSH), free T4 (FT4), and blood lipids. Read More

View Article and Full-Text PDF

European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum thyroid biomarkers based on weekly samplings from 91 healthy participants.

Clin Chem Lab Med 2021 Feb 9. Epub 2021 Feb 9.

Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objectives: Thyroid biomarkers are fundamental for the diagnosis of thyroid disorders and for the monitoring and treatment of patients with these diseases. The knowledge of biological variation (BV) is important to define analytical performance specifications (APS) and reference change values (RCV). The aim of this study was to deliver BV estimates for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroglobulin (TG), and calcitonin (CT). Read More

View Article and Full-Text PDF
February 2021

Identification of Protein Changes in the Urine of Hypothyroid Patients Treated with Thyroxine Using Proteomics Approach.

ACS Omega 2021 Jan 13;6(3):2367-2378. Epub 2021 Jan 13.

Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.

The thyroid gland and thyroid hormones control a multitude of homeostatic functions including maintenance of fluid and electrolyte balance and normal functioning of the kidneys. Thyroid dysfunction alters the sytemic hemodynamic and metabolic balance, thereby affecting the kidney. In this study, we aimed to identify and characterize the urinary proteome of the patients with hypothyroidism. Read More

View Article and Full-Text PDF
January 2021

The inflammation link between periodontal disease and coronary atherosclerosis in patients with acute coronary syndromes: case-control study.

BMC Oral Health 2021 01 6;21(1). Epub 2021 Jan 6.

Department of Cardiology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954, Lublin, Poland.

Background: Coronary atherosclerosis and periodontal disease, due to their prevalence, are a serious epidemiological problem. Pathophysiological evidence points to their possible common inflammatory etiopathological background. The aim of the study was to analyze the relationship between the presence and severity of periodontitis, systemic inflammation and selected parameters of myocardial injury and heart function in patients with acute myocardial infarction. Read More

View Article and Full-Text PDF
January 2021

Does Maternal Normal Range Thyroid Function Play a Role in Offspring Birth Weight? Evidence From a Mendelian Randomization Analysis.

Front Endocrinol (Lausanne) 2020 12;11:601956. Epub 2020 Nov 12.

Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha, China.

Background: The association between normal range thyroid function and offspring birth weight has been postulated, but evidence from observational studies is prone to be confounded. We conducted a two-sample Mendelian randomization (MR) study to explore the causal effects of maternal thyroid stimulating hormone (TSH) and free thyroxine (FT4) on birth weight.

Methods: We utilized public shared summary-level statistics from European-ancestry genome wide association studies. Read More

View Article and Full-Text PDF

Biological variation of total thyroxine (T4), free T4 and thyroid-stimulating hormone in 11 clinically healthy cats.

J Feline Med Surg 2021 Jun 11;23(6):592-597. Epub 2020 Nov 11.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.

Objectives: The aim of this study was to investigate the biological variation of total thyroxine (T4), free T4 (fT4) and thyroid-stimulating hormone (TSH) in 11 clinically healthy cats aged between 3 and 15 years old, in Sydney, Australia.

Methods: Blood was collected weekly for up to 6 weeks and serum T4, fT4 and TSH concentrations were analysed using canine-specific reagents. Restricted maximum likelihood was used to estimate within-subject, between-subject and analytical variance components, which were recorded in terms of the related coefficients of variation. Read More

View Article and Full-Text PDF

Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers.

Clin Endocrinol (Oxf) 2021 May 14;94(5):845-850. Epub 2021 Mar 14.

Clinical Biology Department, Cliniques Universitaires St Luc, Université catholique de Louvain, Brussels, Belgium.

Background: Interpretation of thyroid function tests by means of biological variation (BV) data is essential to identify significant changes between serial measurements at an individual level. Data on thyroid parameters in adults are limited.

Objectives: We aimed at determining the BV of four thyroid function test (thyroid-stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3) and thyroglobulin (Tg)) by applying recent recommendations to acquire BV data on a latest generation of immunoassay. Read More

View Article and Full-Text PDF

A toxicological evaluation of a fulvic and humic acids preparation.

Toxicol Rep 2020 14;7:1242-1254. Epub 2020 Sep 14.

Toxi-Coop Zrt., Berlini utca 47-49, H-1045 Budapest, Hungary.

Humic substances are ubiquitous in soils and waters. These complex superstructures are derived from the decomposition of dead plant and animal matter and are vital to soil health. Their heterogenous composition is specific to their site of origin and is comprised of weakly bound aggregates of small organic compounds that can sequester minerals and make them available to plants. Read More

View Article and Full-Text PDF
September 2020

No Effect of Thyroid Dysfunction and Autoimmunity on Health-Related Quality of Life and Mental Health in Children and Adolescents: Results From a Nationwide Cross-Sectional Study.

Front Endocrinol (Lausanne) 2020 2;11:454. Epub 2020 Sep 2.

Department of Pediatrics and Center for Rare Diseases Ruhr CeSER, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.

In adults, a significant impact of thyroid dysfunction and autoimmunity on health-related quality of life (HRQoL) and mental health is described. However, studies in children and adolescents are sparse, underpowered, and findings are ambiguous. Data from 759 German children and adolescents affected by thyroid disease [subclinical hypothyroidism: 331; subclinical hyperthyroidism: 276; overt hypothyroidism: 20; overt hyperthyroidism: 28; Hashimoto's thyroiditis (HT): 68; thyroid-peroxidase antibody (TPO)-AB positivity without apparent thyroid dysfunction: 61] and 7,293 healthy controls from a nationwide cross-sectional study ("The German Health Interview and Examination Survey for Children and Adolescents") were available. Read More

View Article and Full-Text PDF

Interference of Asfotase Alfa in Immunoassays Employing Alkaline Phosphatase Technology.

J Appl Lab Med 2020 03;5(2):290-299

University of East Anglia, Bob Champion Research and Education Building, Norwich, NR4 7UQ, United Kingdom.

Background: Asfotase alfa (STRENSIQ®, Alexion Pharmaceuticals, Inc.) is the only approved treatment for patients with pediatric-onset hypophosphatasia, a disease caused by a mutation in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. ALP is often used as signaling system in routine immunoassays. Read More

View Article and Full-Text PDF

Lack of Influence of Thyroid Hormone on Bone Mineral Density and Body Composition in Healthy Euthyroid Women.

Front Endocrinol (Lausanne) 2019 10;10:890. Epub 2020 Jan 10.

Family Planning Clinic of Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, São Paulo, Brazil.

The objective of this study was to evaluate whether evolution of bone mineral density (BMD) is associated with the thyroid hormone profile in a cohort of euthyroid women with no other known diseases within 1 year. This was a prospective cohort study conducted at the University of Campinas, Brazil. We used a database with 52 women aged 20-39 who were followed for 1 year in a family planning outpatient clinic. Read More

View Article and Full-Text PDF
January 2020

Measurement repeatability profiles of eight frequently requested measurands in clinical chemistry determined by duplicate measurements of patient samples.

Scand J Clin Lab Invest 2020 May 23;80(3):202-209. Epub 2020 Jan 23.

Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Measurement uncertainties in clinical chemistry are commonly regarded as heteroscedastic - having a constant relative standard deviation irrespective of the concentration of the measurand. The uncertainty is usually determined at two concentrations using stabilized control materials and assumed to represent the analytical goal. The purpose of the present study was to use duplicates of unselected patient samples to calculate the absolute and relative repeatability component of the intra-laboratory measurement uncertainty from duplicates, using the Dahlberg formula and analysis of variance components. Read More

View Article and Full-Text PDF

Thyroid function before and after Roux-en-Y gastric bypass: an observational study.

Surg Obes Relat Dis 2020 Feb 3;16(2):261-269. Epub 2019 Dec 3.

Endocrinology and Metabolism Department, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Brazil.

Background: Population studies have shown a positive association between thyroid-stimulating hormone (TSH) and body mass index. Recent studies have shown a significant increase in the prevalence of subclinical hypothyroidism (SCH) in obesity. Weight reduction after Roux-en-Y gastric bypass (RYGB) seems to significantly decrease TSH levels. Read More

View Article and Full-Text PDF
February 2020

Dietary Relationship with 24 h Urinary Iodine Concentrations of Young Adults in the Mountain West Region of the United States.

Nutrients 2020 Jan 1;12(1). Epub 2020 Jan 1.

Division of Kinesiology & Health, University of Wyoming; Laramie, WY 82070, USA.

Background: Iodine deficiency is not seen as a public health concern in the US. However certain subpopulations may be vulnerable due to inadequate dietary sources. The purpose of the present study was to determine the dietary habits that influence iodine status in young adult men and women, and to evaluate the relationship between iodine status and thyroid function. Read More

View Article and Full-Text PDF
January 2020

The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension.

Int J Endocrinol 2019 1;2019:9325289. Epub 2019 Dec 1.

Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Hyperthyroidism is a clinical state that results from increased thyroid hormone levels which has a significant impact on cardiac function and structure. Graves' disease is the most common cause of hyperthyroidism in iodine-replete areas. Hyperthyroid heart disease may be associated with pulmonary hypertension in patients who have overt hyperthyroidism. Read More

View Article and Full-Text PDF
December 2019

Antithyroid Peroxidase Antibodies in Multinodular Hashimoto's Thyroiditis Indicate a Variant Etiology.

J Thyroid Res 2019 21;2019:4892329. Epub 2019 Jul 21.

Tirunelveli Medical College, Tirunelveli, India.

Introduction: Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder, which predominantly presents as a diffuse goiter, with few studies which report HT presenting as multinodular goiter, with variable frequencies ranging from 59% to 78.6% especially from south Indian populations. This variant clinical presentation may have diagnostic challenges which require further analysis. Read More

View Article and Full-Text PDF

Cortisol, progesterone, 17α-hydroxyprogesterone, and TSH responses in dogs injected with low-dose lipopolysaccharide.

PeerJ 2019 8;7:e7468. Epub 2019 Aug 8.

Biomedical and Diagnostic Sciences Dept., University of Tennessee-College of Veterinary Medicine-Knoxville, Knoxville, TN, United States of America.

Background: Stress and diseases such as endotoxemia induce cortisol synthesis through a complex biosynthetic pathway involving intermediates (progesterone, and 17α-hydroxyprogesterone (17α-OHP)) and suppression of the hypothalamus-pituitary-thyroid axis.

Objective: To measure plasma concentrations of cortisol, progesterone, 17α-OHP, and thyroid stimulating hormone (TSH) in dogs experimentally injected with intravenous low-dose lipopolysaccharide (LPS). Our hypothesis was that LPS treatment would elicit a significant increase in cortisol and its precursors, and a significant decrease in TSH concentration. Read More

View Article and Full-Text PDF

Neonatal Screening for Congenital Hypothyroidism: What Can We Learn From Discordant Twins?

J Clin Endocrinol Metab 2019 12;104(12):5765-5779

Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, National Institutes of Health, Rome, Italy.

Context: Newborn screening program for congenital hypothyroidism (CH) adopting rescreening in at-risk neonates.

Objectives: To estimate the concordance rate for CH in twin pairs discordant at the first screening; to verify whether long-term follow-up of healthy cotwins belonging to CH discordant pairs may be useful to diagnose thyroid hypofunction during development; to evaluate the importance of genetic and environmental influences on liability to permanent and transient CH.

Design And Patients: Forty-seven screening discordant twin pairs were investigated. Read More

View Article and Full-Text PDF
December 2019

Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study.

Endocrinol Diabetes Nutr (Engl Ed) 2020 Jan 10;67(1):28-35. Epub 2019 Jun 10.

Endocrine and Metabolic Unit, Department of Medical and Surgical Sciences, University of Brescia, Italy. Electronic address:

Objective: The purpose of this prospective study was to assess the effects of selenium supplementation on TSH and interferon-γ inducible chemokines (CXCL9, CXCL10 and CXCL11) levels in patients with subclinical hypothyroidism due to Hashimoto's thyroiditis.

Patients And Methods: Patients with subclinical hypothyroidism due to Hashimoto thyroiditis were prospectively enrolled in the SETI study. They received 83mcg of selenomethionine/day orally in a soft gel capsule for 4 months with water after a meal. Read More

View Article and Full-Text PDF
January 2020

Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics.

J Toxicol Environ Health A 2019 9;82(10):603-615. Epub 2019 Jun 9.

a Aix Marseille University, INSERM, INRA, C2VN, BioMeT Department , Marseille , France.

Preparedness for nuclear accident responsiveness includes interventions to protect pregnancies against prolonged exposure to radioactive iodine. The aim of this study was to investigate a new design consisting of repeated administration of potassium iodide (KI, 1 mg/kg) for 8 days in late pregnancy gestational day 9-16 (GD9-GD16) in rats. The later-life effects of this early-life iodine thyroid blocking (ITB) strategy were assessed in offspring two months afterbirth. Read More

View Article and Full-Text PDF

The Impact of Adiposity and Puberty on Thyroid Function in Children and Adolescents.

Child Obes 2019 09 6;15(6):411-415. Epub 2019 Jun 6.

2First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, "Aghia Sophia" Childrens' Hospital, Athens, Greece.

In the context of a worldwide increase in childhood obesity, euthyroid hyperthyrotropinemia has been consistently reported and raises questions about its etiology, its potential metabolic complications, and its management. In this study we analyze the thyroid function with respect to BMI, pubertal status, and sex in children with obesity and discuss our results on an integrative context with the existent data from the literature. In this case-control study, we compared 389 children and adolescents with obesity to 158 controls. Read More

View Article and Full-Text PDF
September 2019

The impact of demographic factors on newborn TSH levels and congenital hypothyroidism screening.

Clin Endocrinol (Oxf) 2019 09 11;91(3):456-463. Epub 2019 Jun 11.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Context: Optimal newborn screening thyroid-stimulating hormone (TSH) cut-offs are contentious. Analysis of demographic factors that impact screen TSH levels may help explain international variance and provide guidance to screening programmes.

Objective: To determine the influence of demographic factors on newborn screening TSH levels and screening performance parameters. Read More

View Article and Full-Text PDF
September 2019

Influence of ferulic acid consumption in ameliorating the cadmium-induced liver and renal oxidative damage in rats.

Environ Sci Pollut Res Int 2019 Jul 18;26(20):20631-20653. Epub 2019 May 18.

Department of Zoology, Mizoram Central University, Aizawl, Mizoram, 796004, India.

The aim of this study relates to the modulatory role of ferulic acid (FA) against cadmium (Cd)-induced oxidative stress in the liver and kidney of male Wistar albino rats. Cd is an extremely toxic industrial and environmental pollutant and is well known for its varied toxic clinical manifestations. FA is a derivative of curcumin and a ubiquitous phenolic compound having a wide range of therapeutic activities. Read More

View Article and Full-Text PDF

Relation of Different Components of Climate with Human Pituitary-Thyroid Axis and FT3/FT4 Ratio: A Study on Euthyroid and SCH Subjects in Two Different Seasons.

Int J Endocrinol 2019 16;2019:2762978. Epub 2019 Jan 16.

Physiology Department, College of Medicine, University of Sulaimani, Sulaymaniyah 46001, Iraq.

Background: Various changes in thyroid hormones (TH) and thyroid-stimulating hormone (TSH) level were observed in different seasons among euthyroid and hypothyroid subjects living in areas with an extreme temperature difference between summer and winter.

Objectives: This study aims at finding the effect of temperate climate on the seasonal variations of TSH and TH in euthyroid and subclinical hypothyroidism (SCH) subjects and at evaluating if the test season has an effect on the number of subjects diagnosed as SCH. It basically focuses on the relation of different components of climate with TH and TSH. Read More

View Article and Full-Text PDF
January 2019