3 results match your criteria trxr tumoral

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The activity and tissue distribution of thioredoxin reductase in basal cell carcinoma.

J Cancer Res Clin Oncol 2016 Nov 6;142(11):2303-7. Epub 2016 Sep 6.

Surgical Oncology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Basal cell carcinoma (BCC) is the most prevalent cancer worldwide. Different mechanisms are proposed to be involved in its pathogenesis such as oxidative stress. Oxidative stress, which is the consequence of the disruption of redox balance in favor of oxidants, is involved in the initiation or progression of many tumors. Read More

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November 2016

Tissue thioredoxin reductase-1 expression in astrocytomas of different grades.

J Neurooncol 2015 Feb 13;121(3):451-8. Epub 2014 Nov 13.

Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Akyokus/Meram, 42080, Konya, Turkey,

Thioredoxin (Trx) is a redox active protein that regulates several physiological and biochemical functions, such as growth, apoptosis and cellular defense. The function of Trx itself is regulated by thioredoxin reductase (TrxR). Studies performed in a variety of human primary tumors have shown that thioredoxin reductase 1 (TrxR1) is overexpressed in tumoral tissues compared with corresponding normal tissues. Read More

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February 2015

Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo.

Invest New Drugs 2010 Jun 7;28(3):205-15. Epub 2009 Mar 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Ethaselen (1, 2-[bis (1, 2-Benzisoselenazolone-3 (2H) -ketone)] ethane, BBSKE), as a novel organoselenium compound targeting thioredoxin reductase (TrxR), has been reported to inhibit tumor growth and TrxR activity in several human tumor cell lines. It has now entered Phase I clinical trails. Here we report the effects of ethaselen and cisplatin (cis-diamminedichloroplatinum II, DDP) combination therapy (ethaselen 36 mg/kg, i. Read More

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