338 results match your criteria trx-1


SS-31 protect retinal pigment epithelial cells from H O -induced cell injury by reducing apoptosis.

Clin Exp Pharmacol Physiol 2021 Mar 28. Epub 2021 Mar 28.

The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.

Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells. Antioxidant supplementation is a plausible strategy to avoid oxidative stress and maintain the function of retina. d-Arg-2,6-dimethyltyrosine-Lys-Phe-NH2 (SS-31) has been used in the treatment of many diseases. Read More

View Article and Full-Text PDF

Thioredoxin-1 Rescues MPP/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4.

Mol Neurobiol 2021 Feb 26. Epub 2021 Feb 26.

Laboratory of Molecular Neurobiology, Medical School, Kunming University of Science and Technology, No.727 Jingming South Road, Kunming, 650500, China.

Parkinson's disease (PD), a common neurodegenerative disease, is typically associated with the loss of dopaminergic neuron in the substantia nigra pars compacta (SNpc). Ferroptosis is a newly identified cell death, which associated with iron accumulation, glutathione (GSH) depletion, lipid peroxidation formation, reactive oxygen species (ROS) accumulation, and glutathione peroxidase 4 (GPX4) reduction. It has been reported that ferroptosis is linked with PD. Read More

View Article and Full-Text PDF
February 2021

An unusual thioredoxin system in the facultative parasite Acanthamoeba castellanii.

Cell Mol Life Sci 2021 Apr 18;78(7):3673-3689. Epub 2021 Feb 18.

Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.

The free-living amoeba Acanthamoeba castellanii occurs worldwide in soil and water and feeds on bacteria and other microorganisms. It is, however, also a facultative parasite and can cause serious infections in humans. The annotated genome of A. Read More

View Article and Full-Text PDF

Cigarette smoke extract amplifies NADPH oxidase-dependent ROS production to inactivate PTEN by oxidation in BEAS-2B cells.

Food Chem Toxicol 2021 Apr 10;150:112050. Epub 2021 Feb 10.

Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou, China; Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China; Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is widely recognized as a global public health problem and the third leading cause of mortality worldwide by 2020. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a dual-specificity protein and lipid phosphatase that plays an important role in COPD. However, the redox regulation of PTEN in the development of COPD was poorly studied. Read More

View Article and Full-Text PDF

Imbalance in thioredoxin system activates NLRP3 inflammasome pathway in epicardial adipose tissue of patients with coronary artery disease.

Mol Biol Rep 2021 Feb 10;48(2):1181-1191. Epub 2021 Feb 10.

Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Iran.

Atherosclerosis is the leading cause of death worldwide and has in part an inflammatory basis. Since epicardial adipose tissue (EAT) is in close contact with coronary arteries we hypothesized that an imbalance in thioredoxin-1 (TRX-1) and thioredoxin interacting protein (TXNIP) in EAT, activates NLRP3 inflammasome and promotes production of IL-1β, leading to the development of atherosclerosis. Thirty-eight patients with coronary artery disease (CAD) and thirty patients with no clinical signs of atherosclerosis who underwent open-heart surgery for valve replacement were classified as CAD and control groups, respectively. Read More

View Article and Full-Text PDF
February 2021

Engineered resveratrol-loaded fibrous scaffolds promotes functional cardiac repair and regeneration through Thioredoxin-1 mediated VEGF pathway.

Int J Pharm 2021 Mar 1;597:120236. Epub 2021 Feb 1.

Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut Health, Farmington 06030, CT, USA; Department of Surgery, University of Connecticut Health, Farmington 06030, CT, USA. Electronic address:

Despite recent advancements, mortality due to coronary heart disease (CHD) remains high. Recently, the use of tissue-engineered grafts and scaffolds has emerged as a candidate for supporting the myocardium after an ischemic event. Resveratrol is a naturally occurring plant-based non-flavonoid polyphenolic compound found in many natural foods, including grapes and red wine. Read More

View Article and Full-Text PDF

Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes.

Oxid Med Cell Longev 2020 31;2020:7386239. Epub 2020 Dec 31.

Department of Veterinary Medicine, College of Animal Sci., Zhejiang University, Hangzhou, Zhejiang 310058, China.

Epigallocatechin-3-gallate (EGCG) is one of the fundamental compounds in green tea. The present study was to evaluate the protective effect of EGCG in oxidative damage and apoptosis induced by hydrogen peroxide (HO) in chicken lymphocytes. Results showed that preincubation of lymphocytes with EGCG significantly decreased HO-reduced cell viability and apoptotic cells with DNA damage, restored the HO-dependent reduction in total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), glutathione (GSH), and glutathione disulfide (GSSG), and suppressed the increase in intracellular reactive oxygen species (ROS), nitric oxide (NO), nitric oxide synthesis (NOS), malondialdehyde (MDA), lipid peroxide (LPO), and protein carbonyl (Carbonyl). Read More

View Article and Full-Text PDF
December 2020

Impairment of the Hif-1α regulatory pathway in Foxn1-deficient (Foxn1 ) mice affects the skin wound healing process.

FASEB J 2021 Feb;35(2):e21289

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Hypoxia and hypoxia-regulated factors (eg, hypoxia-inducible factor-1α [Hif-1α], factor inhibiting Hif-1α [Fih-1], thioredoxin-1 [Trx-1], aryl hydrocarbon receptor nuclear translocator 2 [Arnt-2]) have essential roles in skin wound healing. Using Foxn1 mice that can heal skin injuries in a unique scarless manner, we investigated the interaction between Foxn1 and hypoxia-regulated factors. The Foxn1 mice displayed impairments in the regulation of Hif-1α, Trx-1, and Fih-1 but not Arnt-2 during the healing process. Read More

View Article and Full-Text PDF
February 2021

The effects of low-dose 2-hydroxyethyl methacrylate on apoptosis and survival in human dental pulp cells.

J Formos Med Assoc 2020 Dec 16. Epub 2020 Dec 16.

Graduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: 2-hydroxyethyl methacrylate (HEMA) is one of the most major components in dentin bonding systems. Uncured HEMA is eluted through the dentin and harmful to pulp cells. The study aimed to investigate the death pattern, morphological change and factors of human dental pulp cells (HDPCs) cultured with low-dose HEMA. Read More

View Article and Full-Text PDF
December 2020

Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.

Int Immunopharmacol 2021 Jan 3;90:107221. Epub 2020 Dec 3.

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Salvinorin A (SA), a neoclerodane diterpene, is isolated from the dried leaves ofSalvia divinorum. SA has traditionally been used treatments for chronic pain diseases. Recent research has demonstrated that SA possesses the anti-inflammatory property. Read More

View Article and Full-Text PDF
January 2021

Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway.

Food Funct 2020 Dec 24;11(12):10774-10785. Epub 2020 Nov 24.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang Bayi, China.

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is closely associated with oxidative stress. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key transcription factor that regulates oxidative stress. Isoorientin (IOT), as a dietary C-glucosyl flavone derived from rooibos tea, cereals and legumes, is thought to possess multiple pharmacological activities; however, the protective effect of IOT against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y cells is still poorly understood. Read More

View Article and Full-Text PDF
December 2020

On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins.

J Am Chem Soc 2020 11 2;142(46):19558-19569. Epub 2020 Nov 2.

Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel.

The maleimide group is a widely used reagent for bioconjugation of peptides, proteins, and oligonucleotides employing Michael addition and Diels-Alder cycloaddition reactions. However, the utility of this functionality in chemical synthesis of peptides and proteins remains unexplored. We report, for the first time that Pd complexes can mediate the efficient removal of various succinimide derivatives in aqueous conditions. Read More

View Article and Full-Text PDF
November 2020

ADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity.

Redox Biol 2020 10 24;37:101735. Epub 2020 Sep 24.

Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, São Paulo, Brazil. Electronic address:

The activity of Thioredoxin-1 (Trx-1) is adjusted by the balance of its monomeric, active and its dimeric, inactive state. The regulation of this balance is not completely understood. We have previously shown that the cytoplasmic domain of the transmembrane protein A Disintegrin And Metalloprotease 17 (ADAM17cyto) binds to Thioredoxin-1 (Trx-1) and the destabilization of this interaction favors the dimeric state of Trx-1. Read More

View Article and Full-Text PDF
October 2020

Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.

Front Pharmacol 2020 2;11:559046. Epub 2020 Sep 2.

Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, Luzhou, China.

Acrylamide (ACR) is a common chemical used in various industries and it said to have chronic neurotoxic effects. It is produced during tobacco smoking and is also generated in high-starch foods during heat processing. Notoginsenoside R1 (NR1) is a traditional Chinese medicine, which is used to improve the blood circulation and clotting. Read More

View Article and Full-Text PDF
September 2020

CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact.

Neuropsychiatr Dis Treat 2020 12;16:1929-1941. Epub 2020 Aug 12.

Department of Neuropharmacology, Beijing Key Laboratory of Central Nervous System Injury, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, People's Republic of China.

Background: Compound porcine cerebroside and ganglioside injection (CPCGI), which involves injection of a neurotrophic drug, has been widely used to treat certain brain disorders in the clinic; however, the detailed mechanism is unknown. This study investigated whether CPCGI protects the brain from trauma by stimulating antioxidative nuclear factor erythroid-2-related factor 2 (Nrf2) signaling and suppressing calpain overactivation in a rat model of controlled cortical impact (CCI).

Materials And Methods: The rat model of CCI was used. Read More

View Article and Full-Text PDF

Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.

Small GTPases 2020 Aug 31:1-13. Epub 2020 Aug 31.

Biomedical Research Service, John D. Dingell VA Medical Center and Department of Pharmaceutical Sciences and Medicine, Wayne State University , Detroit, MI, USA.

A growing body of evidence implicates requisite roles for GTP and its binding proteins (Rho GTPases) in the cascade of events leading to physiological insulin secretion from the islet beta cell. Interestingly, chronic exposure of these cells to hyperglycaemic conditions appears to result in sustained activation of specific Rho GTPases (e.g. Read More

View Article and Full-Text PDF

Thioredoxin-1 attenuates atherosclerosis development through inhibiting NLRP3 inflammasome.

Endocrine 2020 10 30;70(1):65-70. Epub 2020 Jun 30.

Department of Cardiology, Yiwu Central Hospital, 519 Nanmen Street, Yiwu, 322000, Zhejiang, China.

Backgrounds: The thioredoxin-1 has atheroprotective effects via regulating oxidative stress and inflammation. In addition, the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome also contributes to atherosclerosis development. However, whether the thioredoxin-1 suppresses atherosclerosis development by modulating the NLRP3 inflammasome remains unclear. Read More

View Article and Full-Text PDF
October 2020

Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1.

Onco Targets Ther 2020 27;13:4691-4704. Epub 2020 May 27.

Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People's Republic of China.

Background: Sodium butyrate (NaB) is a short-chain fatty acid which is produced by bacterial fermentation of nondigestible dietary fiber and has been reported to exert anti-tumor effects in many tumors including colorectal cancer (CRC). However, the role of thioredoxin-1 (Trx-1) in NaB-induced anti-tumor effect has not been completely clarified.

Materials And Methods: Effects of NaB on the growth of CRC cell lines HT29 and SW480 were detected by the Cell Counting Kit-8 (CCK-8) and colony formation assays. Read More

View Article and Full-Text PDF

Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation.

Phytomedicine 2020 Jun 17;71:153241. Epub 2020 May 17.

Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, China. Electronic address:

Background: Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor in acute liver failure (ALF).

Aims: To investigate the protective effect of daphnetin (Daph) on tert-butyl hydroperoxide (t-BHP) and acetaminophen (APAP)-induced hepatotoxicity through altering Nrf2/Trx-1 pathway activation.

Materials And Methods: In vivo, male C57BL/6 mice with Wild-type (WT) and Nrf2 were divided into five groups and acute liver injury model were established by APAP or LPS/GalN after injection with Daph (20, 40, or 80 mg/kg), seperately. Read More

View Article and Full-Text PDF

miR-93, miR-373, and miR-17-5p Negatively Regulate the Expression of TBP2 in Lung Cancer.

Front Oncol 2020 28;10:526. Epub 2020 Apr 28.

Medical Faculty, Kunming University of Science and Technology, Kunming, China.

Recently, several miRNAs have been revealed to play critical roles in oncogenesis and tumor progression of many cancers. Thioredoxin-1 (Trx-1) binding protein-2 (TBP-2) is an internal inhibitor of Trx-1, which plays the role in regulating oxidative stress, inhibiting cell growth, and promoting apoptosis. The expression of TBP-2 is usually decreased in cancer tissues. Read More

View Article and Full-Text PDF

The expression of thioredoxin-1 and inflammatory cytokines in patients with sepsis.

Immunopharmacol Immunotoxicol 2020 Jun 23;42(3):280-285. Epub 2020 Apr 23.

Medical School, Kunming University of Science and Technology, Kunming, China.

: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Inflammatory response and oxidative stress play an important role in the pathophysiological process of sepsis. Thioredoxin-1 (Trx-1) is a small ubiquitous thiol protein with redox/inflammation modulatory properties relevant to the pathogenesis of sepsis. Read More

View Article and Full-Text PDF

Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice.

Neurotoxicology 2020 05 20;78:163-169. Epub 2020 Mar 20.

Medical School, Kunming University of Science and Technology, Kunming, 650500, China. Electronic address:

Methamphetamine (METH) has been reported to induce endoplasmic reticulum (ER) stress and neuronal apoptosis in the central nervous system (CNS) during the development of addiction. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays an important role in inhibiting apoptosis and protects neurons from cytotoxicity through ER and mitochondria-mediated pathways. Our previous study has been reported that Trx-1 protects mice from METH-induced rewarding effect. Read More

View Article and Full-Text PDF

Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum.

Neurochem Int 2020 06 19;136:104728. Epub 2020 Mar 19.

Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, 116044, Dalian, Liaoning, China. Electronic address:

Diabetic encephalopathy (DE) has been defined as one of the major complications of diabetes, characterized by neurochemical and neurodegenerative changes. However, the molecular mechanism of DE are not fully elucidated at present. Here, the primary hippocampal neurons were cultured in vitro with high glucose (HG) to induce diabetes-like effects, and mice were given streptozotocin (STZ) to induce a model of type 1 diabetes mellitus (T1D) mice. Read More

View Article and Full-Text PDF

Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1.

Front Pharmacol 2020 21;11:82. Epub 2020 Feb 21.

Key Laboratory of Tea Plant Biology of Henan Province, College of Life Sciences, Xinyang Normal University, Xinyang, China.

Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence. Numerous studies have demonstrated significant redox alteration in morphine dependence and addiction. Thioredoxin-1 (Trx-1) play important roles in controlling the cellular redox balance. Read More

View Article and Full-Text PDF
February 2020

Molecular and functional explication of thioredoxin mitochondrial-like protein (Trx-2) from big-belly seahorse (Hippocampus abdominalis) and expression upon immune provocation.

Fish Shellfish Immunol 2020 Apr 17;99:495-504. Epub 2020 Feb 17.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea. Electronic address:

Thioredoxin (Trx) is a small ubiquitous multifunctional protein with a characteristic WCGPC thiol-disulfide active site that is conserved through evolution. Trx plays a crucial role in the antioxidant defense system. Further, it is involved in a variety of biological functions including gene expression, apoptosis, and growth regulation. Read More

View Article and Full-Text PDF

Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.

Hum Exp Toxicol 2020 Jun 23;39(6):797-807. Epub 2020 Jan 23.

Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, Luzhou, China.

Acrylamide (ACR) is a water-soluble chemical that is commonly used in chemical and cosmetic manufacture. Many studies have been carried out to investigate the neurotoxicity mechanisms of ACR, resulting in oxidative stress and nerve damages. One of the commonly used traditional Chinese medicines is notoginsenoside R1 (NR1). Read More

View Article and Full-Text PDF

CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis.

Cell Death Discov 2019 4;5:148. Epub 2019 Dec 4.

1Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.

A unique feature of CD40 among the TNF receptor (TNFR) superfamily is its exquisitely contextual effects, as originally demonstrated in normal and malignant B-lymphocytes. We studied renal cell carcinoma (RCC) in comparison to normal (human renal proximal tubule) cells, as a model to better understand the role of CD40 in epithelial cells. CD40 ligation by membrane-presented CD40 ligand (mCD40L), but not soluble CD40 agonist, induced extensive apoptosis in RCC cells; by contrast, normal cells were totally refractory to mCD40L. Read More

View Article and Full-Text PDF
December 2019

Detection of thioredoxin-1 using ultra-sensitive ELISA with enzyme-encapsulated human serum albumin nanoparticle.

Nano Converg 2019 Dec 9;6(1):37. Epub 2019 Dec 9.

Department of Chemical & Biomolecular Engineering, Sogang University, Mapo-Gu, Seoul, 04170, South Korea.

Many methods for early diagnosis of the disease use biomarker tests, which measure indicators of biological state in body fluids or blood. However, a limitation of these methods is their low sensitivity to biomarkers. In this study, human serum albumin (HSA) based nanoparticles capable of encapsulating excess horseradish peroxidase (HRP) are synthesized and applied to the development of enzyme-linked immunosorbent assay (ELISA) kit with ultra-high sensitivity. Read More

View Article and Full-Text PDF
December 2019

Impact of zinc oxide nanoparticles on thioredoxin-interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma-irradiated rats.

Environ Toxicol 2020 Apr 21;35(4):430-442. Epub 2019 Nov 21.

Radiation Biology Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Nasr City, Cairo, Egypt.

Nanoparticle is a microscopic particle that has been existed in a wide range of biotechnological purposes. Zinc oxide nanoparticles (ZnO-NPs) have fewer environmental hazards and have shown positive impacts in the medical field. This work aimed to observe the effects of low and high doses of ZnO-NPs on heart injury induced by ionizing radiation (IR). Read More

View Article and Full-Text PDF

Neurogenic effect of exercise via the thioredoxin-1/ extracellular regulated kinase/β-catenin signaling pathway mediated by β2-adrenergic receptors in chronically stressed dentate gyrus.

J Exerc Nutrition Biochem 2019 Sep;23(3):13-21

Purpose: Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis.

Methods: Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Read More

View Article and Full-Text PDF
September 2019