837 results match your criteria trpm7

Characterization of IL-2 Stimulation and TRPM7 Pharmacomodulation in NK Cell Cytotoxicity and Channel Co-Localization with PIP in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Int J Environ Res Public Health 2021 Nov 12;18(22). Epub 2021 Nov 12.

National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast 4215, Australia.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystemic disorder responsible for significant disability. Although a unifying etiology for ME/CFS is uncertain, impaired natural killer (NK) cell cytotoxicity represents a consistent and measurable feature of this disorder. Research utilizing patient-derived NK cells has implicated dysregulated calcium (Ca) signaling, dysfunction of the phosphatidylinositol-4,5-bisphosphate (PIP)-dependent cation channel, transient receptor potential melastatin (TRPM) 3, as well as altered surface expression patterns of TRPM3 and TRPM2 in the pathophysiology of ME/CFS. Read More

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November 2021

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light-Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro.

Asia Pac J Ophthalmol (Phila) 2021 Nov 16. Epub 2021 Nov 16.

First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou City 350005, China.

Purpose: Blue light triggers apoptosis of retinal pigment epithelium (RPE) cells and causes retinal damage. The aim of this study was to elucidate the protective role of transient receptor potential melastatin 7 (TRPM7) in photodamaged RPE cells.

Methods: RPE cells were isolated from Sprague-Dawley (SD) rats and exposed to varying intensities of blue light (500-5000 lux) in vitro. Read More

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November 2021

Sacubitril Ameliorates Cardiac Fibrosis Through Inhibiting TRPM7 Channel.

Front Cell Dev Biol 2021 29;9:760035. Epub 2021 Oct 29.

State Key Laboratory of Natural Medicines, Department of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.

Heart failure caused by cardiac fibrosis has become a major challenge of public health worldwide. Cardiomyocyte programmed cell death (PCD) and activation of fibroblasts are crucial pathological features, both of which are associated with aberrant Ca influx. Transient receptor potential cation channel subfamily M member 7 (TRPM7), the major Ca permeable channel, plays a regulatory role in cardiac fibrosis. Read More

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October 2021

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics.

Elife 2021 Nov 12;10. Epub 2021 Nov 12.

Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany.

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such as Zn, Mg, and Ca, and thus shapes cellular excitability, plasticity, and metabolic activity. The molecular appearance and operation of TRPM7 channels in native tissues have remained unresolved. Read More

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November 2021

Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy.

Cancer Lett 2022 Jan 6;525:179-197. Epub 2021 Nov 6.

Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, 209 Tongshan Rd, Xuzhou, Jiangsu 221004, China. Electronic address:

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitous cation channel possessing kinase activity. TRPM7 mediates a variety of physiological responses by conducting flow of cations such as Ca, Mg, and Zn. Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn release to the cytosol, presumably from the intracellular Zn-accumulating vesicles where TRPM7 localizes. Read More

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January 2022

Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome.

Hum Reprod 2021 Nov 6. Epub 2021 Nov 6.

IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam.

Study Question: Does use of medium containing amphiregulin improve meiotic maturation efficiency in oocytes of women with polycystic ovary syndrome (PCOS) undergoing in vitro maturation (IVM) preceded by a capacitation culture step capacitation IVM (CAPA-IVM)?

Summary Answer: Use of medium containing amphiregulin significantly increased the maturation rate from oocytes retrieved from follicles with diameters <6 or ≥6 mm pre-cultured in capacitation medium.

What Is Known Already: Amphiregulin concentration in follicular fluid is correlated with human oocyte developmental competence. Amphiregulin added to the meiotic trigger has been shown to improve outcomes of IVM in a range of mammalian species. Read More

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November 2021

NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by Cytosolic Acidification.

Front Physiol 2021 18;12:727549. Epub 2021 Oct 18.

Department of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine, College of Science and Mathematics, Wright State University, Dayton, OH, United States.

Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic mechanism of these widely used drugs is the inhibition of cyclooxygenase 1 and 2 (COX1, 2) enzymes that catalyze the conversion of arachidonic acid into prostaglandins. At higher doses, NSAIDs are used for prevention of certain types of cancer and as experimental treatments for Alzheimer's disease. Read More

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October 2021

Proton pump inhibitors and osteoporosis risk: exploring the role of TRPM7 channel.

Eur J Clin Pharmacol 2021 Oct 29. Epub 2021 Oct 29.

Department of Pharmacology, Maliba Pharmacy College, Uka Tarsadia University Bardoli, Dist. Surat, 394350, Bardoli, India.

Background: Long-term use of proton pump inhibitors (PPIs) has been linked to an increased risk of osteoporosis, with various indirect mechanisms so far identified. Although no direct underlying mechanism for effect on bone cells have been investigated with the use of PPIs. Melastatin-like transient receptor potential 7 (TRPM7)channel has been engaged in the proliferation of bone cells. Read More

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October 2021

Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos.

Cell Rep 2021 Oct;37(3):109851

Institute of Pharmacology, Heidelberg University, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg 69120, Germany. Electronic address:

Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca and Mg. Deletion of the Ca and Mg conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization, blastocoel formation, and correct specification of the lineages of the trophectoderm and inner cell mass unaltered despite that free cytoplasmic Ca and Mg is reduced at the two-cell stage. Although Trpm7 embryos are able to hatch from the zona pellucida, no expansion of Trpm7 trophoblast cells can be observed, and Trpm7 embryos are not identifiable in utero at E6. Read More

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October 2021

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Int J Environ Res Public Health 2021 10 12;18(20). Epub 2021 Oct 12.

National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, Gold Coast 4215, Australia.

The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders including amyotropic lateral sclerosis, multiple sclerosis, and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS is a debilitating disorder with an obscure aetiology, hence considerable examination of its pathobiology is warranted. Read More

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October 2021

Viewpoints on the Role of Transient Receptor Potential Melastatin Channels in Cardiovascular System and Disease: A Systematic Review.

Curr Probl Cardiol 2021 Oct 10:101012. Epub 2021 Oct 10.

Department of Genetics and Molecular biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Transient receptor potential (TRP) family play critical roles in cardiovascular system. TRPM family as largest TRP subfamily is non-voltage Ca2+-activated selective channels which has 8 members. This study aimed to discuss the role of TRPM family in cardiovascular system and diseases. Read More

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October 2021

The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation.

J Biol Chem 2021 Nov 8;297(5):101292. Epub 2021 Oct 8.

Department of Biological Sciences, St John's University, Queens, New York, USA. Electronic address:

Zinc deficiency has been linked to human diseases, including cancer. MDMX, a crucial zinc-containing negative regulator of p53, has been found to be amplified or overexpressed in various cancers and implicated in the cancer initiation and progression. We report here that zinc depletion by the ion chelator TPEN or Chelex resin results in MDMX protein degradation in a ubiquitination-independent and 20S proteasome-dependent manner. Read More

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November 2021

TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis.

Elife 2021 09 27;10. Epub 2021 Sep 27.

Department of Biological Sciences, University of Illinois at Chicago, Chicago, United States.

Transient receptor potential melastatin 7 (TRPM7) contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal death induced by ischemia. However, the physiological role of TRPM7 in central nervous system (CNS) neuron remains unclear. Read More

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September 2021

Selected transient receptor potential channel genes' expression in peripheral blood mononuclear cells of multiple sclerosis.

Hum Exp Toxicol 2021 Sep 26:9603271211043476. Epub 2021 Sep 26.

Department of Medical Biology, Faculty of Medicine, 64230University of Manisa Celal Bayar, Manisa, Turkey.

Transient receptor potential channels have responsibilities in many cellular processes such as cytokine production, cell differentiation, and cytotoxicity by affecting intracellular cation levels or intracellular signal pathways. Multiple sclerosis is a chronic autoimmune central nervous system (CNS) disease caused by environmental and genetic factors. In this study, we aim to investigate TRPV1-TRPV4, TRPM2, TRPM4, TRPM7, TRPC6, and TRPA1 mRNA expression levels, which are associated with the inflammatory process, in the peripheral blood mononuclear cells (PBMCs) of relapsing-remitting multiple sclerosis (RRMS) patients. Read More

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September 2021

Cytoskeletal Remodeling Mimics Endothelial Response to Microgravity.

Front Cell Dev Biol 2021 9;9:733573. Epub 2021 Sep 9.

Department of Biomedical and Clinical Sciences L. Sacco, Università di Milano, Milan, Italy.

Mechanical cues contribute to the maintenance of a healthy endothelium, which is essential for vascular integrity. Indeed endothelial cells are mechanosensors that integrate the forces in the form of biochemical signals. The cytoskeleton is fundamental in sensing mechanical stimuli and activating specific signaling pathways. Read More

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September 2021

Cardioprotective effect of fingolimod against calcium paradox-induced myocardial injury in the isolated rat heart.

Can J Physiol Pharmacol 2021 Sep 24. Epub 2021 Sep 24.

University of Cape Town, Human Biology, 5.14 Anatomy Building, Observatory, Cape Town, South Africa, 7925;

Fingolimod (FTY720) inhibits Ca-permeable, Mg-sensitive channels called transient receptor potential melastatin 7 (TRPM7), but its effects on Ca paradox (CP)-induced myocardial damage have not been evaluated. We studied the effect of FTY720 on CP-induced myocardial damage, and used other TRPM7 channel inhibitors nordihydroguaiaretic acid (NDGA) and Mg to test if any effect of FTY720 was via TRPM7 inhibition. Langendorff-perfused Wistar rat hearts were treated with FTY720 or NDGA and subjected to a CP protocol consisting of Ca depletion followed by Ca repletion. Read More

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September 2021

Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases.

Immunology 2021 Sep 24. Epub 2021 Sep 24.

Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, China.

An autoimmune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure to self-antigens. It often leads to structural and functional damage to organs and systemic disorders. To date, there are no effective interventions to prevent the progression of autoimmune diseases. Read More

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September 2021

Diagnostic Dilemma in an Adolescent Girl with an Eating Disorder, Intellectual Disability, and Hypomagnesemia.

Nephron 2021 19;145(6):717-720. Epub 2021 Aug 19.

Division of Pediatric Nephrology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.

Neurological disorders, including seizures, migraine, depression, and intellectual disability, are frequently associated with hypomagnesemia. Specifically, magnesium (Mg2+) channel transient receptor potential melastatin (TRPM) 6 and TRPM7 are essential for brain function and development. Both channels are also localized in renal and intestinal epithelia and are crucial for Mg2+(re)absorption. Read More

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A comprehensive review of hypomagnesemia.

Dis Mon 2021 Sep 9:101285. Epub 2021 Sep 9.

Rosalind Franklin University of Medicine and Health Sciences, North Chicago, IL, United States of America; Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, United States; E2Bio Life Sciences, 2906 Central Street, Suite 161, Evanston, IL 60201, United States of America. Electronic address:

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September 2021

Distinct calcium regulation of TRPM7 mechanosensitive channels at plasma membrane microdomains visualized by FRET-based single cell imaging.

Sci Rep 2021 09 9;11(1):17893. Epub 2021 Sep 9.

Department of Integrated Biological Science, Pusan National University, Pusan, 46241, Republic of Korea.

Transient receptor potential subfamily M member 7 (TRPM7), a mechanosensitive Ca channel, plays a crucial role in intracellular Ca homeostasis. However, it is currently unclear how cell mechanical cues control TRPM7 activity and its associated Ca influx at plasma membrane microdomains. Using two different types of Ca biosensors (Lyn-D3cpv and Kras-D3cpv) based on fluorescence resonance energy transfer, we investigate how Ca influx generated by the TRPM7-specific agonist naltriben is mediated at the detergent-resistant membrane (DRM) and non-DRM regions. Read More

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September 2021

Society of General Physiologists Symposium on "Ion Channels and Transporters in Immunity, Inflammation and Antitumor Immunity" (held online on September 11, 2020).

Bioelectricity 2020 Dec 16;2(4):418-423. Epub 2020 Dec 16.

Department of Life Sciences, Imperial College London, London, United Kingdom.

Ion channels and ionic transporters are expressed in every cell in the body, including the cells of the immune system. This international meeting was dedicated to some of the latest advances in the field and covered a range of topics in seven presentations. Zinc transport by the ZIP7 transporter expressed in the endoplasmic reticulum, transporting Zn into the cytoplasm, was shown to be essential for B-cell development and functioning. Read More

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December 2020

Elucidation of the Physiological Functions of Membrane Proteins as Novel Drug Target Candidate Molecules.

Biol Pharm Bull 2021 ;44(9):1167-1173

Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University.

For pharmaceutical research focused on identifying novel drug target candidate molecules, it is essential to explore unknown biological phenomena, elucidate underlying molecular mechanisms and regulate biological processes based on these findings. Proteins expressed on the plasma membrane and endoplasmic reticulum (ER) membrane play important roles in linking extracellular environmental information to intracellular processes. Stimulating membranous proteins induces various kinds of changes in cells, such as alterations in gene expression levels and enzymatic activities. Read More

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January 2021

Modulation of the Cardiac Myocyte Action Potential by the Magnesium-Sensitive TRPM6 and TRPM7-like Current.

Int J Mol Sci 2021 Aug 14;22(16). Epub 2021 Aug 14.

Institute of Cardiology, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania.

The cardiac Mg-sensitive, TRPM6, and TRPM7-like channels remain undefined, especially with the uncertainty regarding TRPM6 expression in cardiomyocytes. Additionally, their contribution to the cardiac action potential (AP) profile is unclear. Immunofluorescence assays showed the expression of the TRPM6 and TRPM7 proteins in isolated pig atrial and ventricular cardiomyocytes, of which the expression was modulated by incubation in extracellular divalent cation-free conditions. Read More

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Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells.

Cells 2021 07 26;10(8). Epub 2021 Jul 26.

Laboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.

Background: A low level of serum magnesium ion (Mg) is associated with type 2 diabetes mellitus (T2D). However, the molecular mechanism of Mg deficiency has not been fully clarified. The current study sought to assesses the effect of reactive oxygen species on the expression of Mg channels and miRNA. Read More

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TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.

Development 2021 08 16;148(16). Epub 2021 Aug 16.

Department of Molecular Physiology and Biophysics, Vanderbilt University, 7425B MRB IV, 2213 Garland Ave., Nashville, TN 37232, USA.

The melastatin subfamily of the transient receptor potential channels (TRPM) are regulators of pancreatic β-cell function. TRPM7 is the most abundant islet TRPM channel; however, the role of TRPM7 in β-cell function has not been determined. Here, we used various spatiotemporal transgenic mouse models to investigate how TRPM7 knockout influences pancreatic endocrine development, proliferation and function. Read More

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Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.

Sci Rep 2021 07 29;11(1):15445. Epub 2021 Jul 29.

Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

The expression of the channels-enzymes TRPM6 and TRPM7 in the human heart remains poorly defined, and TRPM6 is generally considered not to be expressed in cardiomyocytes. We examined their expression at protein and mRNA levels using right atrial samples resected from patients (n = 72) with or without ischemic heart disease (IHD) and samples from all chamber walls of explanted human hearts (n = 9). TRPM6 and TRPM7 proteins were detected using immunofluorescence on isolated cardiomyocytes, ELISA on tissue homogenates, and immunostaining of cardiac tissue, whereas their mRNAs were detected by RT-qPCR. Read More

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Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs.

J Cell Sci 2021 07 12;134(13). Epub 2021 Jul 12.

Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, 661 North Pleasant Street, Amherst, MA 01003, USA.

Ca2+ influx during oocyte maturation and after sperm entry is necessary to fill the internal Ca2+ stores and for complete egg activation. We knocked out the transient receptor potential vanilloid member 3 (TRPV3) and the T-type channel, CaV3.2, to determine their necessity for maintaining these functions in mammalian oocytes/eggs. Read More

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Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 2: Functional and Molecular Properties of ASOR/PAC Channels and Their Roles in Cell Volume Dysregulation and Acidotoxic Cell Death.

Front Cell Dev Biol 2021 9;9:702317. Epub 2021 Jul 9.

Department of Physiology, School of Medicine, Fukuoka University, Fukuoka, Japan.

For survival and functions of animal cells, cell volume regulation (CVR) is essential. Major hallmarks of necrotic and apoptotic cell death are persistent cell swelling and shrinkage, and thus they are termed the necrotic volume increase (NVI) and the apoptotic volume decrease (AVD), respectively. A number of ubiquitously expressed anion and cation channels play essential roles not only in CVR but also in cell death induction. Read More

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Magnesium transport in the aglomerular kidney of the Gulf toadfish (Opsanus beta).

J Comp Physiol B 2021 09 23;191(5):865-880. Epub 2021 Jul 23.

Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, FL, USA.

Despite having an aglomerular kidney, Gulf toadfish can survive in water ranging from nearly fresh up to 70 parts per thousand salinity. In hyperosmotic environments, the major renal function is to balance the passive Mg load from the environment with an equal excretion. However, the molecular transporters involved in Mg secretion are poorly understood. Read More

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September 2021