Sci Rep 2019 02 12;9(1):1849. Epub 2019 Feb 12.
Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gα-PLC pathway. Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P) maintains TRPC4 and TRPC5 channel function, the Gα-PLC pathway inhibits channel activity by depleting PI(4,5)P. Here we investigated the difference in PI(4,5)P sensitivity between homomeric and heteromeric TRPC channels. Read More