5 results match your criteria trpc5 homotetramer

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Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function.

Sci Adv 2019 07 24;5(7):eaaw7935. Epub 2019 Jul 24.

School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.

The transient receptor potential canonical subfamily member 5 (TRPC5), one of seven mammalian TRPC members, is a nonselective calcium-permeant cation channel. TRPC5 is of considerable interest as a drug target in the treatment of progressive kidney disease, depression, and anxiety. Here, we present the 2. Read More

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Differential PI(4,5)P sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.

Sci Rep 2019 02 12;9(1):1849. Epub 2019 Feb 12.

Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gα-PLC pathway. Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P) maintains TRPC4 and TRPC5 channel function, the Gα-PLC pathway inhibits channel activity by depleting PI(4,5)P. Here we investigated the difference in PI(4,5)P sensitivity between homomeric and heteromeric TRPC channels. Read More

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February 2019

Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease.

Brain 2015 Oct 30;138(Pt 10):3030-47. Epub 2015 Jun 30.

1 Department of Physiology and Institute of Dermatological Science, Seoul National University College of Medicine, Seoul, 110-799, South Korea

Aberrant glutathione or Ca(2+) homeostasis due to oxidative stress is associated with the pathogenesis of neurodegenerative disorders. The Ca(2+)-permeable transient receptor potential cation (TRPC) channel is predominantly expressed in the brain, which is sensitive to oxidative stress. However, the role of the TRPC channel in neurodegeneration is not known. Read More

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October 2015

The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.

Channels (Austin) 2012 Sep-Oct;6(5):333-43. Epub 2012 Aug 10.

Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαq protein coupled receptor or epidermal growth factor in particular. Read More

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Regulation of the cellular localization and function of human transient receptor potential channel 1 by other members of the TRPC family.

Cell Calcium 2008 Apr 11;43(4):375-87. Epub 2007 Sep 11.

Department of Cell Biology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México CP 04510, D.F., Mexico.

Members of the Canonical Transient Receptor Potential (TRPC) family of ionic channels are able to form homo- and heterotetrameric channels. Depending on the study, TRPC1 has been detected on both the surface and inside the cell, probably in the endoplasmic reticulum (ER). Likewise, TRPC1 has been described both as a store-operated channel and as one unable to function when forming a homotetramer. Read More

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