Life Sci 2019 Aug 13;231:116567. Epub 2019 Jun 13.
Department of Oral Physiology, School of Dentistry, Kyungpook National University, 2177, Dalgubeol-daero, Jung-gu, Daegu, 41940, Republic of Korea.
Aims: Metabotropic glutamate receptor 5 (mGluR5), a member of group I mGluR, exerts its effect via elevation of intracellular Ca level. We here characterized Ca signals in the tsA201 cells transfected with mGluR5 and investigated the role of passages for mGluR5-induced Ca signals in synaptic plasticity.
Main Methods: Using a genetically encoded Ca indicator, GCamp2, Ca signals were reliably induced by bath application of (S)-3,5-dihydroxyphenylglycine, the group I mGluR agonist, in the tsA201 cells transfected with mGluR5. Read More