Am J Physiol Renal Physiol 2011 Jan 13;300(1):F49-59. Epub 2010 Oct 13.
Department of Medicine, Renal-Electrolyte Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
The urothelium is proposed to be a sensory tissue that responds to mechanical stress by undergoing dynamic membrane trafficking and neurotransmitter release; however, the molecular basis of this function is poorly understood. Transient receptor potential (TRP) channels are ideal candidates to fulfill such a role as they can sense changes in temperature, osmolarity, and mechanical stimuli, and several are reported to be expressed in the bladder epithelium. However, their complete expression profile is unknown and their cellular localization is largely undefined. Read More