1,295 results match your criteria trophic ulcers

Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review).

Int J Mol Med 2021 Sep 19;48(3). Epub 2021 Jul 19.

Swiss Stem Cell Foundation, 6900 Lugano, Switzerland.

Cell therapy is becoming an attractive alternative for the treatment of patients with no‑option critical limb ischemia (CLI). The main benefits of cell therapy are the induction of therapeutic angiogenesis and neovascularization that lead to an increase in blood flow in the ischemic limb and tissue regeneration in non‑healing cutaneous trophic lesions. In the present review, the current state of the art of strategies in the cell therapy field are summarized, focusing on intra‑operative autologous cell concentrates in diabetic patients with CLI, examining different sources of cell concentrates and their mechanisms of action. Read More

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September 2021

An innovative approach in the treatment of trigeminal trophic syndrome.

J Dermatolog Treat 2021 Jul 13:1-3. Epub 2021 Jul 13.

Division of Dermatology, Dell Medical School, University of Texas at Austin, Austin, Texas.

Background: Trigeminal trophic syndrome (TTS) is a rare disorder that presents as ulceration of the nasal ala, and less often ipsilateral cheek, cutaneous lip, and forehead, following damage to the trigeminal nerve. TTS is often very difficult to treat due to anesthesia and paresthesia along the distribution of the trigeminal nerve, which often leads to a large behavioral component of this disease.

Methods: In this single case report, a thermoplastic mask was sutured in place overlying the chronic ulcerations of TTS in a 57-year-old man. Read More

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How did the ancient bacterium, , cause an epidemic of chronic duodenal ulceration?

JGH Open 2021 Jun 18;5(6):636-642. Epub 2021 May 18.

Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia.

The association of with chronic duodenal ulceration was a seminal observation in the short history of gastroenterology. However, is now known to be an ancient bacterium, whereas there is persuasive evidence that the epidemic of duodenal ulceration began in the second half of the 19th century and continued into the second half of the 20th century. Possible explanations for the epidemic include genomic changes in the organism and environmental or other influences on the human host. Read More

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Treatment options for soft tissue defects in severe foot trauma in children.

J Wound Care 2021 Jun;30(6):432-438

Department of Paediatric Orthopaedic Surgery, Amiens University Hospital and Jules Verne University of Picardie, Amiens, France.

Objective: Severe foot trauma in children is a therapeutic challenge, with presence of devitalised and soiled distal tissues. Several reconstruction and covering procedures can be applied, including artificial dermis (AD), negative pressure wound therapy (NPWT), fasciocutaneous flaps and free flaps. Here, we have developed and evaluated an algorithm for treating severe foot injuries with skin defects in children. Read More

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Trophic ulcer over lateral malleolus successfully treated using a bangle for off-loading pressure.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-2. Epub 2021 Apr 23.

Department of Dermatology and Venereology, AIIMS, Bhubaneswar, Odisha, India.

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Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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[Combined use of minimally invasive methods in treatment of varicose veins in an elderly woman].

Angiol Sosud Khir 2021 ;27(1):75-81

Medical Centre of Phlebology and Lymphology "ARD-CLINIC", Krasnodar, Russia.

The authors describe herein a clinical case report regarding a 70-year-old woman presenting with lower-limb varicosity in the system of the great and small saphenous veins, aneurysmal dilatation of the proximal portion of the great saphenous vein, and an open trophic ulcer of the crus with concomitant hypertension and coronary artery disease. Given these factors, she was subjected to endovenous laser coagulation of the great and small saphenous veins, microfoam echosclerotherapy of the distal portion of the trunk of the great saphenous vein and an incompetent perforating vein of the crus, followed by complete obliteration thereof. On POD 7, she developed positive dynamics in the process of healing of the trophic ulcer, and on POD 50 the ulcer healed completely. Read More

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[Results of comprehensive conservative treatment of patients with no-option chronic limb-threatening ischaemia].

Angiol Sosud Khir 2021 ;27(1):24-32

Department of Cardiovascular Surgery, Military Central Hospital #108, Hanoi, Vietnam.

Aim: The study was aimed at comparing efficacy of conventional conservative therapy and comprehensive treatment including a plasmid VEGF-165-gene therapy drug in 'no-option' chronic limb-threatening ischaemia with different prevalence of trophic ulcers and infection during a 1-year follow-up period.

Patients And Methods: A total of 101 patients (54% being men and 46% women, mean age 69 years) with 'no-option' chronic limb-threatening ischaemia underwent comprehensive conservative treatment. They were subdivided into 4 groups according to the WIFI classification: WIFI 130 (n=38), 131 (n=23), 230 (n=16), 231 (n=24). Read More

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Unusual non-trophic ulcerations in leprosy: A case series of 17 patients.

Trop Doct 2021 Mar 15:49475521998499. Epub 2021 Mar 15.

Professor, Department of Microbiology, 76140King George's Medical University, Lucknow, India.

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley-Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. Read More

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Wiad Lek 2020 ;73(12 cz 1):2664-2666


Objective: The aim: To estimate the patients' quality of life after surgery made by the in-house devices and methods.

Patients And Methods: Materials and methods: According to the peculiarities of surgical treatment, the set of instruments used and the methods of its application during surgery, all patients were assigned into two groups: group І (comparison group, or retrospective group) involved 48 (58.5%) patients who received treatment at the Vascular Surgery Department and had contraindications to endovascular laser and radiofrequency ablation, as evidenced by ultrasonographic color angioscanning (USCAS). Read More

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February 2021

Sulodexide for Diabetic-Induced Disabilities: A Systematic Review and Meta-Analysis.

Adv Ther 2021 03 27;38(3):1483-1513. Epub 2021 Jan 27.

MATMED S.R.O., Private Angiology Facility, Hodonin, Czech Republic.

Introduction: Micro- and macrovascular complications of diabetes are leading morbidities in the world population. They are responsible not only for increased mortality but also severe disabilities, which jeopardize quality of life (e.g. Read More

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Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO).

Curr Vasc Pharmacol 2021 01 18. Epub 2021 Jan 18.

Department of Vascular Surgery, Shijingshan Hospital, Beijing. China.

Background: Thromboangiitis obliterans (TAO) is a chronic, non-atherosclerotic, progressive inflammatory vascular disease affecting the small- and medium-size arteries and veins of the extremities.

Objective: To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO.

Methods: Patients with TAO who underwent anticoagulation as the mainstay of treatment were included in this prospective study. Read More

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January 2021

Characteristics of structured medical hemostatic sponges as a medical devices for stop bleeding and for close the wound.

Pol Merkur Lekarski 2020 Dec;48(288):422-426

I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Medical sponge is a tool that has absorbent and antiseptic properties, as well as stimulates tissue regeneration and is used in surgery, neurosurgery, dentistry, otolaryngology and gynecology to stop blood loss or to close wound surfaces (burns, trophic ulcers). To summarize the information of the professional literature on medical (hemostatic) sponges, their classification and applications, the areas of their use in medical practice and also modern excipients and active pharmaceutical ingredients that can be used in their technology.

Aim: The aim of the study was to summarize data on the characteristics, classification of medical sponges, auxiliary substances and active pharmaceutical ingredients used in the technology of these agents and medical use. Read More

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December 2020

Trigeminal Trophic Syndrome as an Unusual Cause of Chronic and Non-Healing Ala Nasi Ulcer: A Case Report.

World J Plast Surg 2020 Sep;9(3):346-348

School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Trigeminal trophic syndrome is an unusual cause of facial ulcers that affects the sensitive area of the trigeminal nerve. Trigeminal trophic syndrome (TTS) is an unusual condition characterized by anesthesia, paraesthesias and ala nasi ulceration, following peripheral or central damage to the trigeminal nerve. We reported a 27-year-old man who presented with a left ala nasi ulcer accompanied by pruritus and paraesthesia for two months and one month before admission, he was a case of car accident that was admitted in ICU due to diffuse axonal injury (DAI). Read More

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September 2020

Algorithm of Medical-Surgical Treatment in the Peripheral Arterial Disease of the Diabetic Patient.

Maedica (Bucur) 2020 Sep;15(3):310-317

1st General Surgery Clinique, "I. Cantacuzino" Clinical Hospital, Bucharest, Romania.

We live in a society with a growing number of diabetics. That is why the number of diabetic patients with peripheral arterial disease is expanding, as is the number of cases of chronic ischemia, which threatens limb viability, or chronic limb-threatening ischemia (CLTI). The appearance of diabetic foot ulcers with an ischemic component represents the maximum risk of amputation in the absence of a firm and rapid revascularization intervention. Read More

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September 2020


Wiad Lek 2020 ;73(10):2150-2155


Objective: The aim: Was following: the improvement of the treatment results of the lower limbs ulcers, caused by the diabetes mellitus by using our technique of the platelet-rich plasma application; the study of the features of the morphological and immunohistochemical changes, and the effect of the growth factors of the platelet-rich plasma on the regeneration and healing of the ulcers.

Patients And Methods: Materials and methods: 38 patients with the trophic ulcers of the lower limbs, caused by diabetes mellitus were involved in the study. To assess the morphological features of the reparative processes before and after the treatment with PRP, the histological and immunohystochemical studies of the biopsy specimen of ulcers were carried out. Read More

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December 2020

[Retrograde mechanochemical ablation of the great saphenous vein in treatment of stage III chronic venous insufficiency].

Angiol Sosud Khir 2020 ;26(3):69-73

2nd Department of Surgical Diseases, Belarusian State Medical University, Minsk, Republic of Belarus.

Presented herein is a clinical case report regarding successful treatment of a trophic ulcer of the right tibia by means of endovenous mechanochemical ablation of the great saphenous vein using the FlebogrifTM device. According to ultrasonography findings, the patient was found to have insufficiency of the saphenofemoral junction, axial truncal reflux, and the absence of incompetent perforator veins in the area of trophic disorders. Taking into account the clinical and ultrasound picture of the disease, the decision was made on the feasibility of performing crossectomy and retrograde mechanochemical ablation of the great saphenous vein. Read More

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October 2020

[The effectiveness of combined laser therapy in patients with trophic leg ulcer and chronic venous insufficiency].

Vopr Kurortol Fizioter Lech Fiz Kult 2020 ;97(5):45-51

National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.

New prospects associated with the use of laser radiation of different wavelengths in the ultraviolet (365 nm) and the green emission spectrum (525 nm) have appeared in recent years. The high prevalence of the trophic leg ulcers necessitates the search for more effective methods of conservative treatment.

Purpose Of The Study: Development and scientific justification for the low-intensity laser radiation of different wavelengths combined use in patients with trophic leg ulcers and chronic venous insufficiency (CVI). Read More

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December 2020

[Trigeminal trophic syndrome : Late complication after herpes zoster infection with loss of ala nasi].

Hautarzt 2021 May;72(5):439-441

Klinik für Dermatologie, Dermatochirurgie und Allergologie, Klinikum Bremen-Mitte, Sankt-Jürgen-Str. 1, 28203, Bremen, Deutschland.

This article presents the case of refractory facial ulcers with loss of ala nasi as a rare differential diagnosis of chronic facial wounds. We diagnosed trigeminal trophic syndrome as a late complication of a herpes zoster infection. Education to avoid self-manipulation and an occlusive local therapy in combination with neuromodulating drug therapy are at the forefront of therapeutic measures. Read More

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The painless eye: Neurotrophic keratitis in a child suffering from hereditary sensory autonomic neuropathy type IV.

Indian J Ophthalmol 2020 Oct;68(10):2270-2272

Department of Pediatric Ophthalmology and Strabismus, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Hereditary sensory autonomic neuropathy (HSAN) is a group of inherited disorders (total 5 types) that are associated with sensory dysfunction and varying degrees of autonomic dysfunction. HSAN type IV (HSAN-IV) or congenital insensitivity to pain and anhidrosis (CIPA) is a rare genetic disorder inherited in an autosomal recessive manner. We report a case of this very rare genetic disease in a 3-year-old girl child, born to a family in north India with ocular features of neurotrophic keratitis. Read More

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October 2020

Evaluation of the Effect of Plasma from Patients with Trophic Ulcers on the Function of Dermal Fibroblasts, Mesenchymal Stem Cells, and Endothelial Cells.

Bull Exp Biol Med 2020 Aug 10;169(4):558-563. Epub 2020 Sep 10.

Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

We studied the effect of platelet lysate and platelet-poor plasma from patients with trophic ulcers with and without type 2 diabetes mellitus on proliferation, migration, and apoptosis of human dermal fibroblast, mesenchymal stem cells, and endothelial cells. It is shown that plasma obtained from patients with type 2 diabetes mellitus produced inhibitory effects. Read More

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3D co-culture model of endothelial colony-forming cells (ECFCs) reverses late passage adipose-derived stem cell senescence for wound healing.

Stem Cell Res Ther 2020 08 14;11(1):355. Epub 2020 Aug 14.

Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Background: Extensive passage of adipose-derived stem cells (ASCs) in vitro leads to loss of function. Endothelial colony-forming cells (ECFCs) can be isolated from adult peripheral blood. A 3D co-culture system may rescue in vitro ASC senescence. Read More

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Large Congenital Epulis: A Neonatal Tumour with Striking Appearance, but Simple Management.

Fetal Pediatr Pathol 2020 Aug 11:1-3. Epub 2020 Aug 11.

General Surgery, Government Medical College and Hospital, Nagpur, India.

Background: Congenital epulis is a benign tumor of upper gingiva. Larger lesions interfere with mouth closing and normal feeding and may obstruct airways. We present a neonate with a large epulis. Read More

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[Results of treatment with oral anticoagulants in patients with lower limb deep vein thrombosis].

Angiol Sosud Khir 2020 ;26(2):42-50

Department for General Surgery and Urology, Volgograd State Medical University of the RF Ministry of Public Health, Volgograd, Russia.

Analysed herein is the incidence rate of decompensated forms of venous insufficiency in patients who endured lower limb deep vein thrombosis and were prescribed either warfarin, rivaroxaban in therapeutic doses or rivaroxaban in a preventive dose. The study enrolled a total of 129 patients presenting with thrombotic lesions of deep veins of the lower limbs. The patients were divided into three groups depending on the anticoagulant therapy prescribed. Read More

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September 2020

[Treatment of torpid trophic ulcers in patients of the older age group.]

Adv Gerontol 2020 ;33(2):373-378

Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova str., Novosibirsk 630060, Russian Federation, e-mail:

Chronic ulcers or non-healing ulcers are more common in the elderly (20 out of 1 000 people), whose age is closer to 80 years. The application of the principles of regenerative medicine, actively developing, in the treatment of such diseases, is based on the use of both autologous blood derivatives and autologous mononuclear cells. Objective: to evaluate the effectiveness of the use of plasma enriched with platelets in the treatment of torpid ulcers of the lower extremities in patients of the older age group. Read More

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September 2020

Trigeminal trophic syndrome: an important simulator of discoid cutaneous lupus erythematosus - a case series.

Lupus 2020 Sep 26;29(10):1282-1286. Epub 2020 Jun 26.

Department of Dermatology, University of São Paulo, Brazil.

Trigeminal trophic syndrome occurs secondary to trigeminal nerve injury, leading to anaesthesia and paraesthesia, with consequent vigorous facial skin manipulation and lesion production, simulating other facial diseases such as ulcerative discoid lupus erythematosus, tumours and other artificially produced lesions. Ulceration and destruction of the ala nasi is a typical feature besides scratching end excoriations in the cutaneous segment affected. In this series, we present the features of five patients with trigeminal trophic syndrome, highlighting possible confusion with cutaneous lupus. Read More

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September 2020

Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine.

Front Immunol 2020 27;11:942. Epub 2020 May 27.

Banc de Sang i Teixits, Barcelona, Spain.

Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We have developed processes for the formulation of several CB-PRP preparations, which have different composition and attributes. Here we describe the molecular characteristics of these preparations and we make recommendations as to their most appropriate clinical application based on functional and immunomodulatory profiles. Read More

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Therapeutic needling: A novel and simple technique to treat nonhealing trophic ulcers in leprosy.

Dermatol Ther 2020 07 23;33(4):e13691. Epub 2020 Jun 23.

Department of Dermatology, All India Institute of Medical Sciences, Gorakhpur, India.

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Trigeminal Trophic Syndrome Secondary to Refractory Trigeminal Neuralgia Treated with CyberKnife® Radiosurgery.

Cureus 2020 Apr 14;12(4):e7670. Epub 2020 Apr 14.

Radiation Oncology, Cyberknife Centre, Ruber Internacional, Madrid, ESP.

Trigeminal trophic syndrome (TTS) is a rare condition in which there is the involvement of the skin innervated by branches of the trigeminal nerve. Because of an alteration in the sensory function of the trigeminal nerve, an exaggerated manipulation of the skin by the patient occurs, with secondary ulcers in the affected areas. They are usually unilateral and located mainly at the beginning of the nose wing. Read More

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In Vivo Antimicrobial and Wound-Healing Activity of Resveratrol, Dihydroquercetin, and Dihydromyricetin against , and .

Pathogens 2020 Apr 17;9(4). Epub 2020 Apr 17.

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.

An increase in the spread of antibiotic-resistant opportunistic microorganisms causes serious problems in the treatment of purulent infections, burns, and trophic ulcers. We tested the antimicrobial activity in vivo of three polyphenols, Resveratrol, Dihydroquercetin (Taxifolin), and Dihydromyricetin (Ampelopsin) from Norway spruce bark to promote the elimination of and from wounds. Purulent infection was modelled on wounds in rats infected with suspensions containing 10 CFU (colony-forming unit)/mL of pathogens. Read More

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