1,107 results match your criteria trophic ulcer

An innovative approach in the treatment of trigeminal trophic syndrome.

J Dermatolog Treat 2021 Jul 13:1-3. Epub 2021 Jul 13.

Division of Dermatology, Dell Medical School, University of Texas at Austin, Austin, Texas.

Background: Trigeminal trophic syndrome (TTS) is a rare disorder that presents as ulceration of the nasal ala, and less often ipsilateral cheek, cutaneous lip, and forehead, following damage to the trigeminal nerve. TTS is often very difficult to treat due to anesthesia and paresthesia along the distribution of the trigeminal nerve, which often leads to a large behavioral component of this disease.

Methods: In this single case report, a thermoplastic mask was sutured in place overlying the chronic ulcerations of TTS in a 57-year-old man. Read More

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How did the ancient bacterium, , cause an epidemic of chronic duodenal ulceration?

JGH Open 2021 Jun 18;5(6):636-642. Epub 2021 May 18.

Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia.

The association of with chronic duodenal ulceration was a seminal observation in the short history of gastroenterology. However, is now known to be an ancient bacterium, whereas there is persuasive evidence that the epidemic of duodenal ulceration began in the second half of the 19th century and continued into the second half of the 20th century. Possible explanations for the epidemic include genomic changes in the organism and environmental or other influences on the human host. Read More

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Treatment options for soft tissue defects in severe foot trauma in children.

J Wound Care 2021 Jun;30(6):432-438

Department of Paediatric Orthopaedic Surgery, Amiens University Hospital and Jules Verne University of Picardie, Amiens, France.

Objective: Severe foot trauma in children is a therapeutic challenge, with presence of devitalised and soiled distal tissues. Several reconstruction and covering procedures can be applied, including artificial dermis (AD), negative pressure wound therapy (NPWT), fasciocutaneous flaps and free flaps. Here, we have developed and evaluated an algorithm for treating severe foot injuries with skin defects in children. Read More

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Trophic ulcer over lateral malleolus successfully treated using a bangle for off-loading pressure.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-2. Epub 2021 Apr 23.

Department of Dermatology and Venereology, AIIMS, Bhubaneswar, Odisha, India.

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Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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[Combined use of minimally invasive methods in treatment of varicose veins in an elderly woman].

Angiol Sosud Khir 2021 ;27(1):75-81

Medical Centre of Phlebology and Lymphology "ARD-CLINIC", Krasnodar, Russia.

The authors describe herein a clinical case report regarding a 70-year-old woman presenting with lower-limb varicosity in the system of the great and small saphenous veins, aneurysmal dilatation of the proximal portion of the great saphenous vein, and an open trophic ulcer of the crus with concomitant hypertension and coronary artery disease. Given these factors, she was subjected to endovenous laser coagulation of the great and small saphenous veins, microfoam echosclerotherapy of the distal portion of the trunk of the great saphenous vein and an incompetent perforating vein of the crus, followed by complete obliteration thereof. On POD 7, she developed positive dynamics in the process of healing of the trophic ulcer, and on POD 50 the ulcer healed completely. Read More

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[Results of comprehensive conservative treatment of patients with no-option chronic limb-threatening ischaemia].

Angiol Sosud Khir 2021 ;27(1):24-32

Department of Cardiovascular Surgery, Military Central Hospital #108, Hanoi, Vietnam.

Aim: The study was aimed at comparing efficacy of conventional conservative therapy and comprehensive treatment including a plasmid VEGF-165-gene therapy drug in 'no-option' chronic limb-threatening ischaemia with different prevalence of trophic ulcers and infection during a 1-year follow-up period.

Patients And Methods: A total of 101 patients (54% being men and 46% women, mean age 69 years) with 'no-option' chronic limb-threatening ischaemia underwent comprehensive conservative treatment. They were subdivided into 4 groups according to the WIFI classification: WIFI 130 (n=38), 131 (n=23), 230 (n=16), 231 (n=24). Read More

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Unusual non-trophic ulcerations in leprosy: A case series of 17 patients.

Trop Doct 2021 Mar 15:49475521998499. Epub 2021 Mar 15.

Professor, Department of Microbiology, 76140King George's Medical University, Lucknow, India.

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley-Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. Read More

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Wiad Lek 2020 ;73(12 cz 1):2664-2666


Objective: The aim: To estimate the patients' quality of life after surgery made by the in-house devices and methods.

Patients And Methods: Materials and methods: According to the peculiarities of surgical treatment, the set of instruments used and the methods of its application during surgery, all patients were assigned into two groups: group І (comparison group, or retrospective group) involved 48 (58.5%) patients who received treatment at the Vascular Surgery Department and had contraindications to endovascular laser and radiofrequency ablation, as evidenced by ultrasonographic color angioscanning (USCAS). Read More

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February 2021

Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO).

Curr Vasc Pharmacol 2021 01 18. Epub 2021 Jan 18.

Department of Vascular Surgery, Shijingshan Hospital, Beijing. China.

Background: Thromboangiitis obliterans (TAO) is a chronic, non-atherosclerotic, progressive inflammatory vascular disease affecting the small- and medium-size arteries and veins of the extremities.

Objective: To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO.

Methods: Patients with TAO who underwent anticoagulation as the mainstay of treatment were included in this prospective study. Read More

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January 2021

Trigeminal Trophic Syndrome as an Unusual Cause of Chronic and Non-Healing Ala Nasi Ulcer: A Case Report.

World J Plast Surg 2020 Sep;9(3):346-348

School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Trigeminal trophic syndrome is an unusual cause of facial ulcers that affects the sensitive area of the trigeminal nerve. Trigeminal trophic syndrome (TTS) is an unusual condition characterized by anesthesia, paraesthesias and ala nasi ulceration, following peripheral or central damage to the trigeminal nerve. We reported a 27-year-old man who presented with a left ala nasi ulcer accompanied by pruritus and paraesthesia for two months and one month before admission, he was a case of car accident that was admitted in ICU due to diffuse axonal injury (DAI). Read More

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September 2020


Wiad Lek 2020 ;73(10):2150-2155


Objective: The aim: Was following: the improvement of the treatment results of the lower limbs ulcers, caused by the diabetes mellitus by using our technique of the platelet-rich plasma application; the study of the features of the morphological and immunohistochemical changes, and the effect of the growth factors of the platelet-rich plasma on the regeneration and healing of the ulcers.

Patients And Methods: Materials and methods: 38 patients with the trophic ulcers of the lower limbs, caused by diabetes mellitus were involved in the study. To assess the morphological features of the reparative processes before and after the treatment with PRP, the histological and immunohystochemical studies of the biopsy specimen of ulcers were carried out. Read More

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December 2020

[Retrograde mechanochemical ablation of the great saphenous vein in treatment of stage III chronic venous insufficiency].

Angiol Sosud Khir 2020 ;26(3):69-73

2nd Department of Surgical Diseases, Belarusian State Medical University, Minsk, Republic of Belarus.

Presented herein is a clinical case report regarding successful treatment of a trophic ulcer of the right tibia by means of endovenous mechanochemical ablation of the great saphenous vein using the FlebogrifTM device. According to ultrasonography findings, the patient was found to have insufficiency of the saphenofemoral junction, axial truncal reflux, and the absence of incompetent perforator veins in the area of trophic disorders. Taking into account the clinical and ultrasound picture of the disease, the decision was made on the feasibility of performing crossectomy and retrograde mechanochemical ablation of the great saphenous vein. Read More

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October 2020

[The effectiveness of combined laser therapy in patients with trophic leg ulcer and chronic venous insufficiency].

Vopr Kurortol Fizioter Lech Fiz Kult 2020 ;97(5):45-51

National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.

New prospects associated with the use of laser radiation of different wavelengths in the ultraviolet (365 nm) and the green emission spectrum (525 nm) have appeared in recent years. The high prevalence of the trophic leg ulcers necessitates the search for more effective methods of conservative treatment.

Purpose Of The Study: Development and scientific justification for the low-intensity laser radiation of different wavelengths combined use in patients with trophic leg ulcers and chronic venous insufficiency (CVI). Read More

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December 2020

[Trigeminal trophic syndrome : Late complication after herpes zoster infection with loss of ala nasi].

Hautarzt 2021 May;72(5):439-441

Klinik für Dermatologie, Dermatochirurgie und Allergologie, Klinikum Bremen-Mitte, Sankt-Jürgen-Str. 1, 28203, Bremen, Deutschland.

This article presents the case of refractory facial ulcers with loss of ala nasi as a rare differential diagnosis of chronic facial wounds. We diagnosed trigeminal trophic syndrome as a late complication of a herpes zoster infection. Education to avoid self-manipulation and an occlusive local therapy in combination with neuromodulating drug therapy are at the forefront of therapeutic measures. Read More

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Evaluation of the Effect of Plasma from Patients with Trophic Ulcers on the Function of Dermal Fibroblasts, Mesenchymal Stem Cells, and Endothelial Cells.

Bull Exp Biol Med 2020 Aug 10;169(4):558-563. Epub 2020 Sep 10.

Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

We studied the effect of platelet lysate and platelet-poor plasma from patients with trophic ulcers with and without type 2 diabetes mellitus on proliferation, migration, and apoptosis of human dermal fibroblast, mesenchymal stem cells, and endothelial cells. It is shown that plasma obtained from patients with type 2 diabetes mellitus produced inhibitory effects. Read More

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3D co-culture model of endothelial colony-forming cells (ECFCs) reverses late passage adipose-derived stem cell senescence for wound healing.

Stem Cell Res Ther 2020 08 14;11(1):355. Epub 2020 Aug 14.

Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Background: Extensive passage of adipose-derived stem cells (ASCs) in vitro leads to loss of function. Endothelial colony-forming cells (ECFCs) can be isolated from adult peripheral blood. A 3D co-culture system may rescue in vitro ASC senescence. Read More

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[Treatment of torpid trophic ulcers in patients of the older age group.]

Adv Gerontol 2020 ;33(2):373-378

Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova str., Novosibirsk 630060, Russian Federation, e-mail:

Chronic ulcers or non-healing ulcers are more common in the elderly (20 out of 1 000 people), whose age is closer to 80 years. The application of the principles of regenerative medicine, actively developing, in the treatment of such diseases, is based on the use of both autologous blood derivatives and autologous mononuclear cells. Objective: to evaluate the effectiveness of the use of plasma enriched with platelets in the treatment of torpid ulcers of the lower extremities in patients of the older age group. Read More

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September 2020

Trigeminal trophic syndrome: an important simulator of discoid cutaneous lupus erythematosus - a case series.

Lupus 2020 Sep 26;29(10):1282-1286. Epub 2020 Jun 26.

Department of Dermatology, University of São Paulo, Brazil.

Trigeminal trophic syndrome occurs secondary to trigeminal nerve injury, leading to anaesthesia and paraesthesia, with consequent vigorous facial skin manipulation and lesion production, simulating other facial diseases such as ulcerative discoid lupus erythematosus, tumours and other artificially produced lesions. Ulceration and destruction of the ala nasi is a typical feature besides scratching end excoriations in the cutaneous segment affected. In this series, we present the features of five patients with trigeminal trophic syndrome, highlighting possible confusion with cutaneous lupus. Read More

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September 2020

Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine.

Front Immunol 2020 27;11:942. Epub 2020 May 27.

Banc de Sang i Teixits, Barcelona, Spain.

Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We have developed processes for the formulation of several CB-PRP preparations, which have different composition and attributes. Here we describe the molecular characteristics of these preparations and we make recommendations as to their most appropriate clinical application based on functional and immunomodulatory profiles. Read More

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Therapeutic needling: A novel and simple technique to treat nonhealing trophic ulcers in leprosy.

Dermatol Ther 2020 07 23;33(4):e13691. Epub 2020 Jun 23.

Department of Dermatology, All India Institute of Medical Sciences, Gorakhpur, India.

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[Comprehensive treatment of indolent trophic ulcers of venous aetiology].

Angiol Sosud Khir 2020 ;26(1):62-68

Department of Surgery, Faculty of Advanced and Primary Medical Training of Specialists, Dagestan State Medical University of the RF Ministry of Public Health, Makhachkala, Russia.

Aim: The study was undertaken to evaluate efficacy of comprehensive treatment with the use of erbium laser radiation in patients suffering from venous trophic ulcers of lower limbs.

Patients And Methods: The study included a total of seventy-six 45-to-80-year-old patients. Of these, there were 43 (56. Read More

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September 2020

Ulcerative C2 neurocutaneous dysesthesia (trigeminal trophic syndrome in an alternative distribution).

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Dermatology, Oregon Health & Science University, Portland, OR.

Trigeminal trophic syndrome is an uncommon condition characterized by paresthesia, itch, and self-inflicted wounds following the trigeminal dermatome(s). Similar processes adhering to cervical nerve distributions have been reported, calling into question the specificity of trigeminal trophic syndrome for the trigeminal network. Herein, we report patient with trigeminal trophic syndrome adhering to the C2 dermatome, a previously unreported distribution. Read More

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January 2020

Effectiveness and safety of autologous platelet-rich plasma therapy with total contact casting versus total contact casting alone in treatment of trophic ulcer in leprosy: An observer-blind, randomized controlled trial.

Indian J Dermatol Venereol Leprol 2020 May-Jun;86(3):262-271

Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Background: Trophic ulcers secondary to leprosy pose a great stigma to patients and remain a challenge to the treating dermatologists. Platelet-rich plasma (PRP) introduces growth factors directly into the wound and aids in rapid healing. The role of PRP in the treatment of trophic ulcers in leprosy patients has not yet been established by randomized controlled trials. Read More

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November 2020

Trigeminal Trophic Syndrome: A Cause of Dysesthesia and Persistent Facial Ulceration.

Am J Med 2020 06 22;133(6):685-686. Epub 2020 Jan 22.

Division of Dermatology, University of Louisville, Louisville, Ky.

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Efficacy of Topical Insulin Therapy for Chronic Trophic Ulcers in Patients with Leprosy: A Randomized Interventional Pilot Study.

Adv Skin Wound Care 2020 Feb;33(2):1-6

Mehak Singh, MD, is in private practice in Bhopal, Madhyapradesh, India. Manoj Pawar, MD, is Assistant Professor, Department of Dermatology, Dr Vasantrao Pawar Medical College, Nashik, India. Acknowledgments: This study investigated the use of topical insulin, which is not FDA approved for topical use. The authors have disclosed no financial relationships related to this article. Submitted December 17, 2018; accepted in revised form July 9, 2019.

Background: Chronic trophic ulcers (CTUs), especially those located over the plantar region, are a leading cause of deformity and disability in patients with leprosy. Despite the various treatment modalities available, CTUs can be chronic and refractory to treatment. The successful use of topical insulin in various types of wounds led researchers to evaluate its safety and efficacy in the treatment of plantar CTUs. Read More

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February 2020

Trigeminal Trophic Syndrome Secondary to Meningioma Recurrence.

Actas Dermosifiliogr (Engl Ed) 2020 Mar 23;111(2):171-173. Epub 2019 Dec 23.

Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, España.

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Trigeminal trophic syndrome: Strange evolution of maxillofacial surgery.

EXCLI J 2019 16;18:931-935. Epub 2019 Oct 16.

Department of Surgical Sciences, Paediatrics and Gynecology, University of Verona, Policlinico G. B. Rossi. Piazzale L. Scuro n.10, 37134. Verona, Italy.

Trigeminal trophic syndrome (TTS) is a rare facial/cranial affection that arises in ulcerations, itch and paresthesia. Etiology is debated, however trigeminal nerve damage seems to be frequent in pathogenetic patterns. The disease may affect any region innervated by the trigeminal nerve, especially the maxillary branch. Read More

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October 2019

HbA1C as a marker of retrograde glycaemic control in diabetes patient with co-existed beta-thalassaemia: A case report and a literature review.

J Clin Pharm Ther 2020 Apr 17;45(2):379-383. Epub 2019 Nov 17.

Laboratory for Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.

What Is Known And Objective: The HbA1C marker used in assessing diabetes control quality is not sufficient in diabetes patients with thalassaemia.

Case Description: A male diabetic patient with thalassaemia was hospitalized due to distal neuropathic pain, right toe trophic ulcer, unacceptable five-point glycaemic profile and recommended HbA1C value. After simultaneously initiated insulin therapy and management of ulcer by hyperbaric oxygen, the patient showed improved glycaemic control and ulcer healing, which led to the patient's discharge. Read More

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