11,641 results match your criteria triggering factors


Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study.

Int J Cardiol 2021 Sep 14. Epub 2021 Sep 14.

Sorbonne Université, Université Pierre et Marie Curie site St Antoine, F-75012 Paris, France; FACT (French Alliance for CV clinical Trials), F-CRIN Network, Inserm U-1148, Paris, France; Hôpitaux de Paris, Clinical Pharmacology Department, Plateforme de Recherche Clinique de L'Est Parisien (URCEST-CRCEST-CRBHUEP-SU), Hôpital Saint Antoine, Paris, France.

Introduction: Triggering receptor expressing on myeloid cells (TREM)-1 is involved in the pathophysiology of ischemic heart disease. Plasma soluble TREM-1 levels (sTREM-1) has been associated with increased risk of major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients. However, the causative link between TREM-1 and MACE remains unknown and requires further investigation before developing potential therapeutic approaches. Read More

View Article and Full-Text PDF
September 2021

[Definition of tumor rupture in gastrointestinal stromal tumor].

Authors:
Y B Zhou

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Sep;24(9):762-768

Department of Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Tumor rupture is a common clinical event in the process of tumorigenesis, progression, diagnosis and treatment of gastrointestinal stromal tumor, which is closely associated with tumor recurrence, metastasis and poor prognosis. Tumor rupture may be associated with some intrinsic biological aggressiveness qualities, such as large tumor size, high mitotic count, and KIT exon 11 deletion mutations involving codons 557 and 558, and may be relatively more frequent with small intestine GIST and excellent response to imatinib neoadjuvant therapy resulting in tumor tissue rapid liquefacient and necrosis. The triggering factors involve sudden increase in abdominal pressure, external pressure, collision and improper surgical operation, etc. Read More

View Article and Full-Text PDF
September 2021

The Effectiveness of Diet Restriction in Elderly with Migraine.

Noro Psikiyatr Ars 2021 7;58(3):217-220. Epub 2020 Jan 7.

Department of Neurology, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey.

Introduction: Migraine type headache is a type of pain with a high socioeconomic burden that limits the activities of daily life of individuals of all ages. The pathogenesis is not fully understood. There are a lot of migraine's trigger factors and foods are one of them. Read More

View Article and Full-Text PDF
January 2020

Current Concepts in Capsular Contracture: Pathophysiology, Prevention, and Management.

Semin Plast Surg 2021 Aug 13;35(3):189-197. Epub 2021 Jul 13.

Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada.

Over 400,000 women in the United States alone will have breast implant surgery each year. Although capsular contracture represents the most common complication of breast implant surgery, surgeons continue to debate the precise etiology. General agreement exists concerning the inflammatory origin of capsular fibrosis, but the inciting events triggering the inflammatory cascade appear to be multifactorial, making it difficult to predict why one patient may develop capsular contracture while another will not. Read More

View Article and Full-Text PDF

Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy.

Blood Purif 2021 Sep 15:1-7. Epub 2021 Sep 15.

Department of Nephrology, Ghent University Hospital, Ghent, Belgium.

Introduction: Hyperlactatemia is a regular condition in the intensive care unit, which is often associated with adverse outcomes. Control of the triggering condition is the most effective treatment of hyperlactatemia, but since this is mostly not readily possible, extracorporeal renal replacement therapy (RRT) is often tried as a last resort. The present study aims to evaluate the factors that may contribute to the decision whether to start RRT or not and the potential impact of the start of RRT on the outcome in patients with severe lactic acidosis (SLA) (lactate ≥5 mmol/L). Read More

View Article and Full-Text PDF
September 2021

Cross-Seeded Fibrillation Induced by Pyroglutamate-3 and Truncated Aβ Variants Leads to Aβ Structural Polymorphism Modulation and Elevated Toxicity.

ACS Chem Neurosci 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Binghamton University, State University of New York, Binghamton, New York 13902, United States.

The pathological amyloid plaques in Alzheimer's disease (AD) patients contain not only the wild-type β-amyloid (wt-Aβ) peptide sequences but also a variety of post-translationally modified variants. The pyroglutamate-3 Aβ (pyroE3-Aβ), which is generated from its truncated precursors ΔE3-Aβ, shows the highest abundance among all modified Aβ variants. Previous works have shown that pyroE3-Aβ and/or ΔE3-Aβ, compared with the wild-type sequences, led to a more rapid fibrillation process and final fibrils with higher neuronal cytotoxicity levels. Read More

View Article and Full-Text PDF
September 2021

Reporting at Least One Adverse Effect Post-COVID-19 Vaccination From Primary Health Care in Muscat.

Cureus 2021 Aug 10;13(8):e17055. Epub 2021 Aug 10.

Medicine, Al Nahdha Hospital, Muscat, OMN.

Introduction Vaccinations against COVID-19 were licensed with limited testing assurances to the public triggering a widespread hesitancy around expected adverse reactions. Limited data was reported from Arabian Gulf countries on vaccine adverse effects. Objectives This study looked at the rate of reporting at least one side effect post-COVID-19 vaccination and its associated factors (sociodemographic characteristics, clinical condition, and type of vaccines). Read More

View Article and Full-Text PDF

FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication.

Cell Chem Biol 2021 Sep 11. Epub 2021 Sep 11.

Natural Science Division, Ochanomizu University, Bunkyō-ku, Tokyo 112-8610, Japan; Institute for Human Life Innovation, Faculty of Core Research, Ochanomizu University, Bunkyō-ku, Tokyo 112-8610, Japan.

The metabolic oxidative degradation of cellular lipids severely restricts replication of hepatitis C virus (HCV), a leading cause of chronic liver disease, but little is known about the factors regulating this process in infected cells. Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2). Genetic depletion and ectopic expression experiments show FADS2 is a key determinant of cellular sensitivity to ferroptosis. Read More

View Article and Full-Text PDF
September 2021

Ultrasound-Guided Meniscal Injection of Autologous Growth Factors: A Brief Report.

Cartilage 2021 Sep 13:19476035211037390. Epub 2021 Sep 13.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Meniscal degeneration is a common finding even in young patients' knees, and it is regarded as a predictor for the onset of early osteoarthritis (OA). When symptomatic, it represents a challenge since arthroscopic surgery provides unpredictable results: recent evidence has shown that partial meniscectomy is not better than conservative management up to 2 years of follow-up, and the removal of meniscal tissue may accelerate OA progression toward OA. Intra-articular injection of corticosteroids or hyaluronic acid may help in providing temporary symptomatic relief, but no influence should be expected on the quality of the meniscal tissue. Read More

View Article and Full-Text PDF
September 2021

Childhood Vaccinations and Type 1 Diabetes.

Front Immunol 2021 26;12:667889. Epub 2021 Aug 26.

Paediatric Clinic, Department of Medicine and Surgery, University Hospital, University of Parma, Parma, Italy.

Type 1 diabetes (T1D) is the most common paediatric endocrine disease, and its frequency has been found to increase worldwide. Similar to all conditions associated with poorly regulated glucose metabolism, T1D carries an increased risk of infection. Consequently, careful compliance by T1D children with schedules officially approved for child immunization is strongly recommended. Read More

View Article and Full-Text PDF

Coronavirus Disease 2019 Emergency and Remote Eye Movement Desensitization and Reprocessing Group Therapy With Adolescents and Young Adults: Overcoming Lockdown With the Butterfly Hug.

Front Psychol 2021 25;12:701381. Epub 2021 Aug 25.

Association EMDR Italy, Varedo, Italy.

The coronavirus disease 2019 (COVID-19) pandemic has represented an individual and collective trauma with an impact on mental health. Restrictive measures such as lockdowns have increased risk factors for the development or triggering of various psychopathologies. Timely psychological intervention has constituted a protective factor that has been indicated as a form of prevention. Read More

View Article and Full-Text PDF

Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!

Cell Mol Neurobiol 2021 Sep 12. Epub 2021 Sep 12.

CNC - Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Rua Larga, Polo I, 1st Floor, 3004-504, Coimbra, Portugal.

Oxygen sensing and homeostasis is indispensable for the maintenance of brain structural and functional integrity. Under low-oxygen tension, the non-diseased brain has the ability to cope with hypoxia by triggering a homeostatic response governed by the highly conserved hypoxia-inducible family (HIF) of transcription factors. With the advent of advanced neuroimaging tools, it is now recognized that cerebral hypoperfusion, and consequently hypoxia, is a consistent feature along the Alzheimer's disease (AD) continuum. Read More

View Article and Full-Text PDF
September 2021

Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases.

Front Pharmacol 2021 24;12:745061. Epub 2021 Aug 24.

Institute of Clinical Research, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang, China.

Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. Read More

View Article and Full-Text PDF

Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.

Nature 2021 Sep 8. Epub 2021 Sep 8.

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in large part by triggering macrophage phagocytosis of cancer cells. However, cancer cells evade phagocytosis using mechanisms that are incompletely understood. Here we develop a platform for unbiased identification of factors that impede antibody-dependent cellular phagocytosis (ADCP) using complementary genome-wide CRISPR knockout and overexpression screens in both cancer cells and macrophages. Read More

View Article and Full-Text PDF
September 2021

Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice.

Front Aging Neurosci 2021 20;13:716917. Epub 2021 Aug 20.

Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, United States.

Growing evidence suggests that hypertension and aging are prominent risk factors for the development of late-onset Alzheimer's disease (LOAD) by inducement of neuroinflammation. Recent study showed that neuroinflammation activated microglia induces reactive astrocytes, termed A1 astrocytes, that highly upregulate numerous classical complement cascade genes that are destructive to neurons in neurodegeneration diseases. Moreover, triggering receptor expressed on myeloid cells 2 (TREM2) is considered as one of the strongest single-allele genetic risk factors and plays important roles in neuroinflammation for LOAD. Read More

View Article and Full-Text PDF

Translational Research Studies Unraveling the Origins of Psoriatic Arthritis: Moving Beyond Skin and Joints.

Front Med (Lausanne) 2021 17;8:711823. Epub 2021 Aug 17.

Department of Rheumatology & Clinical Immunology, Amsterdam Institute for Infection & Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Patients with psoriatic arthritis (PsA) are suffering from a decreased quality of life despite currently available treatments. In the latest years, novel therapies targeting the IL-17/IL-23 and TNF pathways improved clinical outcome. Despite this, remission of disease is not achieved in a considerable group of patients, continuous treatment is very often required to reach clinical remission, and prevention of PsA in patients with psoriasis (PsO) is currently impossible. Read More

View Article and Full-Text PDF

May predator body-size hamper furtive predation strategy by aphidophagous insects?

PLoS One 2021 2;16(9):e0256991. Epub 2021 Sep 2.

Laboratoire de lutte biologique, Département des sciences biologiques, Université du Québec à Montréal, Montréal, Canada.

Furtive predation is an uncommon predation strategy within aphidophagous insects, as it can be constrained by several factors. So far, the few reported furtive predators are characterized by their small body-size, vermiform shape, and slow movement. They live within the aphid colonies, without triggering significant defensive acts, nor disrupting colony structure. Read More

View Article and Full-Text PDF
September 2021

Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy.

Autophagy 2021 Sep 1:1-3. Epub 2021 Sep 1.

Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.

A progressive decline in the macroautophagic/autophagic flux is a hallmark of pancreatic β-cell failure in type 2 diabetes (T2D) but the responsible intrinsic factors and underlying molecular mechanisms are incompletely understood. A stress-sensitive multicomponent cellular loop of the Hippo pathway kinase LATS2 (large tumor suppressor 2), MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1) and autophagy regulates β-cell survival and metabolic adaptation. Chronic metabolic stress leads to LATS2 hyperactivation which then induces MTORC1, subsequently impairing the cellular autophagic flux and consequently triggering β-cell death. Read More

View Article and Full-Text PDF
September 2021

Exploring the experiences of nurses' moral distress in long-term care of older adults: a phenomenological study.

BMC Nurs 2021 Aug 31;20(1):156. Epub 2021 Aug 31.

Nursing Division, School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia.

Background: Moral distress is a poorly defined and frequently misunderstood phenomenon, and little is known about its triggering factors during ICU end-of-life decisions for nurses in Iran. This study aimed to explore the experiences of nurses' moral distress in the long-term care of older adults via a phenomenological study.

Methods: A qualitative, phenomenological study was conducted with 9 participants using in-depth semi-structured interviews. Read More

View Article and Full-Text PDF

Protective Effect of Sirt1 against Radiation-Induced Damage.

Radiat Res 2021 Aug 30. Epub 2021 Aug 30.

Department of Oncology, Institute of Integrative Oncology, Tianjin Union Medical Center of Nankai University, Tianjin, P.R. China.

Radiotherapy is an important method for the treatment of malignant tumors. It can directly or indirectly lead to the formation of free radicals and DNA damage, resulting in a series of biological effects, including tumor cell death and normal tissue damage. These radiation effects are typically accompanied by the abnormal expression of sirtuin 1 (Sirt1), which deacetylates histones and non-histones. Read More

View Article and Full-Text PDF

Personalising add-on treatment with inhaled corticosteroids in patients with chronic obstructive pulmonary disease: a benefit-harm modelling study.

Lancet Digit Health 2021 Aug 24. Epub 2021 Aug 24.

Department of Epidemiology, Epidemiology, Biostatistics, and Prevention Institute, University of Zurich, Zurich, Switzerland. Electronic address:

Background: Since the benefit-harm balance of adding inhaled corticosteroids to long-acting β-agonists (LABA) and long-acting muscarinic antagonists (LAMA) for patients with chronic obstructive pulmonary disease is unclear, we evaluated this addition for a range of patient profiles.

Methods: Analyses considered the effects of low-to-moderate doses of inhaled corticosteroids, LABA, and LAMA compared with LABA and LAMA alone, outcome incidences, and preference weights assigned to averted moderate-to-severe exacerbations (benefit) and severe pneumonia, candidiasis, and dysphonia (harm). Using exponential models, we estimated the preference weight-adjusted 2-year net clinical benefit (ie, benefits outweighing harms) indices. Read More

View Article and Full-Text PDF

A Systematic Review of Severe Neurological Manifestations in Pediatric Patients with Coexisting SARS-CoV-2 Infection.

Neurol Int 2021 Aug 17;13(3):410-427. Epub 2021 Aug 17.

Department of Microbiology, Immunology and Pharmacology, School of Medicine, St. George's University, St. George, Grenada.

SARS-CoV-2 infection in children produces mild respiratory symptoms or no symptoms at all in most cases. Some pediatric patients develop a severe complication associated with high mortality, the multisystem inflammatory syndrome in children (MIS-C). In both scenarios, there are reports of neurological manifestations. Read More

View Article and Full-Text PDF

Amniotic membrane conditioned medium (AMCM) reduces inflammatory response on human limbal myofibroblast, and the potential role of lumican.

Mol Vis 2021 15;27:370-383. Epub 2021 Jun 15.

Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.

Purpose: Viral infections such as herpetic keratitis (HSK) activate the innate immune response in the cornea triggering opacity and loss of vision. This condition is performed mainly by myofibroblasts that exacerbate secretion of inflammatory cytokines. Amniotic membrane transplantation (AMT) reduces ocular opacity and scarring inhibiting secretion of inflammatory cytokines and proliferation of myofibroblasts. Read More

View Article and Full-Text PDF

Signaling Pathways and Downstream Effectors of Host Innate Immunity in Plants.

Int J Mol Sci 2021 Aug 21;22(16). Epub 2021 Aug 21.

Department of Botany, Dyal Singh College, University of Delhi, Delhi 110003, India.

Phytopathogens, such as biotrophs, hemibiotrophs and necrotrophs, pose serious stress on the development of their host plants, compromising their yields. Plants are in constant interaction with such phytopathogens and hence are vulnerable to their attack. In order to counter these attacks, plants need to develop immunity against them. Read More

View Article and Full-Text PDF

The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.

Int J Mol Sci 2021 Aug 16;22(16). Epub 2021 Aug 16.

University of Coimbra, Faculty of Sport Sciences and Physical Education, Coimbra Institute for Clinical and Biomedical Research, 3004-504 Coimbra, Portugal.

(1) Background: One mechanism through which physical activity (PA) provides benefits is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4/5), in response to exercise, is not fully understood. Therefore, the aim was to provide an updated overview on the neurotrophin (NT) variation levels of BDNF and NT-4/5 as a consequence of a long-term aerobic exercise intervention, and to understand and describe whether the upregulation of circulating NT levels is a result of neurotrophic factors produced and released from the brain, and/or from neurotrophic secreting peripheral organs. Read More

View Article and Full-Text PDF

Coordinating DNA Replication and Mitosis through Ubiquitin/SUMO and CDK1.

Int J Mol Sci 2021 Aug 16;22(16). Epub 2021 Aug 16.

Centre for Molecular Biology Severo Ochoa (CBMSO, CSIC-UAM), Chromatin, Cancer and the Ubiquitin System Lab, Department of Genome Dynamics and Function, 28049 Madrid, Spain.

Post-translational modification of the DNA replication machinery by ubiquitin and SUMO plays key roles in the faithful duplication of the genetic information. Among other functions, ubiquitination and SUMOylation serve as signals for the extraction of factors from chromatin by the AAA ATPase VCP. In addition to the regulation of DNA replication initiation and elongation, we now know that ubiquitination mediates the disassembly of the replisome after DNA replication termination, a process that is essential to preserve genomic stability. Read More

View Article and Full-Text PDF

Analysis of Signaling Activity in Psoriasis.

Int J Mol Sci 2021 Aug 10;22(16). Epub 2021 Aug 10.

Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia.

In our previous work, we built the model of dependent pathways involved in the development of the psoriatic lesions. Peroxisome proliferator-activated receptor gamma () is a nuclear receptor and transcription factor which regulates the expression of many proinflammatory genes. We tested the hypothesis that low levels of expression promote the development of psoriatic lesions triggering the -related signaling cascade. Read More

View Article and Full-Text PDF

Cytosine-Rich DNA Fragments Covalently Bound to Carbon Nanotube as Factors Triggering Doxorubicin Release at Acidic pH. A Molecular Dynamics Study.

Int J Mol Sci 2021 Aug 6;22(16). Epub 2021 Aug 6.

Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, ul. Niezapominajek 8, 30239 Cracow, Poland.

This works deals with analysis of properties of a carbon nanotube, the tips of which were functionalized by short cytosine-rich fragments of ssDNA. That object is aimed to work as a platform for storage and controlled release of doxorubicin in response to pH changes. We found that at neutral pH, doxorubicin molecules can be intercalated between the ssDNA fragments, and formation of such knots can effectively block other doxorubicin molecules, encapsulated in the nanotube interior, against release to the bulk. Read More

View Article and Full-Text PDF

Migraine and Its Association with Hyperactivity of Cell Membranes in the Course of Latent Magnesium Deficiency-Preliminary Study of the Importance of the Latent Tetany Presence in the Migraine Pathogenesis.

Nutrients 2021 Aug 5;13(8). Epub 2021 Aug 5.

Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, 01-809 Warsaw, Poland.

So far, there is no consistent and convincing theory explaining the pathogenesis of migraines. Vascular disorders, the effect of oxidative stress on neurons, and the contribution of magnesium-calcium deficiencies in triggering cortical depression and abnormal glutaminergic neurotransmission are taken into account. However, there are no reliable publications confirming the role of dietary deficits of magnesium and latent tetany as factors triggering migraine attacks. Read More

View Article and Full-Text PDF