Biochem Biophys Res Commun 2020 12 22;533(4):1464-1469. Epub 2020 Oct 22.
The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510510, China; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:
Ferroptosis is a type of non-apoptotic regulated cell death that involves excessive iron accumulation and subsequent lipid peroxidation. Although the antioxidant mechanisms of ferroptosis have been extensively studied recently, little is known about the interactions between the different organelles that control ferroptosis. Here, we show that the translocation of lysosomal cysteine protease cathepsin B (CTSB) into the nucleus is an important molecular event that mediates organelle-specific initiation of ferroptosis in human pancreatic cancer cells. Read More