300 results match your criteria triamcinolone vascularization


Combination therapy of refractory keloid with ultrapulse fractional carbon dioxide (CO ) laser and topical triamcinolone in Asians-long-term prevention of keloid recurrence.

Dermatol Ther 2020 11 12;33(6):e14359. Epub 2020 Oct 12.

Department of Burn and Plastic Surgery, Fourth Center of Chinese People's Liberation Army General Hospital, Beijing, China.

Keloid often recur after treatment, and recent studies in keloid management favor the combination therapy of laser-assisted drug delivery over monotherapy. Unfortunately, the previous researches lack long-term follow-up. In this prospective study, 41 individuals with refractory keloids underwent eight treatment sessions at 4 weeks intervals consisting of ultrapulse fractional carbon dioxide laser (UFCL), followed by postoperative application topical triamcinolone acetonide (40 mg/ml). Read More

View Article and Full-Text PDF
November 2020

Inferior and Intra-/Peri-Articular Superior Sacroiliac Joint Injection Approaches Under Ultrasound Guidance to Treat Metastasis-Related Posterior Pelvic Bone Pain.

Pain Pract 2020 09 12;20(7):769-776. Epub 2020 May 12.

Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

Background: Numerous mechanical and pathologic variables contribute to sacroiliac joint (SIJ) pain. The oncologic population has additional considerations, including tumor burden causing fracture, nerve compression, joint instability, and periosteal inflammation. Post-treatment changes may also restrict joint mobility, causing transitional pain. Read More

View Article and Full-Text PDF
September 2020

Chitosan coated liposomes (CCL) containing triamcinolone acetonide for sustained delivery: A potential topical treatment for posterior segment diseases.

Int J Biol Macromol 2020 Jan 20;143:483-491. Epub 2019 Nov 20.

Department of Industrial Biotechnology, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, Pakistan. Electronic address:

Drug delivery to the posterior eye is limited by epithelial and mucosal barriers limiting the topical administration of drugs leading to invasive modes of repeated long-term painful administration of drugs. Several constructs of liposomes have been prepared to counter this challenge yet are often limited by size and surface charge resulting in poor encapsulation efficiency, low retention time, and poor permeability. In the present study, chitosan coated liposomes (CCL) were prepared to address these challenges. Read More

View Article and Full-Text PDF
January 2020

Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study.

Dermatol Ther 2019 03 29;32(2):e12781. Epub 2019 Jan 29.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Cutaneous injury can ignite excessive fibroproliferative growth that results in keloid formation. Keloids are associated with significant morbidity related to disfigurement and/or symptoms (e.g. Read More

View Article and Full-Text PDF

Rare Complication of Sclerochoroidal Calcifications.

JAMA Ophthalmol 2019 01;137(1):111-112

Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina.

View Article and Full-Text PDF
January 2019

Periocular triamcinolone acetonide injection for treating polypoidal choroidal vasculopathy concurrent with hemorrhagic retinal detachment.

Medicine (Baltimore) 2018 Sep;97(39):e12464

Department of Ophthalmology, Hainan General Hospital, Haikou, China.

To investigate the clinical efficiency of periocular triamcinolone acetonide (TA) injection for treating polypoidal choroidal vasculopathy (PCV) concurrent with hemorrhagic retinal detachment (HRD).Twenty-two cases confirmed with PCV concurrent with HRD characterized by massive subretinal hemorrhage and exudation presented to our department from January 2015 to May 2017 were included in this study. The initial vision varied from counting finger to 0. Read More

View Article and Full-Text PDF
September 2018

Usnic acid inhibits hypertrophic scarring in a rabbit ear model by suppressing scar tissue angiogenesis.

Biomed Pharmacother 2018 Dec 20;108:524-530. Epub 2018 Sep 20.

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address:

Hypertrophic scarring is a common condition in the Chinese population; however, there are currently no satisfactory drugs to treat the disorder. Previous studies showed that angiogenesis plays an important role in the early phase of hypertrophic scarring and inhibition of angiogenesis has been reported as an effective strategy for anti-hypertrophic scar therapy. A recent study showed that usnic acid (UA), an active compound found mainly in lichens, inhibited tumor angiogenesis both in vivo and in vitro. Read More

View Article and Full-Text PDF
December 2018

Treatment Effects in Retinal Angiomatous Proliferation Imaged with OCT Angiography.

Ophthalmologica 2019 18;241(3):143-153. Epub 2018 Sep 18.

Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands,

Purpose: This prospective case series is aimed at exploring optical coherence tomographic angiography (OCT-A) as a treatment monitoring tool in patients treated for retinal angiomatous proliferation (RAP).

Methods: Twelve treatment-naïve RAP patients were included, with a median age of 79 years (range 65-90). Patients were imaged with an experimental 1,040-nm swept-source phase-resolved OCT-A instrument before and after treatment. Read More

View Article and Full-Text PDF

Healing modulation in glaucoma surgery after application of subconjunctival triamcinolone acetate alone or combined with mitomycin C: an experimetal study.

Rev Col Bras Cir 2018 Jul 30;45(4):e1861. Epub 2018 Jul 30.

Universidade Federal de Minas Gerais, Departamento de Oftalmologia, Belo Horizonte, MG, Brasil.

Objective: to study the efficacy and safety of the use of subconjunctival triamcinolone acetate alone or in combination with mitomycin C as a modulator of trabeculectomy healing in rabbits.

Methods: we submitted thirty male, albino, New Zealand rabbits to bilateral trabeculectomy. We divided the animals into four experimental groups with 15 eyes per group: control, mitomycin C, triamcinolone acetate and triamcinolone acetate + mitomycin C. Read More

View Article and Full-Text PDF

A new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective study.

Eur J Plast Surg 2018 8;41(1):69-80. Epub 2017 Jun 8.

1Department of Plastic Surgery, Maastricht University Medical Center, P Debyelaan 25, 6229HX Maastricht, The Netherlands.

Background: Since the management of keloid and hypertrophic scars still remains a difficult clinical problem, there is need for adequate, effective therapy. In this study, we explored for the first time the efficacy and the potential synergetic effect of combined triamcinolone and verapamil for the treatment of hypertrophic and keloid scars. The objective was to assess the efficacy of combined intralesional triamcinolone and verapamil therapy for hypertrophic and keloid scars. Read More

View Article and Full-Text PDF

Comparison of Enalapril, Candesartan and Intralesional Triamcinolone in Reducing Hypertrophic Scar Development: An Experimental Study.

Aesthetic Plast Surg 2018 Apr 18;42(2):352-361. Epub 2018 Jan 18.

Department of Internal Diseases, Faculty of Veterinary Medicine, Yuzuncu Yıl University, Van, Turkey.

Background: The purpose of this study was to compare the effects of oral enalapril, an angiotensin-converting enzyme inhibitor (ACE-I), oral candesartan, an angiotensin receptor blocker (ARB), and intralesional corticosteroid treatments in reducing scar formation.

Methods: Twenty male rabbits were divided into five study groups: A (sham), B (control), C (ACE-I), D (ARB) and E (intralesional corticosteroid). The rabbit ear hypertrophic scar model was used. Read More

View Article and Full-Text PDF

CLINICAL FINDINGS IN TRIAMCINOLONE-ASSOCIATED MACULOPATHY.

Retina 2019 Apr;39(4):761-765

Department of Ophthalmology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Purpose: To describe a crystalline retinopathy observed in patients greater than 1 year after intravitreal injection of triamcinolone acetonide (IVTA).

Methods: A retrospective, interventional, noncomparative, single-center case series of patients who received IVTA and developed subsequent crystalline retinopathy lasting greater than 1 year after injection.

Results: Eighteen eyes of 16 patients in which preretinal crystals were observed >1 year after IVTA were included in the study, with a mean follow-up (range) of 5. Read More

View Article and Full-Text PDF

Incidence of anterior segment neovascularization during intravitreal treatment for macular edema secondary to central retinal vein occlusion.

Arq Bras Oftalmol 2017 Mar-Apr;80(2):97-103

Department of Ophthalmology, Universidade Federal de São Paulo, SP, Brazil.

Purpose:: To analyze the effects of injections of intravitreal triamcinolone acetonide (IVTA) and intravitreal bevacizumab (IVB) on the incidence rates of anterior segment neovascularization (ASN) and neovascular glaucoma (NVG) in patients with macular edema secondary to central retinal vein occlusion (CRVO).

Methods:: In this prospective, randomized, double-masked, sham-controlled study, 35 patients with macular edema following CRVO were randomized to intravitreal bevacizumab, intravitreal triamcinolone acetonide, or sham injections during the first 6 months of the study. The primary outcome was the incidence rate of ASN at month 6. Read More

View Article and Full-Text PDF
September 2017

A Case of Diabetic Macular Edema with Improvement in Severity of Diabetic Retinopathy following Frequent Anti-Vascular Endothelial Growth Factor Treatment.

Nippon Ganka Gakkai Zasshi 2017 May;121(5):425-30

Background: Intravitreal anti-vascular endothelial growth factor (VEGF) drug injections are the gold standard for the treatment of diabetic macular edema (DME). We report a case of DME in which frequent anti-VEGF treatment resulted in improvement of diabetic retinopathy. Case: A 73-year old woman with DME who had previously undergone bilateral posterior subtenon injections of triamcinolone acetonide and vitrectomy OD presented at Kyushu University Hospital. Read More

View Article and Full-Text PDF

Effects of DMSO on a rabbit ear hypertrophic scar model: A controlled randomized experimental study.

J Plast Reconstr Aesthet Surg 2017 Apr 23;70(4):509-517. Epub 2017 Jan 23.

Kirikkale University, Vocational High School of Health Services, Department of Medical Services and Techniques, Kirikkale, Turkey.

Dimethyl sulfoxide (DMSO) is an anti-inflammatory, antibacterial, analgesic drug widely used to treat several diseases as reported in the literature. It has a detractive effect on collagen deposition in the abnormal tissue. This study aimed to investigate the possible therapeutic effects of DMSO on hypertrophic scar formation in rabbits. Read More

View Article and Full-Text PDF

Vision Preservation in Eyes of Polypoidal Choroidal Vasculopathy with Low-Dose Intravitreal Triamcinolone Acetonide.

J Ocul Pharmacol Ther 2017 Jan/Feb;33(1):42-49. Epub 2016 Dec 19.

1 Cathay General Hospital , Taipei, Taiwan .

Purpose: To evaluate the efficacy and adverse effects of using low-dose intravitreal triamcinolone acetonide (IVTA) to preserve vision in polypoidal choroidal vasculopathy (PCV) eyes.

Methods: This retrospective chart review study examined 8 eyes of 7 PCV patients, for whom verteporfin photodynamic therapy (vPDT) or antivascular endothelial growth factor (VEGF) therapy was not affordable/available and also with intolerable risk because of underlying cardiovascular and/or cerebrovascular ischemia. Low-dose IVTA (1 mg/0. Read More

View Article and Full-Text PDF
November 2017

RETINAL ANGIOMATOUS PROLIFERATION CASE REPORT.

Rom J Ophthalmol 2015 Jul-Sep;59(3):167-71

The diagnosis of RAP is similar with the diagnosis of the AMD, but PED, exudate and superficial hemorrhages are more common in RAP. A 75-year-old male presented himself at the Ophthalmology Department of the Emergency County Hospital in Craiova in January 2015, with a 4 months history of vision loss. In his right eye the visual acuity was 4/50 eye non-optical correctable and 5/5 with optical correction in the left eye. Read More

View Article and Full-Text PDF

Treatment for Macular Telangiectasia Type 2.

Dev Ophthalmol 2016 26;55:189-95. Epub 2015 Oct 26.

Macular telangiectasia (MacTel) type 2 is a bilateral disease of unknown cause with localized retinal degeneration and characteristic changes of the retinal vasculature. Funduscopic findings include reduced retinal transparency, crystalline deposits, ectatic capillaries, blunted venules, retinal pigment plaques, foveal atrophy and neovascular complexes. Leakage of telangiectatic macular capillaries is a characteristic finding on fluorescein angiography, and neurosensory atrophy may be present on optical coherence tomography images. Read More

View Article and Full-Text PDF

The Vitreomacular Interface in Diabetic Retinopathy.

J Ophthalmol 2015 3;2015:392983. Epub 2015 Sep 3.

Department of Ophthalmology, University of Arizona Medical Center, Tucson, AZ 85711, USA.

Diabetic retinopathy (DR) is a leading health concern and a major cause of blindness. DR can be complicated by scar tissue formation, macular edema, and tractional retinal detachment. Optical coherence tomography has found that patients with DR often have diffuse retinal thickening, cystoid macular edema, posterior hyaloid traction, and tractional retinal detachment. Read More

View Article and Full-Text PDF
October 2015

The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.

Sci Rep 2015 Apr 30;5:9898. Epub 2015 Apr 30.

Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.

Hypoxic stress is a risk factor of ocular neovascularization. Hypoxia visualization may provide clues regarding the underlying cause of angiogenesis. Recently, we developed a hypoxia-specific probe, protein transduction domain-oxygen-dependent degradation domain-HaloTag-Rhodamine (POH-Rhodamine). Read More

View Article and Full-Text PDF

Severe intraocular pressure response to periocular or intravitreal steroid treatment in Australia and New Zealand: data from the Australian and New Zealand Ophthalmic Surveillance Unit.

Clin Exp Ophthalmol 2015 Apr 8;43(3):234-8. Epub 2014 Oct 8.

Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.

Background: Increase in intraocular pressure is a recognized complication of corticosteroid treatment via intravitreal or periocular injections for treatment of a range of conditions including macular oedema and retinal neovascularization.

Design: This surveillance study was designed to determine the incidence and nature of severe intraocular pressure elevation as a complication of intravitreal or periocular corticosteroid injections in Australia and New Zealand.

Participants: Seventeen cases meeting the defined criteria of severe intraocular pressure elevation, above 35 mmHg, following an intravitreal or periocular corticosteroid injection were included in the study. Read More

View Article and Full-Text PDF

Unilateral choroidal granulomas complicated by choroidal neovascular membrane treated successfully with intravitreal triamcinolone in a patient with sarcoidosis.

BMJ Case Rep 2014 Aug 28;2014. Epub 2014 Aug 28.

University of East Anglia, Norwich, UK James Paget University Hospital NHS Foundation Trust, Great Yarmouth, UK.

This case describes the use of intravitreal triamcinolone in the treatment of unilateral choroidal granulomas secondary to systemic sarcoidosis complicated by choroidal neovascular membrane. A single injection of 2 mg intravitreal triamcinolone was administered as treatment for rapidly progressing choroidal granulomas and associated choroidal neovascular membrane with subretinal fluid. Visual acuity had dropped from 6/5 to 6/48 with the progressing lesions. Read More

View Article and Full-Text PDF

Three-year visual outcome of photodynamic therapy plus intravitreal bevacizumab with or without subtenon triamcinolone acetonide injections for polypoidal choroidal vasculopathy.

Br J Ophthalmol 2014 Dec 22;98(12):1642-8. Epub 2014 Jul 22.

Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.

Purpose: To compare the 3-year visual outcome after double therapy of photodynamic therapy (PDT) with intravitreal bevacizumab (IVB) and triple therapy of PDT combined with IVB and subtenon triamcinolone acetonide (STTA) injections for polypoidal choroidal vasculopathy (PCV).

Design: Retrospective, comparative, interventional case series.

Methods: Medical records for 36 eyes in 36 patients (33 men, 3 women; mean age 73. Read More

View Article and Full-Text PDF
December 2014

Evolving strategies in the management of diabetic retinopathy.

Middle East Afr J Ophthalmol 2013 Oct-Dec;20(4):273-82

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Diabetic retinopathy (DR), the most common long-term complication of diabetes mellitus, remains one of the leading causes of blindness worldwide. Tight glycemic and blood pressure control has been shown to significantly decrease the risk of development as well as the progression of retinopathy and represents the cornerstone of medical management of DR. The two most threatening complications of DR are diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR). Read More

View Article and Full-Text PDF
February 2014

Objective area measurement technique for choroidal neovascularization from fluorescein angiography.

Microvasc Res 2014 Jan 5;91:1-7. Epub 2013 Dec 5.

Department of Biomedical Engineering, Illinois Institute of Technology, 3255 South Dearborn Street, Wishnick Hall Room 314, Chicago, IL 60616, USA. Electronic address:

The purpose of this study was to develop a non-biased method of quantitatively measuring choroidal neovascularization (CNV) areas based on late-phase fluorescein angiography (FA) images. Experimental CNV was induced in Long Evans rats by laser disruption of the Bruch's membrane. FA was performed weekly for 5weeks. Read More

View Article and Full-Text PDF
January 2014

In vitro and in vivo comparison of two suprachoroidal shunts.

Invest Ophthalmol Vis Sci 2013 Aug 13;54(8):5416-23. Epub 2013 Aug 13.

Department of Ophthalmology and Visual Sciences, Yale University School of Medicine, 300 George Street, Suite 8100, New Haven, CT 06511, USA.

Purpose: To compare fibrosis, aqueous humor dynamics, and intraocular pressure (IOP) of two suprachoroidal shunts as part of a new class of glaucoma drainage devices.

Methods: Following proliferation analysis in vitro, 20 rabbits were implanted with either a gold shunt (GS, GMSplus+, SOLX) or a polypropylene shunt (PS, Aquashunt, OPKO). Ten eyes received mitomycin C (MMC) and triamcinolone. Read More

View Article and Full-Text PDF

Choroidal neovascularization in angioid streaks following microincision vitrectomy surgery: a case report.

BMC Ophthalmol 2013 Jul 5;13(1):29. Epub 2013 Jul 5.

Department of Ophthalmology, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan.

Background: Patients with angioid streaks are prone to developing subretinal hemorrhage after ocular or head injury due to the brittleness of Bruch's membrane. However, there have been no reports of any angioid streak patients in whom choroidal neovascularization occurred after vitrectomy surgery. We report herein a patient with angioid streaks who developed choroidal neovascularization after vitrectomy surgery for epiretinal membrane. Read More

View Article and Full-Text PDF

Retinal vasculitis, aneurysms, and neovascularization in Blau syndrome.

JAMA Ophthalmol 2013 May;131(5):677-80

Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.

View Article and Full-Text PDF

Changes in anterior segment morphology after intravitreal injection of bevacizumab and bevacizumab-triamcinolone acetate combination.

Eur J Ophthalmol 2013 Jul-Aug;23(4):504-9. Epub 2013 May 2.

Beyoglou Eye Research and Educational Hospital, Istanbul, Turkey.

Purpose: To evaluate the effects of 2 different amounts of commonly used intravitreal agents on anterior segment morphology in conjunction with intraocular pressure (IOP) changes.

Methods: Two groups of 46 patients who received intravitreal injection of bevacizumab (group 1, 0.05 mL) or bevacizumab-triamcinolone acetate (TA) combination (group 2, 0. Read More

View Article and Full-Text PDF
February 2014

An update on the pharmacotherapy of neovascular age-related macular degeneration.

Expert Opin Pharmacother 2013 Jun 8;14(8):1017-28. Epub 2013 Apr 8.

Vitreous Retina Macula Consultants of New York, 460 Park Avenue, 5th Floor, New York, NY 10022, USA.

Introduction: Neovascular age-related macular degeneration (AMD) is currently the most common cause of legal blindness in industrialized countries. The advent of pharmacotherapy with intravitreal VEGF inhibitors has greatly improved outcomes for the treatment of this disease.

Areas Covered: The present review is divided into two major sections: the period prior to the use of anti-VEGF agents (triamcinolone acetonide, verteporfin photodynamic therapy) and the period following their introduction (pegaptanib sodium, bevacizumab, ranibizumab, aflibercept). Read More

View Article and Full-Text PDF