63,632 results match your criteria trials search


Esthetic Outcomes of Implant-Supported Single Crowns Related to Abutment Type and Material: A Systematic Review.

Int J Prosthodont 2021 Mar-Apr;34(2):229-249

Purpose: To systematically review the influence of abutment material and configuration on the soft tissue esthetic outcomes of implant-supported single crowns (iSCs) after 3 years.

Materials And Methods: An electronic search on MEDLINE (PubMed) from January 2000 to July 2019 was conducted for clinical trials with no language restrictions. The focus question was: In partially edentulous patients with iSCs, does the abutment material (metal vs ceramic) or the configuration (standardized vs customized) have an effect on the soft tissue esthetic outcomes? Randomized controlled trials, controlled clinical trials, and prospective or retrospective case series with at least 10 patients and a minimum of 3 years of follow-up were included. Read More

View Article and Full-Text PDF

Safety and Efficacy of Evacetrapib in Patients with Inadequately-controlled Hypercholesterolemia and High Cardiovascular Risk; A meta-analysis of Randomized Placebo-controlled Trials.

Prostaglandins Leukot Essent Fatty Acids 2021 Apr 12;168:102282. Epub 2021 Apr 12.

Medical Research Group of Egypt (MRGE), Cairo, Egypt; Department of Cardiology, National Heart Institute, Egypt.

Background: Low-density lipoprotein cholesterol (LDL-C) is causally related to cardiovascular disease. Inhibition of cholesteryl ester transfer protein with Evacetrapib may provide an additional treatment option for patients who do not reach their LDL-C goal with statins or patients who cannot tolerate statins. We aimed to evaluate the safety and efficacy of Evacetrapib in patients with inadequately-controlled hypercholesterolemia and high cardiovascular risk. Read More

View Article and Full-Text PDF

Obesity management in primary care: systematic review exploring the influence of therapeutic alliance.

Fam Pract 2021 Apr 21. Epub 2021 Apr 21.

Vice President Research and Innovation office, University of Alberta, Edmonton, Canada.

Purpose: To identify the influence of the therapeutic alliance on the effectiveness of obesity interventions delivered in primary care.

Method: Systematic review of randomized controlled trials of primary care interventions for adult patients living with obesity. Comprehensive search strategy using the terms 'obesity', 'primary care' and 'intervention' of seven databases from 1 January 1998 to March 2018. Read More

View Article and Full-Text PDF

Efficacy of Miniscrew-Assisted Rapid Palatal Expansion (MARPE) in late adolescents and adults: a systematic review and meta-analysis.

Eur J Orthod 2021 Apr 21. Epub 2021 Apr 21.

Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Oral and Maxillofacial Surgery, Nijmegen, The Netherlands.

Background: Miniscrew-Assisted Rapid Palatal Expansion (MARPE) is a non-surgical treatment for transverse maxillary deficiency. However, there is limited evidence concerning its efficacy.

Objectives: This systematic review aims to evaluate the efficacy of MARPE in late adolescents and adults by assessing success rate and skeletal and dental transverse maxillary expansion, as well as treatment duration, dental and periodontal side effects and soft tissue effects. Read More

View Article and Full-Text PDF

Hematopoietic stem cell transplantation for people with β-thalassaemia.

Cochrane Database Syst Rev 2021 Apr 21;4:CD008708. Epub 2021 Apr 21.

St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Background: Thalassaemia is an autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions, resulting in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In β-thalassaemia there is an underproduction of β-globin chains combined with excess of free α-globin chains. The excess free α-globin chains precipitate in red blood cells, leading to their increased destruction (haemolysis) and ineffective erythropoiesis. Read More

View Article and Full-Text PDF

Primary headache research output and association with socioeconomic factors in Southeast Asia: a bibliometric analysis.

Neurol Sci 2021 Apr 20. Epub 2021 Apr 20.

Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City and Global City, Philippines.

Background: Although headache is one of the most common neurologic conditions with a high disease burden, primary data on headache research from Southeast Asia (SEA) was hypothesized to be inadequate. This study aimed to evaluate research productivity among the different countries in SEA and to determine the association between specific bibliometric indices and socioeconomic factors.

Methods: A systematic search was conducted until June 10, 2020 in Scopus, PubMed, Embase, Cochrane Central Register of Controlled Trials, and Index Medicus for South-East Asia Region to include all primary headache studies on migraine, tension-type headache, and trigeminal autonomic cephalalgia, with at least one author affiliated with a SEA country. Read More

View Article and Full-Text PDF

Depression and obesity among females, are sex specificities considered?

Arch Womens Ment Health 2021 Apr 20. Epub 2021 Apr 20.

Biosciences Department, Institute of Health and Society, Federal University of São Paulo, Campus Baixada Santista - UNIFESP/BS, Santos, São Paulo, 1015-020, Brazil.

This study aimed to systematically review the relationship of obesity-depression in the female sex. We carried out a systematic search (PubMed, MEDLINE, Embase) to quantify the articles (controlled trials and randomized controlled trials) regarding obesity and depression on a female population or a mixed sample. Successively, we established whether the sex specificities were studied by the authors and if they reported on collecting data regarding factors that may contribute to the evolution of obesity and depression and that could be responsible for the greater susceptibility of females to those conditions. Read More

View Article and Full-Text PDF

Xueshuantong Injection in Treating Deep Venous Thrombosis: A Systematic Review and Trial Sequential Analysis.

Evid Based Complement Alternat Med 2021 7;2021:6622925. Epub 2021 Apr 7.

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Aims: In recent years, the incidence of deep venous thrombosis (DVT) presents an increasing trend year by year. The current evidence regarding the efficacy and safety of Xueshuantong injection for DVT is controversial. This systematic review (SR) aimed to assess the efficacy and safety of Xueshuantong injection in the treatment of DVT systematically and provide an evidence-based reference for clinical treatment. Read More

View Article and Full-Text PDF

External application of herbal medicine for gout: A protocol for systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Apr;100(16):e25649

Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, Republic of Korea.

Background: Gout affects a significant portion of the population worldwide annually. Numerous studies have been reported mainly in East Asia, explaining the use of traditional herbal decoctions for gout treatment. Our systematic review will be conducted to critically evaluate the evidence for the safety and effectiveness of external applications of herbal medicines on gout. Read More

View Article and Full-Text PDF

Traditional Chinese medicine injection for promoting blood circulation and removing blood stasis in treating angina pectoris of coronary heart disease: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25608

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, PR China.

Background: As a common cardiovascular disease, the morbidity and mortality of coronary heart disease (CHD) are increasing year by year. In recent years, many RCTs have proved that compared with conventional therapy, the combination of TCMIs for promoting blood circulation and removing blood stasis can improve clinical efficacy. However, there is still a lack of direct comparative study between different kinds of TCMIs. Read More

View Article and Full-Text PDF

Glucocorticoid supplementation improves reproductive outcomes in infertile women with antithyroid autoimmunity undergoing ART: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25554

Reproductive Medical Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Thyroid autoimmune disease (TAI) has been verified to be related to multiple adverse pregnancy outcomes. A growing number of evidences highlight the protective roles of glucocorticoid on the treatments of TAI. This meta-analysis aimed to study whether it is beneficial to add glucocorticoid treatment in infertile women with TAI when they are undergoing assisted reproductive technology (ART). Read More

View Article and Full-Text PDF

Complementary and alternative therapies for tension-type headache: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25544

Affiliated Hospital of Shandong University of Traditional Chinese Medicine.

Background: Tension-type headache (TTH) is the most common form of primary headache with high prevalence, which affects the quantity of life seriously. The pharmacological treatment of TTH is not the most effective. Meanwhile, complementary therapies and alternative therapies play an essential role in the treatment of TTH, and there is an absence of comparison between various interventions. Read More

View Article and Full-Text PDF

The efficacy and safety of cupping therapy for treating of intractable peripheral facial paralysis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25388

Jiangxi University of Traditional Chinese Medicine.

Background: Peripheral facial paralysis (PFP) is a common clinical neurological disease and the incidence of intractable peripheral facial paralysis is on the rise. Symptoms include crooked mouth and eyes, tearing and shallow nasolabial folds. The disease seriously affects the physical and mental health of patients. Read More

View Article and Full-Text PDF

Effectiveness and safety of traditional Chinese medicine in the treatment of senile hypotension: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25385

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.

Background: Senile hypotension refers to those whose blood pressure (BP) is lower than 90/60 mm Hg. The consequences can not only cause insufficient cardio-cerebral perfusion, but severe cases may also cause angina pectoris and stroke. At present, Western medicine has no ideal therapeutic drugs for senile hypotension. Read More

View Article and Full-Text PDF

Are intraoral stents effective in reducing oral toxicities caused by radiotherapy? A systematic review and meta-analysis.

J Prosthet Dent 2021 Apr 17. Epub 2021 Apr 17.

Associate Professor, Department Prosthodontics, Presidente Prudente Dental School, University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil.

Statement Of Problem: Intraoral stents have been provided to minimize acute and chronic toxicities induced by radiotherapy, including oral mucositis, salivary changes, trismus, radiation-related caries, and osteoradionecrosis. However, a systematic review and meta-analysis is necessary to determine their effectiveness.

Purpose: The purpose of this systematic review and meta-analysis was to determine the effectiveness of intraoral stent use and determine whether these prosthetic devices can reduce radiation dosage to nontargeted oral tissues and adverse effects related to head and neck radiation. Read More

View Article and Full-Text PDF

A systematic review of factors influencing participation in two types of malaria prevention intervention in Southeast Asia.

Malar J 2021 Apr 20;20(1):195. Epub 2021 Apr 20.

Department of Public Health Sciences, Queen's University, 62 Fifth Field Company Lane, Kingston, ON, K7L3N6, Canada.

Background: Multi-pronged malaria elimination strategies are increasingly being considered for accelerating efforts against malaria transmission in Southeast Asia. Two malaria prevention interventions used in in the region are insecticide-treated bed-nets (ITNs) and mass drug administration (MDA). Universal access to ITNs is recommended and high population coverage (e. Read More

View Article and Full-Text PDF

Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis.

BMC Pulm Med 2021 Apr 20;21(1):127. Epub 2021 Apr 20.

Clinical Epidemiology and Medical Statistics Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.

Background: Complicated parapneumonic effusions and empyema represent advanced stages of pleural infections and are characterized by a high mortality. Medical thoracoscopy is a safe and minimally invasive endoscopic technique prescribed to treat severe pleural infections. However, only a few studies evaluated its success rate. Read More

View Article and Full-Text PDF

Prospects of Saffron and its Derivatives in Alzheimer's Disease.

Arch Iran Med 2021 Mar 1;24(3):233-252. Epub 2021 Mar 1.

Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the old age population, making it a worldwide concern. Unfortunately, few drugs have been presented for treatment of mild and moderate AD. To meet this need, more effective anti-AD agents are emerging. Read More

View Article and Full-Text PDF

Guideline No. 417: Prevention of Venous Thromboembolic Disease in Gynaecological Surgery: (En français : Prévention de la maladie thromboembolique veineuse en chirurgie gynécologique).

J Obstet Gynaecol Can 2021 Apr 17. Epub 2021 Apr 17.

Hamilton, ON.

Objective: The primary objective of this clinical practice guideline is to provide gynaecologists with an algorithm and evidence to guide the use of thromboprophylaxis in gynaecological surgery.

Target Population: All patients undergoing gynaecological surgery for benign or malignant indications.

Benefits, Harms, And Costs: The implementation of this guideline will benefit patients undergoing gynaecological surgery and provide physicians with a standard algorithm for the use of perioperative thromboprophylaxis. Read More

View Article and Full-Text PDF

Compression stockings for preventing deep vein thrombosis in airline passengers.

Cochrane Database Syst Rev 2021 Apr 20;4:CD004002. Epub 2021 Apr 20.

UK Cochrane Centre, Oxford, UK.

Background: Air travel might increase the risk of deep vein thrombosis (DVT). It has been suggested that wearing compression stockings might reduce this risk. This is an update of the review first published in 2006. Read More

View Article and Full-Text PDF

Chest CT and rapid antigen testing for diagnosis of COVID-19 in emergency trauma surgery patients that require urgent care during the pandemic: an umbrella review protocol.

JMIR Res Protoc 2021 Mar 17. Epub 2021 Mar 17.

Neuroscience Institute, INUB-MEDITECH Research Group, Av. Cra. 9 No. 131 A - 02, Bogota, CO.

Background: Many healthcare facilities in low-and middle-income countries are inadequately resourced. COVID-19 has the potential to decimate surgical healthcare services unless health systems take stringent measures to protect healthcare workers (HCWs) from viral exposure and ensure the continuity of specialized care for the patients. Among these measures, timely diagnosis of COVID-19 is paramount to ensure protective measures use and isolation of patients that prevent spread of the infection to healthcare personnel caring for patients with unknown COVID-19 status or contact during the pandemic. Read More

View Article and Full-Text PDF

The effects of myo-inositol vs. metformin on the ovarian function in the polycystic ovary syndrome: a systematic review and meta-analysis.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3105-3115

Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Objective: Recent studies have revealed that myo-inositol could be more influential in patients with polycystic ovary syndrome (PCOS). This study was aimed to determine and compare the effects of myo-inositol and metformin on hormonal and metabolic profiles and fertility outcomes.

Materials And Methods: A comprehensive search was carried out among the English-language databases, including PubMed, Scopus, Cochrane Library, Google Scholar, and Web of Science, and the articles published from April 2010 to February 2019 were tracked down. Read More

View Article and Full-Text PDF

Effects of fungal beta-glucans on health - a systematic review of randomized controlled trials.

Food Funct 2021 Mar 31. Epub 2021 Mar 31.

Department of Nutrition and Dietetics, Harokopio University, 70 El. Venizelou Str., Kallithea 176 76, Greece.

Introduction: Beta-glucans are polysaccharides that exhibit a wide range of biological properties as a result of their varying chemical composition. Like all dietary fibers, they avoid catabolism in the upper gastrointestinal tract, and they reach the large intestine undigested. There, they undergo fermentation by the gut microbiota, a process that has potential beneficial effects for the host. Read More

View Article and Full-Text PDF

Economic evaluation of workplace health promotion interventions focused on Lifestyle: Systematic review and meta-analysis.

J Adv Nurs 2021 Apr 19. Epub 2021 Apr 19.

Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, Seville, Spain.

Aim: To identify and evaluate randomized clinical trials focusing on economic evaluation of workplace health promotion (WHP) interventions based on healthy lifestyles, physical activity and nutrition.

Design: A systematic review and meta-analysis was carried out between March and May 2019, following the PRISMA statement.

Data Sources: The literature search was conducted on Cochrane Library, Scopus, WOS and Medline databases. Read More

View Article and Full-Text PDF

The methodological quality of individual participant data meta-analysis on intervention effects: systematic review.

BMJ 2021 04 19;373:n736. Epub 2021 Apr 19.

Alice Lee Centre for Nursing Studies, National University of Singapore, Singapore.

Objective: To assess the methodological quality of individual participant data (IPD) meta-analysis and to identify areas for improvement.

Design: Systematic review.

Data Sources: Medline, Embase, and Cochrane Database of Systematic Reviews. Read More

View Article and Full-Text PDF

LOCATE: a prospective evaluation of the value of Leveraging Ongoing Citation Acquisition Techniques for living Evidence syntheses.

Syst Rev 2021 Apr 19;10(1):116. Epub 2021 Apr 19.

Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, 4-472 Edmonton Clinic Health Academy, 11405-87 Avenue NW, Edmonton, Alberta, T6G 1C9, Canada.

Background: Living systematic reviews (LSRs) can expedite evidence synthesis by incorporating new evidence in real time. However, the methods needed to identify new studies in a timely manner are not well established.

Objectives: To explore the value of complementary search approaches in terms of search performance, impact on results and conclusions, screening workload, and feasibility compared to the reference standard. Read More

View Article and Full-Text PDF

Eltrombopag Effectiveness and Tolerability in Chronic Immune Thrombocytopenia: A Meta-Analysis.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211005555

Department of Hematology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, Zhengzhou, People's Republic of China.

Eltrombopag is an orally administered, non-peptide, thrombopoietin receptor agonist which initiates thrombopoietin signaling and stimulates the production of normally functioning platelet. We aimed to do a systematic review and meta-analysis of currently available published data to verify whether eltrombopag treatment in patients with chronic immune-mediated thrombocytopenia can prolong survival. We searched for published, randomized, controlled trials in PubMed, Cochrane and Scopus databases using the following search strategy ("Eltrombopag" OR "Benzoates" OR "Hydrazines") AND ("Idiopathic Thrombocytopenic Purpura" OR "immune thrombocytopenia" OR "Idiopathic Thrombocytopenic Purpuras" OR "Immune Thrombocytopenia" OR "Autoimmune Thrombocytopenia" OR "Werlhof"). Read More

View Article and Full-Text PDF

Effect of dexmedetomidine on hemodynamic responses to tracheal intubation: A meta-analysis with meta-regression and trial sequential analysis.

J Clin Anesth 2021 Apr 16;72:110287. Epub 2021 Apr 16.

UOC Anesthesia and Intensive Care Unit, University Hospital of Padua, Padua, Italy; UOC Anesthesia and Intensive Care Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy.

Study Objective: An uncontrolled adrenergic response during tracheal intubation may lead to life-threatening complications. Dexmedetomidine binds to α2-receptors and may attenuate this response. The primary aim of our meta-analysis is to investigate dexmedetomidine efficacy in attenuating sympathetic response to tracheal intubation, compared with placebo or no dexmedetomidine, in terms of heart rate and blood pressure at intubation. Read More

View Article and Full-Text PDF

Comparison of local and regional anesthesia modalities in breast surgery: A systematic review and network meta-analysis.

J Clin Anesth 2021 Apr 16;72:110274. Epub 2021 Apr 16.

Department of Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; King's College London, London, United Kingdom.

Study Objective: Moderate to severe postoperative pain occurs in up to 60% of women following breast operations. Our aim was to perform a network meta-analysis and systematic review to compare the efficacy and side effects of different analgesic strategies in breast surgery.

Design: Systematic review and network meta-analysis. Read More

View Article and Full-Text PDF

The clinical applications of five-alpha reductase inhibitors.

Authors:
Kevin R Loughlin

Can J Urol 2021 Apr;28(2):10584-10588

Harvard Medical School, Vascular Biology Laboratory, Boston Children's Hospital, Boston, Massachusetts, USA.

INTRODUCTION Five-alpha reductase (5-AR) deficiency was first identified by Imperato-McGinley and Walsh as the cause of pseudohermaphroditism in two separate studies. The discoveries led to the development of finasteride (inhibitor of type 2 isoenzyme of 5-AR) and dutasteride (inhibitor of type 1 and type 2 isoenzymes of 5-AR. Both drugs have been proven effective for the treatment of benign prostatic hyperplasia and improve voiding symptoms, reduce the risk of urinary retention and the need for prostate surgery. Read More

View Article and Full-Text PDF