12,334 results match your criteria trials continued

Serological responses following a single dose of SARS-CoV-2 vaccination in allogeneic stem cell transplant recipients.

Transplant Cell Ther 2021 Jul 19. Epub 2021 Jul 19.

The Royal Marsden NHS Hospital, Downs Road, Sutton, SM2 5PT, United Kingdom.

Immunocompromised individuals were not included in formal trials of SARS-CoV-2 mRNA vaccines. Subsequent studies in patients with haematological malignancies and solid organ transplant recipients suggest inferior responses to vaccination. We determined antibody responses to a single dose of vaccines in one of the most vulnerable patient groups, allogeneic haematopoietic cell transplant (allo-HCT) recipients. Read More

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Outlook of Cassava Brown Streak Disease Assessment: Perspectives of the Screening Methods of Breeders and Pathologists.

Front Plant Sci 2021 5;12:648436. Epub 2021 Jul 5.

Root Crops Program, National Crops Resources Research Institute (NaCRRI), Kampala, Uganda.

Cassava production and productivity in Eastern, Central, and Southern Africa are ravaged by cassava brown streak disease (CBSD), causing yield losses of up to 100% when susceptible varieties are grown. Efforts to develop CBSD-resistant clones are underway. However, the methods for screening CBSD resistance currently vary between breeders and pathologists, with the limited empirical data to support their choices. Read More

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Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.

Cell Rep 2021 Jul 10:109450. Epub 2021 Jul 10.

Department of Epidemiology, READDI Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Improving clinical care for individuals infected with SARS-CoV-2 variants is a global health priority. Small-molecule antivirals like remdesivir (RDV) and biologics such as human monoclonal antibodies (mAbs) have demonstrated therapeutic efficacy against SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). It is not known whether combination RDV/mAb will improve outcomes over single-agent therapies or whether antibody therapies will remain efficacious against variants. Read More

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Reliability, validity and important difference estimates for the NCCN-FACT Ovarian Symptom Index-18 (NFOSI-18).

Future Oncol 2021 Jul 21. Epub 2021 Jul 21.

Adelphi Values, Bollington, UK.

To evaluate psychometric performance of the NCCN-FACT Ovarian Cancer Symptom Index-18 (NFOSI-18) in advanced ovarian cancer. Cross-sectional, observational data from patients receiving treatment for ovarian cancer. Other measures included European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core (EORTC QLQ-C30) and associated ovarian cancer module (EORTC QLQ-OV28) and Work Productivity and Activity Impairment. Read More

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Schedules for home visits in the early postpartum period.

Cochrane Database Syst Rev 2021 Jul 21;7:CD009326. Epub 2021 Jul 21.

Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Maternal complications, including psychological/mental health problems and neonatal morbidity, have commonly been observed in the postpartum period. Home visits by health professionals or lay supporters in the weeks following birth may prevent health problems from becoming chronic, with long-term effects. This is an update of a review last published in 2017. Read More

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Advances in mechanical thrombectomy for acute ischaemic stroke from large vessel occlusions.

Stroke Vasc Neurol 2021 Jul 20. Epub 2021 Jul 20.

Interventinal Neuroradiology, Beijing Tiantan Hospital, Beijing, China

Advances in endovascular treatment of acute ischaemic stroke from intracranial large vessel occlusions have continued in the past decade. Here, we performed a detailed review of all the new trials and studies that had the highest evidence, the guidelines for mechanical thrombectomy, the selection of the particular population outside the guidelines and endovascular therapeutic strategies for acute ischemic stroke from occluded intracranial arteries. Read More

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Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.

Neuropharmacology 2021 Jul 17:108724. Epub 2021 Jul 17.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

α5 subunit GABA type A receptor (GABAR) preferring negative allosteric modulators (NAMs) are cognitive enhancers with antidepressant-like effects. α5-NAM success in treating mouse models of neurodevelopmental disorders with excessive inhibition have led to Phase 2 clinical trials for Down syndrome. Despite in vivo efficacy, no study has examined the effects of continued α5-NAM treatment on inhibitory and excitatory synapse plasticity to identify mechanisms of action. Read More

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The role of tyrosine kinase inhibitors in the treatment of HER2+ metastatic breast cancer.

Eur J Cancer 2021 Jul 16;154:175-189. Epub 2021 Jul 16.

Department of Oncology and Hemato-Oncology, University of Milano and European Institute of Oncology, IRCCS, Milano, Italy.

The introduction of trastuzumab and other subsequent human epidermal growth factor receptor 2 (HER2)-targeted therapies dramatically shifted the treatment landscape of HER2+ breast cancer, changing the natural history of the disease. There is no standard-of-care for patients with HER2+ metastatic breast cancer (MBC) in third and later lines of treatment; however, continued use of anti-HER2 therapies is recommended. Small-molecule tyrosine kinase inhibitors (TKIs) that target HER2 and other HER family receptors play a central role in this setting. Read More

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Simplification of complex insulin therapy: a story of dogma and therapeutic resignation.

Diabetes Res Clin Pract 2021 Jul 16;178:108958. Epub 2021 Jul 16.

Ph.D. of Translational Medicine, Chair of Endocrinology and Metabolic Diseases, Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy; Diabetes Unit, Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.

The combination of rapid-acting plus long-acting insulins has been the cornerstone of therapy of patients with type 1 diabetes mellitus (T1DM) and has also become the gold standard of insulin therapy in type 2 diabetes (T2DM). A significant proportion of T2DM patients are overtreated, with potential harms of insulin therapy exceeding its benefits. Treatment simplification aims to decrease the complexity of insulin regimens, including, but not limited to fewer administration times and fewer blood glucose checks. Read More

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Pyrosequencing for diagnosis of multidrug and extensively drug-resistant tuberculosis: A systemic review and meta-analysis.

J Clin Tuberc Other Mycobact Dis 2021 Aug 29;24:100254. Epub 2021 Jun 29.

Addis Ababa University, College of Health Sciences, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa, Ethiopia.

Background: Multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) pose major threats to global health. Diagnosis accuracy and delay have been the major drivers for the upsurge of M/XDR-TB. Pyrosequencing (PSQ) is a novel, real-time DNA sequencing for rapid detection of mutations associated with M/XDR-TB. Read More

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Giant Coronary Artery Aneurysms.

Cureus 2021 Jun 12;13(6):e15611. Epub 2021 Jun 12.

Interventional Cardiology, The Medical Center, Bowling Green, USA.

We present the case of a patient with giant coronary artery aneurysm. He has underlying severe coronary atherosclerosis and concomitant aneurysms of the abdominal aorta and popliteal artery. Our patient was treated surgically in the past due to underlying severe atherosclerosis. Read More

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A Novel Group Cognitive Behavioral Therapy Approach to Adult Non-rapid Eye Movement Parasomnias.

Front Psychiatry 2021 1;12:679272. Epub 2021 Jul 1.

Sleep Disorder Centre, Nuffield House, Guy's Hospital, London, United Kingdom.

Following the success of Cognitive Behavioral Therapy (CBT) for insomnia, there has been a growing recognition that similar treatment approaches might be equally beneficial for other major sleep disorders, including non-rapid eye movement (NREM) parasomnias. We have developed a novel, group-based, CBT-program for NREM parasomnias (CBT-NREMP), with the primary aim of reducing NREM parasomnia severity with relatively few treatment sessions. We investigated the effectiveness of CBT-NREMP in 46 retrospectively-identified patients, who completed five outpatient therapy sessions. Read More

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A Review of Trikafta: Triple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator Therapy.

Cureus 2021 Jul 3;13(7):e16144. Epub 2021 Jul 3.

Internal Medicine, Hennepin Healthcare, Minnesota, USA.

Cystic fibrosis (CF) is a potentially fatal genetic disease that causes serious lung damage. With time, researchers have a more complete understanding of the molecular-biological defects that underlie CF. This knowledge is leading to alternative approaches regarding the treatment of this condition. Read More

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Differences in Antipsychotic Treatment Discontinuation Among Veterans With Schizophrenia in the U.S. Department of Veterans Affairs.

Am J Psychiatry 2021 Jul 14:appiajp202020111657. Epub 2021 Jul 14.

Stanley Medical Research Institute, Kensington, Md. (Weiser); Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel (Weiser, Levi); Department of Psychiatry, Tel Aviv University, Ramat Aviv, Israel (Weiser); Department of Psychiatry, University of Illinois, Chicago (Davis); VA Capitol Healthcare Network (VISN 5) Mental Illness Research, Education, and Clinical Center (MIRECC), Baltimore (Brown, Medoff, Kreyenbuhl); Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore (Brown; Medoff, Kreyenbuhl); Johns Hopkins School of Nursing, Baltimore (Slade); Department of Psychiatry, Division of Psychiatric Services Research, University of Maryland School of Medicine, Baltimore (Fang); Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore (Buchanan); and University of Nicosia Medical School, Nicosia, Cyprus (Davison).

Objective: Effectiveness of antipsychotic drugs is inferred from relatively small randomized clinical trials conducted with carefully selected and monitored participants. This evidence is not necessarily generalizable to individuals treated in daily clinical practice. The authors compared the clinical effectiveness between all oral and long-acting injectable (LAI) antipsychotic medications used in the treatment of schizophrenia in the U. Read More

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Durable complete response to pembrolizumab in microsatellite stable colorectal cancer.

Daru 2021 Jul 12. Epub 2021 Jul 12.

Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Immunotherapy by checkpoint inhibitors, i.e., anti-programmed death-1(PD-1) or anti-programmed death-ligand 1 (PD-L1) antibodies, has gained more attention managing solid tumors. Read More

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Pregnancy and neonatal outcomes in fresh and frozen cycles using blastocysts derived from ovarian stimulation with follitropin delta.

J Assist Reprod Genet 2021 Jul 13. Epub 2021 Jul 13.

Reproductive Medicine & Maternal Health, Ferring Pharmaceuticals, Copenhagen, Denmark.

Purpose: To describe the pregnancy and neonatal outcomes using fresh and vitrified/warmed blastocysts obtained from ovarian stimulation with follitropin delta in controlled trials versus follitropin alfa.

Methods: This investigation evaluated the outcome from 2719 fresh and frozen cycles performed in 1326 IVF/ICSI patients who could start up to three ovarian stimulations in the ESTHER-1 (NCT01956110) and ESTHER-2 (NCT01956123) trials, covering 1012 fresh cycles and 341 frozen cycles with follitropin delta and 1015 fresh cycles and 351 frozen cycles with follitropin alfa. Of the 1326 first cycle patients, 513 continued to cycle 2 and 188 to cycle 3, and 441 patients started frozen cycles after the fresh cycles. Read More

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Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials?

Antimicrob Agents Chemother 2021 Jul 12:AAC0043721. Epub 2021 Jul 12.

Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.

Regulatory clinical trials are required to ensure the continued supply and deployment of effective antimalarial drugs. Patient follow-up in such trials typically lasts several weeks as the drugs have long half-lives and new infections often occur during this period. "Molecular correction" is therefore used to distinguish drug failures from new infections. Read More

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Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y Inhibitor Thereafter.

J Atheroscler Thromb 2021 Jul 10. Epub 2021 Jul 10.

Klinik fuer Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munich.

Aim: The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation is an ongoing debate and novel data has emerged. The aim of this meta-analysis was to assess outcomes of short vs. control DAPT duration. Read More

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Long-Term Outcome of Spinal Cord Stimulation in Complex Regional Pain Syndrome.

Neurosurgery 2021 Jul 9. Epub 2021 Jul 9.

Neurosurgery of KUH NeuroCenter, Kuopio University Hospital, Kuopio, Finland.

Background: Spinal cord stimulation (SCS) is an effective treatment in chronic neuropathic pain, but its efficacy in complex regional pain syndrome (CRPS) needs to be proven.

Objective: To study the outcome of SCS in CRPS as measured by trial success, explantation rate, complications, and changes in opioid and neuropathic pain medication use over a 4-yr follow-up.

Methods: We retrospectively reviewed all medical records of 35 consecutive CRPS patients who underwent SCS trials at 2 hospitals during January 1998 to December 2016. Read More

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Impact of duration of antibiotic prophylaxis on rates of surgical site infection (SSI) in patients undergoing mastectomy without immediate reconstruction, comparing a single prophylactic dose versus continued antibiotic prophylaxis postoperatively: a multicentre, double-blinded randomised control trial protocol.

BMJ Open 2021 Jul 9;11(7):e049572. Epub 2021 Jul 9.

Internal Medicine, Aga Khan University, Karachi, Pakistan.

Introduction: In breast surgeries, prophylactic antibiotics given before the surgical incision as per Joint Commission Surgical Care Improvement Project guidelines have been shown to decrease the rate of postoperative infections. There is, however, no clear consensus on postoperative antibiotic prophylaxis in patients undergoing mastectomy with indwelling drains. This trial protocol proposes to study the difference in rates of surgical site infection (SSI) with or without continuation of postoperative antibiotics in patients undergoing mastectomy without immediate reconstruction and with indwelling drains. Read More

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Systematic review of the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion for the treatment of refractory chronic cluster headache.

Neurologia (Engl Ed) 2021 Jul-Aug;36(6):440-450. Epub 2019 Aug 11.

Agencia de Evaluación de Tecnologías Sanitarias (AETS), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía, Industria y Competitividad, Madrid, Spain.

Introduction: This study aimed to assess the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion (SPG) in the treatment of refractory chronic cluster headache.

Development: Various medical databases were used to perform a systematic review of the scientific literature. The search for articles continued until 31 October 2016, and included clinical trials, systematic reviews and/or meta-analyses, health technology assessment reports, and clinical practice guidelines that included measurements of efficiency/effectiveness or adverse effects associated with the treatment. Read More

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Effect of reflexology on ankle brachial index, diabetic peripheral neuropathy, and glycemic control in older adults with diabetes: A randomized controlled trial.

Complement Ther Clin Pract 2021 Jul 4;44:101437. Epub 2021 Jul 4.

Private Physical Therapy and Rehabilitation Clinic, Isparta, Turkey.

Objective: The purpose of this study was to determine the effect of foot reflexology on ankle brachial index, diabetic peripheral neuropathy and glycemic control in older adults with diabetes.

Methods: A randomized controlled, parallel-group trial study was conducted at the outpatient elderly health center in Bolu, Turkey. 48 adults aged 65 and over enrolled in the elderly health center were randomized into two groups in a ratio of 1:1 (experimental, n = 24; control, n = 24). Read More

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Long term outcomes of ultrathin versus standard thickness second-generation drug eluting stents: Meta-analysis of randomized trials.

Catheter Cardiovasc Interv 2021 Jul 8. Epub 2021 Jul 8.

Department of Cardiology New Haven, Yale School of Medicine, New Haven, Connecticut, USA.

Objective: Identify the effect of ultrathin drug eluting stents on long term outcomes in coronary artery disease.

Background: Although second-generation drug eluting stents (DES) are superior to first-generation DES, persistence of adverse outcomes has led to continued refinement in design. Ultrathin second-generation DES have been shown to improve outcomes at 1-year follow-up. Read More

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Matching-adjusted indirect treatment comparison of onasemnogene abeparvovec and nusinersen for the treatment of symptomatic patients with spinal muscular atrophy type 1.

Curr Med Res Opin 2021 Jul 20:1-12. Epub 2021 Jul 20.

Global Geneconomics and Outcomes Research, Novartis Gene Therapies, Inc, Bannockburn, IL, USA.

Objective: Onasemnogene abeparvovec, a one-time intravenous gene replacement therapy, and nusinersen, an antisense oligonucleotide that requires ongoing intrathecal administration, have been evaluated as treatments for spinal muscular atrophy (SMA) type 1 in separate Phase III trials, but no head-to-head comparison studies have been conducted. Onasemnogene abeparvovec was compared with nusinersen using a matching-adjusted indirect comparison (MAIC) to estimate the treatment effect of onasemnogene abeparvovec relative to nusinersen for the treatment of symptomatic patients with SMA type 1 for up to 24 months of follow-up.

Methods: In the absence of studies for both onasemnogene abeparvovec and nusinersen with a common comparator, a Bayesian naïve indirect treatment comparison (ITC) and MAIC between onasemnogene abeparvovec and nusinersen were conducted to compare efficacy and safety of onasemnogene abeparvovec with nusinersen. Read More

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Median time to pain improvement and the impact of baseline pain severity on pain response in patients with psoriatic arthritis treated with tofacitinib.

RMD Open 2021 07;7(2)

Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, Washington, USA.

Background: Pain is a core domain of psoriatic arthritis (PsA). This post hoc analysis evaluated time to pain improvement and the impact of baseline pain severity on pain response in patients with PsA receiving tofacitinib.

Methods: Data from two trials (NCT01877668; NCT01882439) in patients receiving tofacitinib 5 mg twice daily, placebo switching to tofacitinib 5 mg twice daily at month 3 (placebo-to-tofacitinib) or adalimumab (NCT01877668 only) were included. Read More

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Mobile health in preventive cardiology: current status and future perspective.

Curr Opin Cardiol 2021 Jul 1. Epub 2021 Jul 1.

Department of Medicine, Division of Cardiology Ciccarone Center for the Prevention of Cardiovascular Disease, Digital Health Innovation Laboratory, Johns Hopkins University School of Medicine Johns Hopkins Center for Mobile Technologies to Achieve Equity in Cardiovascular Health (mTECH) Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Purpose Of Review: Despite cutting edge acute interventions and growing preventive strategies supported by robust clinical trials, cardiovascular disease (CVD) has stubbornly persisted as a leading cause of death in the United States and globally. The American Heart Association recognizes mobile health technologies (mHealth) as an emerging strategy in the mitigation of CVD risk factors, with significant potential for improving population health. The purpose of this review is to highlight and summarize the latest available literature on mHealth applications and provide perspective on future directions and barriers to implementation. Read More

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Reach versus effectiveness: The design and protocol of randomized clinical trial testing a smartphone application versus in-person mindfulness-based smoking cessation intervention among young cancer survivors.

Contemp Clin Trials Commun 2021 Jun 19;22:100784. Epub 2021 May 19.

Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St, 9th Floor, Miami, FL, 33136, USA.

Approximately 45% of young cancer survivors (18-40 years) are cigarette smokers. Continued smoking after cancer diagnosis leads to lower survival rates. A major logistical problem with smoking cessation efforts in this group is their geographic dispersion which makes them hard to reach. Read More

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Quality of and Recommendations for Relevant Clinical Practice Guidelines for COVID-19 Management: A Systematic Review and Critical Appraisal.

Front Med (Lausanne) 2021 10;8:630765. Epub 2021 Jun 10.

Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

The morbidity and mortality of coronavirus disease 2019 (COVID-19) are still increasing. This study aimed to assess the quality of relevant COVID-19 clinical practice guidelines (CPGs) and to compare the similarities and differences between recommendations. A comprehensive search was conducted using electronic databases (PubMed, Embase, and Web of Science) and representative guidelines repositories from December 1, 2019, to August 11, 2020 (updated to April 5, 2021), to obtain eligible CPGs. Read More

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A prolonged steroid therapy may be beneficial in some patients after the COVID-19 pneumonia.

Eur Clin Respir J 2021 Jun 24;8(1):1945186. Epub 2021 Jun 24.

Department of Lung Diseases and Tuberculosis, Faculty of Medical Sciences in Zabrze, Silesia Medical University in Katowice, Poland.

: This report introduces two cases presenting absorption of considerable radiological changes in the course of the coronavirus pneumonia in patients treated with prolonged oral steroids.: The first case concerns a male receiving steroids only during hospitalisation in the Infectious Disease Hospital. After discharge, the patient experienced increasing dyspnoea resulting in hospitalisation in our Department of Lung Diseases. Read More

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