664,679 results match your criteria trial effects


Efficacy and tolerability of Melatonin vs Triclofos to achieve sleep for pediatric electroencephalography: A single blinded randomized controlled trial.

Eur J Paediatr Neurol 2021 Jul 7;34:14-20. Epub 2021 Jul 7.

Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India. Electronic address:

Purpose: To compare Melatonin with Triclofos for efficacy (proportion of successful EEG, need of augmentation, sleep onset latency (SOL), yield of discharges, duration of sleep, presence and grade of artifacts) and tolerability (adverse effect profile).

Methods: A randomized trial was performed (block randomization). All children were advised regarding sleep deprivation, EEG technician administered the drug. Read More

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Meta-computational techniques' for managing spare data: An application in off-pump heart surgery.

Comput Methods Programs Biomed 2021 Jul 5;208:106267. Epub 2021 Jul 5.

Department of Mathematics, College of Science Al-Zulfi, Majmaah University, PO Box 66, Al-Majmaah 11952, Saudi Arabia. Electronic address:

Background And Objectives: This research looked at the key considerations to remember when selecting a model for working with sparse data. In the presence of sparse evidence, it proposes ideal conditions for conducting meta-analysis.

Methods: Monte Carlo simulations were used to produce study results, and three forms of continuity correction were used in the research. Read More

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Multicomponent exercise to improve motor functions, cognition and well-being for nursing home residents who are unable to walk - A randomized controlled trial.

Exp Gerontol 2021 Jul 19:111484. Epub 2021 Jul 19.

Institute of Human Movement Science, University of Hamburg, Mollerstr, 10, 20148 Hamburg, Germany; Biological Psychology and Neuroergonomics, TU Berlin, Fasanenstr. 1, 10623 Berlin, Germany. Electronic address:

Background: Older nursing home residents are often characterized by multimorbidity and dependency in activities of daily living. Most exercise studies in this setting aim at residents who are still able to walk despite the huge group of residents that is unable to walk. Thus, little is known about the effectiveness to improve cognitive and motor functions as well as well-being within this target group, e. Read More

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Rethinking emotional eating: Retrospective and momentary indices of emotional eating represent distinct constructs.

Appetite 2021 Jul 19;167:105604. Epub 2021 Jul 19.

Center for Weight, Eating, and Lifestyle Sciences (WELL Center), Drexel University, Philadelphia, PA, USA. Electronic address:

Emotional eating (EE) has been proposed as a key weight loss barrier. However, most investigations of EE rely on retrospective self-reports, which may have poor construct validity. This study evaluated concordance between a common self-report EE measure and a novel method for assessing momentary EE using ecological momentary assessment (EMA). Read More

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Efficacy of temporally intensified exposure for anxiety disorders: A multicenter randomized clinical trial.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Institute of Clinical Psychology & Psychotherapy, Technische Universität Dresden, Dresden, Germany.

Background: The need to optimize exposure treatments for anxiety disorders may be addressed by temporally intensified exposure sessions. Effects on symptom reduction and public health benefits should be examined across different anxiety disorders with comorbid conditions.

Methods: This multicenter randomized controlled trial compared two variants of prediction error-based exposure therapy (PeEx) in various anxiety disorders (both 12 sessions + 2 booster sessions, 100 min/session): temporally intensified exposure (PeEx-I) with exposure sessions condensed to 2 weeks (n = 358) and standard nonintensified exposure (PeEx-S) with weekly exposure sessions (n = 368). Read More

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A Low-Sodium DASH Dietary Pattern Affects Serum Markers of Inflammation and Mineral Metabolism in Adults with Elevated Blood Pressure.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.

Background: The blood pressure-lowering effects of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and reduced sodium intake are well established. The effects on other biomarkers related to vascular health are of interest and might assist in explaining the effects of the DASH diet and sodium reduction.

Objectives: We hypothesized that a low-sodium DASH diet improves (lowers) biomarkers of inflammation [C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR)] and mineral metabolism [phosphorus and fibroblast growth factor-23 (FGF23)]. Read More

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Oils Rich in α-Linolenic Acid or Docosahexaenoic Acid Have Distinct Effects on Plasma Oxylipin and Adiponectin Concentrations and on Monocyte Bioenergetics in Women with Obesity.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Department of Food and Human Nutritional Sciences, University of Manitoba, Manitoba, Canada.

Background: Omega-3 fatty acids, including DHA and α-linolenic acid (ALA), are proposed to improve metabolic health by reducing obesity-associated inflammation. Their effects are mediated in part by conversion to oxylipins. ALA is relatively understudied, and direct comparisons to other omega-3 fatty acids are limited. Read More

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Neither low salivary amylase activity, cooling cooked white rice, nor single nucleotide polymorphisms in starch-digesting enzymes reduce glycemic index or starch digestibility: a randomized, crossover trial in healthy adults.

Am J Clin Nutr 2021 Jul 22. Epub 2021 Jul 22.

INQUIS Clinical Research, Ltd (formerly GI Labs), Toronto, Ontario, Canada.

Background: It was suggested that low salivary-amylase activity (SAA) and cooling or stir-frying cooked starch decreases its digestibility and glycemic index.

Objective: We determined the effects of SAA, cooling, and single-nucleotide polymorphisms (SNPs) in the salivary amylase (AMY1), pancreatic amylase (AMY2A, AMY2B), maltase-glucoamylase (MGAM), and sucrase-isomaltase (SI) genes on starch digestibility and glycemic index of cooked polished rice.

Methods: Healthy subjects [pilot, n = 12; main, n = 20 with low-SAA (<50 U/mL), and n = 20 with high-SAA (>105 U/mL)] consumed test meals containing 25 g (pilot) or 50 g (main) available carbohydrate at a contract research organization using open-label (pilot) or assessor-blinded (main), randomized, crossover, Latin-square designs (trial registration: NCT03667963). Read More

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12 weeks of strength training improves fluid cognition in older adults: A nonrandomized pilot trial.

PLoS One 2021 22;16(7):e0255018. Epub 2021 Jul 22.

Division of Biokinesiology and Physical Therapy, Ostrow School of Dentistry, University of Southern California, Los Angeles, California, United States of America.

Objectives: Resistance training (RT) is a promising strategy to slow or prevent fluid cognitive decline during aging. However, the effects of strength-specific RT programs have received little attention. The purpose of this single-group proof of concept clinical trial was to determine whether a 12-week strength training (ST) program could improve fluid cognition in healthy older adults 60 to 80 years of age, and to explore concomitant physiological and psychological changes. Read More

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Therapeutic Effects of Ba-Duan-Jin versus Pregabalin for Fibromyalgia Treatment: Protocol for a Randomized Controlled Trial.

Rheumatol Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Introduction: Fibromyalgia is characterized by multi-focal pain and is associated with fatigue, unrefreshing sleep and psychological impairment. Pregabalin is one of the most frequently used agents in fibromyalgia treatment. However, it has failed to demonstrate benefit over placebo for reducing fatigue and psychological impairment, and may cause adverse effects (e. Read More

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Non-Invasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals with Posttraumatic Stress Disorder.

Psychosom Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta GA Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta GA Department of Medicine (Cardiology), Emory University School of Medicine, Atlanta, GA Atlanta VA Medical Center, Decatur, GA Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta GA Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA.

Objective: Posttraumatic stress disorder (PTSD) is a disabling condition affecting a large segment of the population, however current treatment options have limitations. New interventions that target the neurobiological alterations underlying symptoms of PTSD could be highly beneficial. Transcutaneous cervical (neck) vagal nerve stimulation (tcVNS) has the potential to represent such an intervention. Read More

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Relationships between early maternal warmth and social connection: A randomized clinical trial with naltrexone.

Psychosom Med 2021 Jul 21. Epub 2021 Jul 21.

University of Pittsburgh, Department of Psychology, Pittsburgh, PA, USA. University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA. San Diego State University, Department of Psychology, San Diego, CA, USA.

Objective: Early experiences of having received maternal warmth predict responses to opportunities to connect with others later in life. However, understanding of neurochemical mechanisms by which such relationships emerge remain incomplete. Endogenous opioids, involved in social connection in both animals and humans, may contribute to this link. Read More

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SITAgliptin for Depressive Symptoms (SITADS) in type 2 diabetes: a feasibility randomized controlled trial.

Psychosom Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RJ, UK Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 1UL and SE5 9RJ, UK Department of Biostatistics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Objective: We tested the feasibility of using sitagliptin - a dipeptidyl peptidase-IV inhibitor - for depressive symptoms in type 2 diabetes (T2D).

Methods: In a feasibility, double-blind, randomised controlled trial, we recruited people aged 18-75 with T2D (HbA1c ≥53 and ≤ 86 mmol/mol prescribed oral hypoglycaemic therapy) and comorbid depressive symptoms (Patient Health Questionnaire-9 [PHQ-9] score ≥ 10) from family practices in South London. Eligible patients were randomised to sitagliptin 100 mg per day or matched placebo for 12 weeks. Read More

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EXPRESS: Factors influencing the use of different methods of consent in a randomised acute stroke trial, the Third International Stroke Trial (IST-3).

Int J Stroke 2021 Jul 22:17474930211037123. Epub 2021 Jul 22.

University of Edinburgh, DCN, Western General Hospital, Edinburgh, United Kingdom of Great Britain and Northern Ireland.

Background Obtaining informed consent in people with acute stroke is complex since many, as a direct result of their stroke, lose capacity to make important decisions. Furthermore reperfusion interventions are time dependent necessitating rapid consent. We developed 4 different consent approaches to facilitate recruitment of a broad range of patients in the Third International Stroke Trial (IST-3). Read More

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Bexagliflozin for type 2 Diabetes: an overview of the data.

Expert Opin Pharmacother 2021 Jul 22. Epub 2021 Jul 22.

Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, Royal Perth Hospital Research Foundation, Faculty of Medicine, Dentistry & Health Sciences, The University of Western Australia, Perth Australia.

Introduction: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a relatively novel glucose-lowering drugs (GLDs) which additionally promote weight loss and blood pressure reduction amongst other beneficial effects.

Areas Covered: This review reflects on the extra-glycaemic effects of SGLT2 inhibitors and their impact on important clinical endpoints, and provides an overview of data relating to a newer member of the SGLT2 inhibitor class, bexagliflozin.

Expert Opinion: SGLT2 inhibitors, while consolidating glycaemic control as adjunctive therapy, indisputably effect cardio-renal benefits in the T2D population which is prevalently afflicted by heightened cardiovascular risk profiles and a disproportionately increased incidence of unfavourable cardiovascular and renal clinical outcomes. Read More

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Freeing capacity in working memory (WM) through the use of long-term memory (LTM) representations.

J Exp Psychol Learn Mem Cogn 2021 Jul 22. Epub 2021 Jul 22.

Faculty of Psychology.

Previous research indicates that long-term memory (LTM) may contribute to performance in working memory (WM) tasks. Across 3 experiments, we investigated the extent to which active maintenance in WM can be replaced by relying on information stored in episodic LTM, thereby freeing capacity for additional information in WM. First, participants encoded word pairs into LTM, and then completed a WM task, also involving word pairs. Read More

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A pilot randomized controlled trial of smartphone-assisted mindfulness-based intervention with contingency management for smokers with mood disorders.

Exp Clin Psychopharmacol 2021 Jul 22. Epub 2021 Jul 22.

School of Nursing.

Cigarette smoking disproportionately affects individuals with mood disorders, but smoking cessation interventions have modest effects in this population. Home mindfulness practice during abstinence incentivized via contingency management (CM) may help those in affective distress quit smoking.

Method: Adult smokers receiving outpatient psychiatric treatment for mood disorders were randomized to receive a smartphone-assisted mindfulness-based smoking cessation intervention with contingency management (SMI-CM, = 25) or enhanced standard treatment (EST, = 24) with noncontingent rewards. Read More

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Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction.

Cochrane Database Syst Rev 2021 07 22;7:CD013877. Epub 2021 Jul 22.

Cochrane UK, Oxford, UK.

Background: Loss of olfactory function is well recognised as a cardinal symptom of COVID-19 infection, and the ongoing pandemic has resulted in a large number of affected individuals with abnormalities in their sense of smell. For many, the condition is temporary and resolves within two to four weeks. However, in a significant minority the symptoms persist. Read More

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N-3 Long Chain Fatty Acids Supplementation, Fatty Acids Desaturase Activity, and Colorectal Cancer Risk: A Randomized Controlled Trial.

Nutr Cancer 2021 Jul 22:1-11. Epub 2021 Jul 22.

Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Introduction: n-3 long-chain polyunsaturated fatty acids (LCPUFA) have anti-inflammatory effects and may reduce colorectal cancer risk. The purpose of this study was to evaluate the effects of n-3 LCPUFA supplementation on markers of rectal cell proliferation and apoptosis and examine how genetic variation in desaturase enzymes might modify this effect.

Methods: We conducted a randomized, double-blind, control six-month trial of 2. Read More

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Rivastigmine for minor visual hallucinations in Parkinson's disease: A randomized controlled trial with 24 months follow-up.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Background: Visual hallucinations are common in patients with Parkinson's disease and represent probably the major independent predictor for cognitive deterioration and nursing home placement.

Objective: To investigate if treatment of minor visual hallucinations in Parkinson's disease with rivastigmine delays the progression to psychosis.

Methods: A multicenter, randomized, double-blind, placebo-controlled trial was conducted which aimed to recruit 168 patients with Parkinson's disease reporting minor visual hallucinations 4 weeks before it. Read More

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High body mass index and sleep problems during pregnancy: A meta-analysis and meta-regression of observational studies.

J Sleep Res 2021 Jul 22:e13443. Epub 2021 Jul 22.

Department of Computer Science, National University of Singapore, Singapore, Singapore.

Despite the well-established correlation of weight and sleeping problems, little is known about the nature of the association. The present study examined whether pregnant women with high body mass index have a risk of developing sleep problems, and identified any covariates that affect this relationship. We systematically searched electronic databases, specialized journals, various clinical trial registries, grey literature databases and the reference list of the identified studies. Read More

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The Effects of Tranexamic Acid on Bleeding Control During and after Percutaneous Nephrolithotomy (PCNL): A Randomized Clinical Trial.

Urol J 2021 Jul 22:6505. Epub 2021 Jul 22.

3. Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Purpose: Tranexamic acid is a fibrinolysis suppressor that is used for a variety of bleeding control procedures such as hematuria, surgery bleeding, and trauma caused bleeding. The advantages of using the tranexamic acid are bleeding control and less need for blood transfusion.

Materials And Methods:  This double blind clinical trial was conducted on 108 patients in Imam Khomeni Hospital, Urmia, Iran 2013-14. Read More

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Interferential Electrical Stimulation Efficacy in the Management of Lower Urinary Tract Dysfunction in Children: A Review of the Literature.

Urol J 2021 Jul 22. Epub 2021 Jul 22.

Pediatric Urology and Regenerative Medicine Research Center, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lower urinary tract dysfunction (LUTD) is the most common problem of the referral children to the pediatric urology clinics. If this condition does not treat early in life, it will be a lifelong problem. During recent decades, electrical stimulation therapy has been expanded and extensively used for the treatment of LUTD in both adults and children. Read More

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Comparison of the effects of 2 ventilatory strategies using tidal volumes of 6 and 8 ml/kg on pulmonary shunt and alveolar dead space volume in upper abdominal cancers surgery.

Med J Islam Repub Iran 2021 19;35:79. Epub 2021 Jun 19.

Lung Disease Research Center, Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.

High tidal volume leads to inflammation, and low tidal volume leads to atelectasia and hypoxemia. This study was conducted to compare the effect of 6 mL/kg with positive end-expiratory pressure (PEEP) and 8 mL/kg without PEEP on pulmonary shunt and dead space volume. This clinical trial was done on 36 patients aged 20 to 65 years old with ASA I-II. Read More

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A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis.

Avicenna J Phytomed 2021 Jul-Aug;11(4):332-342

Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Recently, saffron ( L. from the Iridaceae family) has been characterized by its antioxidant, anti-inflammatory and analgesic effects. This study aimed to evaluate the effect of saffron on disease activity in patients with rheumatoid arthritis (RA). Read More

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December 2019

Postprandial effects of a whey protein-based multi-ingredient nutritional drink compared with a normal breakfast on glucose, insulin, and active GLP-1 response among type 2 diabetic subjects: a crossover randomised controlled trial.

J Nutr Sci 2021 12;10:e49. Epub 2021 Jul 12.

Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.

Postprandial hyperglycaemia is recognised as an important target in type 2 diabetes management. Dietary pattern, meal composition, and amount of food intake are major factors for maintaining postprandial blood glucose levels. The aim of this study was to investigate the effect of consuming a whey protein-based multi-ingredient nutritional drink (WD) on postprandial glycaemic, insulinaemic, and active glucagon-like peptide-1 (GLP-1) responses in comparison to a typical breakfast, which is boiled white rice with chicken (BC) in patients with type 2 diabetes mellitus (T2DM). Read More

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Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit.

J Nutr Sci 2021 12;10:e48. Epub 2021 Jul 12.

Clinical Research Development Unit, Imam Khomeini Hospital, Urmia University of Medical Sciences, Ershad Ave, 5756151818 Urmia, West Azerbaijan Province, Iran.

Today, trauma is known to be the third leading cause of death in most countries. Studies have demonstrated below-normal plasma levels of antioxidants in trauma patients. The present study aimed to assess the efficacy of Coenzyme Q10 (CoQ10) on oxidative stress, clinical outcomes and anthropometrical parameters in traumatic mechanical ventilated patients admitted to the intensive care unit. Read More

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Clinical outcomes of maitland mobilization in patients with Myofascial Chronic Neck Pain: A randomized controlled trial.

Pak J Med Sci 2021 Jul-Aug;37(4):1172-1178

Dr. Nadia Saleem, MS (Rehab), Assistant Professor, Bakhtawar Amin College of Rehabilitation Sciences, Multan Pakistan.

Background And Objective: Myofascial neck pain is a common musculoskeletal problem caused by presence of trigger points and local and referred pain patterns. Chronic neck pain is responsible for the involvement of joints, ligaments, fascia and connective tissue as well. The objective of this study was to assess the effect of Maitland mobilization in patients with myofascial chronic neck pain. Read More

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January 2021

Effect of Postoperative High-Concentration Oxygen on Recovery After Thyroid Surgery: A Prospective, Open, Randomized, Controlled Study.

Front Endocrinol (Lausanne) 2021 5;12:595571. Epub 2021 Jul 5.

West China School of Nursing, Sichuan University/Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the effectiveness of high-concentration oxygen on the improvement of throat symptoms and voice changes after thyroid surgery and its protection of the parathyroid function.

Methods: A total of 600 patients undergoing thyroid surgery who met the inclusion criteria were randomly divided into the experimental group (n = 300) and the control group (n = 300) by using a random number generator. The patients in the experimental group underwent high-oxygen treatment [FiO80 (8 L/min)] for 6 continuous hours after returning to the ward after surgery. Read More

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No Effects of Mental Fatigue and Cerebral Stimulation on Physical Performance of Master Swimmers.

Front Psychol 2021 5;12:656499. Epub 2021 Jul 5.

LAFISE - Laboratório de Fisiologia do Exercício, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Mental fatigue is a psychobiological state caused by extended periods of cognitive effort, and evidence suggests that mentally fatigued athletes present impaired physical performance. Different ergogenic aids have been proposed to counteract the deleterious effects of mental fatigue, but whether brain stimulation can counteract mental fatigue is still unknown. This scenario is even more obscure considering the effects of these interventions (mental fatigue induction and brain stimulation) in a very experienced population consisting of master athletes. Read More

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