10,702 results match your criteria tregs


Mechanisms of exTreg induction.

Eur J Immunol 2021 May 11. Epub 2021 May 11.

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

CD4 CD25 Foxp3 regulatory T cells (Tregs) play an important role in the maintenance of the immune system by regulating immune responses and resolving inflammation. Tregs exert their function by suppressing other immune cells and mediating peripheral self-tolerance. Under homeostatic conditions, Tregs are stable T cell populations. Read More

View Article and Full-Text PDF

Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation.

Transpl Immunol 2021 May 8:101405. Epub 2021 May 8.

Department of Biofunctional Microbiota, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Cell Biology, Biomedical Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address:

Background: Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are attractive immune cells to induce immune tolerance. To explore a strategy for improving the efficacy of MDSC therapies, we examined the impact of adoptive transfer of several types of MDSCs on graft rejection in a murine heart transplantation model.

Methods: We analyzed the effects of induced syngeneic and allogeneic bone marrow-derived MDSCs (BM-MDSCs) on graft survival and suppressive capacity. Read More

View Article and Full-Text PDF

Changes in peripheral blood regulatory T cells, and IL-6 and IL-10 levels predict response of pediatric medulloblastoma and germ cell tumors with residual or disseminated disease to craniospinal irradiation.

Int J Radiat Oncol Biol Phys 2021 May 8. Epub 2021 May 8.

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

Purpose: Radiotherapy modulates immune cells and cytokines resulting in both clinically beneficial and detrimental effects. The changes in peripheral blood T lymphocyte subsets and cytokines during radiotherapy for pediatric brain tumors and the association of these changes with therapeutic outcomes have not been well described.

Methods And Materials: The study population consisted of children (n=83, ages 3∼18) with primary brain tumors (medulloblastoma, glioma, germ cell tumors, and CNS embryonal tumor-NOS), with or without residual or disseminated (R/D) diseases who were starting standard post-operative focal or craniospinal-irradiation (CSI). Read More

View Article and Full-Text PDF

Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy.

MAbs 2021 Jan-Dec;13(1):1913791

Roche Innovation Center Zurich, Zurich, Switzerland.

Simlukafusp alfa (FAP-IL2v, RO6874281/RG7461) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAP) and an IL-2 variant with a retained affinity for IL-2Rβγ > IL-2 Rβγ and abolished binding to IL-2 Rα. Here, we investigated the immunostimulatory properties of FAP-IL2v and its combination with programmed cell death protein 1 (PD-1) checkpoint inhibition, CD40 agonism, T cell bispecific and antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. The binding and immunostimulatory properties of FAP-IL2v were investigated and compared with FAP-IL2wt. Read More

View Article and Full-Text PDF

The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging.

Front Oncol 2021 22;11:669066. Epub 2021 Apr 22.

Department of Biological Sciences, School of Dental Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

An increased accumulation of immune-dysfunction-associated CD4Foxp3 regulatory T cells (T) is observed in aging oral mucosa during infection. Here we studied the function of T during oral cancer development in aging mucosa. First, we found heightened proportions of T and myeloid-derived suppressor cells (MDSC) accumulating in mouse and human oral squamous cell carcinoma (OSCC) tissues. Read More

View Article and Full-Text PDF

Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?

Front Immunol 2021 23;12:633845. Epub 2021 Apr 23.

Department of Pediatrics, Pediatric Rheumatology, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative stress. Activation of NRF2 therefore seems to represent a putative therapeutic target in SLE, which is nevertheless challenged by several findings suggesting tissue and cell specific differences in the effect of NRF2 expression. Read More

View Article and Full-Text PDF

[The role of regulatory T cells in multiple myeloma progression].

Authors:
Yawara Kawano

Rinsho Ketsueki 2021 ;62(4):299-304

Department of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Faculty of Life Sciences, Faculty of Life Sciences, Kumamoto University.

Regulatory T cells (Tregs) are a subset of CD4+ T lymphocytes that suppress the functions of antigen-presenting cells and effector T cells, characterized by the expression of transcription factor forkhead box P3 (FOXP3). Recent studies have reported an increase in the number of Tregs in the bone marrow (BM) of multiple myeloma (MM) patients. However, the role and mechanisms of Treg accumulation in the BM of MM patients remain debatable. Read More

View Article and Full-Text PDF

The predictive value of tumor infiltrating leukocytes in Hepatocellular Carcinoma: A systematic review and meta-analysis.

Eur J Surg Oncol 2021 May 4. Epub 2021 May 4.

Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. Electronic address:

Background: For Hepatocellular carcinoma (HCC) surgery either through resection or transplantation often provides the only chance for cure. Since hepatocarcinogenesis and postsurgical prognosis is not only dependent on cirrhosis but also on immune activation and exhaustion, many studies have investigated tumor infiltrating leukocyte (TIL) subsets. This systematic review and meta-analysis aims at describing the cell groups and their predictive power regarding overall (OS), disease free (DFS) and recurrence free survival (RFS). Read More

View Article and Full-Text PDF

The effect of exercise on regulatory T cells: A systematic review of human and animal studies with future perspectives and methodological recommendations.

Exerc Immunol Rev 2021 ;27:142-166

Department of "Performance and Health (Sports Medicine)", Institute of Sport and Sport Science, Technical University Dortmund, Dortmund, Germany.

Many of the exercise-related health-promoting effects are attributed to beneficial immunomodulation. The restoration of immune homeostasis is context-dependent, meaning either to increase anti-inflammatory signaling to counteract disease progression of non-communicable (auto)inflammatory diseases or to enhance (local) activity of proinflammatory immune cells to slow down or inhibit cancer progression. Regulatory CD4+ T cells (Tregs) represent the main regulatory component of the adaptive immune system that fine-tunes inflammatory responses, keeps them in check and prevents long-lasting autoimmunity. Read More

View Article and Full-Text PDF
January 2021

Infliximab modifies regulatory T cells and co-inhibitory receptor expression on circulating T cells in psoriasis.

Int Immunopharmacol 2021 May 6;96:107722. Epub 2021 May 6.

Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China; Institute of Psoriasis, Tongji University School of Medicine, Shanghai 200072, China; Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. Electronic address:

Background: Psoriasis is a T cell-mediated autoimmune skin disease. Accumulating evidence has demonstrated that co-inhibitory receptors (CIRs) play a vital role in regulating T cell-mediated immune response, especially in neoplasm and autoimmunity. However, the immuno-function of CIRs in the development of psoriasis remains unclear. Read More

View Article and Full-Text PDF

Cell therapy in transplantation: A comprehensive review of the current applications of cell therapy in transplant patients with the focus on Tregs, CAR Tregs, and Mesenchymal stem cells.

Int Immunopharmacol 2021 May 6;97:107669. Epub 2021 May 6.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, 009821 Tehran, Iran. Electronic address:

Organ transplantation is a practical treatment for patients with end-stage organ failure. Despite the advances in short-term graft survival, long-term graft survival remains the main challenge considering the increased mortality and morbidity associated with chronic rejection and the toxicity of immunosuppressive drugs. Since a novel therapeutic strategy to induce allograft tolerance seems urgent, focusing on developing novel and safe approaches to prolong graft survival is one of the main goals of transplant investigators. Read More

View Article and Full-Text PDF

Repurposing Nintedanib for Pathological Cardiac Remodeling and Dysfunction.

Pharmacol Res 2021 May 6:105605. Epub 2021 May 6.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, AL 35294-1913, USA. Electronic address:

Heart Failure (HF) is the leading cause of death worldwide. Myocardial fibrosis, one of the clinical manifestations implicated in almost every form of heart disease, contributes significantly to HF development. However, there is no approved drug specifically designed to target cardiac fibrosis. Read More

View Article and Full-Text PDF

Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.

Arthritis Res Ther 2021 May 8;23(1):137. Epub 2021 May 8.

Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Aldehyde dehydrogenase 1 family member A1 (RALDH1)-producing dermal dendritic cells (DCs), a conventional DC subset regulating skin fibrosis, are decreased in the involved skin of patients with systemic sclerosis (SSc). In this study, we investigated the contribution of Fli1 deficiency, a potential predisposing factor of SSc, to the phenotypical alteration of RALDH1-producing dermal DCs by using SSc model mice and SSc skin samples.

Methods: Bleomycin (BLM)-induced skin fibrosis was generated with Fli1 and wild-type mice. Read More

View Article and Full-Text PDF

Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.

J Neurooncol 2021 May 8. Epub 2021 May 8.

Division of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Purpose: Tumor infiltration by immunosuppressive myeloid cells or tumor-associated macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult counterparts, higher TAM signatures do not correlate with aggressive tumor behavior in pediatric brain tumors. While prominent TAM infiltrates exist before and after radiation, the degree to which irradiated macrophages and microglia support progression or leptomeningeal metastasis remains unclear. Read More

View Article and Full-Text PDF

Single-cell profiles and prognostic impact of tumor-infiltrating lymphocytes co-expressing CD39, CD103, and PD-1 in ovarian cancer.

Clin Cancer Res 2021 May 7. Epub 2021 May 7.

Deeley Research Centre, BC Cancer

Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly defined. CD39, CD103, and PD-1 have been independently proposed as markers of tumor-reactive CD8+ TIL in various cancers. We evaluated the phenotype, clonality and prognostic significance of TIL expressing various combinations of these markers in high-grade serous ovarian cancer (HGSC), a malignancy in need of more effective immunotherapeutic approaches. Read More

View Article and Full-Text PDF

c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice.

Eur J Immunol 2021 May 7. Epub 2021 May 7.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.

The NF-κB transcription factor c-Rel is a critical regulator of regulatory T cell (Treg) ontogeny, controlling multiple points of the stepwise developmental pathway. Here, we found that the thymic Treg development defect in c-Rel-deficient (cRel ) mice is quantitative not qualitative based on analyses of T cell receptor (TCR) repertoire and TCR signalling strength. However, these parameters were altered in the thymic Treg-precursor population, which is also markedly diminished in cRel mice. Read More

View Article and Full-Text PDF

Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function.

Oxid Med Cell Longev 2021 19;2021:5512322. Epub 2021 Apr 19.

Department of Cardiovascular surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Ketogenic diet (KD) is popular in diabetic patients but its cardiac safety and efficiency on the heart are unknown. The aim of the present study is to determine the effects and the underlined mechanisms of KD on cardiac function in diabetic cardiomyopathy (DCM). We used db/db mice to model DCM, and different diets (regular or KD) were used. Read More

View Article and Full-Text PDF

Lack of Specific Regulatory T-Cell Depletion and Cytoreduction Associated with Extensive Toxicity after Administration of Low and High Doses of Cyclophosphamide.

AIDS Res Hum Retroviruses 2021 May 6. Epub 2021 May 6.

University of Pittsburgh, Division of Infectious Diseases, Pittsburgh, Pennsylvania, United States;

Up-to 93% of the HIV latent reservoir is comprised of defective proviruses, suggesting that a functional cure is possible through the elimination of a small population of cells containing intact virus, instead of the entire reservoir. Cyclophosphamide (Cy) is an established chemotherapeutic agent for immune cell cancers. In high doses, Cy is a nonselective cytoreductor, used in allogeneic stem-cell transplantation, while in a low dose, metronomic schedule, Cy selectively depletes regulatory T cells (Tregs). Read More

View Article and Full-Text PDF

Mesenchymal stem cells derived from human dental follicle modulate the aberrant immune response in atopic dermatitis.

Immunotherapy 2021 May 6. Epub 2021 May 6.

Division of Pediatric Allergy & Immunology, Marmara University, Istanbul, Turkey.

Atopic dermatitis (AD) is an inflammatory cutaneous disorder. The advancements in the understanding of AD immunological pathogenesis have caused the development of therapies that suppress the dysregulated immune response. We aimed to evaluate the immunomodulatory effect of dental stem cells (dental follicle-mesenchymal stem cells [DF-MSCs]) on AD patients. Read More

View Article and Full-Text PDF

Tetrahedral Framework Nucleic Acids Induce Immune Tolerance and Prevent the Onset of Type 1 Diabetes.

Nano Lett 2021 May 6. Epub 2021 May 6.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.

A failure in immune tolerance leads to autoimmune destruction of insulin-producing β-cells, leading to type 1 diabetes (T1D). Inhibiting autoreactive T cells and inducing regulatory T cells (Tregs) to re-establish immune tolerance are promising approaches to prevent the onset of T1D. Here, we investigated the ability of tetrahedral framework nucleic acids (tFNAs) to induce immune tolerance and prevent T1D in nonobese diabetic (NOD) mice. Read More

View Article and Full-Text PDF

1,25-Dihydroxyvitamin D3 Supplementation during Pregnancy Is Associated with Allergic Rhinitis in the Offspring by Modulating Immunity.

J Immunol Res 2021 14;2021:6638119. Epub 2021 Apr 14.

Department of Otolaryngology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.

Background: Maternal supplementation with 1,25-dihydroxyvitamin D3 (VD3) has immunologic effects on the developing fetus through multiple pathways. This study was aimed at investigating the effects of VD3 supplementation on immune dysregulation in the offspring during allergic rhinitis.

Methods: Different doses of VD3 as well as control were given to pregnant female mice. Read More

View Article and Full-Text PDF

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.

Front Immunol 2021 19;12:661990. Epub 2021 Apr 19.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a cohort of 211 PLHIV on stable antiretroviral therapy and in 56 HIV-uninfected controls using flow cytometry. We show that marked differences exist in T cell maturation and differentiation between PLHIV and HIV-uninfected controls: PLHIV had reduced percentages of CD4+ T cells and naïve T cells and increased percentages of CD8+ T cells, effector T cells, and T helper 17 (Th17) cells, together with increased Th17/regulatory T cell (Treg) ratios. Read More

View Article and Full-Text PDF

Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs.

Front Immunol 2021 19;12:634509. Epub 2021 Apr 19.

The Research Institute of the McGill University Health Centre, Division of Pediatric Allergy Immunology and Dermatology, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.

Tregitopes (T regulatory epitopes) are IgG-derived peptides with high affinity to major histocompatibility complex class II (MHCII), that are known to promote tolerance by activating T regulatory cell (Treg) activity. Here we characterized the effect of IgG Tregitopes in a well-established murine model of allergic asthma, demonstrating antigen-specific tolerance adoptive transfer of Tregitope-and-allergen-activated Tregs. Asthma is a heterogeneous chronic inflammatory condition affecting the airways and impacting over 300 million individuals worldwide. Read More

View Article and Full-Text PDF

MHC class II antigen presentation by lymphatic endothelial cells in tumors promotes intratumoral regulatory T cell suppressive functions.

Cancer Immunol Res 2021 May 5. Epub 2021 May 5.

Pathology and Immunology, Geneva Medical School

Several solid malignancies trigger lymphangiogenesis, facilitating metastasis. Tumor-associated lymphatic vessels significantly contribute to the generation of an immunosuppressive tumor microenvironment (TME). Here, we have investigated the ability of tumoral lymphatic endothelial cells (LECs) to function as MHC class II-restricted antigen-presenting cells in the regulation of antitumor immunity. Read More

View Article and Full-Text PDF

Circulating T regulatory cells in patients with psoriasis with and without atherosclerosis: A pilot comparative study before and after photochemotherapy.

Photodermatol Photoimmunol Photomed 2021 May 5. Epub 2021 May 5.

Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, PO box, 11562.

Evidence is accumulating proving the role of T regulatory cells (Tregs) in both psoriasis and atherosclerosis pathogenesis and treatment. Psoralen-ultraviolet A (PUVA) remains a standard line of therapy for psoriasis, particularly darker phototypes, whenever the risk-benefit ratio is waived carefully. Despite the well-known therapeutic effect of UV phototherapy on psoriasis cutaneous lesions, it is still unclear if its immunomodulatory function can positively impact cardiac comorbidities in patients with psoriasis, such as atherosclerosis. Read More

View Article and Full-Text PDF

Isolation and expansion of thymus-derived regulatory T cells for use in paediatric heart transplant patients.

Eur J Immunol 2021 May 5. Epub 2021 May 5.

MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's, College London, Guy's Hospital, London, UK.

Regulatory T-cells (Tregs) are a subset of T-cells generated in the thymus with intrinsic immunosuppressive properties. Phase I clinical trials have shown safety and feasibility of Treg infusion to promote immune tolerance and new studies are ongoing to evaluate their efficacy. During heart transplantation, thymic tissue is routinely discarded providing an attractive source of Tregs. Read More

View Article and Full-Text PDF

Donor Treg expansion by liposomal α-galactosylceramide modulates Tfh cells and prevents sclerodermatous chronic graft-versus-host disease.

Immun Inflamm Dis 2021 May 4. Epub 2021 May 4.

Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background And Aim: Chronic graft-versus-host disease (cGVHD) is a major cause of nonrelapse morbidity and mortality following hematopoietic stem cell transplantation (HSCT). α-Galactosylceramide (α-GC) is a synthetic glycolipid that is recognized by the invariant T-cell receptor of invariant natural killer T (iNKT) cells in a CD1d-restricted manner. Stimulation of iNKT cells by α-GC leads to the production of not only immune-stimulatory cytokines but also immune-regulatory cytokines followed by regulatory T-cell (Treg) expansion in vivo. Read More

View Article and Full-Text PDF

CAR and TRuC redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII.

Mol Ther 2021 Apr 30. Epub 2021 Apr 30.

Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202. Electronic address:

Regulatory T cells (Treg) control immune responses in autoimmune disease, transplantation, and enable antigen-specific tolerance induction in protein replacement therapies. Tregs can exert a broad array of suppressive functions through their T cell receptor (TCR) in a tissue-directed and antigen-specific manner. This capacity can now be harnessed for tolerance induction by "redirecting" polyclonal Tregs to overcome low inherent precursor frequencies and simultaneously augment suppressive functions. Read More

View Article and Full-Text PDF

Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine 2021 Apr 29;67:103345. Epub 2021 Apr 29.

Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

Background: near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that uses antibody-photoabsorber (IRDye700DX, IR700) conjugates (APCs) which bind to target cells and are photoactivated by NIR light inducing rapid necrotic cell death. NIR-PIT targeting human epidermal growth factor receptor (hEGFR) has been shown to destroy hEGFR expressing human tumor cells and to be effective in immunodeficient mouse models. NIR-PIT can also be targeted to cells in the tumor microenvironment, for instance, CD25-targeted NIR-PIT can be used to selectively deplete regulatory T cells (Tregs) within a tumor. Read More

View Article and Full-Text PDF

Induction of stable human FOXP3 Tregs by a parasite-derived TGF-β mimic.

Immunol Cell Biol 2021 Apr 30. Epub 2021 Apr 30.

BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

Immune homeostasis in the intestine is tightly controlled by FOXP3 regulatory T cells (Tregs), defects in which are linked to development of chronic conditions, such as inflammatory bowel disease (IBD). As a mechanism of immune evasion, several species of intestinal parasites boost Treg activity. The parasite Heligmosomoides polygyrus is known to secrete a molecule (Hp-TGM) which mimics the ability of TGF-β to induce FOXP3 expression in CD4 T cells. Read More

View Article and Full-Text PDF