248 results match your criteria treatment vascular-related

Lung vessel volume evaluated with CALIPER software is an independent predictor of mortality in COVID-19 patients: a multicentric retrospective analysis.

Eur Radiol 2022 Jan 13. Epub 2022 Jan 13.

Department of Diagnosis and Treatment Services, Radiodiagnostics, Azienda Ospedaliero Universitaria Maggiore Della Carità, Novara, Italy.

Introduction: Computer-Aided Lung Informatics for Pathology Evaluation and Ratings (CALIPER) software has already been widely used in the evaluation of interstitial lung diseases (ILD) but has not yet been tested in patients affected by COVID-19. Our aim was to use it to describe the relationship between Coronavirus Disease 2019 (COVID-19) outcome and the CALIPER-detected pulmonary vascular-related structures (VRS).

Materials And Methods: We performed a multicentric retrospective study enrolling 570 COVID-19 patients who performed a chest CT in emergency settings in two different institutions. Read More

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January 2022

Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms.

Phytother Res 2022 Jan 13. Epub 2022 Jan 13.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. Read More

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January 2022

[A single-center retrospective analysis of 77 traumatic arterial injuries of lower extremities].

Zhonghua Wai Ke Za Zhi 2022 Jan 1;60(1):63-68. Epub 2022 Jan 1.

Department of Vascular Surgery,Yichang Central People's Hospital,the First Clinical Medical College of China Three Gorges University,Yichang 443003,China.

To analyze the treatment and clinical prognosis of lower extremity arterial injury caused by trauma. The clinical data of 77 patients with traumatic lower extremity arterial injury admitted to Department of Vascular Surgery,Yichang Central People's Hospital from January 2013 to June 2021 were collected. There were 65 males and 12 females, with an average age of 47. Read More

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January 2022

Treatment dilemmas: strategies for priapism, chronic leg ulcer disease, and pulmonary hypertension in sickle cell disease.

Hematology Am Soc Hematol Educ Program 2021 12;2021(1):411-417

The Ohio State University Wexner Medical Center, Department of Internal Medicine, Columbus, OH.

Sickle cell disease is a disorder characterized by chronic hemolytic anemia and multiorgan disease complications. Although vaso-occlusive episodes, acute chest syndrome, and neurovascular disease frequently result in complication and have well-documented guidelines for management, the management of chronic hemolytic and vascular-related complications, such as priapism, leg ulcers, and pulmonary hypertension, is not as well recognized despite their increasing reported prevalence and association with morbidity and mortality. This chapter therefore reviews the current updates on diagnosis and management of priapism, leg ulcers, and pulmonary hypertension. Read More

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December 2021

[The clinical application of two-complex and one-plane technique for renal artery location in transperitoneal laparoscopic radical nephrectomy].

Zhonghua Wai Ke Za Zhi 2021 Nov;59(11):912-917

Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To examine the clinical application effects of two-complex and one-plane technique for the renal artery dissected location in transperitoneal laparoscopic radical nephrectomy(LRN). Clinical data of patients diagnosed as renal tumor between January 2016 and December 2019 that treated with transperitoneal LRN and the two-complex and one-plane technique was performed to locate and dissect the renal arteries were analyzed retrospectively. A total of 206 qualified patients were enrolled, included 71 cases from Kaifeng Central Hospital and 135 cases from the First Affiliated Hospital of Zhengzhou University. Read More

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November 2021

Using three-dimensional visualization as an optimal tool to plan and validate an aortopexy in a congenital heart disease patient with severe tracheal stenosis.

Interact Cardiovasc Thorac Surg 2021 Nov 5. Epub 2021 Nov 5.

Clinic for Children's Heart Medicine, University Heart & Vascular Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

We present a patient with severe tracheal stenosis resulting from a compression by the innominate artery 6 months after an arterial switch operation in a dextro-transposition of the great arteries. Segmentation and three-dimensional (3D) visualization were derived from a contrast-enhanced dual-source computed tomography and post-processing was performed using a dedicated open-source platform (3D Slicer). Post-processing allowed a comprehensible visualization of the relationship of the innominate artery to the trachea when compared to standard computer tomography reformations. Read More

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November 2021

Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis.

Dis Markers 2021 13;2021:7897994. Epub 2021 Oct 13.

Department of Otolaryngology, HwaMei Hospital, University of Chinese Academy of Sciences, China.

Background: The safety of radiotherapy techniques in the treatment of vestibular schwannoma (VS) shows a high rate of tumor control with few side effects. Neuropeptide Y (NPY) may have a potential relevance to the recurrence of VS. Further research is still needed on the key genes that determine the sensitivity of VS to radiation therapy. Read More

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October 2021

Targeting the Angiopoietin/Tie Pathway: Prospects for Treatment of Retinal and Respiratory Disorders.

Drugs 2021 Oct 29;81(15):1731-1749. Epub 2021 Sep 29.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1406 S. Coulter St., Amarillo, TX, 79106, USA.

Anti-angiogenic approaches have significantly advanced the treatment of vascular-related pathologies. The ephemeral outcome and known side effects of the current vascular endothelial growth factor (VEGF)-based anti-angiogenic treatments have intensified research on other growth factors. The angiopoietin/Tie (Ang/Tie) family has an established role in vascular physiology and regulates angiogenesis, vascular permeability, and inflammatory responses. Read More

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October 2021

Nailfold capillaries and myositis specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis.

Rheumatology (Oxford) 2021 Sep 8. Epub 2021 Sep 8.

Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Kasumi, Minami-ku, Hiroshima, Japan.

Objectives: This study aimed to quantify nailfold capillary (NFC) abnormalities in anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) patients and to evaluate the association with clinical parameters, including serum biomarkers. In addition, we aimed to clarify the period leading to remission of NFC abnormalities during immunosuppressive treatment in patients with DM.

Methods: A prospective observational study was conducted including patients (n = 10) who first visited Hiroshima University Hospital and were diagnosed with DM or clinically amyopathic dermatomyositis (CADM) with anti-MDA5 antibodies. Read More

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September 2021

Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes.

Sci Rep 2021 08 17;11(1):16656. Epub 2021 Aug 17.

NHMRC Clinical Trials Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

To determine whether continuous subcutaneous insulin infusion (CSII) vs. multiple daily injections (MDI) therapy from near-diagnosis of type 1 diabetes is associated with reduced glycaemic variability (GV) and altered microRNA (miRNAs) expression. Adolescents (74% male) within 3-months of diabetes diagnosis (n = 27) were randomized to CSII (n = 12) or MDI. Read More

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Impact of Peels Extracts from an Italian Ancient Tomato Variety Grown under Drought Stress Conditions on Vascular Related Dysfunction.

Molecules 2021 Jul 15;26(14). Epub 2021 Jul 15.

Cardiovascular Research Laboratory, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56100 Pisa, Italy.

Background: Tomato by-products contain a great variety of biologically active substances and represent a significant source of natural antioxidant supplements of the human diet. The aim of the work was to compare the antioxidant properties of a by-product from an ancient Tuscan tomato variety, Rosso di Pitigliano (RED), obtained by growing plants in normal conditions (-Ctr) or in drought stress conditions (-Ds) for their beneficial effects on vascular related dysfunction.

Methods: The antioxidant activity and total polyphenol content (TPC) were measured. Read More

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Jujuboside B Inhibits Neointimal Hyperplasia and Prevents Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration Activation of AMPK/PPAR-γ Signaling.

Front Pharmacol 2021 24;12:672150. Epub 2021 Jun 24.

Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The uncontrolled proliferation and migration of vascular smooth muscle cells is a critical step in the pathological process of restenosis caused by vascular intimal hyperplasia. Jujuboside B (JB) is one of the main biologically active ingredients extracted from the seeds of Zizyphus jujuba (SZJ), which has the properties of anti-platelet aggregation and reducing vascular tension. However, its effects on restenosis after vascular intervention caused by VSMCs proliferation and migration remain still unknown. Read More

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Multicenter Experience With Large Diameter Balloon-Expandable Stent-Grafts for the Treatment of Infrarenal Penetrating Aortic Ulcers.

J Endovasc Ther 2021 Dec 30;28(6):871-877. Epub 2021 Jun 30.

Department of Vascular Surgery, Ludwig-Maximilians University Hospital, Munich, Germany.

Purpose: To describe the use of large-diameter balloon-expandable stent-grafts (BeGraft aortic stent-graft, Bentley InnoMed GmbH, Hechingen, Germany) in the treatment of infrarenal penetrating aortic ulcer (iPAU).

Materials And Methods: Retrospective analysis of patients undergoing endovascular treatment with the BeGraft aortic stent-graft in 8 European centers from January 2017 to October 2020. Demographics, perioperative data, and midterm outcomes were collected. Read More

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December 2021

Effects of the Vertebral Artery Ostium/Subclavian Artery Angle on In-Stent Restenosis after Vertebral Artery Ostium Stenting.

Biomed Res Int 2021 27;2021:5527988. Epub 2021 Apr 27.

Department of Neurology, Chinese PLA General Hospital, First Medical Center, Beijing, China.

Methods: Between January 2016 and October 2018, sixty-four consecutive patients who underwent a total of 66 stenting procedures were screened for symptomatic and asymptomatic atherosclerotic VAOS. Of these patients, 57 had complete follow-up data. The baseline patient demographics and morphological features of the VAO were recorded. Read More

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Vessel segmentation from volumetric images: a multi-scale double-pathway network with class-balanced loss at the voxel level.

Med Phys 2021 Jul 31;48(7):3804-3814. Epub 2021 May 31.

Xi'an Key Lab of Radiomics and Intelligent Perception, School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi, 710069, China.

Purpose: Vessel segmentation from volumetric medical images is becoming an essential pre-step in aiding the diagnosis, guiding the therapy, and patient management for vascular-related diseases. Deep learning-based methods have drawn many attentions, but most of them did not fully utilize the multi-scale spatial information of vessels. To address this shortcoming, we propose a multi-scale network similar to the well-known multi-scale DeepMedic. Read More

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Blood supply of the male breast nipple-areola complex evaluated by CTA.

J Plast Reconstr Aesthet Surg 2021 Oct 10;74(10):2588-2595. Epub 2021 Mar 10.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuai Fu Yuan 1#, Dongcheng Dist., Beijing 100730, China. Electronic address:

Purpose: In addition to women, men also undergo breast surgeries, and early studies on the blood supply of breasts are nearly all conducted in female subjects. The vasculature of the male breast is seldom studied. Understanding the male-specific blood supply of the breast is important for pre-operative planning and reducing complications. Read More

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October 2021

Vascular Abnormalities Detected with Chest CT in COVID-19: Spectrum, Association with Parenchymal Lesions, Cardiac Changes, and Correlation with Clinical Severity (COVID-CAVA Study).

Diagnostics (Basel) 2021 Mar 29;11(4). Epub 2021 Mar 29.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland.

Although vascular abnormalities are thought to affect coronavirus disease 2019 (COVID-19) patients' outcomes, they have not been thoroughly characterized in large series of unselected patients. The Swiss national registry coronavirus-associated vascular abnormalities (CAVA) is a multicentric cohort of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who underwent a clinically indicated chest computed tomography (CT) aiming to assess the prevalence, severity, distribution, and prognostic value of vascular and non-vascular-related CT findings. Clinical outcomes, stratified as outpatient treatment, inpatient without mechanical ventilation, inpatient with mechanical ventilation, or death, will be correlated with CT and biological markers. Read More

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Variations in the position of the aorta and vertebral safe zones in supine, prone, and lateral decubitus for adolescent idiopathic scoliosis.

Eur Spine J 2021 07 22;30(7):1950-1958. Epub 2021 Mar 22.

Orthopaedic Surgery, Spinal Unit, Hospital Universitario Niño Jesús, C/ Menéndez Pelayo 65, 28009, Madrid, Spain.

Purpose: Analyze the modifications in the "safe zones" of T4-L4 vertebral bodies relative to aorta according to patient positioning, as well as in the relationship between the aorta and the vertebrae.

Methods: Patients with adolescent idiopathic scoliosis who underwent surgical treatment during 2017 were included. Preoperative whole spine MRI in supine, prone, and LD positions was performed. Read More

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Impact of standardized computed tomographic angiography for minimally invasive mitral and tricuspid valve surgery.

J Cardiothorac Surg 2021 Mar 20;16(1):34. Epub 2021 Mar 20.

Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

Background: Femoral cannulation for extracorporeal circulation (ECC) is a standard procedure for minimally invasive cardiac surgery (MICS) of the atrio-ventricular valves. Vascular pathologies may cause serious complications. Preoperative computed tomography-angiography (CT-A) of the aorta, axillary and iliac arteries was implemented at our department. Read More

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STEPFORWARD study: a randomised controlled feasibility trial of a self-aligning prosthetic ankle-foot for older patients with vascular-related amputations.

BMJ Open 2021 03 18;11(3):e045195. Epub 2021 Mar 18.

York Trials Unit, Department of Health Sciences, University of York, York, UK.

Objectives: To determine the feasibility of conducting a full-scale randomised controlled trial (RCT) of the effectiveness and cost-effectiveness of a self-aligning prosthetic ankle-foot compared with a standard prosthetic ankle-foot.

Design: Multicentre parallel group feasibility RCT.

Setting: Five prosthetics centres in England recruiting from July 2018 to August 2019. Read More

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Variations in the Profiles of Vascular-Related Factors Among Different Sub-Types of Polycystic Ovarian Syndrome in Northern China.

Front Endocrinol (Lausanne) 2020 26;11:527592. Epub 2021 Feb 26.

Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Recently, a growing body of evidence has suggested that abnormal ovarian angiogenesis, secondary to the imbalance between various angiogenic markers, is involved in the pathogenesis of PCOS, and this has led to the use of various interventions (such as Diane-35) to restore the normal ovarian angiogenesis. Therefore, we conducted the current investigation to determine the role of such markers (endothelial growth factor (VEGF), endostatin (ES), and thrombospondin-1 (TSP-1)) in the pathogenesis of PCOS along with the associated changes in ovarian blood flow in patients with PCOS compared to healthy controls, both before and after a course of oral contraception. A total of 381 patients with PCOS and 98 healthy females of childbearing age were recruited from July 2014 to June 2017 at the Reproductive Center of the Second Affiliated Hospital of Harbin Medical University. Read More

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[Indications and outcomes of TAVI (transcatheter aortic valve implantation) in Iceland].

Laeknabladid 2021 Mar;107(3):123-129

Faculty of Medicine, University of Iceland, Department of Cardiology Landspitali University Hospital, Reykjavik, Iceland.

Introduction: Surgical aortic valve replacement (SAVR) has been the standard of treatment for aortic stenosis but transcatheter aortic valve implantation (TAVI) is increasingly used as treatment in Iceland and elsewhere. Our objective was to assess the outcome of TAVI in Iceland, focusing on indications, complications and survival.

Material And Methods: This retrospective study included all TAVI-procedures performed in Iceland between January 2012 and June 2020. Read More

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Vascular surgery-related violations of the Emergency Medical Treatment and Labor Act.

J Vasc Surg 2021 08 4;74(2):599-604.e1. Epub 2021 Feb 4.

Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Mass. Electronic address:

Objective: The Emergency Medical Treatment and Labor Act (EMTALA) is a federal law established in 1986 to ensure that patients who present to an emergency department receive medical care regardless of means. Violations are reported to the Centers for Medicare and Medicaid Services and can result in significant financial penalties. Our objective was to assess all available EMTALA violations for vascular-related issues. Read More

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Pre-clinical investigation of mesenchymal stromal cell-derived extracellular vesicles: a systematic review.

Cytotherapy 2021 04 2;23(4):277-284. Epub 2021 Feb 2.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran; Department of Biology, University of Science and Culture, Tehran, Iran. Electronic address:

The therapeutic potential of naturally secreted micro- and nanoscale extracellular vesicles (EVs) makes them attractive candidates for regenerative medicine and pharmaceutical science applications. To date, the results of numerous publications have shown the practicality of using EVs to replace mesenchymal stromal cells (MSCs) or liposomes. This article presents a systematic review of pre-clinical studies conducted over the past decade of MSC-derived EVs (MSC-EVs) used in animal models of disease. Read More

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Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.

Tumori 2021 Dec 1;107(6):NP37-NP40. Epub 2021 Feb 1.

Haematology Unit, ASL ROMA 1, Santo Spirito Hospital of Rome, Italy.

Background: Multiple myeloma is a plasma cell dyscrasia accounting for 1% of neoplastic diseases and is the second most common hematologic malignancy after lymphoma. Pulmonary arterial hypertension is characterized by increased blood pressure in the pulmonary circulation and the development of pulmonary vascular remodeling. Increased resistance in the pulmonary vessels strains the right ventricle, leading to right heart failure. Read More

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December 2021

Developmental programming: Adipose depot-specific transcriptional regulation by prenatal testosterone excess in a sheep model of PCOS.

Mol Cell Endocrinol 2021 03 25;523:111137. Epub 2020 Dec 25.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Prenatal testosterone (T)-treated female sheep manifest adipose depot-specific disruptions in inflammatory/oxidative state, adipocyte differentiation and thermogenic adipocyte distribution. The objective of this study was to identify common and divergent gene pathways underlying prenatal T excess-induced adipose depot-specific disruptions. RNA sequencing and network analyses were undertaken with visceral (VAT), subcutaneous (SAT), epicardiac (ECAT) and perirenal (PRAT) adipose tissues from control and prenatal T-treated (100 mg T propionate twice a week from days 30-90 of gestation) female sheep at 21 months of age. Read More

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Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies.

Transl Oncol 2021 Feb 15;14(2):100984. Epub 2020 Dec 15.

Roche Innovation Center Munich, Nonnenwald 2, 82377 Penzberg, Germany. Electronic address:

Vanucizumab is a novel bispecific antibody inhibiting vascular endothelial growth factor (VEGF-A) and angiopoietin-2 (Ang-2) that demonstrated safety and anti-tumor activity in part I of a phase I study of 42 patients with advanced solid tumors. Part II evaluated the pharmacodynamic effects of vanucizumab 30 or 15 mg/kg every 2 weeks in 32 patients. Serial plasma samples, paired tumor, and skin-wound-healing biopsies were taken over 29 days to evaluate angiogenic markers. Read More

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February 2021

Re-organization of the Vascular Surgery Department During the Acute Phase of the COVID19 Outbreak: Lessons Learned and Future Perspectives.

Ann Vasc Surg 2021 Apr 13;72:191-195. Epub 2021 Jan 13.

The Sapienza University of Rome, Rome, Italy.

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represents a serious threat to public health because it leads to a wide spectrum of clinical manifestations. The region Lombardia (Italy) has suffered from severe problems during the acute phase of the outbreak in Italy (March-April 2020). The aim of our analysis is to report the experience of the Department of Vascular Surgery of Pavia, including the learned lessons and future perspectives, considering that the COVID-19 outbreak is in its acute phase in other continents. Read More

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Hydrogen sulfide and vascular regulation - An update.

J Adv Res 2021 Jan 16;27:85-97. Epub 2020 May 16.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Background: Hydrogen sulfide (HS) is considered to be the third gasotransmitter after carbon monoxide (CO) and nitric oxide (NO). It plays an important role in the regulation of vascular homeostasis. Vascular remodeling have has proved to be related to the impaired HS generation. Read More

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January 2021

Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases.

Int J Mol Sci 2020 Dec 4;21(23). Epub 2020 Dec 4.

Department of Chemistry & Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

Vascular-related retinal diseases dramatically impact quality of life and create a substantial burden on the healthcare system. Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are leading causes of irreversible blindness. In recent years, the scientific community has made great progress in understanding the pathology of these diseases and recent discoveries have identified promising new treatment strategies. Read More

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December 2020