106,859 results match your criteria treatment trend


Prevalence of positivity to antibodies to hepatitis C virus among volunteer blood donors in China: a meta-analysis.

Public Health 2021 Sep 24;199:87-95. Epub 2021 Sep 24.

Laboratory Department, Ankang City Maternal and Child Health Hospital, Ankang, Shaanxi, 725000, China. Electronic address:

Objectives: Safe blood transfusion plays an important role in the prevention of transfusion-transmissible infections, and hepatitis C virus (HCV) infection is one of the major problems associated with this procedure. This meta-analysis aimed to determine the prevalence of HCV infection in Chinese blood donors.

Study Design: The study design of this study is a meta-analysis. Read More

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September 2021

Nanoscale Sulfur Improves Plant Growth and Reduces Arsenic Toxicity and Accumulation in Rice ( L.).

Environ Sci Technol 2021 Sep 27. Epub 2021 Sep 27.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, Massachusetts 01003, United States.

Rice is known to accumulate arsenic (As) in its grains, posing serious health concerns for billions of people globally. We studied the effect of nanoscale sulfur (NS) on rice seedlings and mature plants under As stress. NS application caused a 40% increase in seedling biomass and a 26% increase in seed yield of mature plants compared to untreated control plants. Read More

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September 2021

MXene/Carbon Nanotube Hybrids: Synthesis, Structures, Properties and Applications.

ChemSusChem 2021 Sep 27. Epub 2021 Sep 27.

Wuxi Institute of Commerce, Institute of Automotive Technology, 809 Qianhu Rd., 214153, Wuxi, CHINA.

Since the successful preparation of few-layer transition metal carbides from three-dimensional MAX phases in 2011, MXenes (known as a family of layered transition metal carbides, nitrides and carbonitrides) have been intensively studied. Though MXenes have been adopted as active materials in many applications, issues including aggregation and restacking are likely to hamper their potential applications. In order to address these prevailing challenges, the concept of MXene/CNT hybrids was proposed initially in 2015, where CNTs were incorporated as the spacers and conductive additives. Read More

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September 2021

How much does depth matter? Magnetically controlled growing rod distraction directly influenced by rod tissue depth.

Spine Deform 2021 Sep 27. Epub 2021 Sep 27.

Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

Purpose: Magnetically controlled growing rod (MCGR) for the treatment of early-onset scoliosis (EOS) is a relatively innovative technique. MCGR benefits over traditional growing rods are known but limitations and complications are being revealed. The purpose of this study was to examine the importance of tissue depth on rod lengthening. Read More

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September 2021

Impact of Disclosure over Time on the Emotional Well-Being of Children with Perinatally Acquired HIV Infection in South Africa.

J Dev Behav Pediatr 2021 Sep 24. Epub 2021 Sep 24.

Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Psychiatry, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objective: The aim of this study was to describe the disclosure process in children with perinatally acquired HIV infection (PHIV+) and its impact on their emotional well-being and adherence to antiretroviral therapy (ART) in South Africa.

Methods: This prospective cohort study followed PHIV+ children aged 7 to 13 years attending counseling over 18 months. Standardized disclosure tools were used by a counselor with both child and caregiver present. Read More

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September 2021

Cluster-derived obstructive sleep apnea phenotypes and outcomes at five year follow-up.

J Clin Sleep Med 2021 Sep 28. Epub 2021 Sep 28.

Multidisciplinary Sleep Unit, Pneumology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Study Objectives: Obstructive sleep apnea (OSA) is a heterogeneous, complex disease. We aimed to identify OSA phenotypes through cluster analysis and to perform a long-term follow-up to validate the phenotypes.

Methods: We applied a Partitioning Around Medioids technique in a cohort of 1217 participants recently diagnosed with OSA. Read More

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September 2021

A Safe Mobilisation Program to Improve Functional Mobility and Reduce Fall Risks in Cognitively Impaired Older Adults with Higher Level Gait Disorders: A Pilot Study.

Dement Geriatr Cogn Disord 2021 Sep 16:1-8. Epub 2021 Sep 16.

Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Background: The association between gait and cognition, and their combined impact on postural stability may underlie the increased fall risk in older adults with dementia. However, there are few interventions to improve functional mobility and reduce fall risks in people with cognitive impairment.

Objectives: This study aims to investigate the feasibility and acceptability of a Safe Mobilisation Program for cognitively impaired older adults with higher level gait disorders. Read More

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September 2021

SIRT 3 was involved in seed oil protection testis from oxidative stress: and analyses.

Pharm Biol 2021 Dec;59(1):1314-1325

Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education in Ningxia Medical University, Yinchuan, China.

Context: L. (Solanaceae) seed oil (LBSO) exerts LBSO exerts protective effects in the testis and via upregulating SIRT3.

Objective: This study evaluates the effects and mechanism of LBSO in the d-galactose (d-gal)-induced ageing testis. Read More

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December 2021

Prediction of Major Bleeding in Anticoagulated Patients for Venous Thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores.

TH Open 2021 Jul 9;5(3):e319-e328. Epub 2021 Aug 9.

Department of Internal Medicine, Instituto de Salud Carlos III, Universidad Católica de Murcia, Hospital Germans Trias i Pujol, CIBERES, Badalona (Barcelona), Madrid, Spain.

The performance of validated bleeding risk scores in patients with venous thromboembolism (VTE) could be different depending on the time after index event or the site of bleeding. In this study we compared the "classic" Registro Informatizado de Enfermedad TromboEmbólica (RIETE) score and the more recently developed VTE-BLEED score for the prediction of major bleeding in patients under anticoagulant therapy in different time intervals after VTE diagnosis. Out of 82,239 patients with acute VTE, the proportion of high-risk patients according to the RIETE and VTE-BLEED scores was 7. Read More

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Association of HLA class I homozygosity with unfavorable clinical outcomes in patients with non-small cell lung cancer treated with chemo-immunotherapy or immunotherapy as first-line therapy.

Heliyon 2021 Sep 2;7(9):e07916. Epub 2021 Sep 2.

Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Homozygosity at HLA-I locus has been reported to be an unfavorable predictive biomarker of second-line or beyond immunotherapy in patients with different types of cancer. The linkage between HLA-I zygosity and survival in NSCLC patients treated with first-line immunotherapy with or without chemotherapy has not been reported.

Methods: Next generation sequencing with HLA genotyping was performed on patients with advanced NSCLC treated with immune checkpoint inhibitors with or without chemotherapy as first-line (N = 29). Read More

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September 2021

The Differences and Changes of Semi-Quantitative and Quantitative CT Features of Coronavirus Disease 2019 Pneumonia in Patients With or Without Smoking History.

Front Med (Lausanne) 2021 8;8:663514. Epub 2021 Sep 8.

Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China.

To assess CT features of COVID-19 patients with different smoking status using quantitative and semi-quantitative technologies and to investigate changes of CT features in different disease states between the two groups. 30 COVID-19 patients with current smoking status (29 men, 1 woman) admitted in our database were enrolled as smoking group and 56 COVID-19 patients without smoking history (24 men, 32 women) admitted during the same period were enrolled as a control group. Twenty-seven smoking cases and 55 control cases reached recovery standard and were discharged. Read More

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September 2021

Perioperative Outcome of Robotic Approach Manual Videothoracoscopic Major Resection in Patients Affected by Early Lung Cancer: Results of a Randomized Multicentric Study (ROMAN Study).

Front Oncol 2021 9;11:726408. Epub 2021 Sep 9.

Department of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Introduction: We report the results of the first prospective international randomized control trial to compare the perioperative outcome and surgical radicality of the robotic approach with those of traditional video-assisted surgery in the treatment of early-stage lung cancer.

Methods: Patients with clinical stage T1-T2, N0-N1 non-small cell lung cancer (NSCLC) were randomly assigned to robotic-assisted thoracoscopic surgery (RATS) or video-assisted thoracic surgery (VATS) resection arms. The primary objective was the incidence of adverse events including complications and conversion to thoracotomy. Read More

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September 2021

Combined Scutellarin and CHNO Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.

Front Oncol 2021 9;11:663262. Epub 2021 Sep 9.

Institute of Neurological Disease, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.

Glioma, the most common intracranial tumor, harbors great harm. Since the treatment for it has reached the bottleneck stage, the development of new drugs becomes a trend. Therefore, we focus on the effect of scutellarin (SCU) and its combination with CHNO (abbreviated as ) on glioma and its possible mechanism in this study. Read More

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September 2021

A comprehensive analysis of genetic diversity of EBV reveals potential high-risk subtypes associated with nasopharyngeal carcinoma in China.

Virus Evol 2021 Jan 4;7(1):veab010. Epub 2021 Jun 4.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China.

Epstein-Barr virus (EBV), a widespread oncovirus, is associated with multiple cancers including nasopharyngeal carcinoma (NPC), gastric cancer and diverse lymphoid malignancies. Recent studies reveal that specific EBV strains or subtypes are associated with NPC development in endemic regions. However, these NPC specific subtypes were only identified in a portion of infected individuals due possibly to the limited samples size studied or the complicated population structures of the virus. Read More

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January 2021

Wavelet Transform Artificial Intelligence Algorithm-Based Data Mining Technology for Norovirus Monitoring and Early Warning.

J Healthc Eng 2021 17;2021:6128260. Epub 2021 Sep 17.

Department of Infectious Disease Control, Urumqi Center for Disease Control and Prevention, Urumqi 830026, Xinjiang, China.

Norovirus monitoring and early warning can be used for diagnosis without etiological testing, and the treatment of this disease does not require the antibiotics. It often occurs in preschool children and affects their growth and development, so the coping measures for this disease are more prevention than treatment. In this study, the clinical data of 2133 children with diarrhea were collected. Read More

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September 2021

Comparisons of Treatment for HER2-Positive Breast Cancer between Chinese and International Practice: A Nationwide Multicenter Epidemiological Study from China.

J Oncol 2021 15;2021:6621722. Epub 2021 Sep 15.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: To better understand the status of medical treatment for human epidermal growth factor receptor 2 (HER2)-positive breast cancer and the differences between the Chinese and the international clinical practice.

Methods: This was a retrospective, nationwide, multicenter, epidemiological study of advanced breast cancer patients from China. Between January 01, 2012, and December 31, 2014, a total of 3649 patients, covering 7 geographic regions and 21 institutions, participated in this series of studies. Read More

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September 2021

Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway.

Front Physiol 2021 8;12:669202. Epub 2021 Sep 8.

Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Non-alcoholic fatty liver disease (NAFLD)is accompanied by typical inflammatory damage and cell death. As a pro-inflammatory form of cell death, pyroptosis participates in important pathological processes involved in NAFLD. Regulatory roles of both CCCTC-binding factor (CTCF) and dipeptidyl peptidase-4 (DPP4) have been reported in NAFLD, but it is still unclear whether the mechanism of action of gardenoside, a potential therapeutic for NAFLD, can be driven these proteins. Read More

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September 2021

Preclinical Evidence of Berberine on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Animal Studies.

Front Pharmacol 2021 9;12:742465. Epub 2021 Sep 9.

Department of Pharmacy, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.

As lifestyle and diet structure impact our health, non-alcoholic fatty liver disease (NAFLD) is prevalent all over the world. Some phytomedicines containing berberine (BBR) have been extensively used for centuries in Ayurvedic and traditional Chinese medicine. The goal of this systematic review is to investigate the preclinical evidence of BBR on NAFLD models. Read More

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September 2021

A Low Literacy, Multimedia Health Information Technology Intervention to Enhance Patient-Centered Cancer Care in Safety Net Settings Increased Cancer Knowledge in a Randomized Controlled Trial.

Cancer Control 2021 Jan-Dec;28:10732748211036783

Department of Medical Social Sciences and Center for Patient-Centered Outcomes, 12244Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

We tested whether a low-literacy-friendly, multimedia information and assessment system used in daily clinical practice enhanced patient-centered care and improved patient outcomes. This was a prospective, parallel-group, randomized controlled trial with 2 arms, CancerHelp-Talking Touchscreen (CancerHelp-TT) versus control, among adults with Stage I-III breast or colorectal cancer receiving chemotherapy and/or radiation therapy in safety net settings. Each patient was assessed for outcomes at 4 timepoints: after starting treatment (baseline), during treatment, immediately after treatment, and at follow-up assessment. Read More

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September 2021

Trends and distribution of coronary heart disease mortality rate in Hexi Corridor, Gansu, China from 2006 to 2015.

Rev Cardiovasc Med 2021 Sep;22(3):1003-1008

Department of Cardiology, Gansu Provincial People's Hospital, 730000 Lanzhou, Gansu, China.

This study described the trend and distribution of coronary heart disease (CHD) in the Hexi Corridor region of Gansu. The CHD mortality rates from 2006-2015 were obtained through the Death Reporting System of Gansu Centers for Disease Control (CDC) for 2006-2015. The overall mortality rate of CHD in the Hexi Corridor showed a decreasing trend, increasing in winter and spring and lowest in summer. Read More

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September 2021

Dyslipidemia in pediatrician's practice.

Rev Cardiovasc Med 2021 Sep;22(3):817-834

Department of Normal Physiology, Kuban State Medical University, 350063 Krasnodar, Russia.

Atherosclerosis ranks first among cardiovascular system diseases. It is the "disease of the century", and more than 50% of people with circulatory pathology die of it. The clinical manifestation of atherosclerosis is observed at the middle and older ages, but it is known that the pathological process develops much earlier. Read More

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September 2021

Characteristics and recognition of early infections in patients treated with commercial anti- CD19 CAR-T cells.

Eur J Haematol 2021 Sep 26. Epub 2021 Sep 26.

BMT Unit, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv, Israel.

The characteristics of infections following chimeric antigen receptor T (CAR-T) cells targeting CD19 in real-word population is obscure. We analyzed infections characteristics in the first month among consecutive patients with diffuse large B cell lymphoma (DLBCL) (n=60, median age, 69.3 years), treated with commercial CAR-T cells. Read More

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September 2021

Is There a Gender Difference in the Response to onabotulinumtoxinA in Chronic Migraine? Insights from a Real-Life European Multicenter Study on 2879 Patients.

Pain Ther 2021 Sep 26. Epub 2021 Sep 26.

Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, Via Vetoio 1 Coppito, 67100, L'Aquila, Italy.

Introduction: Migraine is mostly a female disorder because of its lower prevalence in men. Less than 20% of patients included in the available studies on migraine treatments are men; hence, the evidence on migraine treatments might not apply to men. The aims of the present study were to provide reliable information on the effectiveness of onabotulinumtoxinA (BT-A) for chronic migraine in men and to compare clinical benefits between men and women. Read More

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September 2021

Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome.

Ann Hematol 2021 Sep 25. Epub 2021 Sep 25.

Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey.

The aims of this study were to determine the possible relationships between the levels of hemin, hemopexin, acid sphingomyelinase, nitrite/nitrate (NOx), and other parameters in patients with SCD and to assess whether they were associated with vaso-occlusive crises (VOCs) or acute chest syndrome (ACS). Patients with SCD (homozygous or sickle beta-thalassemia) who were confirmed to have VOC or ACS were included. Blood samples were obtained at admission, on the third day of hospitalization, and at steady state. Read More

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September 2021

A randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus.

Med Oral Patol Oral Cir Bucal 2021 Sep 25. Epub 2021 Sep 25.

Department of Oral Medicine and Pathology and Hospital Dentistry School of Dentistry, National and Kapodistrian University of Athens 2 Thivon St., Goudi 11527, Athens, Greece

Background: Oral lichen planus (OLP) is a common, frequently symptomatic, immune-mediated disease. Various treatments have been used for symptomatic OLP, including corticosteroids and immunosuppressants administered topically or systemically. The aim of this study was to compare the effectiveness of topical dexamethasone vs. Read More

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September 2021

Individual and joint effects of metal exposure on metabolic syndrome among Chinese adults.

Chemosphere 2021 Sep 20;287(Pt 3):132295. Epub 2021 Sep 20.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hongkong Road, Wuhan, Hubei, 430030, China. Electronic address:

Growing evidence suggests that metal exposure contributes to metabolic syndrome (MetS), but little is known about the effects of combined exposure to metal mixtures. This cross-sectional study included 3748 adults who were recruited from the Medical Physical Examination Center of Tongji Hospital, Wuhan, China. The levels of 21 metal(loid)s in urine were measured by inductively coupled plasma mass spectrometry. Read More

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September 2021

Prediction on the combined toxicities of stimulation-only and inhibition-only contaminants using improved inverse distance weighted interpolation.

Chemosphere 2021 Aug 28;287(Pt 3):132045. Epub 2021 Aug 28.

School of Environmental Science & Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China; Hubei Provincial Engineering Laboratory of Solid Waste Treatment, Disposal and Recycling, Wuhan, Hubei, 430074, China; Hubei Provincial Research Center of Water Quality Safety and Water Pollution Control Engineering Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China; State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. Electronic address:

The evaluation of ecological risks of contaminant mixtures to organisms is very challenging due to the non-linear response of organisms to each component, especially under the co-existence of both stimulators and inhibitors. Whether the stimulatory effect can reduce or even offset the inhibitory effect would be critical to the risk assessment and the treatment measures of mixed pollutants. Here, the combined toxicity of sodium fluoride (NaF), a stimulator with stimulation rate >100%, and six compounds that cannot induce hormesis (four ionic liquids (ILs) and two pesticides) were studied. Read More

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Parotid gland stem cell sparing radiotherapy for head and neck cancer patients: a double-blind randomized controlled trial.

Int J Radiat Oncol Biol Phys 2021 Sep 23. Epub 2021 Sep 23.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen; 9700 RB Groningen, The Netherlands.. Electronic address:

Background: Radiotherapy for head and neck cancer (HNC) frequently leads to salivary gland damage and subsequent xerostomia. The radiation response of parotid glands of rats, mice, and patients critically depends on dose to its stem cells, mainly located in the gland's main ducts (stem cell rich (SCR) region). Therefore, this double-blind randomized controlled trial aimed to test the hypothesis that parotid gland stem cell sparing radiotherapy preserves parotid gland function better than currently-used whole parotid gland sparing radiotherapy. Read More

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September 2021

Effect of Light Therapy on Cancer-related Fatigue: A Systematic Review and Meta-Analysis.

J Pain Symptom Manage 2021 Sep 23. Epub 2021 Sep 23.

Department of Rehabilitation Sciences (Andy SK Cheng), The Hong Kong Polytechnic University, Hong Kong, China.

Context: Light therapy is a non-pharmacological therapy that is currently being studied in cancer-related symptoms and is certificated as a low-risk intervention by FDA. Cancer-related fatigue (CRF) is the most common symptom reported by cancer patients.

Objective: To examine the effectiveness of light therapy for CRF in cancer patients through a systematic review and meta-analysis. Read More

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September 2021