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Pregnancy and COVID-19: Prevention, Vaccination, Therapy and Beyond.

Turk J Med Sci 2021 Sep 19. Epub 2021 Sep 19.

Coronavirus disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of medications, route of delivery and risk of obstetric complications. The aim of this review is to summarize the current literature in the management of pregnant women during the COVID-19 pandemic. Read More

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September 2021

Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019), a Dutch population based study.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Radboud university medical centre, Radboud Institute for Health Sciences, Department of Surgery, Nijmegen, The Netherlands.

Aim: Anastomotic leakage (AL) after colon cancer (CC) and rectal cancer (RC) surgery often requires reintervention. Prevalence and morbidity may change over time with evolutions in treatment strategies and changes in patient characteristics. This nationwide study aimed to evaluate changes in the incidence, risk factors and mortality from AL during the past nine years. Read More

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September 2021

Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy.

Eur J Cancer 2021 Sep 15;157:214-224. Epub 2021 Sep 15.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have activity across many tumor types, but activation of the immune system may also lead to significant, often steroid-refractory immune-related adverse events (irAEs). We sought to determine the activity of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in treatment or prevention of auto-immune irAE in ICI-treated patients.

Methods: Institutional databases from 2 melanoma centers were reviewed for patients treated with ICIs and tocilizumab. Read More

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September 2021

Postsurgical status of articular cartilage after arthroscopic posterior cruciate ligament reconstruction in patients with or without concomitant meniscal pathology.

Clin Imaging 2021 Sep 8;80:406-412. Epub 2021 Sep 8.

Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Several factors present at the time of posterior cruciate ligament reconstruction (PCLR) may cause the subsequent progression of articular cartilage lesions. This study aimed to evaluate postsurgical articular cartilage lesions which can be seen on MRI in patients who underwent arthroscopic PCLR with or without concomitant meniscal pathology.

Material And Methods: A total of sixty-five patients (mean age 35. Read More

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September 2021

Heterotrophic nitrification and aerobic denitrification process: Promising but a long way to go in the wastewater treatment.

Sci Total Environ 2021 Sep 10;805:150212. Epub 2021 Sep 10.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

The traditional biological nitrogen removal (BNR) follows the conventional scheme of sequential nitrification and denitrification. In recent years, novel processes such as anaerobic ammonia oxidation (anammox), complete oxidation of ammonia to nitrate in one organism (comammox), heterotrophic nitrification and aerobic denitrification (HN-AD), and dissimilatory nitrate reduction to ammonium (DNRA) are gaining tremendous attention after the discovery of metabolically versatile bacteria. Among them, HN-AD offers several advantages because individual bacteria could achieve one-stage nitrogen removal under aerobic conditions in the presence of organic carbon. Read More

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September 2021

Neurokinin-1 Receptor as a potential drug target for COVID-19 treatment.

Authors:
Riffat Mehboob

Biomed Pharmacother 2021 Sep 13;143:112159. Epub 2021 Sep 13.

Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan; Lahore Medical Research Center, LLP, Lahore, Pakistan. Electronic address:

Novel Coronavirus infection (COVID-19) has become a pandemic in these days. It is an acute respiratory and infectious disease with no known etiology and treatment. It is continuously causing losses of precious lives and economy at a global scale on daily basis. Read More

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September 2021

Biochar based photocatalyst for degradation of organic aqueous waste: A review.

Chemosphere 2021 Sep 7;287(Pt 3):132200. Epub 2021 Sep 7.

Department of Biotechnology, Shivaji University, Vidyanagar, Kolhapur, 416004, India; Department of Biochemistry, Shivaji University, Vidyanagar, Kolhapur, 416004, India. Electronic address:

The advancement in the treatment technology for wastewater containing recalcitrant pollutants to lower the overall cost and time of the treatment processes is the prime demand. Biochar (BC) based photocatalyst have proved their potential application in the photo-degradation of a wide range of organic pollutants. The structural and chemical properties of the BC enhance the efficacy of photocatalyst, improving its optical properties with increased stability. Read More

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September 2021

The relationship between kinesiophobia and health-related quality of life in patients with rheumatoid arthritis: A controlled cross-sectional study.

Joint Bone Spine 2021 Sep 15:105275. Epub 2021 Sep 15.

Department of Physical Medicine and Rehabilitation, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Erzincan, Turkey.

Objectives: To evaluate the kinesiophobia and kinesiophobia-related factors in patients with rheumatoid arthritis (RA) and provide a better perspective on the relationship between kinesiophobia and patients' health-related quality of life (HRQoL).

Methods: A total of 88 patients (67 females, 21 males) with RA and 93 healthy volunteers (67 females, 26 males) were included in the study between March 2020 and July 2020. Kinesiophobia was evaluated using the Tampa Scale of Kinesiophobia (TSK) and HRQoL was evaluated using the 36-item Short-Form Health Survey (SF-36). Read More

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September 2021

A SMART approach to optimizing delivery of an mHealth intervention among cancer survivors with posttraumatic stress symptoms.

Contemp Clin Trials 2021 Sep 15:106569. Epub 2021 Sep 15.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America; Department of Psychology in Psychiatry, Weill Cornell Medicine, New York, NY, United States of America.

Background/aims: Many cancer survivors who received intensive treatment such as hematopoietic stem cell transplantation (HCT) experience posttraumatic stress disorder (PTSD) symptoms. PTSD is associated with lower quality of life and other symptoms that require clinical treatment. The iterative treatment decisions that happen in clinical practice are not adequately represented in traditional randomized controlled trials (RCT) of PTSD treatments. Read More

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September 2021

Impact of desiccation pre-exposure on deltamethrin-induced oxidative stress in Bombina variegata juveniles.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Sep 15:109191. Epub 2021 Sep 15.

Department of Physiology, Institute for Biological Research "Siniša Stanković", National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.

Global warming represents a severe threat to existing ecosystems, especially for anuran tadpoles who encounter significant fluctuations in their habitats. Decreasing water levels in permanent and temporary water bodies is a significant risk for larval survival or fitness. On the other hand, the natural environment of amphibians is extremely polluted by various xenobiotics. Read More

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September 2021

Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.

Cancer Lett 2021 Sep 15. Epub 2021 Sep 15.

Chronic Disease Research Institute, The Children's Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address:

Obesity is a global public health issue. Obesity-related chronic low-grade inflammation (meta-inflammation) can lead to aberrant adipokine release and promote cardiometabolic diseases and obesity-related tumors. However, the mechanisms involved in the initiation of inflammatory responses in obesity and obesity-related tumors as well as metastasis are not fully understood. Read More

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September 2021

Cell-based therapeutics for the treatment of hematologic diseases inside the bone marrow.

J Control Release 2021 Sep 15. Epub 2021 Sep 15.

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:

Cell-based therapies could overcome the limitations of traditional drugs for the treatment of refractory diseases. Cell exchange between the bone marrow and blood is bidirectional. Several kinds of cells in the blood have the capability to enter the bone marrow by interacting with sinusoidal cells under specific physiological or pathological conditions. Read More

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September 2021

Differential effects of ergometer-cycling and Whole-Body-Vibration training on serological BDNF and IGF-1 in the treatment of adolescent depression - is there an impact of BDNF-p.Val66Met variants?

Physiol Behav 2021 Sep 15:113596. Epub 2021 Sep 15.

Department of Child and Adolescent Psychiatry, Psychotherapy and Paediatric Neurology, Gemeinschaftskrankenhaus Herdecke & Chair of Child and Adolescent Psychiatry, Witten/Herdecke University, Witten, Germany.

Background: Pathogenesis and treatment of adolescent depression may be influenced by growth-factors, including brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). We investigated, if treatment response to two different add-on exercise-therapies in juvenile depression, differ in the changes of BDNF and IGF-1 serology. A subgroup analysis for genetic variations in BDNF p. Read More

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September 2021

Parkinson's disease outside the brain: targeting the autonomic nervous system.

Lancet Neurol 2021 Oct;20(10):868-876

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Patients with Parkinson's disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even precede motor deficits. This dysregulation might reflect early pathology and therefore could be targeted for the development of prodromal or diagnostic biomarkers. Only a few objective clinical tests assess disease progression and are used to evaluate the entire spectrum of autonomic dysregulation in patients with Parkinson's disease. Read More

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October 2021

Informed Consent Challenges and Strategies: A Qualitative Study of the Orthodontists' Perspective.

Orthod Craniofac Res 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Medicine & Dentistry, University of Alberta, Alberta, Canada.

Objective: To identify the barriers and strategies perceived by orthodontists when obtaining consent from their adult patients concerning patients' comprehension or recollection of treatment information. Settings and Sample Population The sample comprised 12 orthodontists working in 8 different cities in Alberta, Canada.

Methods: An exploratory investigation using qualitative inquiry was conducted. Read More

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September 2021

The COVID-19 pandemic: a new epoch and fresh challenges for cancer patients and caregivers-a descriptive cross-sectional study.

Support Care Cancer 2021 Sep 18. Epub 2021 Sep 18.

Department of Onco-Anesthesia and Palliative Medicine, Dr B.R.A. Institute Rotary Cancer Hospital, AIIMS, New Delhi, 110029, India.

Purpose: Cancer patients and their caregivers are overwhelmed with features of uncertainty, fear, shock, worry, anxiety, sadness, and grief. To add on to their misery, the COVID-19 pandemic has severely afflicted the cancer care delivery. The study was conducted to observe the challenges faced by cancer patients and their caregivers and to formulate strategies for oncological setups to overcome those challenges. Read More

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September 2021

The peril and promise of sensitivity in eating disorders.

Int J Eat Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Differential susceptibility, a reconceptualization of the diathesis-stress model of psychopathology, describes gene-environment interactions that reflect individual differences in responsiveness to environmental influences, both detrimental and beneficial. This model has been described metaphorically by the classification of orchids, which thrive under optimal care but wither under adverse conditions, and dandelions, which weather broad environmental circumstances but are less responsive to careful cultivation. Etiological research in the field of eating disorders has largely focused on the identification of specific behavioral phenotypes, temperamental traits, genotypes and neurobiological processes that confer risk. Read More

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September 2021

Injectable Natural Polymer Hydrogels for Treatment of Knee Osteoarthritis.

Adv Healthc Mater 2021 Sep 17:e2101479. Epub 2021 Sep 17.

Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.

Osteoarthritis (OA) is a serious chronic and degenerative disease that increasingly occurs in the aged population. Its current clinical treatments are limited to symptom relief and cannot regenerate cartilage. Although a better understanding of OA pathophysiology has been facilitating the development of novel therapeutic regimen, delivery of therapeutics to target sites with minimal invasiveness, high retention, and minimal side effects remains a challenge. Read More

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September 2021

Applying User-Centered Design to Develop Practical Strategies that Address Overuse in Primary Care.

J Gen Intern Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Veterans Affairs, Center for Clinical Management Research, Ann Arbor, MI, USA.

Introduction: Engaging patients and frontline clinicians in re-designing clinical care is essential for improving care delivery in a complex clinical environment. This study sought to assess an innovative user-centered design approach to improving clinical care quality, focusing on the use cases of de-intensifying non-beneficial care within the following areas: (1) de-intensifying diabetes treatment in high-risk patients; (2) stopping screening for carotid artery stenosis in asymptomatic patients; and (3) stopping colorectal cancer screening in average-risk, older adults.

Methods: The user-centered design approach, consisting of patient and patient-clinician charrettes (defined as intensive workshops where key stakeholders collaborate to develop creative solutions to a specific problem) and participant surveys, has been described previously. Read More

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September 2021

Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies.

NPJ Breast Cancer 2021 Sep 17;7(1):124. Epub 2021 Sep 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

To find metastatic recurrence biomarkers of triple-negative breast cancer (TNBC) treated by neoadjuvant chemotherapy and anti-EGFR antibodies (NAT), we evaluated tumor genomic, transcriptomic, and immune features, using MSK-IMPACT assay, gene arrays, Nanostring technology, and TIL assessment on H&E. Six patients experienced a rapid fatal recurrence (RR) and other 6 had later non-fatal recurrences (LR). Before NAT, RR had low expression of 6 MHC class I and 13 MHC class II genes but were enriched in upregulated genes involved in the cell cycle-related pathways. Read More

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September 2021

CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells.

Transl Psychiatry 2021 Sep 17;11(1):479. Epub 2021 Sep 17.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is a progressive autosomal dominant neurodegenerative disease caused by abnormal CAG repeats in the exon 10 of ATXN3. The accumulation of the mutant ataxin-3 proteins carrying expanded polyglutamine (polyQ) leads to selective degeneration of neurons. Since the pathogenesis of SCA3 has not been fully elucidated, and no effective therapies have been identified, it is crucial to investigate the pathogenesis and seek new therapeutic strategies of SCA3. Read More

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September 2021

Circular Ribonucleic Acid Expression Alteration in the Spinal Cord Tissue after Spinal Cord Injury in Rats.

Neuroimmunomodulation 2021 Sep 14:1-20. Epub 2021 Sep 14.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Background And Purpose: Increased researches focus into pathophysiological mechanisms of spinal cord injury (SCI), particularly toward the relationship between relevant biomarkers and the degree of SCI and prognosis. Circular ribonucleic acids (circRNAs) possess microRNA (miRNA) binding sites that can play the role of miRNA sponges and thus participate in the expression of parental gene modification. This study focused on rat SCI models and explore the relationship between circRNAs and SCI at a genomic level. Read More

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September 2021

Evaluation of renal effects of liposomal amphotericin B in children with malignancies with KDIGO and RIFLE criteria.

Nephrol Ther 2021 Sep 14. Epub 2021 Sep 14.

Department of pediatric infectious diseases, Dr Behçet Uz children's diseases and surgery training and research hospital, İzmir, Turkey.

Background: Amphotericin B is a broad-spectrum antifungal agent and is the backbone of the treatment for medically important opportunistic fungal pathogens in children. This study aimed to compare the nephrotoxicity associated with L-AmB in children with acute lymphoblastic leukemia and acute myeloid leukemia.

Materials And Methods: A total of 112 pediatric acute lymphoblastic leukemia or acute myeloid leukemia patients who received treatment with L-AmB (Ambisome®) at the University of Health Sciences Dr Behcet Uz Children's Hospital over 7 years were included. Read More

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September 2021

Tuberculosis treatment delay and nosocomial exposure remain important risks for patients undergoing regular hemodialysis.

J Microbiol Immunol Infect 2021 Sep 1. Epub 2021 Sep 1.

Pulmonary Research Center, Division of Pulmonary Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background And Objective: Studies have reported an increased tuberculosis (TB) incidence among patients with end-stage renal disease (ESRD). This nationwide nested Case-control study investigated the risk of active TB due to nosocomial exposure and its correlation with the delay in TB treatment in hemodialysis patients.

Methods: Adult (aged ≥20 years) patients with incident ESRD over 2000-2010 were identified from Taiwan National Health Insurance Research Database; 2331 patients with incident active TB (Case) were matched with 11,655 patients without TB (control) by age, sex, year of ESRD onset, Charlson comorbidity index, chronic obstructive pulmonary disease, and diabetes mellitus, at a 1:5 case-to-control ratio. Read More

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September 2021

Adapting for Adaptive Radiotherapy (ART): The need to evolve our roles as Therapeutic Radiographers.

Radiography (Lond) 2021 Sep 14. Epub 2021 Sep 14.

Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Radiotherapy Department, Hill's Road, Cambridge, UK. Electronic address:

Objectives: 4D Adaptive Radiotherapy (4D-ART) has been stated as the future baseline standard-of-care for technical radiotherapy. Its goal is to optimise radiation dose received by 'adapting' to changes 'seen' in each individual patient, for each treatment delivery (fraction), throughout each treatment delivery. The drive for technological developments to achieve this is ongoing. Read More

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September 2021

Severe Acute Respiratory Syndrome Coronavirus 2: Manifestations of Disease and Approaches to Treatment and Prevention in Humans.

Comp Med 2021 Sep 17. Epub 2021 Sep 17.

The coronavirus disease 2019 (COVID-19) pandemic was caused by a novel coronavirus, severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2). This virus has challenged civilization and modern science in ways that few infectious diseases and natural disasters have previously, causing globally significant human morbidity and mortality and triggering economic downturns across financial markets that will be dealt with for generations. Despite this, the pandemic has also brought an opportunity for humanity to come together and participate in a shared scientific investigation. Read More

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September 2021

Primary breast double-hit lymphoma management and outcomes: a real-world multicentre experience.

Cancer Cell Int 2021 Sep 17;21(1):498. Epub 2021 Sep 17.

Haematopoietic Stem Cell Transplantation Centre, State Key Laboratory of Experimental Hematology, National Clinical Research centre for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288 Nanjing Road, Tianjin, 300020, China.

Background: Primary breast double-hit lymphoma (PB-DHL) is a rare, highly aggressive malignancy that poses challenges regarding accurate diagnosis and selecting optimal treatment regimens.

Methods: We retrospectively reviewed 48 cases of patients diagnosed with PB-DHL in six academic centres between June 2014 and June 2020 in China. Study-specific data were recorded, including treatment options, therapeutic evaluation, prognostic factors and relapse patterns, and the overall survival (OS) and progression-free survival (PFS) were evaluated. Read More

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September 2021

In search of the last malaria cases: ethnographic methods for community and private-sector engagement in malaria elimination in Vietnam, Laos, and Cambodia.

Malar J 2021 Sep 17;20(1):370. Epub 2021 Sep 17.

Socio-Ecological Health Research Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Despite significant strides made in reducing malaria morbidity and mortality in the Greater Mekong Subregion, malaria transmission continues amongst the most 'hard-to-reach', such as forest-goers and mobile and migrant populations, who face access obstacles to malaria diagnosis and treatment. As such, regional malaria elimination strategies endeavour to incorporate the private sector and local communities in improving surveillance and detection of the last malaria cases in remote forested areas. The question remains, however, whether such strategies can reach these hard-to-reach populations and effectively reduce their disproportionate burden of malaria. Read More

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September 2021

Bacterial-based cancer therapy: An emerging toolbox for targeted drug/gene delivery.

Biomaterials 2021 Sep 10;277:121124. Epub 2021 Sep 10.

Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China. Electronic address:

Precise targeting and high therapeutic efficiency are the major requisites of personalized cancer treatment. However, some unique features of the tumor microenvironment (TME) such as hypoxia, low pH and elevated interstitial fluid pressure cause cancer cells resistant to most therapies. Bacteria are increasingly being considered for targeted tumor therapy owing to their intrinsic tumor tropism, high motility as well as the ability to rapidly colonize in the favorable TME. Read More

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September 2021

Antibiotic-metal complexes in wastewaters: fate and treatment trajectory.

Environ Int 2021 Sep 14;157:106863. Epub 2021 Sep 14.

Department of Civil Engineering, Lassonde School of Engineering, York University, North York, Toronto, Ontario M3J 1P3, Canada. Electronic address:

Unregulated usage, improper disposal, and leakage from pharmaceutical use and manufacturing sites have led to high detection levels of antibiotic residues in wastewater and surface water. The existing water treatment technologies are insufficient for removing trace antibiotics and these residual antibiotics tend to interact with co-existing metal ions and form antibiotic-metal complexes (AMCs) with altered bioactivity profile and physicochemical properties. Typically, antibiotics, including tetracyclines, fluoroquinolones, and sulphonamides, interact with heavy metals such as Fe, Co, Cu, Ni, to form AMCs which are more persistent and toxic than parent compounds. Read More

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September 2021