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The Effects of Inhumane Treatment in North Korean Detention Facilities on the Posttraumatic-Stress Disorder Symptoms of North Korean Refugees.

Psychiatry Investig 2021 Jul 22;18(7):688-694. Epub 2021 Jul 22.

Department of Social Welfare, Catholic Kwandong University, Gangneung, Republic of Korea.

Objective: The study investigated the effects of severe human rights abuses in North Korean on Posttraumatic-stress disorder (PTSD) in North Korean Refugees (NKRs).

Methods: The study included 300 NKRs (245 females and 55 males) who completed self-report questionnaires that assessed PTSD, experiences of imprisonment, and exposure to inhumane treatment, by authorities in North Korea. A moderation analysis was conducted using a hierarchical multiple regression model to determine whether a moderation effect existed. Read More

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Key toolkits of non-pharmacological management in COPD: during and beyond COVID-19.

Front Biosci (Landmark Ed) 2021 Jul;26(7):246-252

Institute for Liver and Digestive Health, Division of Medicine, University College London, NW3 2PF London, UK.

Individuals with COPD are at higher risk of severe disease and mortality if they contract COVID-19. Shielding and social distancing have negatively impacted the delivery of routine care for COPD patients, which should be maintained to avoid further deterioration. We aimed to review the literature about the key toolkits of non-pharmacological treatments of COPD patients before and during the COVID-19 pandemic. Read More

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Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review.

Front Biosci (Landmark Ed) 2021 Jul;26(7):235-245

1st Department of Otolaryngology - Head & Neck Surgery, Medical School, National & Kapodistrian University of Athens (NKUA), Hippokrateio Hospital, 11527 Athens, Greece.

: Several studies suggest that there is an association between the metastatic nodal tumor volume and the clinical outcome in patients with solid cancers. However, despite the prognostic potential of nodal volume, a standardized method for estimating the nodal volumetric parameters is lacking. Herein, we conducted a systematic review of the published scientific literature towards investigating the prognostic value of nodal volume in the carcinomas of head and neck, taking into consideration the primary tumor site and the human papillomavirus (HPV) status. Read More

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Restricted sub-tree learning to estimate an optimal dynamic treatment regime using observational data.

Authors:
Kelly Speth Lu Wang

Stat Med 2021 Aug 2. Epub 2021 Aug 2.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Dynamic treatment regimes (DTRs), consisting of a sequence of tailored treatment decision rules that span multiple stages of care, present a unique opportunity in our drive toward personalized medicine. Given that estimation of optimal DTRs is often exploratory and communication with clinicians is vital, robust and flexible methods that yield interpretable results are needed. Tree-based methods utilizing a purity measure defined on the full set of covariates have enjoyed much success in meeting this goal. Read More

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The promise and role of point of care testing to reduce the global burden of sickle cell disease through early diagnosis and linkage to care.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Sickle cell disease (SCD) is a devastating and under-recognised global child health issue affecting over 300,000 infants annually, with the highest prevalence in India and sub-Saharan Africa. Most affected infants born in low- and middle-income countries (LMIC) lack access to SCD testing and die from complications in the first years of life without a formal diagnosis. The majority of deaths are preventable with early diagnosis and provision of inexpensive interventions. Read More

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Hsa_circ_0016788 regulates glycolysis and proliferation via miR-506-3p/PARP14 axis of hepatocellular carcinoma.

J Gastroenterol Hepatol 2021 Aug 2. Epub 2021 Aug 2.

Department of Hepato-Biliary-Pancreatic Surgery, the First Affiliated Hospital of University of South China.

Background: Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide. Recent researches have shown that circular RNAs (circRNAs) could affect the progress of HCC, but the mechanism still indistinct. In this work, we explored the roles of circRNA_0016788 in HCC. Read More

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Haemophilia care: the only constant is change.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Division of Hematology and the Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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Phase II study of azacitidine with pembrolizumab in patients with intermediate-1 or higher-risk myelodysplastic syndrome.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Programmed cell death protein 1 (PD-1) and PD-ligand 1 (PD-L1) expression is upregulated in cluster of differentiation 34 (CD34) bone marrow cells from patients with myelodysplastic syndromes (MDS). Hypomethylating agent (HMA) treatment results in further increased expression of these immune checkpoints. We hypothesised that combining an anti-PD-1 antibody with HMAs may have efficacy in patients with MDS. Read More

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Current status of haemophilia inhibitor management in mainland China: a haemophilia treatment centres survey on treatment preferences and real-world clinical practices.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Laboratory of Blood Disease Gene Therapy, CAMS Key Laboratory of Gene Therapy for Blood Diseases, CAMS Center for Stem Cell Medicine, PUMC Department of Stem Cell and Regenerative Medicine, Tianjin, China.

To investigate the current experience and expertise for haemophilia inhibitor patient management in haemophilia treatment centres (HTCs) in mainland China. Questionnaires were distributed to 'tertiary tier A' hospital HTCs across China to collect information on treatment preferences for bleeding control, prophylaxis and inhibitor eradication, as well as their regimens in real-world clinical practice. Of 40 questionnaires distributed, 39 were returned. Read More

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Pilot evaluation of a consumer wearable device to assess sleep in a clinical polysomnography trial of suvorexant for treating insomnia in patients with Alzheimer's disease.

J Sleep Res 2021 Aug 2:e13328. Epub 2021 Aug 2.

Merck & Co., Inc., Kenilworth, NJ, USA.

The orexin receptor antagonist suvorexant was previously reported to significantly improve total sleep time (TST), by 28 min per night versus placebo after 4 weeks, in a sleep laboratory polysomnography (PSG) study of patients with Alzheimer's disease and insomnia. The study included an exploratory evaluation of a consumer-grade wearable "watch" device for assessing sleep that we report on here. Participants who met diagnostic criteria for both probable Alzheimer's disease dementia and insomnia were randomized to suvorexant 10-20 mg (N = 142) or placebo (N = 143) in a double-blind, 4-week trial. Read More

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Recurrent bacterial infections, but not fungal infections, characterise patients with ELANE-related neutropenia: a French Severe Chronic Neutropenia Registry study.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Registre des Neutropénies Chroniques, Centre de Référence des Neutropénies Chroniques, Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Among 143 patients with elastase, neutrophil-expressed (ELANE)-related neutropenia enrolled in the French Severe Chronic Neutropenia Registry, 94 were classified as having severe chronic neutropenia (SCN) and 49 with cyclic neutropenia (CyN). Their infectious episodes were classified as severe, mild or oral, and analysed according to their natural occurrence without granulocyte-colony stimulating factor (G-CSF), on G-CSF, after myelodysplasia/acute leukaemia or after haematopoietic stem-cell transplantation. During the disease's natural history period (without G-CSF; 1913 person-years), 302, 957 and 754 severe, mild and oral infectious events, respectively, occurred. Read More

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Estimating the marginal effect of a continuous exposure on an ordinal outcome using data subject to covariate-driven treatment and visit processes.

Stat Med 2021 Aug 2. Epub 2021 Aug 2.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

In the statistical literature, a number of methods have been proposed to ensure valid inference about marginal effects of variables on a longitudinal outcome in settings with irregular monitoring times. However, the potential biases due to covariate-driven monitoring times and confounding have rarely been considered simultaneously, and never in a setting with an ordinal outcome and a continuous exposure. In this work, we propose and demonstrate a methodology for causal inference in such a setting, relying on a proportional odds model to study the effect of the exposure on the outcome. Read More

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Intravenous immunoglobulin for corticosteroid-resistant intestinal Henoch-Schönlein purpura: worth a controlled trial against corticosteroids?

Rheumatology (Oxford) 2021 Aug;60(8):3868-3871

Pediatrics and Pediatric Emergency Unit, The Children Hospital, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Objectives: Henoch-Schönlein purpura (HScP) may present in children with severe, occasionally refractory, gastrointestinal (GI) involvement. The use of corticosteroids (CSs) is commonplace in the management of the disease, but to date no standardized protocol is available and, although rare, resistance to CS therapy may be challenging to clinicians. IVIG has been proposed as an effective alternative to CSs, but to date no controlled trial has been conducted to ascertain their real efficacy. Read More

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p53 Inhibition Provides a Pivotal Protective Effect against Cerebral Ischemia-Reperfusion Injury via the Wnt Signaling Pathway.

Cerebrovasc Dis 2021 Aug 2:1-9. Epub 2021 Aug 2.

Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou, China.

Introduction: Cerebral ischemia-reperfusion injury enhances brain injury and increases its morbidity and mortality. The purpose of our study was to further explore the specific pathogenesis of cerebral ischemia disease by studying the role of p53 in cerebral ischemia-reperfusion injury and its mechanism to provide a new target for the treatment of cerebral ischemia.

Methods: Middle cerebral artery occlusion (MCAo) was established in rats. Read More

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Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?

Gerontology 2021 Aug 2:1-14. Epub 2021 Aug 2.

Kantonsspital Graubünden, Chur, Switzerland.

Youth, working age and the elderly: On a timeline, chronological age (CA) and biological age (BA) may dissociate; nosological entities manifest themselves at different BAs. In determining which disease corresponds to a given age decade, statistical registries of causes of death are unreliable and this does not change with SARS CoV-2 infection. Beyond adolescence, ageing metrics involve estimations of changes in fitness, including prediction models to estimate the number of remaining years left to live. Read More

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CXCL13 Levels Indicate Treatment Responsiveness to Fingolimod in MS Patients.

Eur Neurol 2021 Aug 2:1-3. Epub 2021 Aug 2.

Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

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Mesoporous silica nanoparticles loaded with fluorescent coumarin-5-fluorouracil conjugates as mitochondrial-targeting theranostic probes for tumor cells.

Nanotechnology 2021 Aug 2. Epub 2021 Aug 2.

Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Jinming Road, Kaifeng, Henan, 475004, CHINA.

Chemotherapy is currently a principal method for treating tumors. Selective delivery of chemotherapeutic drugs to the subcellular organs of cancer cells is an attractive treatment strategy for cancer. Mitochondria are important organelles that play complex roles in cancer, such as providing energy and controlling various cell death mechanisms. Read More

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3D-printed bioceramic scaffolds with FeSmicroflowers for magnetothermal and chemodynamic therapy of bone tumor and regeneration of bone defects.

Biofabrication 2021 Aug 2. Epub 2021 Aug 2.

Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics Chinese Academy of Sciences, 1295 Dingxi Road, Changning District, Shanghai, 200050, CHINA.

Elimination of residual osteosarcoma cells and repair of bone defects remain major challenges for osteosarcoma in clinic. To address this problem, it is required that multifunctional therapeutic platform possess high tumor-killing efficiency and simultaneous bone regeneration capabilities. In this work, an intelligent therapeutic platform was developed to achieve highly-efficient tumor therapy and simultaneous significantly improved bone defect repairing ability, which was realized by in situ growing ferromagnetic Fe3S4 layers with tuned microstructures on the surface of 3D-printed akermanite bioceramic scaffolds via hydrothermal method. Read More

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Recent Advances in Anticancer and Antimicrobial Activity of Silver Nanoparticles Synthesized Using Phytochemicals and Organic Polymers.

Nanotechnology 2021 Aug 2. Epub 2021 Aug 2.

Department of Mechanical Systems Engineering, Yamagata University, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, Yamagata, Yamagata, 992-8510, JAPAN.

Development of eco-friendly synthetic methods has resulted in the production of biocompatible Ag NPs for applications in medical sector. To overcome the prevailing antibiotic resistance in bacteria, Ag NPs are being extensively researched over the past few years due to their broad spectrum & robust antimicrobial properties. Silver nanoparticles are also being studied widely in advanced anticancer therapy as an alternative anticancer agent to combat cancer in an effective manner. Read More

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