923,763 results match your criteria treatment report


Recovery among sexual minorities in the united states population: Prevalence, characteristics, quality of life and functioning compared with heterosexual majority.

Drug Alcohol Depend 2022 Jan 10;232:109290. Epub 2022 Jan 10.

Recovery Research Institute, Massachusetts General Hospital, Psychiatry Department, 151 Merrimac St, Boston, MA 02114, USA; Harvard Medical School, Department of Psychiatry, 401 Park Drive, Boston, MA 02215, USA. Electronic address:

Background: Lesbian, gay, and bisexual individuals ("sexual minorities" [SMs]) are overrepresented among individuals suffering from alcohol and other drug (AOD) problems. However, little is known regarding differences, particularly in functioning and well-being, between SMs and heterosexuals in recovery from AOD problems.

Method: Cross-sectional, nationally representative sample of US adults who resolved an AOD problem (N = 2002; National Recovery Study [Kelly et al. Read More

View Article and Full-Text PDF
January 2022

Amivantamab (JNJ-61186372) induces clinical, biochemical, molecular, and radiographic response in a treatment-refractory NSCLC patient harboring amplified triple EGFR mutations (L858R/ T790M/G796S) in cis.

Lung Cancer 2022 Jan 4;164:52-55. Epub 2022 Jan 4.

University of California Irvine School of Medicine, Department of Medicine, Orange, CA 92868, USA; Chao Family Comprehensive Cancer Center, Orange, CA 92868, USA. Electronic address:

The sequential use of 1-/2-generation to 3-generation epidermal growth factor (EGFR) tyrosine kinase inhibitors (TKIs) has led to the emergence of triple EGFR mutations generally consisting of the founder mutation (del 19 or L858R), gatekeeper mutation (T790M) and mutation (C797S) that abolishes the covalent binding of osimertinib to the EGFR protein (i.e., del 19 or L858R/T790M/C797S). Read More

View Article and Full-Text PDF
January 2022

Head and neck radiotherapy leading to extensive late oral soft-tissue necrosis.

Oral Oncol 2022 Jan 12;125:105710. Epub 2022 Jan 12.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. Electronic address:

Radiotherapy is generally used as an adjuvant treatment in malignant head and neck tumors, which can cause a series of toxicities to tissues involved in the radiation field. Hard tissue necrosis surrounding the tumor is widely debated and recognized; however, oral mucosa necrosis as a late effect of head and neck radiotherapy is a toxicity that has been little explored and understood in the literature. The present report describes a 53-year-old Caucasian, diabetic man with a painful yellowish mass in the buccal mucosa, remaining oral mucositis with history of radiotherapy completed 90 days ago as adjuvant treatment for a polymorphic adenocarcinoma in the palate. Read More

View Article and Full-Text PDF
January 2022

Progression of perforated cystadenoma of the appendix to pseudomyxoma peritonei over 18 years. A case report.

Int J Surg Case Rep 2022 Jan 10;91:106756. Epub 2022 Jan 10.

Program in Peritoneal Surface Malignancies, Washington Cancer Institute, Washington, DC, USA. Electronic address:

Introduction And Importance: In the past, mucinous appendiceal neoplasms (MAN) greater than 2 cm in diameter were treated by a right colon resection. New data shows that treatment options are to be determined by the histopathologic grade of the appendiceal tumor and the condition of the wall of the appendix (intact vs. breached). Read More

View Article and Full-Text PDF
January 2022

A novel, dual action chimera comprising DNA methylating agent and near-IR xanthene-cyanine photosensitizer for combined anticancer therapy.

Photodiagnosis Photodyn Ther 2022 Jan 12:102722. Epub 2022 Jan 12.

Department of Chemical Sciences, Faculty of Natural Sciences, Ariel University, Ariel, 40700, Israel. Electronic address:

A facile synthesis, biological evaluation and photodynamic properties of novel activatable anticancer molecular hybrids (chimeras) Ch and I-Ch are described. The chimeras consist of DNA methylating methyl triazene moiety and fluorogenic xanthene-cyanine (XCy) or iodinated xanthene-cyanine (I-XCy) photosensitizer. These two anticancer core structures are bound by means of a self-immolative 4-aminobenzyl alcohol linker. Read More

View Article and Full-Text PDF
January 2022

Are short courses of antibiotic therapy as effective as standard courses for COPD exacerbations? A systematic review and meta-analysis.

Pulm Pharmacol Ther 2022 Jan 12:102111. Epub 2022 Jan 12.

Research Unit for General Practice and Section of General Practice, Department of Public Health, Copenhagen, Denmark.

Background: The best duration of antibiotic treatment for chronic obstructive pulmonary disease (COPD) exacerbations is uncertain.

Objective: To evaluate whether a short course of antibiotic therapy is as effective as the standard longer treatment for exacerbations of patients with COPD.

Methods: We searched Pubmed/MEDLINE and trials in relevant systematic reviews from the inception up to March 2021, with no language restrictions. Read More

View Article and Full-Text PDF
January 2022

Myocardial inflammation and sudden death in the inherited cardiomyopathies.

Can J Cardiol 2022 Jan 12. Epub 2022 Jan 12.

Cardiology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

The best studied of the inherited cardiomyopathies, hypertrophic (HCM), dilated (DCM) and arrhythmogenic (ACM), present overlapping clinical phenotypes with varying, often unrecognized risk of sudden death. Risk assessment is informed by patient sex and by the specific disease-causing variant. HCM and arrhythmogenic right ventricular cardiomyopathy (ARVC) remain important causes of sudden death. Read More

View Article and Full-Text PDF
January 2022

Ethnopharmacological study of medicinal plants in Sarvabad, Kurdistan province, Iran.

J Ethnopharmacol 2022 Jan 12:114985. Epub 2022 Jan 12.

Department of Ethnobotany, Institute of Botany, Ilia State University, Tbilisi, Georgia.

Ethnopharmacological Relevance: Traditional medicine has a long history and plays an important role in the Kurdish community in Sarvabad county, Kurdistan province, Iran. Despite the great diversity of medicinal plants, cultural history, and variety of herbal medicine uses among Kurdish tribes, very few cohesive ethnopharmacological studies of this unique region are available in the scientific literature. Our study tried to gather medicinal plant species and document the associated indigenous knowledge of the ethnic groups in the Sarvabad district for the first time. Read More

View Article and Full-Text PDF
January 2022

Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins.

Neurochem Int 2022 Jan 12:105282. Epub 2022 Jan 12.

Department of Pharmacology, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, 731-0153, Japan. Electronic address:

Despite a clear correlation between the infiltration of periodontal pathogens in the brain and cognitive decline in Alzheimer's disease (AD), the precise mechanism underlying bacteria crossing the blood-brain barrier (BBB) remains unclear. The periodontal pathogen Porphyromonas gingivalis produces a unique class of cysteine proteases termed gingipains. Gingipains appear to be key virulence factors that exacerbate sporadic AD. Read More

View Article and Full-Text PDF
January 2022

Transcriptomic changes in the hypothalamus of ovariectomized mice: Data from RNA-seq analysis.

Ann Anat 2022 Jan 12:151886. Epub 2022 Jan 12.

Department of Anatomy and Histoembryology, School of Basic Medical Science, Peking University, Beijing 100191, China. Electronic address:

Background: Menopausal symptoms can affect the physical and mental health of females and are often related to abnormal function of the hypothalamus. In this study, we evaluated changes in the hypothalamus transcriptome in ovariectomized mice to identify key mRNAs, and systematically elucidated the possible molecular mechanisms underlying the menopausal syndrome to provide a theoretical basis for clinical diagnosis and treatment.

Methods: Forty-six adult female C57BL/6J mice were randomly divided into SHAM and OVX groups, 23 mice per group. Read More

View Article and Full-Text PDF
January 2022

Durable Metabolic Improvements 2 Years After Duodenal Mucosal Resurfacing (DMR) in Patients With Type 2 Diabetes (REVITA-1 Study).

Diabetes Res Clin Pract 2022 Jan 12:109194. Epub 2022 Jan 12.

Gastroenterology and Hepatology, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

Aims: Duodenal mucosal resurfacing (DMR) is an endoscopic procedure developed to improve metabolic parameters and restore insulin sensitivity in patients with diabetes. Here we report long-term DMR safety and efficacy from the REVITA-1 study.

Materials And Methods: REVITA-1 was a prospective, single-arm, open-label, multicenter study of DMR feasibility, safety, and efficacy in patients with type 2 diabetes (hemoglobin A1c [HbA1c] of 7. Read More

View Article and Full-Text PDF
January 2022

N-methyladenosine modification regulates imatinib resistance of gastrointestinal stromal tumor by enhancing the expression of multidrug transporter MRP1.

Cancer Lett 2022 Jan 12. Epub 2022 Jan 12.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medical University, Nanjing, 211166, China. Electronic address:

N-methyladenosine (mA) is a frequently occurring mRNA modification, which regulates mRNA stability, splicing, and translation. However, its role in drug resistance of gastrointestinal stromal tumor (GIST) is not known. Here, we report that mA modification levels are elevated in imatinib-resistant GIST cells and tissues, and that methyltransferase METTL3 is one of the main protein responsible for this aberrant modification. Read More

View Article and Full-Text PDF
January 2022

Safety of transcranial magnetic stimulation in unipolar depression: A systematic review and meta-analysis of randomized-controlled trials.

J Affect Disord 2022 Jan 12. Epub 2022 Jan 12.

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan; Institute of Cognitive Neuroscience, National Central University, Jhongli, Taiwan; Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Institute of Brain Science, National Yang-Ming Chiao-Tung University, Taipei, Taiwan; Institute of Brain Science and Brain Research Center, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan. Electronic address:

Background: To study the safety and patients' tolerance of transcranial magnetic stimulation (TMS), we conducted a systematic review and meta-analysis of the major depressive disorder population.

Methods: Our study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched the literature published before April 30th, 2021 and performed a random-effects meta-analyses which included drop-out due to adverse events, serious adverse events and other non-serious adverse events as primary and secondary outcomes. Read More

View Article and Full-Text PDF
January 2022

Treatment of Temporomandibular Joint Heterotopic Ossificans: A Novel Protocol With Multimodal Therapy Based on Literature Review and Presentation of a Unique Case Reportc.

J Oral Maxillofac Surg 2021 Dec 23. Epub 2021 Dec 23.

Program Director and Attending Surgeon, Department of Oral & Maxillofacial Surgery, Walter Reed National Military Medical Center.

Purpose: The purpose of this study was to create a treatment protocol for cases of heterotopic ossification (HO) of the temporomandibular joint (TMJ), particularly those refractory to current TMJ HO protocols. In addition, we demonstrate the success of this protocol on a unique case of recurrent HO that failed multiple TMJ HO protocols in the setting of an improvised explosive device (IED) blast in a wounded warrior.

Methods: An electronic literature review was conducted via PubMed and Web of Science. Read More

View Article and Full-Text PDF
December 2021

Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.

Lancet Haematol 2022 Jan 12. Epub 2022 Jan 12.

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.

Background: Melphalan flufenamide (melflufen), an alkylating peptide-drug conjugate, plus dexamethasone showed clinical activity and manageable safety in the phase 2 HORIZON study. We aimed to determine whether melflufen plus dexamethasone would provide a progression-free survival benefit compared with pomalidomide plus dexamethasone in patients with previously treated multiple myeloma.

Methods: In this randomised, open-label, head-to-head, phase 3 study (OCEAN), adult patients (aged ≥18 years) were recruited from 108 university hospitals, specialist hospitals, and community-based centres in 21 countries across Europe, North America, and Asia. Read More

View Article and Full-Text PDF
January 2022

Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2021 Dec 30;42(3):63-69. Epub 2021 Dec 30.

Macedonian Academy of Sciences and Arts, Skopje, R. N. Macedonia.

Solitary fibrous tumor (SFT) is a rare and still controversial entity. This type of tumor first appeared in the literature as a pleural lesion, but, over the last decades, it has been reported in many extrathoracic sites. As a tumor of the adrenal gland, SFT is still rare and very uncommon, thus extensive research among the English language literature has been performed. Read More

View Article and Full-Text PDF
December 2021

The genome of low-chill Chinese plum 'Sanyueli' (Prunus salicina Lindl.) provides insights into the regulation of the chilling requirement of flower buds.

Mol Ecol Resour 2022 Jan 15. Epub 2022 Jan 15.

Fruit Research Institute, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian, 350013, China.

Chinese plum (Prunus salicina Lindl.) is a stone fruit that belongs to the Prunus genus and plays an important role in the global production of plum. In this study, we report the genome sequence of the Chinese plum 'Sanyueli', which is known to have a low-chill requirement for flower bud break. Read More

View Article and Full-Text PDF
January 2022

Early-onset persistent type IIIb endoleak following incraft stent graft implantation in an abdominal aortic aneurysm patient.

Catheter Cardiovasc Interv 2022 Jan 15. Epub 2022 Jan 15.

Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.

The type IIIb endoleak a rare complication of endovascular aneurysmal repair caused by endoprosthesis problem leading to deteriorating rupture, which is one of the major reasons for lifelong imaging surveillance. We report a case of an early-onset type IIIb endoleak from a tear in main body bifurcation (flow divider) area like crotch point tearing of pants following additional intervention to reduce immediate type Ia endoleak. Successful treatment of the endoleak was achieved by surgical conversion. Read More

View Article and Full-Text PDF
January 2022

Impact of prior sternotomy on survival and allograft function after heart transplantation: A single center matched analysis.

J Card Surg 2022 Jan 14. Epub 2022 Jan 14.

Division of Cardiac Surgery IRCCS Azienda Ospedaliero-Universitaria di Bologna, St. Orsola Policlinic-Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Background: Orthotopic heart transplantation (OHT) remains the gold standard for the treatment of end-stage heart failure. The number of patients who have had at least one prior sternotomy while awaiting transplantation has increased over the years reaching 50% in the last ISHLT registry report. We analysed our institutional transplant activity focusing on prior-sternotomy setting to identify the real burden of this preoperative variable and its potential consequences. Read More

View Article and Full-Text PDF
January 2022

The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model.

Mol Divers 2022 Jan 15. Epub 2022 Jan 15.

Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan.

The TOPK enzyme (also known as PBK) is a serine-threonine protein kinase that is rarely detected in normal tissues yet is found to be overexpressed and activated in a variety of cancers such as lung, colorectal, breast, and esophageal cancer. Its prevalence in cancerous cells is associated with their poor prognosis and responsiveness to treatment. This enzyme plays a vital role in cell division, specifically in regulating cytokinesis. Read More

View Article and Full-Text PDF
January 2022

Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma.

Mol Biomed 2022 Jan 15;3(1). Epub 2022 Jan 15.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma characterized by poor prognosis. The complexity of MCL pathogenesis arises from aberrant activities of diverse signaling pathways, including BTK, PI3K-AKT-mTOR and MYC-BRD4. Here, we report that MCL-related signaling pathways can be altered by a single small molecule inhibitor, SRX3305. Read More

View Article and Full-Text PDF
January 2022

NTRK-rearranged spindle cell neoplasm of the lower extremity: radiologic-pathologic correlation.

Skeletal Radiol 2022 Jan 14. Epub 2022 Jan 14.

Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasm is a recently characterized soft tissue tumor and has been classified as provisional by the World Health Organization. Detection of the genetic rearrangement is important because these tumors are amenable to targeted tyrosine kinase inhibitor therapy, which can play a key role in patients with unresectable or advanced disease. Although the spectrum of histopathology associated with this entity is broad, one notable feature is the infiltrative growth pattern, which is most reminiscent of lipofibromatosis-like neural tumor. Read More

View Article and Full-Text PDF
January 2022

Aminopyridine analogs selectively target metastatic pancreatic cancer.

Oncogene 2022 Jan 14. Epub 2022 Jan 14.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Metastatic outgrowth is supported by metabolic adaptations that may differ from the primary tumor of origin. However, it is unknown if such adaptations are therapeutically actionable. Here we report a novel aminopyridine compound that targets a unique Phosphogluconate Dehydrogenase (PGD)-dependent metabolic adaptation in distant metastases from pancreatic cancer patients. Read More

View Article and Full-Text PDF
January 2022

Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells.

Acta Pharmacol Sin 2022 Jan 14. Epub 2022 Jan 14.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Ovarian cancer is one of the most common gynecologic malignancies in women and has a poor prognosis. Taxanes are a class of standard first-line chemotherapeutic agents for the treatment of ovarian cancer. However, tumor-intrinsic and acquired resistance to taxanes poses major challenges to improving clinical outcomes. Read More

View Article and Full-Text PDF
January 2022

Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics.

Commun Biol 2022 Jan 14;5(1):56. Epub 2022 Jan 14.

Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., 1-1, Suzuki-Cho, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-8681, Japan.

Mimetics of growth factors and cytokines are promising tools for culturing large numbers of cells and manufacturing regenerative medicine products. In this study, we report single-chain tandem macrocyclic peptides (STaMPtides) as mimetics in a new multivalent peptide format. STaMPtides, which contain two or more macrocyclic peptides with a disulfide-closed backbone and peptide linkers, are successfully secreted into the supernatant by Corynebacterium glutamicum-based secretion technology. Read More

View Article and Full-Text PDF
January 2022

Alleviating time poverty among the working poor: a pre-registered longitudinal field experiment.

Sci Rep 2022 Jan 14;12(1):719. Epub 2022 Jan 14.

Rotman School of Management, University of Toronto, Toronto, Canada.

Poverty entails more than a scarcity of material resources-it also involves a shortage of time. To examine the causal benefits of reducing time poverty, we conducted a longitudinal field experiment over six consecutive weeks in an urban slum in Kenya with a sample of working mothers, a population who is especially likely to experience severe time poverty. Participants received vouchers for services designed to reduce their burden of unpaid labor. Read More

View Article and Full-Text PDF
January 2022

Successful Management of Radiation-Associated Insufficiency Fracture of the Tibial Plateau with Low-Intensity Pulsed Ultrasound.

Am J Case Rep 2022 Jan 15;23:e934372. Epub 2022 Jan 15.

Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Kitakyushu, Fukuoka, Japan.

BACKGROUND Clinical management of radiation-associated pathological fracture is challenging because of a high nonunion rate and potential for morbidity. We report a case of radiation-associated insufficiency fracture of the tibial plateau after surgery, perioperative chemotherapy, and adjuvant radiation therapy for synovial sarcoma of the proximal calf that was successfully treated with low-intensity pulsed ultrasound (LIPUS). CASE REPORT A healthy 52-year-old Japanese woman presented with a slowly growing, painful soft tissue mass over her proximal calf. Read More

View Article and Full-Text PDF
January 2022

SEZ6L2 Antibody-Associated Cerebellar Ataxia Responsive to Sequential Immunotherapy.

Neurol Neuroimmunol Neuroinflamm 2022 Mar 14;9(2). Epub 2022 Jan 14.

From the Department of Neurology (A.M., J.S.), North Karelia Central Hospital, Joensuu; Department of Neurology (A.M.), University of Eastern Finland, Kuopio, Finland; Department of Neurology (A.H.), Tampere University Hospital; Clinical Neurosciences (J.S.), University of Turku, Turku, Finland.

Objectives: Seizure-related 6 homolog like 2 (SEZ6L2) antibody-associated ataxia is an extremely rare disease. Six patients have been reported and none of them improved significantly with immunotherapy. Herein, we present the case of a patient with cerebellar ataxia and SEZ6L2 antibodies who benefited from immunotherapy, which dramatically altered the course of her disease. Read More

View Article and Full-Text PDF

Tourette Disorder and Sleep.

Biomed J 2022 Jan 11. Epub 2022 Jan 11.

Seattle Children's Hospital, University of Washington, Seattle, WA, United States. Electronic address:

Healthy sleep is of utmost importance for growth, development, and overall health. Strong evidence shows that sleep is affected negatively in patients and particularly children with Tourette Disorder (TD). There is also a frequent association of TD with ADHD which alone has negative effects on sleep and cumulatively worsens the associated sleep findings. Read More

View Article and Full-Text PDF
January 2022

Disparities in Supportive Care Needs Over Time between Racial and Ethnic Minority and Non-Minority Patients with Advanced Lung Cancer.

J Pain Symptom Manage 2022 Jan 11. Epub 2022 Jan 11.

Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Division of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Context: Little is known about inequities in supportive care needs among diverse patients with advanced lung cancer.

Objectives: We aimed to examine differences in supportive care needs between racial/ethnic minority and non-minority patients with lung cancer and identify how these needs change over time.

Methods: We performed a prospective cohort study of patients newly diagnosed with advanced lung cancer (stage III and IV). Read More

View Article and Full-Text PDF
January 2022