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Medicine (Baltimore) 2021 Apr;100(14):e25352

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Academic Emergency Hospital Sibiu - Dermatology Clinic, Sibiu, Romania.

Rationale: Pityriasis rosea Gibert is an erythematous-papulosquamous dermatosis that frequently occurs in young adults. The etiopathogenesis of PR is still unknown, but is frequently associated with episodes of upper respiratory tract infections. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

Hautarzt 2021 Apr 1. Epub 2021 Apr 1.

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Long-term methotrexate (MTX) treatment is known to cause MTX-associated lymphoproliferative disorder (MTX-LPD). A 58-year-old woman with psoriasis vulgaris and pityriasis rubra pilaris was treated with a combination of MTX and ustekinumab for 4 months when she developed generalized lymphadenopathy. The initial histopathological analysis indicated Hodgkin's lymphoma; however, assessing the patient's clinical history revealed the diagnosis of MTX-LPD. Read More

Br J Dermatol 2021 Mar 17. Epub 2021 Mar 17.

Dermatology department, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central.

We read with great interest the article of J. Ricar and P. Cetkovska and congratulate the authors for the excellent outcome achieved. Read More

Curr Med Mycol 2020 Jun;6(2):37-42

nd Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background And Purpose: Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in immunocompromised children. The purpose of our study was to evaluate the incidence of IFIs in pediatric patients with underlying hematologic malignancies and determine the patient characteristics, predisposing factors, diagnosis, treatment efficacy, and outcome of IFIs.

Materials And Methods: For the purpose of the study, a retrospective analysis was performed on cases with proven and probable fungal infections from January 2001 to December 2016 (16 years). Read More

Case Rep Dermatol 2021 Jan-Apr;13(1):12-17. Epub 2021 Jan 21.

Division of Dermatology, Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare and severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by intermittent pyrexia, acute onset of generalized ulceronecrotic lesions, and histopathology suggestive of PLEVA. Prompt diagnosis and treatment are necessary to halt the progression of this potentially fatal disease; however, the widely variable presentation of FUMHD in addition to its rarity poses a diagnostic challenge. We report the case of a previously healthy 43-year-old woman who presented to the emergency department with 1 month of generalized rash and intermittent fevers. Read More

Hautarzt 2021 Mar 12;72(3):215-224. Epub 2021 Feb 12.

Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München LMU, Frauenlobstr. 9-11, 80337, München, Deutschland.

Dermatoses of the hands and feet cover a wide range of skin diseases that can occur in children and adolescents and are a frequent question in dermatological practice. Our synopsis of the most important differential diagnoses and their treatment is intended to provide better orientation for daily practice. A precise and detailed history is essential to establish a diagnosis, followed by clinical examination and specific examination methods. Read More

Dermatol Online J 2021 Jan 15;27(1). Epub 2021 Jan 15.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA.

The severe acute respiratory syndrome coronavirus two (SARS-CoV-2), which causes the 2019 coronavirus disease (COVID-19), has infected patients worldwide. Physicians have increasingly identified cutaneous findings as a significant clinical manifestation of COVID-19. In this review, we describe the clinical presentation, onset, duration, associated symptoms, treatment, and outcome of cutaneous manifestations thus far reported to be related to COVID-19. Read More

Probiotics Antimicrob Proteins 2021 Feb 1. Epub 2021 Feb 1.

Praj-Matrix - R&D Centre (Division of Praj Industries Limited) 402/403/1098, Urawade, Pirangut, Mulshi, Pune, 412115, Maharashtra, India.

Members of the genus Malassezia are known to be opportunistic pathogens responsible for causing skin disorders such as seborrheic dermatitis or dandruff, pityriasis versicolor, folliculitis, atopic dermatitis, and psoriasis. Due to the side effects caused by prolonged use of current topical antifungal agents, development of an alternative treatment is necessary. Fermentative production of antimicrobial metabolites from Bacillus amyloliquefaciens MTCC 10456 was carried out, and their antagonistic activity against Malassezia furfur and Malassezia globosa was evaluated. Read More

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Dermatology and Allergy Center, University Hospital of Odense, Odense, Denmark.

Pityriasis rubra pilaris (PRP) is a rare dermatosis characterised by hyperkeratotic follicular papules, orange-red scaly plaques and palmoplantar keratoderma. The aetiology of the disease is in most cases unclear and treatment can be challenging. Familial cases of PRP may result from pathogenic variants in the caspase recruitment domain family member 14 (CARD14). Read More

Dermatol Ther 2021 Jan 30;34(1):e14679. Epub 2020 Dec 30.

Department of Biosciences, Piracicaba Dental School - UNICAMP, Piracicaba, Brazil.

Pityriasis rosea (PR) is a dermatological disease with an erythemato-papulosquamous manifestation, distributed on the trunk and extremities affecting healthy people, especially children and young people between 10 and 35 years of age. The evolution is 6 to 8 weeks and may remain for 3 to 6 months. It regresses spontaneously and can leave changes in the skin color but reversibly. Read More

Front Immunol 2020 17;11:594735. Epub 2020 Nov 17.

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by the CD4 helper T cells (Th17 cells) and subsets of innate lymphoid cells. IL-17A is associated with the pathogenesis of inflammatory diseases, including psoriasis, atopic dermatitis, hidradenitis suppurativa, alopecia areata, pityriasis rubra pilaris, pemphigus, and systemic sclerosis. Interleukin-23 (IL-23) plays a pivotal role in stimulating the production of IL-17 by activating the Th17 cells. Read More

Br J Dermatol 2020 Dec 4. Epub 2020 Dec 4.

Department of Dermatovenereology, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.

J Eur Acad Dermatol Venereol 2021 Apr 23;35(4):e246-e247. Epub 2020 Dec 23.

Department of Dermatology, Hotel Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.

Clin Exp Dermatol 2021 Apr 18;46(3):462-472. Epub 2020 Nov 18.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

The current COVID-19 pandemic is caused by the SARS-CoV-2 coronavirus. The initial recognized symptoms were respiratory, sometimes culminating in severe respiratory distress requiring ventilation, and causing death in a percentage of those infected. As time has passed, other symptoms have been recognized. Read More

G Ital Dermatol Venereol 2020 Nov 12. Epub 2020 Nov 12.

Dermatology Clinic of Terni, Università degli Studi di Perugia, Terni, Italy.

Arch Dermatol Res 2020 Nov 5. Epub 2020 Nov 5.

Department of Dermatology, University of California, Irvine, Irvine, CA, 92697, USA.

While isotretinoin has been the gold-standard of therapy for severe acne since its approval in 1982, its anti-inflammatory properties makes it a potentially applicable and versatile therapy for a wide variety of dermatologic conditions yet to be explored. This systematic review comprehensively recounts the success of oral isotretinoin in non-acne cutaneous diseases and provide insight into future directions of isotretinoin utility. A systematic literature review was performed using PubMed. Read More

Cureus 2020 Sep 30;12(9):e10733. Epub 2020 Sep 30.

Dermatology, San Diego Family Dermatology, National City, USA.

Erythrasma is a bacterial infection of the skin typically caused by Corynebacterium minutissimum. This pathogen infects the stratum corneum in warm and wet areas of the skin. Most commonly, the axillary, inguinal, and interdigital regions are affected. Read More

Dermatol Ther 2020 11 9;33(6):e14485. Epub 2020 Nov 9.

Faculty of Medicine, Department of Dermatology, Akdeniz University, Antalya, Turkey.

COVID-19 pandemic has a significant impact on public health, whether directly or indirectly. The first case was seen in Turkey on March 11, and the World Health Organization (WHO) declared a pandemic on March 12, 2020. The study aimed to document the effect of pandemic on dermatology outpatient clinics in Turkey. Read More

Dermatol Ther (Heidelb) 2020 Dec 23;10(6):1229-1253. Epub 2020 Oct 23.

, Rue Frans Binjé 8, 1030, Brussels, Belgium.

Rosacea is a common facial dermatosis but its definition and classification are still unclear, especially in terms of its links with demodicosis. Triggers of rosacea (ultraviolet light, heat, spicy foods, alcohol, stress, microbes) are currently considered to induce a cascading innate and then adaptive immune response that gets out of control. Recent histological and biochemical studies support the concept that this inflammatory response is a continuum, already present from the onset of the disease, even when no clinical signs of inflammation are visible. Read More

J Eur Acad Dermatol Venereol 2021 Jan 8;35(1):230-240. Epub 2020 Dec 8.

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Background: The diagnosis of a patient with erythroderma may be difficult and sometimes pose a challenge for both dermatologist and pathologist. The role of dermoscopy in this area seems to be poorly investigated. There are only a few reports, with limited number of patients, describing dermoscopic features in erythroderma of various origins. Read More

Indian J Sex Transm Dis AIDS 2020 Jan-Jun;41(1):100-101. Epub 2020 Jun 18.

Department of Medicine, Christian Medical College, Ludhiana, Punjab, India.

A 24-year-old woman, known to be human immunodeficiency virus positive for 6 years, presented with an itchy rash on the body. She had dull erythematous to hyperpigmented scaly plaques over the body, with extensor predominance. Inflammatory papules and nodules were noted on the face. Read More

Dermatol Ther 2020 11 21;33(6):e14403. Epub 2020 Oct 21.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

Dermatol Ther 2020 11 20;33(6):e14390. Epub 2020 Oct 20.

Department of Dermatology and Venereology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Dermatology is a field of medicine where urgent cases occur commonly. However, access to specialized emergency dermatology services is very limited. Following the declaration of the COVID-19 pandemic, the cessation of all elective dermatology visits was widely urged. Read More

Eur J Dermatol 2020 Oct;30(5):569-579

Department of Dermatology, Venereology, and Allergology, University Medical Center, Göttingen, Germany, Robert-Koch-Straße 40, D-37075 Göttingen, Germany.

Background: Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory dermatosis. Treatment is challenging and mostly based on scarce empirical evidence from large case series.

Objective: To investigate patient characteristics and therapy outcomes in patients with PRP. Read More

J Cosmet Dermatol 2020 Nov 5;19(11):3145-3149. Epub 2020 Oct 5.

Department of Medical Microbiology, Yıldız Academia Hospital, İstanbul, Turkey.

Background: Demodex folliculorum mite infestation is associated with many diseases such as rosacea, pityriasis found with acne vulgaris, and blepharitis.

Aim: In this research, the aim of this study was to investigate an association between patients who have metabolic syndrome and presence of Demodex folliculorum.

Patients/methods: This research was planned prospectively as a case-control study. Read More

Dermatol Ther 2020 11 10;33(6):e14356. Epub 2020 Oct 10.

Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy.

Pityriasis rosea (PR) is an exanthematous disease whose etiology is related to reactivation of herpes human herpesviruses 6 (HHV-6) and 7 (HHV-7). We observed two cases of PR arising during omalizumab therapy for chronic spontaneous urticaria (CSU). Here we report for the first time PR occurring during omalizumab treatment. Read More

BMC Dermatol 2020 09 29;20(1). Epub 2020 Sep 29.

Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.

Background: The impact of Malassezia yeasts on skin mycobiome and health has received considerable attention recently. Pityriasis versicolor (PV), a common dermatosis caused by Malassezia genus worldwide, is a manifestation of dysbiosis. PV can be associated with hyper- and/or hypopigmented skin lesions. Read More

Curr Pediatr Rev 2020 Sep 23. Epub 2020 Sep 23.

Department of Paediatrics, The Chinese University of Hong Kong, and Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital. Hong Kong.

Background: Pityriasis rosea is a common acute, self-limited papulosquamous dermatosis that primarily affects children and young adults. The condition and its clinical variants may pose a diagnostic challenge, especially in the absence of the herald patch.

Objective: This article aimed to familiarize pediatricians with clinical manifestations, evaluation, diagnosis, and management of pityriasis rosea. Read More

J Cutan Pathol 2021 Jan 30;48(1):133-139. Epub 2020 Sep 30.

Dermatology Department, Hospital Universitario HM Montepríncipe, Madrid, Spain.

Pityriasis rubra pilaris (PRP) is an erythematous-desquamative dermatitis that is sometimes associated with non-scarring alopecia. Despite the fact that the disease can be disfiguring, scarring alopecia has rarely been described in this disease. Here, we present a 69-year-old woman who developed an erythrodermic episode of PRP associated with telogen effluvium that left an area of persistent alopecia of the scalp and resulted in hair loss in the eyebrows. Read More