233,860 results match your criteria treatment patterns


Seasonal variation in oestrogenic potency and biological effects of wastewater treatment works effluents assessed using ERE-GFP transgenic zebrafish embryo-larvae.

Aquat Toxicol 2021 May 19;237:105864. Epub 2021 May 19.

Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom. Electronic address:

Effluents from wastewater treatment works (WwTW) exhibit both temporal and spatial variation in oestrogenicity, however few studies have attempted to quantify how this variation affects biological responses in fish. Here we used an oestrogen-responsive green fluorescent protein (ERE-GFP) transgenic zebrafish (Danio rerio) to quantify oestrogenic activity and health effects for exposure to three different WwTW effluents. Endpoints measured included survival/hatching rate, GFP induction (measured in target tissues or gfp mRNA induction in whole embryos) and vtg mRNA induction in whole embryos. Read More

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Dermatomyositis: Patterns of MRI findings in muscles, fascia and skin of pelvis and thigh.

Eur J Radiol 2021 Jun 6;141:109812. Epub 2021 Jun 6.

Department of Radiodiagnosis, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Purpose: This review discusses characteristic, subtle, and florid changes in muscle, fascia, skin, and subcutaneous tissue of the lower limbs in MR imaging in patients with dermatomyositis.

Material And Methods: This review is based on the analysis of 43 patients with dermatomyositis who were imaged from January 2014 to March 2021 in our institute as well a critical review of literature of MRI in dermatomyositis.

Results: Muscle involvement is predominantly bilaterally symmetric and involves anterior, posterior as well as medial compartments of the thigh. Read More

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Individuals with recurrent low back pain exhibit further altered frontal plane trunk control in remission than when in pain.

Clin Biomech (Bristol, Avon) 2021 May 28;87:105391. Epub 2021 May 28.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.

Background: Movement alterations due to low back pain (LBP) could lead to long-term adverse consequences if they do not resolve after symptoms subside. This study aims to determine if altered trunk control associated with recurrent low back pain persists beyond symptom duration.

Methods: Twenty young adults with recurrent LBP were tested once during an LBP episode and once in symptom remission, and twenty matched back-healthy participants served as controls. Read More

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Identification and profiles of microRNAs in different development stages of miniature pig secondary palate.

Genomics 2021 Jun 9. Epub 2021 Jun 9.

Department of geriatric dentistry, Capital Medical University School of Stomatology, Tiantan Xili No.4, Beijing 100050, China; Laboratory of Molecular Signaling and Stem Cells Therapy, Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Tiantan Xili No.4, Beijing 100050, China. Electronic address:

Cleft palate is one of the most frequent craniofacial malformation birth defects. Miniature pigs (Sus scrofa) are a valuable alternative large animal model to explore human palate development. Presently, the microRNA (miRNA) expression profiles in miniature pigs during palatogenesis from embryonic day (E) 30 to 50 were identified. Read More

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Disease Behaviour During the Peri-Diagnostic Period in Patients with Suspected Interstitial Lung Disease: The STARLINER Study.

Adv Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Diseases, University Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.

Introduction: Disease behaviour may guide diagnosis and treatment decisions in patients with interstitial lung disease (ILD). STARLINER aimed to characterise disease behaviour in patients with suspected ILD during the peri-diagnostic period using real-time home-based assessments.

Methods: STARLINER (NCT03261037) was an international, multicentre study. Read More

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Treatment Patterns, Effectiveness, and Satisfaction Among Patients with Type 2 Diabetes Treated with Insulin in Saudi Arabia: Results of the RIMODIS Study.

Diabetes Ther 2021 Jun 11. Epub 2021 Jun 11.

Sanofi Medical Department, Jeddah, Saudi Arabia.

Introduction: The alarming increase in type 2 diabetes mellitus (T2DM) in Saudi Arabia is aggravated by increasing obesity, sedentary lifestyle, and population aging. The RIMODIS study aimed at describing the practices in the therapeutic management of patients with T2DM treated with different insulin regimens.

Methods: This national, multicenter, non-interventional, cross-sectional disease registry on the real-life therapeutic management of insulin-treated patients with T2DM in Saudi Arabia enrolled 3010 patients. Read More

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CAPP-seq analysis of circulating tumor DNA from patients with EGFR T790M-positive lung cancer after osimertinib.

Int J Clin Oncol 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Background: We here applied cancer personalized profiling by deep sequencing (CAPP-seq) to analysis of circulating tumor DNA (ctDNA) to identify resistance mechanisms in osimertinib-treated patients with EGFR T790M-positive non-small cell lung cancer (NSCLC).

Methods: The study included patients with EGFR activating mutation-positive advanced NSCLC who were positive for T790M in tumor tissue or plasma after previous treatment with an EGFR tyrosine kinase inhibitor, who received osimertinib at Kindai University Hospital between August 2014 and September 2017, and for whom plasma collected after progression on osimertinib was available. Clinical data were extracted from medical records. Read More

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Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota.

Food Funct 2021 Jun 12. Epub 2021 Jun 12.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University (Guangzhou Campus), Guangzhou, China. and Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, China.

Dietary factors can reshape the gut microbiota and consequently affect disease progression. We previously reported that tetrahydrocurcumin (THC), the major active metabolite of curcumin (Cur), could ameliorate allergic inflammation in asthmatic mice. Herein, we aimed to investigate whether THC or Cur exerts anti-inflammatory effects on allergic asthma via modulating gut microbiota. Read More

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Antibiotic susceptibility of human gut-derived facultative anaerobic bacteria is different under aerobic versus anaerobic test conditions.

Microbes Infect 2021 Jun 8:104847. Epub 2021 Jun 8.

National Centre for Microbial Resource, National Centre for Cell Sciences, Pune, Maharashtra 411007, India. Electronic address:

Facultative anaerobes are the most common cause of infections in anoxic parts of the human body, including deep wound, vagina, periodontal pockets, gastrointestinal tract, genitourinary tract and lungs. Generally, antibiotic susceptibility tests (AST) for facultative anaerobes are performed under aerobic conditions due to ease of handling and rapid growth. However, variation in susceptibility of facultative anaerobes to antibiotics under aerobic and anaerobic conditions can lead to failure of antibiotic treatment. Read More

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COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system.

PLoS One 2021 11;16(6):e0252591. Epub 2021 Jun 11.

Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, PA, United States of America.

Introduction: During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The standard of care for pharmacological interventions evolved during this period as new and repurposed treatments were used alone and in combination. Though these medications have been studied individually, data are limited regarding the relative impact of different medication combinations. Read More

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How does onchocerciasis-related skin and eye disease in Africa depend on cumulative exposure to infection and mass treatment?

PLoS Negl Trop Dis 2021 Jun 11;15(6):e0009489. Epub 2021 Jun 11.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Onchocerciasis (river-blindness) in Africa is targeted for elimination through mass drug administration (MDA) with ivermectin. Onchocerciasis may cause various types of skin and eye disease. Predicting the impact of MDA on onchocercal morbidity is useful for future policy development. Read More

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Impact of Parental Impulsivity on Attention Deficit Hyperactivity Disorder and Oppositional Defiant Disorder: Do Mothers' Attitudes Predict Symptom Severity in Children?

J Nerv Ment Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Child and Adolescent Psychiatry, Balıkesir Atatürk Research and Training Hospital, Balıkesir Department of Child and Adolescent Psychiatry, University of Health Sciences, Dr Sami Ulus Maternity and Children's Research and Training Hospital, Ankara Department of Psychiatry, Balıkesir Atatürk Research and Training Hospital, Balıkesir Department of Child and Adolescent Psychiatry, Aksaray University Research and Training Hospital, Aksaray Department of Child And Adolescent Psychiatry, University of Health Sciences, Ankara Research and Training Hospital Department of Child and Adolescent Psychiatry, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.

Abstract: Attention deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder that occurs early in school-aged children, and it is highly comorbid with oppositional defiant disorder (ODD). Parents of children with ADHD frequently show mental problems related to impulsivity. The aim of this study was to examine the relationship between impulsivity of the mothers and the symptom patterns and severity of children. Read More

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PD-L1 Expression in Metaplastic Breast Carcinoma Using the PD-L1 SP142 Assay and Concordance Among PD-L1 Immunohistochemical Assays.

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

Departments of Pathology Medicine Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.

Immunotherapy for the treatment of programmed death-ligand 1 (PD-L1) positive locally advanced or metastatic triple negative breast cancer may benefit patients with metaplastic breast cancer (MpBC). Previous study of PD-L1 in MpBC scored tumor cells (TCs), different from Food and Drug Administration-approved scoring methods. We sought to define PD-L1 expression in MpBCs and to evaluate concordance of 3 PD-L1 assays. Read More

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Older Adult Patients Use More Aminosalicylate Monotherapy Compared With Younger Patients With Inflammatory Bowel Disease: TARGET-IBD.

J Clin Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill Atrium Health Gastroenterology and Hepatology, Charlotte Target RWE, Health Evidence Solutions, Durham, NC Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai Division of Pediatric Gastroenterology, The Susan & Leonard Feinstein IBD Clinical Center at Icahn School of Medicine at Mount Sinai, New York, NY IBD Center, The University of Chicago Medicine, Chicago, IL Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Goal: The goal of this study was to describe medication utilization patterns in older inflammatory bowel disease (IBD) patients.

Background: Despite a growing population of older patients with Crohn's disease (CD) and ulcerative colitis (UC), questions remain regarding medication utilization patterns in comparison to younger populations.

Materials And Methods: We collected data from the 34 sites in TARGET-IBD, a multicenter, observational cohort. Read More

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Protocol of Muscular Assessment in Patients With Severe Obstructive Sleep Apnea Syndrome. A Case-Control Study.

JMIR Res Protoc 2021 Jun 11. Epub 2021 Jun 11.

Department Otorhinolaryngology. Hospital Universitario Sanitas la Zarzuela, Madrid, ES.

Background: Myofunctional therapy is currently a reasonable therapeutic option to treat obstructive sleep apnea-hypopnea syndrome (OSAHS). This therapy is based on performing regular exercises of the upper airway muscles to increase their tone and prevent their collapse. Over the past decade there has been an increasing number of publications in this area; however, to our knowledge, there are no studies focused on the patients who can most benefit from this therapy. Read More

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Patterns of recombinant growth hormone therapy use and growth responses among children with chronic kidney disease.

Pediatr Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Division of Pediatric Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Background: Recombinant growth hormone (rGH) is an efficacious therapy for growth failure in children with chronic kidney disease (CKD). We described rGH use and estimated its relationship with growth and kidney function in the Chronic Kidney Disease in Children (CKiD) cohort.

Methods: Participants included those with growth failure, prevalent rGH users, and rGH initiators who did not meet growth failure criteria. Read More

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Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA.

Radiol Imaging Cancer 2021 Apr;3(4):e200157

From the Departments of Radiation Oncology (K.J.L., M.N.C., C.D.J., J.W., Y.C., C.W., C.R.K., F.F.Y.), Radiology (K.J.L.), Biostatistics and Bioinformatics (J.G.), and Medicine (A.H.), Duke University School of Medicine, 2301 Erwin Rd, Durham, NC 27710; Department of Electrical and Computer Engineering, Duke University Pratt School of Engineering, Durham, NC (K.J.L.); Radiology Medical Group of Napa, Napa, Calif (M.N.C.); Department of Radiation Oncology, Columbia University School of Medicine, New York, NY (E.X.); and Inivata, Cambridge, England (G.J.).

The radiologic appearance of locally advanced lung cancer may be linked to molecular changes of the disease during treatment, but characteristics of this phenomenon are poorly understood. Radiomics, liquid biopsy of cell-free DNA (cfDNA), and next-generation sequencing of circulating tumor DNA (ctDNA) encode tumor-specific radiogenomic expression patterns that can be probed to study this problem. Preliminary findings are reported from a radiogenomic analysis of CT imaging, cfDNA, and ctDNA in 24 patients (median age, 64 years; range, 49-74 years) with stage III lung cancer undergoing chemoradiation on a prospective pilot study (NCT00921739) between September 2009 and September 2014. Read More

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Herbivore-induced and constitutive volatiles are controlled by different oxylipin-dependent mechanisms in rice.

Plant Cell Environ 2021 Jun 10. Epub 2021 Jun 10.

Institute of Plant Science and Resources, Okayama University, Kurashiki, Japan.

Despite the importance of volatile organic compounds (VOCs) for plants, control mechanisms for their basal and stress-induced biosynthesis and release remain unclear. We sampled and characterized headspace and internal leaf volatile pools in rice (Oryza sativa), after a simulated herbivory treatment which triggers an endogenous jasmonate burst. Certain volatiles, such as linalool, were strongly upregulated by simulated herbivory stress. Read More

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A snapshot of HIV-1 capsid-host interactions.

Curr Res Struct Biol 2020 19;2:222-228. Epub 2020 Oct 19.

Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT, 06511, USA.

From cellular deposition of the HIV-1 capsid to integration of the viral genome, the capsid constitutes a primary target of a variety of host proteins that work to either promote or inhibit HIV-1 infection. Successful progression of HIV-1 infection depends on interactions between the capsid and host factors involved in stability, cellular transport, nuclear import, and genome integration. The virus must also guard its reverse-transcribing genome inside the capsid from host restriction factors that bind the capsid and suppress infection. Read More

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October 2020

Identifying Patterns of Failure and Risk Factors for Recurrence in Patients of Paratesticular Sarcomas: Protocol of a Systematic Review and Meta-Analysis.

Int J Surg Protoc 2021 May 28;25(1):84-91. Epub 2021 May 28.

Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi, IN.

Introduction: Para testicular sarcomas are rare mesenchymal tumors that affect patients of all ages. Unlike other sites of sarcoma, they tend to be of lower grade and have a higher propensity for lymphatic spread. Management is hampered by the small number of patients who differ in terms of tumor grade and histology. Read More

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Markerless Real-Time 3-Dimensional kV Tracking of Lung Tumors During Free Breathing Stereotactic Radiation Therapy.

Adv Radiat Oncol 2021 Jul-Aug;6(4):100705. Epub 2021 Apr 20.

Department of Radiation Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Purpose: Accurate verification of tumor position during irradiation could reduce the probability of target miss. We investigated whether a commercial gantry-mounted 2-dimensional (2D) kilo-voltage (kV) imaging system could be used for real-time 3D tumor tracking during volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT). Markerless tumor tracking on kV fluoroscopic images was validated using a life-like moving thorax phantom and subsequently performed on kV images continuously acquired before and during free-breathing VMAT lung SBRT. Read More

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Disease burden, management patterns and multidisciplinary clinical approaches for patients with MPS IVA and VI in selected Latin American Countries.

Mol Genet Metab Rep 2021 Sep 25;28:100769. Epub 2021 May 25.

Hospital Dr. Verdi Cevallos Balda, Portoviejo, Ecuador.

Background: There is a paucity of real-world epidemiological data on patients with mucopolysaccharidoses (MPS) in Latin America. This real-world study assessed the disease burden, management patterns and multidisciplinary clinical approaches for MPS-IVA and MPS-VI patients in Latin America (Colombia, Ecuador, Mexico, Peru).

Methods: Data were collected from physicians/specialists experienced in treating MPS patients between April-June 2020, via an online patient-diary survey. Read More

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September 2021

MRI-Directed Brachytherapy for Cancer of the Uterine Cervix: A Case Report, Review, and Perspective on the Importance of Widespread Use of This Technological Advance in the United States.

Cureus 2021 Jun 7;13(6):e15495. Epub 2021 Jun 7.

Radiation Oncology, University of Mississippi Medical Center, Jackson, USA.

Cervical cancer remains a major health challenge in the United States (US), especially among the low socioeconomic and African American populations. The demographics of Mississippi constitute a relatively high percentage of this high-risk population. External beam radiation therapy (EBRT) combined with concurrent chemotherapy and followed by brachytherapy is the gold standard of treatment for stage IB3 through IVA cervical cancer. Read More

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Transcriptome Profile Analysis of Reveals the Drought Stress-Induced Long Non-coding RNAs Associated With Photosynthesis, Chlorophyll Synthesis, Fatty Acid Synthesis and Degradation.

Front Plant Sci 2021 25;12:643182. Epub 2021 May 25.

Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

Long non-coding RNAs (lncRNAs) play an important role in the response of plants to drought stress. The previous studies have reported that overexpression of and could enhance drought tolerance and improve the oil content in and , and most of the efforts have been invested in the gene function analysis, there is little understanding of how genes that involved in these important pathways are regulated. In the present study, the transcriptomic results of and over-expressed (OE) lines were compared with the RNAi lines, mutant lines and control lines under long-term and short-term drought treatment, a series of differentially expressed lncRNAs were identified, and their regulation patterns in mRNA were also investigated in above mentioned materials. Read More

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Epidemiological Characteristics and Drug Resistance Analysis of Cerebrospinal Fluid Microbial Infections in Wenzhou Area.

Infect Drug Resist 2021 3;14:2091-2103. Epub 2021 Jun 3.

Department of Laboratory Medicine, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.

Objective: Central nervous system infections (CNSI) are serious diseases that endanger human health. Identifying pathogens and their susceptibility to antibiotics, and promptly using antibiotics under this guidance is essential for treatment. The purpose of this study is to investigate the pathogen characteristics of CNSI patients, which can help clinicians choose appropriate empiric antibiotic . Read More

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A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome.

Nat Commun 2021 06 10;12(1):3523. Epub 2021 Jun 10.

Institut de Recherches Internationales Servier, Departments of Translational Medicine and Immuno-Inflammatory Diseases Research and Development, Suresnes, France.

There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Read More

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Predictive value of the new ESGO-ESTRO-ESP endometrial cancer risk classification on survival and recurrence in the Danish population.

Int J Gynecol Cancer 2021 Jun 10. Epub 2021 Jun 10.

Department of Gynecology and Obstetrics, Aarhus Universitetshospital, Aarhus, Denmark.

Objective: To compare the performance of the new ESGO-ESTRO-ESP (European Society of Gynecological Oncology-European Society for Radiotherapy & Oncology-European Society for Pathology) 2020 risk classification system with the previous 2016 risk classification in predicting survival and patterns of recurrence in the Danish endometrial cancer population.

Methods: This Danish national cohort study included 4516 patients with endometrial cancer treated between 2005 and 2012. Five-year Kaplan-Meier adjusted and unadjusted survival estimates and actuarial recurrence rates were calculated for the previous and the new classification systems. Read More

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Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL.

RMD Open 2021 Jun;7(2)

Rheumatology Unit, Department of Gastroentorogy, Dematology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden.

Objectives: Our knowledge about the effect of tocilizumab (TCZ) on the synovium in rheumatoid arthritis (RA) is limited. The aim of this study was to investigate the effect of TCZ on citrullination and on inflammation in the synovial tissue and in the peripheral blood.

Methods: 15 patients with RA underwent synovial biopsy before and 8 weeks after TCZ initiation. Read More

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Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade.

Science 2021 06;372(6547)

The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD 21287, USA.

Next-generation tissue-based biomarkers for immunotherapy will likely include the simultaneous analysis of multiple cell types and their spatial interactions, as well as distinct expression patterns of immunoregulatory molecules. Here, we introduce a comprehensive platform for multispectral imaging and mapping of multiple parameters in tumor tissue sections with high-fidelity single-cell resolution. Image analysis and data handling components were drawn from the field of astronomy. Read More

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Screening and functional identification of antioxidant microRNA-size sRNAs from Spirulina platensis using high-throughput sequencing.

Funct Plant Biol 2021 Jun 11. Epub 2021 Jun 11.

MiRNA-size small RNAs, abbreviated as sRNAs, are increasingly being discovered as research progresses and omics technologies development in prokaryotes. However, there is a paucity of data concerning whether or not sRNAs exist in cyanobacteria and regulate the resistance to oxidative stress. In this investigation, small RNA libraries were constructed from the control, 50-nM and 100-nM H2O2 treatments of Spirulina platensis. Read More

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