Biol Psychiatry 2021 Jan 27. Epub 2021 Jan 27.
Graduate Program in Neuroscience, Emory University, Atlanta, Georgia; Yerkes National Primate Research Center, The Robert W. Woodruff Health Sciences Center, Emory University, Atlanta, Georgia; Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia; Children's Healthcare of Atlanta, Atlanta, Georgia. Electronic address:
Background: The PI3-kinase (PI3K) complex is a well-validated target for mitigating cocaine-elicited sequelae, but pan-PI3K inhibitors are not viable long-term treatment options. The PI3K complex is composed of p110 catalytic and regulatory subunits, which can be individually manipulated for therapeutic purposes. However, this possibility has largely not been explored in behavioral contexts. Read More