239,969 results match your criteria treatment moderate


ADHD and autism symptoms in youth: a network analysis.

J Child Psychol Psychiatry 2021 May 13. Epub 2021 May 13.

Departamento de Psiquiatria da Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Background: Previous research investigating the overlap between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (henceforth, autism) symptoms in population samples have relied on latent variable modeling in which averaged scores representing dimensions were derived from observed symptoms. There are no studies evaluating how ADHD and autism symptoms interact at the level of individual symptom items.

Methods: We aimed to address this gap by performing a network analysis on data from a school survey of children aged 6-17 years old (N = 7,405). Read More

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A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial.

Int Immunopharmacol 2021 Apr 30;96:107743. Epub 2021 Apr 30.

Department of Medical Services and Clinical Research, NeuroGen Brain & Spine Institute, Navi Mumbai, India.

Objective: Ozone therapy has tremendous therapeutic potential owing to its antiviral, anti-inflammatory and antioxidant properties, and potential to improve oxygenation. A pilot clinical trial was conducted to evaluate the safety and efficacy ofintravenous ozonised saline treatment in patients with moderate COVID-19 pneumonia.

Patients And Methods: 10 patients were administered 200 ml freshly prepared ozonised saline intravenously over 1 h once a day for 8 days along with standard medical treatment. Read More

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High BRAF variant allele frequencies are associated with distinct pathological features and responsiveness to target therapy in melanoma patients.

ESMO Open 2021 May 10;6(3):100133. Epub 2021 May 10.

Pathology Unit, Candiolo Cancer Institute, FPO-IRCCs, Turin, Italy. Electronic address:

Background: BRAF mutant melanoma patients are commonly treated with anti-BRAF therapeutic strategies. However, many factors, including the percentage of BRAF-mutated cells, may contribute to the great variability in patient outcomes.

Patients And Methods: The BRAF variant allele frequency (VAF; defined as the percentage of mutated alleles) of primary and secondary melanoma lesions, obtained from 327 patients with different disease stages, was assessed by pyrosequencing. Read More

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Do computed tomography findings agree with traditional osteological examination? The case of porous cranial lesions.

Int J Paleopathol 2021 May 10;33:209-219. Epub 2021 May 10.

Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Objective: The current study evaluates the feasibility of using clinical cranial computed tomography (CT) scans for assessing the presence and morphology of porous cranial lesions (cribra orbitalia, porotic hyperostosis).

Methods: Observers (n = 4) conducted three independent evaluations of porous cranial lesions based on photographs, 2-D CT, and 3-D CT scans of archaeological crania. Evaluations of the crania from each viewing scenario were compared to findings from direct macroscopic observation. Read More

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Surgical treatment for cryptoglandular and Crohn's perianal fistulas: Protocol of an umbrella review.

PLoS One 2021 13;16(5):e0251460. Epub 2021 May 13.

Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Introduction: A high prevalence of cryptoglandular and Crohn's perianal fistulas has been reported worldwide, and several surgical options are available for the management of anal fistula, with varying clinical efficacy. However, currently, the available evidence for the effectiveness of these surgical approaches are lacking and of concern in terms of the credibility and strength. The purpose of this study is to evaluate the credibility of the published systematic reviews and meta-analyses that assess the efficacy and safety of the surgical options for cryptoglandular and Crohn's perianal fistulas through an umbrella review. Read More

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Clinical course and management of 73 hospitalized moderate patients with COVID-19 outside Wuhan.

PLoS One 2021 13;16(5):e0249655. Epub 2021 May 13.

Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, P. R. China.

Moderate cases account for the majority in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and can also progress to severe/critical condition. Here, we investigated the clinical course and management of hospitalized moderate SARS-CoV-2 patients. The medical records and follow-up data were analyzed from the SARS-CoV-2 patients outside Wuhan. Read More

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Ex vivo comparison of leak testing of canine jejunal enterotomies: Saline infusion versus air insufflation.

Vet Surg 2021 May 13. Epub 2021 May 13.

Department of Statistics, College of Liberal Arts and Sciences University of Florida, Gainesville, Florida, USA.

Objective: To compare the ability to detect leakage of enterotomy closures by intraluminal injection of saline or air.

Study Design: Ex vivo study.

Animals: Grossly normal jejunal segments (n = 60) from five fresh canine cadavers. Read More

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Circulating endotoxin and inflammation: associations with fitness, physical activity and the effect of a six-month programme of cycling exercise during haemodialysis.

Nephrol Dial Transplant 2021 May 13. Epub 2021 May 13.

Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.

Background: Intradialytic cycling (IDC) may provide cardiovascular benefit to individuals receiving haemodialysis, but the exact mechanism behind these improvements remains unclear. The primary aim of this study was to investigate the effect of a six-month programme of IDC on circulating endotoxin (secondary analysis from the CYCLE-HD trial). Secondary aims were to investigate changes in circulating cytokines (IL-6, IL-10, TNF-α, CRP and IL6/IL-10), and their associations with physical activity, fitness and cardiovascular outcomes. Read More

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Clinical and Biochemical Features of Hypopituitarism Among Brazilian Children With Zika Virus-Induced Microcephaly.

JAMA Netw Open 2021 May 3;4(5):e219878. Epub 2021 May 3.

Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.

Importance: The Zika virus infects progenitor neuron cells, disrupts cerebral development, and, in mice, drives hypothalamic defects. Patients with microcephaly caused by congenital Zika infection present with midline cerebral defects, which may result in hypopituitarism.

Objective: To analyze postnatal growth and the presence of clinical and biochemical features associated with hypopituitarism in children with congenital Zika infections. Read More

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Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial.

J Int Med Res 2021 May;49(5):3000605211013550

Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh.

Objective: We evaluated whether ivermectin combined with doxycycline reduced the clinical recovery time in adults with COVID-19 infection.

Methods: This was a randomized, blinded, placebo-controlled trial in patients with mild-to-moderate COVID-19 symptoms randomly assigned to treatment (n = 200) and placebo (n = 200) groups. The primary outcome was duration from treatment to clinical recovery. Read More

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Contrasting Clinician and Insurer Perspectives to Managing Irritable Bowel Syndrome: Multilevel Modeling Analysis.

Am J Gastroenterol 2021 Apr;116(4):748-757

1Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Health, Lebanon, New Hampshire, USA; 2Vatche & Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; 3Department of Psychiatry, Dartmouth-Hitchcock Health, Lebanon, New Hampshire, USA; 4Department of Gastroenterology, Central Clinical School, Monash University, Melbourne, Australia; 5Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; 6Division of Gastroenterology, Michigan Medicine, Ann Arbor, Michigan, USA.

Introduction: Insurance coverage is an important determinant of treatment choice in irritable bowel syndrome (IBS), often taking precedence over desired mechanisms of action or patient goals/values. We aimed to determine whether routine and algorithmic coverage restrictions are cost-effective from a commercial insurer perspective.

Methods: A multilevel microsimulation tracking costs and outcomes among 10 million hypothetical moderate-to-severe patients with IBS was developed to model all possible algorithms including common global IBS treatments (neuromodulators; low fermentable oligo-, di-, and mono-saccharides, and polyols; and cognitive behavioral therapy) and prescription drugs treating diarrhea-predominant IBS (IBS-D) or constipation-predominant IBS (IBS-C) over 1 year. Read More

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Contemporary use of guideline-based higher potency P2Y12 receptor inhibitor therapy in patients with moderate-to-high risk non-ST-segment elevation myocardial infarction: Results from the Canadian ACS reflective II cross-sectional study.

Clin Cardiol 2021 May 13. Epub 2021 May 13.

Terrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Canada.

Background: After myocardial infarction, guidelines recommend higher-potency P2Y12 receptor inhibitors, namely ticagrelor and prasugrel, over clopidogrel.

Hypothesis: We aimed to determine the contemporary use of higher-potency antiplatelet therapy in Canadian patients with non-ST-elevation myocardial infarction (NSTEMI).

Methods: A total of 684 moderate-to-high risk NSTEMI patients were enrolled in the prospective Canadian ACS Reflective II registry at 12 Canadian hospitals and three clinics in five provinces between July 2016 and May 2018. Read More

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Corroboration of Height Velocity Prediction Markers for rhGH With an Oral GH Secretagogue Treatment in Children With GHD.

J Endocr Soc 2021 Jun 25;5(6):bvab029. Epub 2021 Feb 25.

Lumos Pharma, Inc., Austin, TX, USA.

Context: Recombinant human growth hormone (rhGH) is approved for treatment of pediatric growth hormone deficiency (GHD), with greatest growth responses observed in those with severe GHD. Orally administered GH secretagogues (GHS) may be useful treatment in patients with moderate GHD. Distinguishing children with severe moderate GHD could identify children who would be better treated with rhGH or GHS. Read More

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Efficacy of erenumab in chronic migraine patients with and without ictal allodynia.

Cephalalgia 2021 May 13:3331024211010305. Epub 2021 May 13.

Amgen Inc., Thousand Oaks, CA, USA.

Background: Ictal cutaneous allodynia, common in chronic migraine, is associated with reduced responses to acute treatment with triptans. Allodynia's impact on the efficacy of newer preventive treatments such as erenumab is unknown.

Methods: subgroup analysis of a double-blind, randomized, placebo-controlled 12-week study of erenumab in chronic migraine, contrasting those with no allodynia with those with moderate-severe allodynia assessed with the Allodynia Symptom Checklist-12, was undertaken. Read More

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Factors related to the onset and recurrence of flares in hidradenitis suppurativa patients treated with adalimumab.

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Background: Hidradenitis suppurativa (HS) is characterized by periodic worsening of symptoms. However, clinical parameters associated with flare are still to be established. The aim was too investigate factors associated with flare outbreak in HS patients in treatment with adalimumab. Read More

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Patterns of family relationships in pediatric oncology: implications for children's adjustment upon treatment completion.

Support Care Cancer 2021 May 12. Epub 2021 May 12.

Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.

Objective: Family characteristics influence children's adaptation following a cancer diagnosis. Little is known about the importance of family relationships on children's social and emotional health immediately after treatment completion. In this study, we identify subtypes of family relationships and evaluate how these profiles relate to child adjustment upon treatment completion. Read More

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Early neuroimaging and ultrastructural correlates of injury outcome after neonatal hypoxic-ischaemia.

Brain Commun 2021 26;3(2):fcab048. Epub 2021 Mar 26.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan.

Hypoxic ischaemia encephalopathy is the major cause of brain injury in new-borns. However, to date, useful biomarkers which may be used to early predict neurodevelopmental impairment for proper commencement of hypothermia therapy is still lacking. This study aimed to determine whether the early neuroimaging characteristics and ultrastructural correlates were associated with different injury progressions and brain damage severity outcomes after neonatal hypoxic ischaemia. Read More

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The Effect of Footwear, Running Speed, and Location on the Validity of Two Commercially Available Inertial Measurement Units During Running.

Front Sports Act Living 2021 26;3:643385. Epub 2021 Apr 26.

Menrva Research Group, Schools of Mechatronic Systems Engineering and Engineering Science, Simon Fraser University, Metro Vancouver, BC, Canada.

Most running-related injuries are believed to be caused by abrupt changes in training load, compounded by biomechanical movement patterns. Wearable technology has made it possible for runners to quantify biomechanical loads (e.g. Read More

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Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance).

JNCI Cancer Spectr 2021 Jun 12;5(3):pkab025. Epub 2021 Apr 12.

Department of Medical Oncology, Dana-Farber/Harvard Cancer Center, Boston, MA, USA.

Background: Obesity and inactivity are associated with increased risk of cancer-related and overall mortality in breast cancer, but there are few data in metastatic disease.

Methods: Cancer and Leukemia Group B 40502 was a randomized trial of first-line taxane-based chemotherapy for patients with metastatic breast cancer. Height and weight were collected at enrollment. Read More

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Orofacial pain in 1916 patients with early or moderate Parkinson disease.

Pain Rep 2021 13;6(1):e923. Epub 2021 Apr 13.

Department of Neurology, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.

Introduction: Several studies have reported that some types of orofacial pain are more common in patients with Parkinson disease (PD) than the general population.

Objectives: In this study, we aimed to investigate the prevalence of self-reported orofacial pain in a larger group of patients with PD than has been previously studied.

Methods: We analysed data from 1916 participants with PD in a cross-sectional study recruited to the UK Parkinson's Pain Study who had detailed assessments of pain, motor, and nonmotor symptoms. Read More

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Barriers and facilitators to the adoption of artificial intelligence in radiation oncology: A New Zealand study.

Tech Innov Patient Support Radiat Oncol 2021 Jun 21;18:16-21. Epub 2021 Apr 21.

Waikato Hospital, Regional Cancer Centre Selwyn Street Level 1 Lomas Street Hamilton, Waikato 3240 New Zealand.

Introduction: Advances in computing capabilities and automated data collection have led to an increase in the use of Artificial Intelligence (AI) in radiation therapy. This has implications to workflow and workforce planning in radiation oncology departments. A survey was conducted in New Zealand to determine the likelihood of departments adopting AI into their practice. Read More

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Knowledge of patient emotional health status: impact on clinical care in glaucoma and retinal services.

BMJ Open Ophthalmol 2021 21;6(1):e000640. Epub 2021 Apr 21.

Dana Center for Preventive Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, USA.

Objective: Knowledge of a patient's emotional health status and using patient-centred communication may be key to providing early intervention and referral to appropriate treatment/support services for ophthalmology patients. This study aims to determine if and how ophthalmologists use anxiety and depression scores to determine clinical care of patients with chronic eye disease.

Methods And Analysis: This cross-sectional study included 10 ophthalmologists and a convenience sample of 100 of their patients (>18 years). Read More

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Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis.

Eur Thyroid J 2021 Apr 11;10(2):125-139. Epub 2020 Sep 11.

Endocrine Unit, Department of Medical Therapeutics, School of Medicine, Kapodistrian University of Athens, Athens, Greece.

Introduction: Tyrosine kinase inhibitors (TKIs) have been used in patients with advanced medullary thyroid carcinoma (MTC); however, data on their effectiveness and safety are limited. The aim of this systematic review and meta-analysis was to document clinical response and toxicities of TKIs in advanced MTC.

Methods: We systematically searched major databases for articles or abstracts on TKI use in MTC patients until May 2018. Read More

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Clinical Impact of the Early Use of Monoclonal Antibody LY-CoV555 (Bamlanivimab) on Mortality and Hospitalization Among Elderly Nursing Home Patients: A Multicenter Retrospective Study.

Cureus 2021 May 10;13(5):e14933. Epub 2021 May 10.

Medicine, Temple University, Philadelphia, USA.

Importance Coronavirus disease 2019 (COVID-19) outbreaks are frequent occurrences in nursing homes and long-term care facilities (LTCFs), resulting in subsequent hospitalization and death. Rationale Virus-neutralizing monoclonal antibodies demonstrate a significant decrease in both viral load and hospital transfer rate among patients with mild-to-moderate COVID-19 infection. Objective To assess the clinical outcomes of COVID-19 patients with mild-to-moderate symptoms in LTCFs who received LY-CoV555 as compared to those who did not receive this treatment. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Oceania and South East Asia.

Kidney Int Suppl (2011) 2021 May 12;11(2):e86-e96. Epub 2021 Apr 12.

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Oceania and South East Asia (OSEA) is a socioeconomically, culturally, and ethnically diverse region facing a rising epidemic of noncommunicable diseases, including chronic kidney disease (CKD). The second iteration of the International Society of Nephrology Global Kidney Health Atlas aimed to provide a comprehensive evaluation of kidney care in OSEA. Of the 30 countries/territories in OSEA, 15 participated in the survey, representing 98. Read More

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Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients.

Front Psychiatry 2021 26;12:641430. Epub 2021 Apr 26.

Université Clermont Auvergne, CHU Clermont-Ferrand, Inserm, Neuro-Dol, Service de Pharmacologie médicale, Centres Addictovigilance et Pharmacovigilance, Centre Evaluation et Traitement de la Douleur, Service Psychiatrie-Addictologie, Clermont-Ferrand, France.

Chronic pain and substance use disorders frequently co-occur. Indeed, chronic pain is highly prevalent, affecting 23-68% of patients receiving opioid agonist treatments (OAT) worldwide. The majority of available estimates come from American studies, but data are still lacking in Europe. Read More

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Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis.

Clin Microbiol Rev 2021 Jun 12;34(3). Epub 2021 May 12.

Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

SUMMARYSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million COVID-19-positive cases and a mortality rate of about 2.2%, as of 10 December 2020. About 20% of COVID-19 patients exhibit moderate to severe symptoms. Read More

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Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial.

BMC Oral Health 2021 May 12;21(1):253. Epub 2021 May 12.

Department of Research & Biostatistics, School of Public Health, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan.

Background: Treating periodontitis through non-surgical periodontal therapy (NSPT) may improve glycemic control in type-2 Diabetes Mellitus (T2DM) patients. However, the evidence to maintain this improvement beyond four months is insufficient. Hence, this trial was conducted to assess clinical efficacy of NSPT on glycemic control in T2DM patients. Read More

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Sedation versus protective stabilization for dental treatment of children with caries and challenging behavior at the dentist (CHOOSE): a study protocol for a non-randomized clinical trial.

BMC Oral Health 2021 May 12;21(1):256. Epub 2021 May 12.

Faculty of Dentistry, Universidade Federal de Goias, Primeira Avenida, s/n, Goiânia, GO, CEP 74605-220, Brazil.

Background: There is a lack of evidence on the effectiveness of moderate sedation in pediatric dentistry, compared to protective stabilization, which remains routinely used in Brazil despite moral questions. This prospective non-randomized clinical trial's objective is to evaluate the effectiveness of moderate sedation, compared to the protective stabilization, in the dental care of children with dental behavior management problems.

Methods: Participants will be 152 children under seven years of age with early childhood caries (ECC) who need specialized dental treatment due to a history of challenging behavior during dental care. Read More

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Varying Outcomes among Patients with Large Angiomyolipomas according to the Treatment Method.

Urol Int 2021 May 12:1-7. Epub 2021 May 12.

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Purpose: This study aimed to evaluate the outcomes of large angiomyolipoma (AML) treatment by selective arterial embolization (SAE) versus nephron-sparing surgery (NSS) using a robotic surgical system.

Materials And Methods: Between January 2011 and June 2018, we retrospectively reviewed 25 patients who underwent robot-assisted partial nephrectomy (RAPN) or SAE for large AMLs. Ten patients underwent RAPN, and 15 underwent SAE. Read More

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