2,038,374 results match your criteria treatment malignancies


[Interventional Radiology in Oncology - Update 2021].

Dtsch Med Wochenschr 2021 Aug 3;146(15):966-970. Epub 2021 Aug 3.

Institut für Diagnostische und Interventionelle Radiologie des Universitätsklinikums Köln.

Interventional radiology plays a crucial role in oncology. The most common interventional treatments are transarterial embolisation as well as percutaneous thermal ablations. Transarterial embolisation, such as transarterial chemoembolization (TACE) or selective internal radiation therapy (SIRT) are well established, usually palliatively intended treatment options for primary and secondary hepatic malignancies. Read More

View Article and Full-Text PDF

Facial nerve palsy due to a parotid abscess: Two case reports and a review of literature.

Int J Surg Case Rep 2021 Jul 30;85:106255. Epub 2021 Jul 30.

Department of Otorhinolaryngology and Head and Neck Surgery, Radboudumc, Nijmegen, the Netherlands.

Introduction And Importance: Parotid gland swelling with facial nerve palsy is highly suggestive of a malignancy. Facial nerve palsy is however rarely caused by a parotid abscess. We hereby present two cases, propose treatment and present a review of the literature. Read More

View Article and Full-Text PDF

Therapeutic roles of antibody drug conjugates (ADCs) in relapsed/refractory lymphomas.

Hematol Oncol Stem Cell Ther 2021 Jul 28. Epub 2021 Jul 28.

Department of Blood & Marrow Transplant and Cellular Immunotherapy (BMT CI), Moffitt Cancer Center, United States. Electronic address:

Relapsed or refractory lymphoma is commonly treated with combination chemoimmunotherapy and cellular immunotherapy. Modest response rates and associated toxicities are obstacles to achieving durable remission using traditional cytotoxic chemotherapy, especially in frail patients with advanced disease. Antibody drug conjugates represent a new class of novel targeted agents with significant improvement in therapeutic efficacy in the treatment of lymphomas. Read More

View Article and Full-Text PDF

Assessment of Clonotypic Rearrangements and Minimal Residual Disease in Lymphoid Malignancies: A Large Cancer Center Experience Using clonoSEQ.

Arch Pathol Lab Med 2021 Aug 3. Epub 2021 Aug 3.

Malignant Hematology (Shah, Pinilla-Ibarz, Shain), Moffitt Cancer Center, Tampa, Florida.

Context.—: Measurable (minimal) residual disease (MRD) is an independent prognostic factor for survival outcomes in patients with lymphoid and plasma cell malignancies and has been incorporated into consensus criteria regarding treatment response, strategy, and clinical trial endpoints. clonoSEQ (a next-generation sequencing [NGS]-MRD assay) uses multiplex polymerase chain reaction and NGS to identify clonotypic rearrangements at the immunoglobulin (Ig) H, IgK, IgL, T-cell receptor (TCR)-β, and TCR-γ loci, and translocated B-cell lymphoma 1/IgH and 2/IgH sequences for MRD assessment. Read More

View Article and Full-Text PDF

Pituitary metastases from neuroendocrine neoplasms: case report and narrative review.

Pituitary 2021 Aug 3. Epub 2021 Aug 3.

Oncological Endocrinology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.

Purpose: Pituitary metastases (PM) are uncommon findings and are mainly derived from breast and lung cancers. No extensive review of PM from neuroendocrine neoplasms (NENs) is on record. Here we describe a clinical case of PM from pancreatic NEN and review the clinical features of PM from NENs reported in the literature. Read More

View Article and Full-Text PDF

FAP imaging in rare cancer entities-first clinical experience in a broad spectrum of malignancies.

Eur J Nucl Med Mol Imaging 2021 Aug 3. Epub 2021 Aug 3.

National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Purpose:  Ga-FAPI (fibroblast activation protein inhibitor) is a rapidly evolving and highly promising radiotracer for PET/CT imaging, presenting excellent results in a variety of tumor entities, particularly in epithelial carcinomas. This retrospective analysis sought to evaluate the potential and impact of FAPI-PET/CT in rare cancer diseases with respect to improvement in staging and therapy, based on tracer uptake in normal organs and tumors.

Material And Methods: Fifty-five patients with rare tumor entities, defined by a prevalence of 1 person out of 2000 or less, received a  Ga-FAPI-PET/CT scan. Read More

View Article and Full-Text PDF

Diverting Enterostomy Improves Overall Survival of Patients with Severe Steroid-Refractory Gastrointestinal Acute Graft-versus-host Disease.

Ann Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of Digestive Surgery and Transplantation, University of Lille Nord de France, Lille, France Stem Cell Transplantation Unit, University of Lille Nord de France, Lille, France Department of biostatistics, University of Lille Nord de France, Lille, France Department of Nutrition, University of Lille Nord de France, Lille, France.

Objective: To evaluate the benefit of diverting enterostomy (DE) in patients with severe steroid-refractory (SR) gastrointestinal acute graft-versus-host-disease (GI-aGVHD) following allogeneic hematopoietic stem-cell transplantation (ASCT).

Summary And Background Data: Severe GI-aGVHD refractory to the first line steroid therapy is a rare but dramatic life-threatening complication. Second lines of immunosuppressors have limited effects and increase the risk of sepsis. Read More

View Article and Full-Text PDF

Temozolomide in grade III gastroenteropancreatic neuroendocrine neoplasms (G3 GEPNENs): A multicentre retrospective review.

Oncologist 2021 Aug 3. Epub 2021 Aug 3.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada.

Background: G3 GEPNENs are often aggressive, and the optimal treatment is unclear for this subgroup of NENs. Temozolomide (TEM)-based regimens have been increasingly used to treat grade 1-2 NENs, but their efficacy in G3 NENs remains undetermined. We aimed to assess the clinical efficacy of TEM-containing regimens in advanced grade 3 GEPNENs. Read More

View Article and Full-Text PDF

An Atypical Presentation of Hemophagocytic Lymphohistiocytosis (HLH) Secondary to Occult Hodgkin Lymphoma.

Case Rep Hematol 2021 24;2021:6672257. Epub 2021 Jul 24.

Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue Box MED, Rochester, NY 14642, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome of immune system dysregulation characterized by the phagocytosis of various cells by histiocytes in the bone marrow. HLH can present in one of the two ways: primary HLH, which is caused by mutations in genes essential to T and NK-cell function, and secondary HLH, typically caused by Epstein-Barr virus (EBV) infection or malignancy. Because of the rapid progression and high mortality of this disease, prompt diagnosis is essential to good outcomes. Read More

View Article and Full-Text PDF

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.

Acta Pharmacol Sin 2021 Aug 2. Epub 2021 Aug 2.

Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi evolved from natural HDACi largazole. Here, we report the preclinical study of bisthianostat alone and in combination with bortezomib in the treatment of multiple myeloma (MM), as well as preliminary first-in-human findings from an ongoing phase 1a study. Read More

View Article and Full-Text PDF

The neutralizing antibody response post COVID-19 vaccination in patients with myeloma is highly dependent on the type of anti-myeloma treatment.

Blood Cancer J 2021 Aug 2;11(8):138. Epub 2021 Aug 2.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Recent data suggest a suboptimal antibody response to COVID-19 vaccination in patients with hematological malignancies. Neutralizing antibodies (NAbs) against SARS-CoV-2 were evaluated in 276 patients with plasma cell neoplasms after vaccination with either the BNT162b2 or the AZD1222 vaccine, on days 1 (before the first vaccine shot), 22, and 50. Patients with MM (n = 213), SMM (n = 38), and MGUS (n = 25) and 226 healthy controls were enrolled in the study (NCT04743388). Read More

View Article and Full-Text PDF

PD-L1 Expression in colorectal carcinoma and its correlation with clinicopathological parameters, microsatellite instability and BRAF mutation.

Indian J Pathol Microbiol 2021 Jul-Sep;64(3):490-496

Department of Surgical Gastroenterology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh, India.

Context: : Programmed cell death ligand-1 (PD-L1) is the key inhibitor of the cytotoxic immune response thus causing progression of tumors and adverse prognosis in many malignancies.

Objective: The current study investigates PD-L1 expression in colorectal carcinoma and its correlation with clinicopathological parameters, microsatellite instability, and BRAF mutation.

Material And Methods: 110 cases of colorectal carcinoma were evaluated for PD-L1 expression using SP263 clone in tissue microarray. Read More

View Article and Full-Text PDF

Clinical Outcome of Sacral Chordoma Patients Treated with Pencil Beam Scanning Proton Therapy.

Clin Oncol (R Coll Radiol) 2021 Jul 31. Epub 2021 Jul 31.

Center for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland; Inselspital, University Hospital Bern, Bern, Switzerland; Department of Radiation Oncology, University Hospital of Zürich, Zürich, Switzerland. Electronic address:

Aims: Sacral chordomas are locally aggressive, radio-resistant tumours. Proton therapy has the potential to deliver high radiation doses, which may improve the therapeutic ratio when compared with conventional radiotherapy. We assessed tumour control and radiation-induced toxicity in a cohort of sacral chordoma patients treated with definitive or postoperative pencil beam scanning proton therapy. Read More

View Article and Full-Text PDF

Sarcopenia is Associated with Reduced Survival following Surgery for Adrenocortical Carcinoma.

Endocr Res 2021 Aug 3:1-10. Epub 2021 Aug 3.

Department of Endocrine Surgery - Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aim: Adrenocortical cancer (ACC) is an aggressive malignancy and robust prognostic factors remain unclear. The presence of sarcopenia has been shown to negatively impact survival for other malignancies, but has not been extensively analyzed in ACC.

Methods: Patients who underwent resection of their ACC between 2010 and 2020 were identified; therapeutic, operative, and outcome data were analyzed. Read More

View Article and Full-Text PDF

Uncommon and peculiar soft tissue sarcomas: Multidisciplinary review and practical recommendations. Spanish Group for Sarcoma research (GEIS -GROUP). Part II.

Cancer Treat Rev 2021 Jul 16;99:102260. Epub 2021 Jul 16.

Hospital Vall D'Hebron, Medical Oncology Department, Barcelona, Spain.

Among all Soft Tissue sarcomas there are some subtypes with low incidence and/or peculiar clinical behaviour, that need to be consider separately. Most of them are orphan diseases, whose biological characteristics imply a clearly different diagnostic and therapeutic approach from other more common sarcoma tumors. We present a brief and updated multidiciplinary review, focused on practical issues, aimed at helping clinicians in decision making. Read More

View Article and Full-Text PDF

Radiomics and functional imaging in lung cancer: the importance of radiological heterogeneity beyond FDG PET/CT and lung biopsy.

Eur J Radiol 2021 Jul 27;142:109874. Epub 2021 Jul 27.

Department of Surgical Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital Via di Grottarossa 1035-1039 00189 Rome, Italy. Electronic address:

Purpose: [F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET/CT) has a central role in the lung nodules' characterization even if, with SUV < 2.5, percutaneous CT-guided Lung Biopsy (CTLB) is needed to assess nodule nature. In that scenario, CT Texture Analysis (CTTA) could be a non-invasive imaging biomarker. Read More

View Article and Full-Text PDF

Transmission study of the Abdominal Compression plate (BodyFIX Diaphragm Control) for abdominal and stereotactic body radiotherapy.

J Appl Clin Med Phys 2021 Aug 2. Epub 2021 Aug 2.

Department of Radiation Oncology, Olivia Newton John Cancer Research & Wellness Centre, Austin Health, Heidelberg, Vic., Australia.

Purpose: Abdominal Compression is one of the methods available to minimize breathing motion during stereotactic body radiotherapy (SBRT), particularly for abdominal malignancies. It might be necessary to treat some tumors with radiation entering through the compression device. One clinically available compression plate device (Elekta BodyFIX Diaphragm Control) was evaluated to understand its impact on dosimetry during clinical treatments. Read More

View Article and Full-Text PDF

Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells.

PLoS Pathog 2021 Aug 2;17(8):e1009783. Epub 2021 Aug 2.

Department of Oncology, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, Wisconsin, United States of America.

The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral infection contribute to the development of EBV-associated tumors. Here we show that the Hippo signaling effectors, YAP and TAZ, promote lytic EBV reactivation in epithelial cells. The transcriptional co-activators YAP/TAZ (which are inhibited by Hippo signaling) interact with DNA-binding proteins, particularly TEADs, to induce transcription. Read More

View Article and Full-Text PDF

Importance of addressing malnutrition in cancer and implementation of a quality improvement project in a gastrointestinal cancer clinic.

Nutr Clin Pract 2021 Aug 2. Epub 2021 Aug 2.

Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Malnutrition is exceedingly common in cancer patients, with some of the highest rates seen in gastrointestinal (GI) malignancies. Malnutrition and cachexia in cancer patients is associated with worse quality of life, poor treatment tolerance, and increased morbidity and mortality. The importance of early recognition of malnutrition in cancer patients is key, and numerous screening tools have been validated to aid practitioners in this diagnosis. Read More

View Article and Full-Text PDF

PAX8, an Emerging Player in Ovarian Cancer.

Adv Exp Med Biol 2021 ;1330:95-112

Institute of Experimental Endocrinology and Oncology 'G. Salvatore' (IEOS) - CNR, National Research Council, Naples, Italy.

Ovarian Cancer is one of the most lethal and widespread gynecological malignancies. It is the seventh leading cause of all cancer deaths worldwide. High-Grade Serous Cancer (HGSC), the most commonly occurring subtype, alone contributes to 70% of all ovarian cancer deaths. Read More

View Article and Full-Text PDF
January 2021

Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms.

Adv Exp Med Biol 2021 ;1330:55-73

Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.

Ovarian cancer, one of the three leading malignancies in women, has high incidence and mortality worldwide. It is hard to diagnose until very late stages and the 5-year survival rate is very low, due mostly to its distant metastasis. Chemotherapy is currently the most common treatment to inhibit cancer growth, but long-term use could result in resistance and tumor recurrence in addition to damages to normal tissues and functions of the patients. Read More

View Article and Full-Text PDF
January 2021

Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature.

J Cancer Res Clin Oncol 2021 Aug 2. Epub 2021 Aug 2.

Department of General, Visceral and Vascular Surgery, University Hospital of Jena, Jena, Germany.

Purpose: Abscess or fistula of the anal region is an uncommon presentation of malignancy. Under the assumption of a benign condition, diagnostics is often delayed, resulting in advanced tumour stages at first diagnosis. Due to the case rarity, treatment guidelines for cancers of anorectal region masquerading as abscess or fistula are missing. Read More

View Article and Full-Text PDF

Current update on vaginal malignancies.

Abdom Radiol (NY) 2021 Aug 2. Epub 2021 Aug 2.

Department of Radiology, University of Florida School of Medicine - Jacksonville, 655 West 8th Street, C90, 2nd Floor, Clinical Center, Jacksonville, FL, 32209, USA.

Primary vaginal cancers are rare and account for 1-3% of all gynecologic malignancies. There are several histological subtypes that affect a wide range of the population. Imaging plays an important role in the diagnosis, staging, and treatment planning of vaginal cancers. Read More

View Article and Full-Text PDF

Prognosis of primary or metachronous prostate cancer in multiple primary genitourinary cancers; a single center experience with long-term results.

Aging Male 2021 Dec;24(1):37-41

Department of Urology, Sultan Abdulhamid Han Education and Research Hospital, Istanbul, Turkey.

Objective: This study aims to analyze the challenges, approaches and long-term results of primary or metachronous prostate cancer (PCa) in cases with multiple primary genitourinary cancers.

Methodology: A total of 17 patients were included in the study. Patients with multiple primary genitourinary cancers were divided into two groups according to the diagnosis of primary or metachronous PCa as group 1 and group 2. Read More

View Article and Full-Text PDF
December 2021

The complex relationship between infertility and female genital tract cancer: A review.

Urologia 2021 Aug 2:3915603211036426. Epub 2021 Aug 2.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.

Introduction: The link between female infertility and gynecological cancer has always been a debated and challenging topic. Although cervical cancer has the worst impact on female fertility, as it is usually diagnosed in patients of reproductive age, endometrial and ovarian cancer are also diagnosed and treated often in relatively younger patients in which fertility preservation is a relevant issue. The aim of this review is to highlight the correlation between therapy for female infertility and the developing cancer's risk and to describe the fertility sparing treatments in gynecological oncology. Read More

View Article and Full-Text PDF

The incidence and type of cancer in patients with ataxia-telangiectasia via a retrospective single-centre study.

Br J Haematol 2021 Aug 1. Epub 2021 Aug 1.

Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.

Ataxia-telangiectasia (A-T) is a hereditary immune system disorder with neurodegeneration. Its first neurologic symptoms include ataxic gait in early childhood, with slowly progressive cerebellar ataxia, oculomotor apraxia, oculocutaneous telangiectasia, and progressive muscle weakness. Neonatal screening for severe T-cell deficiency was recently found to diagnose A-T patients with a significantly reduced naïve T-cell pool. Read More

View Article and Full-Text PDF

Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Nodal Metastasis Managed with Surgical Resection.

Eur Urol Open Sci 2021 Jul 10;29:10-14. Epub 2021 May 10.

Department of Urology, Mayo Clinic, Jacksonville, FL, USA.

Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare renal malignancy that usually follows an indolent course. The few existing reports of metastatic MTSCC show poor response to systemic therapy. Here we describe the unusual case of a 39-yr-old male with MTSCC presenting as a large renal mass with bulky retroperitoneal lymphadenopathy managed with complete resection of disease. Read More

View Article and Full-Text PDF

External Validation of Two Nomograms Developed for Ga-PSMA-11 Applied to the Prostate-specific Membrane Antigen Tracer F-DCFPyl: Is Prediction of the Optimal Timing of Salvage Therapy Feasible?

Eur Urol Open Sci 2021 Jun 29;28:47-51. Epub 2021 Apr 29.

Department of Urology, The Netherlands Cancer Institute, Prostate Cancer Network Netherlands, Amsterdam, The Netherlands.

Two nomograms have been developed to predict the outcome of positron emission tomography (PET)/computed tomography (CT) imaging withGa-labeled ligands for prostate-specific membrane antigen (Ga-PSMA) for patients with rising prostate-specific antigen after radical prostatectomy (RP). These nomograms quantify the ability of PSMA PET/CT to detect prostate cancer recurrences, and therefore provide critical information in determining the optimal timing for PSMA PET/CT in guiding salvage therapies. We validated the ability of these nomograms to accurately predict PET/CT outcome using another ligand tracer, F-DCFPyL. Read More

View Article and Full-Text PDF

Long-term Testis Cancer Survivors in Canada-Mortality Risks in a Large Population-based Cohort.

Eur Urol Open Sci 2020 Dec 20;22:54-60. Epub 2020 Nov 20.

Division of Urology, Department of Surgery, Western University, London, Ontario, Canada.

Background: Testis cancer (TC) patients are young with excellent cancer prognosis. Hence, the risk of late-onset treatment-related morbidity and mortality is of concern due to longer survival after treatment.

Objective: We set to characterize long-term survival of TC patients through a Canadian population dataset. Read More

View Article and Full-Text PDF
December 2020