139,110 results match your criteria treatment laser

Optical profile: A key determinant of antibacterial efficacy of photodynamic therapy in dentistry.

Photodiagnosis Photodyn Ther 2021 Jul 24:102461. Epub 2021 Jul 24.

Department of Biomedical Engineering, Ming Chuan University, No. 5, Deming Road., Gweishan District, Taoyuan, Taiwan, 33348. Electronic address:

Background: Periodontal disease affects 20-50% of population worldwide, posing a global health challenge. It has been reported to be more prevalent among adults. Actinobacillus actinomycetemcomitans (A. Read More

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Alginate-azo/chitosan nanocapsules in vitro drug delivery for hepatic carcinoma cells: UV-stimulated decomposition and drug release based on trans-to-cis isomerization.

Int J Biol Macromol 2021 Jul 24. Epub 2021 Jul 24.

College of Chemical and Molecular Engineering, Nanjing Tech University, Nanjing 210000, PR China. Electronic address:

In this study, a nanocapsule (AL-azo/CH) was prepared with the anionic alginate-azo (AL-azo) and cationic chitosan (CH) via layer-by-layer method. Doxorubicin hydrochloride (DOX), an anticancer drug, was entrapped inside the AL-azo nanocapsules to form the DOX-loaded nanocapsules (DOX/AL-azo/CH). When the DOX/AL-azo/CH nanocapsules were irradiated with 365-nm light, the electrostatic attraction between the layers would be weakened as the trans-to-cis isomerization of AL-azo, which would lead to the UV-responsive decomposition and drug-release. Read More

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Managing Complex Perianal Fistulizing Disease.

J Laparoendosc Adv Surg Tech A 2021 Jul 27. Epub 2021 Jul 27.

Department of Colorectal Surgery, Digestive Disease Surgical Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Perianal disease is a particularly morbid phenotype of Crohn's disease, affecting up to one third of patients, with a significantly diminished quality of life. Conventional medical therapy and surgical interventions have limited efficacy. Medical treatment options achieve long-term durable remission in only a third of patients. Read More

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Urodynamic effects of prostatic urethral lift procedure for male voiding LUTS.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Radboudumc, 6034, Urology, Nijmegen, Gelderland, Netherlands;

Aims: Primary objective is to investigate whether prostatic urethral lift (PUL) results in an improvement of urodynamic parameters that define bladder outlet obstruction (urethral resistance algorithm [URA], Schäfer grade, PdetQmax, PdetOpen).

Methods: 20 patients (main inclusion criteria: ≥ 50 years of age, BPO, IPSS ≥ 13, prostate volume ≤ 60 mL, no middle prostate lobe) were enrolled in the study and a PUL was performed. Patients underwent urodynamic investigation and filled out the IPSS and QoL before and after PUL. Read More

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The impact of lasers in percutaneous nephrolithotomy outcomes: results from a systematic review and meta-analysis of randomized comparative trials.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Ng Teng Fong General Hospital, 242949, Urology, Singapore, Singapore;

Background Percutaneous nephrolithotomy (PCNL) is the first choice treatment of renal stones larger than 2 cm. We aimed to evaluate if lasers perform as equal as non-laser devices in patients with kidney stones candidate to PCNL. Materials and methods A comprehensive literature search was performed in MEDLINE via PubMed, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) to assess the differences in the perioperative course, incidence of postoperative complications, and stone free-rate (SFR) in patients with kidney stones undergoing laser versus non-laser PCNL in randomized studies. Read More

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Bacterial reduction effect of four different dental lasers on titanium surfaces in vitro.

Lasers Med Sci 2021 Jul 27. Epub 2021 Jul 27.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.

Compare the effectiveness of selected dental lasers for decontamination of machined titanium surfaces in vitro. Seventy-two sterile machined surface titanium discs were individually inoculated with strains of Streptococcus mutans (Sm), Streptococcus oralis (So), Aggregatibacter actinomycetemcomitans (Aa), or all three bacteria together (MIX) at 34.0 C, 20. Read More

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Multidrug-resistant protein inhibitor and phosphodiesterase inhibitor potentiate the vasodilator effect induced by photobiomodulation in isolated aortic rings.

Lasers Med Sci 2021 Jul 27. Epub 2021 Jul 27.

Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.

A previous work indicates that the red LASER (660 nm) induces vascular relaxation by nitric oxide (NO)-dependent mechanism. NO activates soluble guanylate cyclase (sGC) which produces cGMP, the main effector in the vasodilation pathway. An interesting pharmacological strategy is to control the levels of intracellular cGMP, preventing its efflux (with multidrug-resistant protein blockers, such as MK-571), or preventing its degradation (such as sildenafil, which inhibits the enzyme responsible for cGMP degradation, the phosphodiesterase-5 PDE5). Read More

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Experiences and Perspectives of Patients With Striae: A Survey With Treatment Implications.

Dermatol Surg 2021 Jul 20. Epub 2021 Jul 20.

Laser and Skin Surgery Center of New York, New York, New York Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago, Illinois Dermatology, Laser and Vein Specialists of the Carolinas, Charlotte, North Carolina.

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Thulium laser vapo-enucleation treatment for prostates >100 cc following urinary retention.

Urologia 2021 Jul 27:3915603211016325. Epub 2021 Jul 27.

University Hospitals of Leicester NHS Trust, Leicester, UK.

Introduction: Practical advantages of Thulium in the endoscopic treatment of BPH include its technical versatility, precision and safety, offering reduced need for haemostasis and risk of injury. Evidence has shown Holmium laser to be effective in the treatment of chronic retention, however no studies address the use of Thulium laser for larger prostates after urinary retention.

Objectives: We have selected this group in our retrospective analysis on the efficacy of Thulium laser vapo-enucleation for men with both urinary retention and large prostate volumes greater than 100 cc. Read More

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Acid-Sensitive Supramolecular Nanoassemblies with Multivalent Interaction: Effective Tumor Retention and Deep Intratumor Infiltration.

ACS Appl Mater Interfaces 2021 Jul 27. Epub 2021 Jul 27.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China.

It remains a conundrum to reconcile the contradiction between effective tumor retention and deep intratumor infiltration for nanotherapeutics due to the sophisticated drug delivery journey. Herein, we reported an acid-sensitive supramolecular nanoassemblies (DCD SNs) based on the multivalent host-gest inclusions of two polymer conjugates for conquering diverse physiological blockages and amplifying therapeutic efficacy. The multiple inclusions of repetitive units on the hydrophilic polymer backbone reinforced the binding affinity and induced robust self-assembly, ameliorating instability of the self-assemblies and facilitating to prolong the drug retention time. Read More

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Self-assembled AuCu/Au [email protected] tumor nanotheranostics with PT/fluorescence imaging-guided synergetic PTT/PDT.

J Mater Chem B 2021 Jul 27. Epub 2021 Jul 27.

School of Chemistry and Chemical Engineering, Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China.

Exploring and developing a new type of nanoplatform with diagnosis and treatment to effectively cure tumors and reduce side effects has become a hot spot for researchers and is of great significance. Herein, a cancer theranostic nanoplatform with dual-imaging, dual-phototherapy and laser-responsiveness to tumor microenvironment was successfully assembled by liposome (Lip) co-loaded with oil-soluble Au4Cu4 nanoclusters (NCs) and water-soluble Au25 NCs via a simple film hydration method and subsequent extraction process. The prepared Au4Cu4/[email protected] nanoplatform with core-shell structure and about 50 nm of uniform sphere shape presented highly biocompatible, stability and passive targeting due to the enhanced permeability and retention (EPR) effect. Read More

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Fluorescent Semiconductor Nanorods for the Solid-Phase Polymerase Chain Reaction-Based, Multiplexed Gene Detection of .

ACS Appl Mater Interfaces 2021 Jul 27. Epub 2021 Jul 27.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

The spread of infectious diseases with significantly high mortality rates can wreak devastating damage on global health systems and economies, underscoring the need for better disease diagnostic platforms. Solid-phase polymerase chain reaction (SP-PCR) potentially combines the advantages of conventional PCR-based diagnostics with the capability of multiplexed detection, given that the spatial separation between primers circumvents unwanted primer-primer interactions. However, the generally low efficiency of solid-phase amplification results in poor sensitivity and limits its use in detection schemes. Read More

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Single-Cell Mass Spectrometry Imaging of Multiple Drugs and Nanomaterials at Organelle Level.

ACS Nano 2021 Jul 27. Epub 2021 Jul 27.

Ministry of Education (MOE) Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.

Mass spectrometry imaging (MSI) techniques make possible the spatial chemical identification of analytes, especially for biological samples. As a universal energy source, laser is one of the most commonly used sampling methods in MSI techniques. However, due to the limitation of laser spot size, subcellular spatial resolution imaging, which is significant for life science researches, always remains a challenge for laser-based MSI. Read More

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Influence of road salt thawing peaks on the inflow composition and activated sludge properties in municipal wastewater treatment.

Water Sci Technol 2021 Jul;84(2):314-322

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040 Vienna, Austria.

Operational data over 2 years from three large Austrian wastewater treatment plants (WWTPs) with design capacities of 4 million, 950,000 and 110,000 population equivalent (PE) were examined. Salt peaks, due to thawing road salt were detected and quantified by electrical conductivity, temperature and chloride measurement in the inflow of the WWTPs. Daily NaCl inflow loads up to 1,147 t/d and PE-specific loads of 0. Read More

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A Honeycomb-Like Bismuth/Manganese Oxide Nanoparticle with Mutual Reinforcement of Internal and External Response for Triple-Negative Breast Cancer Targeted Therapy.

Adv Healthc Mater 2021 Jul 23:e2100518. Epub 2021 Jul 23.

The State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Technology, South China University of Technology, School of Physics, South China University of Technology, Guangzhou, Guangdong, 510640, China.

Triple-negative breast cancer (TNBC) exhibits aggressive behavior and high levels of metastasis owing to its complex heterogeneous structure and lack of specific receptors. Here, tumor cell membrane (CM)-coated bismuth/manganese oxide nanoparticles (NPs) with high indocyanine green (ICG) payload up to 50.6 wt% (mBMNI NPs) for targeted TNBC therapy are constructed. Read More

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Evaluation of lipolysis and toxicological parameters of low-level laser therapy at different wavelengths and doses in the abdominal subcutaneous tissue.

Lasers Med Sci 2021 Jul 23. Epub 2021 Jul 23.

Department of Cosmetics and Aesthetic, Lutheran University of Brazil, Canoas, RS, 92425-900, Brazil.

Investigate the effects of low-level lasers therapy (LLLT) aiming abdominal lipolysis. Female Wistar rats received applications of LLLT directly in the abdominal skin twice a week (5 weeks). Except the control group (n = 5), animals received treatments with red wavelength 660 nm being (I) R3. Read More

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FROZEN! Intracellular multi-electrolyte analysis measures millimolar lithium in mammalian cells.

Analyst 2021 Jul 23. Epub 2021 Jul 23.

Department of Physics, City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, Hong Kong, SAR, P.R. China.

Lithium salts are commonly used as medication for Bipolar Disorder (BD) and depression. However, there are limited methods to quantify intracellular lithium. Most methods to analyze intracellular electrolytes require tedious sample processing, specialized and often expensive machinery, sometimes involving harmful chemicals, and a bulk amount of the sample. Read More

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Salvage Following Transoral Laser Microsurgery for Early Glottic Cancer in National Veteran Database.

Laryngoscope 2021 Jul 23. Epub 2021 Jul 23.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California-San Diego, San Diego, California, U.S.A.

Objectives: Transoral laser microsurgery (TLM) is commonly utilized for early glottic cancer and offers favorable oncologic and functional outcomes. However, the survival implications of salvage therapy for recurrent or persistent disease have not been definitively characterized.

Study Design: Retrospective, national database cohort study. Read More

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Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses.

Dermatology 2021 Jul 26:1-13. Epub 2021 Jul 26.

Dermatology Service, Memorial Sloan Kettering, New York, New York, USA.

Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Read More

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Dextran-polylactide micelles loaded with doxorubicin and DiR for image-guided chemo-photothermal tumor therapy.

Int J Biol Macromol 2021 Jul 23. Epub 2021 Jul 23.

National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China. Electronic address:

Image-guided chemo-photothermal therapy based on near-infrared (NIR) theranostic agents has found promising applications in treating tumors. In this multimodal treatment, it is of critical importance to image real-time distribution of photothermal agents in vivo and to monitor therapeutic outcomes for implementing personalized treatment. In this study, an optimally synthesized dextran-polylactide (DEX-PLA) copolymer was assembled with doxorubicin (DOX) and DiR, a kind of NIR dye, to construct desirable micelles ((DiR + DOX)/DEX-PLA) for performing image-guided chemo-photothermal therapy. Read More

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Synthesis and ex vivo evaluation of PLGA chitosan surface modulated double walled transdermal Pluronic nanogel for the controlled delivery of Temozolomide.

Int J Biol Macromol 2021 Jul 23. Epub 2021 Jul 23.

School of Pharmacy, Faculty of Medical Sciences, University of West Indies, St. Augustine, Trinidad and Tobago.

A surface modulated biodegradable transdermal strategy has been exploited for improving the biopharmaceutical properties of Temozolomide augmented in Poly Lactic-co-glycolic acid (PLGA) chitosan double walled nanogel (PCNGL). The PCNGL was synthesized by dual approach methodology showing consistent nanosize particle range of 210 nm and PDI 0.325 ± 0. Read More

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Antibacterial efficacy of triple antibiotic medication with macrogol (3Mix-MP), traditional triple antibiotic paste, calcium hydroxide and ethanol extract of propolis: an intratubular dentine ex vivo confocal laser scanning microscopy study.

J Endod 2021 Jul 23. Epub 2021 Jul 23.

School of Dentistry - Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil. Electronic address:

Introduction: This study aimed to assess the effectiveness of antibacterial activity of medications used in regenerative endodontic treatment.

Methods: Sixty-seven dentin cylinders of single-rooted teeth were contaminated with a culture of E. faecalis (ATCC 29212) for 5 days. Read More

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Peripheral Hypertrophic Subepithelial Corneal Degeneration on a Laser-Assisted In Situ Keratomileusis Flap.

Eye Contact Lens 2021 Jul 21. Epub 2021 Jul 21.

Princess Alexandra Hospital (Y.L.), Brisbane, Australia; Ashford Advanced Eye Care (B.R.L.), Adelaide, Australia; The Queen Elizabeth Hospital (B.R.L.), Adelaide, Australia; South Australian Institute of Ophthalmology (B.R.L.), Adelaide, Australia; and University of Adelaide (B.R.L.), Adelaide, Australia.

Abstract: We describe the first reported case of a patient developing peripheral hypertrophic subepithelial corneal degeneration (PHSCD) in the setting of previous femtosecond laser in situ keratomileusis (LASIK). Superficial keratectomy was performed successfully with the complete restoration of the visual acuity, no LASIK flap complications, and no recurrence of PHSCD at 1-year follow-up. Our case indicates that superficial keratectomy can be a safe and effective treatment for PHSCD in the setting of LASIK and raises awareness of the possibility of PHSCD developing in eyes that have undergone prior LASIK. Read More

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Systemic Immunosuppression and Risk of Endophthalmitis After Intravitreal Anti-Vascular Endothelial Growth Factor Injections.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(S1):S17-S22. Epub 2021 Jul 1.

Background And Objective: To evaluate the impact of systemic immunosuppressive therapy on the rates and outcomes of endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injections.

Patients And Methods: A retrospective, single-center, comparative cohort study examining eyes undergoing intravitreal anti-VEGF injections from January 2016 to September 2019. Cohorts were created based on concurrent immunosuppressive therapy at time of injection. Read More

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Research Developments in the Treatment of Retinal Disease: Finalists From the 4th Annual Retina Research Scholar Honoree Program.

Rishi P Singh

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(S1):996. Epub 2021 Jul 1.

Cole Eye Institute, Cleveland Clinic, Associate Editor, OSLI Retina.

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What is Being Reported About Vaginal "Lasers"?: An Examination of Adverse Events Reported to the Food and Drug Administration on Energy-Based Devices.

Aesthet Surg J 2021 Jul 26. Epub 2021 Jul 26.

Magee-Womens Hospital University of Pittsburgh Medical Center, Magee Womens Research Institute, Pittsburgh, PA.

Background: Description of energy-based genitourinary non-surgical devices (energy-based devices) safety data is outlined given their rapid adoption.

Objectives: To describe adverse events (AEs) for energy-based devices in the Manufacturer and User Facility Device Experience (MAUDE) database, and to compare to similar devices and other subspecialty applications. We hypothesized that products with genitourinary applications had similar AEs to dermatologic or general surgery applications. Read More

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Effects of standing and walking training using a laser pointer based on stimulus-driven attention for behavioural outcome in spatial neglect: A single-case study.

Neuropsychol Rehabil 2021 Jul 26:1-15. Epub 2021 Jul 26.

Department of Rehabilitation, Saitama Medical University International Medical Centre, Saitama, Japan.

The therapy for unilateral spatial neglect (USN) is unclear. This case report investigated the effect of standing and walking training using a laser pointer based on stimulus-driven attention for USN. The patient was a right-handed 79-year-old man with cardiogenic cerebral embolism in the right middle and posterior cerebral arteries. Read More

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Self-Induced Bilateral Retinal Detachments and Traumatic Cataracts in a Patient With Bohring-Opitz Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):400-402. Epub 2021 Jul 1.

A 9-year-old female with a history of Bohring-Opitz syndrome (BOS), Down syndrome, and autism initially presented with bilateral cataracts and a total retinal detachment in her left eye secondary to chronic self-injurious behavior. The authors report the first case of self-induced retinal detachment and traumatic cataracts in a patient with BOS. For patients who present with self-injurious behavior, the authors advocate for behavioral modifications at home, including the use of "no-no's," supplemental medication if necessary, and behavioral therapy to reduce the risk of self-induced visual injury. Read More

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Atypical Late-Onset Exudative Retinal Detachment in a Treatment-Naïve Infant With Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):403-406. Epub 2021 Jul 1.

A male infant born at 23 weeks gestation with a birthweight of 660 grams presented with retinopathy of prematurity (ROP) that began progressing at 44 weeks. He subsequently developed Zone III, Stage 3, pre-plus disease in both eyes (OU), as well as scattered exudates in the macula, dragged vessels temporally, and an exudative retinal detachment temporally in the left eye after a period of regressing and stable ROP. After bilateral laser photocoagulation, there was regression of the neovascularization, resolution of the exudative detachment, and eventual stabilization of disease OU by 12 months postmenstrual age. Read More

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Resolution of Foveal Lipid Deposition in Adult-Onset Coats Disease With Combined Focal Laser Photocoagulation and Anti-VEGF Therapy.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):396-399. Epub 2021 Jul 1.

A major cause of poor visual prognosis in Coats disease is the formation of fibrovascular changes following dense foveal lipid deposition. The authors document the multimodal imaging findings of a 38-year-old woman and a 23-year-old man with adult-onset Coats disease who presented with macular edema and foveal lipid accumulation. Thermal laser targeting individual capillary macroaneurysms combined with intravitreal anti-vascular endothelial growth factor (VEGF) therapy was performed. Read More

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