17,970 results match your criteria treatment insomnia

The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials.

Sleep Med Rev 2021 Apr 21;58:101493. Epub 2021 Apr 21.

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, UK. Electronic address:

Sleep restriction therapy (SRT) is an established treatment for insomnia that has been used in clinical practise for over 30 y. It is commonly delivered as part of multicomponent cognitive-behavioural therapy (CBT-I) but has also been linked to beneficial effects as a standalone intervention. In order to quantify the efficacy of SRT we performed a comprehensive meta-analysis of randomised controlled trials (RCTs) comparing SRT to minimally active or non-active control groups. Read More

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Post-ICU Care in the Outpatient Setting.

Am Fam Physician 2021 May;103(10):590-596

University of Iowa Carver College of Medicine, Iowa City, IA, USA.

More than 5 million patients in the United States are admitted to intensive care units (ICUs) annually, and an increasing percentage of patients treated in the ICU survive to hospital discharge. Because these patients require follow-up in the outpatient setting, family physicians should be prepared to provide ongoing care and screening for post-ICU complications. Risk factors for complications after ICU discharge include previous ICU admissions, preexisting mental illness, greater number of comorbidities, and prolonged mechanical ventilation or higher opioid exposure while in the ICU. Read More

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Depressive and stress symptoms in insomnia patients predict group cognitive-behavioral therapy for insomnia long-term effectiveness: A data-driven analysis.

J Affect Disord 2021 Apr 24;289:117-124. Epub 2021 Apr 24.

Sleep Disorder Center, San Raffaele Hospital Milan, Italy.

Background: Insomnia Disorder is characterized by high degree of phenotypic heterogeneity, that might influence treatment response.

Methods: 123 of 294 insomnia patients initially recruited (66.7% females, age=40. Read More

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Overview of sleep management during COVID-19.

Philip M Becker

Sleep Med 2021 Apr 24. Epub 2021 Apr 24.

Sleep Medicine Associates of Texas, Department of Psychiatry, University of Texas Medical Center at Dallas, 12327 Brittany Circle, Dallas, TX 75230 USA. Electronic address:

The sleep of millions has suffered during the global COVID-19 pandemic. Prevalence rates of 20-45% are reported globally for insomnia symptoms during the pandemic. Affected populations include the public and health care workers. Read More

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Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors.

Acta Oncol 2021 May 11:1-8. Epub 2021 May 11.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Purpose: The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes.

Methods: A prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. Read More

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Benzodiazepine Use in Opioid Maintenance Treatment Programme: Risks and Clinical Outcomes.

Acta Med Port 2021 Mar 1;34(3):209-216. Epub 2021 Mar 1.

Drug Addiction Treatment Centre. Agualva-Cacém. Cacém. Portugal.

Introduction: The co-association of benzodiazepines and opioids is associated with an increased risk of overdose, death, and poorer psychosocial prognosis. The aim of this study is to characterize the prevalence, pattern of use, and primary clinical outcomes in benzodiazepines users in a public opioid maintenance treatment unit.

Material And Methods: We conducted a cross-sectional study involving 236 patients treated with opioid substitutes (methadone and buprenorphine). Read More

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Hypnotic Effect of . Hydroalcoholic Extract in Pentobarbital-Treated Mice.

Neurol Res Int 2021 21;2021:5521019. Epub 2021 Apr 21.

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Current drugs used in the management of insomnia are associated with side effects. The use of medicinal herbs for insomnia treatment has recently been suggested.

Objective: The present study aimed to determine the hypnotic activity of the hydroalcoholic extract of . Read More

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Psychiatric disorders as risk factors for type 2 diabetes: an umbrella review of systematic reviews with and without meta-analyses.

Diabetes Res Clin Pract 2021 May 6:108855. Epub 2021 May 6.

Department of Psychology, University of Southern Denmark, Odense, Denmark; STENO Diabetes Centre Odense, Odense University Hospital, Odense, Denmark; School of Psychology, Deakin University, Geelong, Australia. Electronic address:

Having a psychiatric disorder may increase the risk of developing type 2 diabetes[T2D] and this umbrella review aims to determine whether people with a psychiatric disorder have an increased risk of developing T2D and to investigate potential underlying mechanisms. A literature search was performed to identify systematic reviews of longitudinal studies investigating different psychiatric disorders as risk factors for incident T2D in humans (≥18 years). A total of 8,612 abstracts were identified, 180 full-text articles were read, and 25 systematic reviews were included. Read More

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The effect of sleep-wake intraindividial variability in digital cognitive behaviour therapy for insomnia: A mediation analysis of a large-scale RCT.

Sleep 2021 May 8. Epub 2021 May 8.

Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.

Study Objectives: Digital Cognitive Behavioural Therapy for Insomnia (dCBT-I) is an effective treatment for insomnia. However, less is known about mediators of its benefits. The aim of the present study was to test if intraindividual variability in sleep (IIV) was reduced with dCBT-I, and whether any identified reduction was a mediator of dCBT-I on insomnia severity and psychological distress. Read More

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Effect of early intervention for anxiety on sleep outcomes in adolescents: a randomized trial.

Eur Child Adolesc Psychiatry 2021 May 7. Epub 2021 May 7.

Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian Research Center, NORCE, Bergen, Norway.

The potential effect of early intervention for anxiety on sleep outcomes was examined in a sample of adolescents with anxiety (N = 313, mean 14.0 years, SD = 0.84, 84% girls, 95. Read More

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Case Report: Virtual Reality Neurofeedback Therapy as a Novel Modality for Sustained Analgesia in Centralized Pain Syndromes.

Front Psychiatry 2021 20;12:660105. Epub 2021 Apr 20.

Transitional Year Program, Garnet Health Medical Center, Middletown, NY, United States.

Neurofeedback (NFB) Therapy is a form of biofeedback, using the electroencephalogram (EEG) that has been in use since the 1970s, serving as a non-pharmacological intervention for epilepsy and psychiatric conditions such as anxiety, depression, insomnia, PTSD, post-concussive syndrome, and now, centralized pain. Chronic pain can increase neuronal activity and eventually causes poor modulation of pain messages. With the emergence of Virtual Reality (VR) in acute pain management, and the contraindications of opioids in chronic pain, applying novel biotechnologies seems like the next frontier in multimodal pain management. Read More

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The Adjunctive Effect of Acupuncture for Advanced Cancer Patients in a Collaborative Model of Palliative Care: Study Protocol for a 3-Arm Randomized Trial.

Integr Cancer Ther 2021 Jan-Dec;20:15347354211012749

The University of Hong Kong, Hong Kong, China.

Background: Cancer is the second leading cause of death before the age of 70. Improved cancer survival has put increasing demands on cancer care. Palliative care is the specialized multi-disciplinary care providing relief from the pain, symptoms, and stress of serious illness. Read More

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Acupuncture treatment for post-stroke insomnia: A systematic review and meta-analysis of randomized controlled trials.

Jialei Yang

Complement Ther Clin Pract 2021 Apr 23;44:101396. Epub 2021 Apr 23.

Department of Traditional Chinese Medicine, Beijing Tian Tan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China. Electronic address:

Objectives: The meta-analysis aimed to assess the effectiveness and safety of acupuncture for the treatment of post-stroke insomnia.

Methods: Randomized controlled trials were identified from five databases before April 2020. The primary outcomes were the rate of improvement and the Pittsburgh sleep quality index (PSQI) scores; the secondary outcomes included the follow-up PSQI scores and safety. Read More

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Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: a systematic review and meta-analysis of randomized controlled trials.

Neurosci Biobehav Rev 2021 May 3. Epub 2021 May 3.

Department of Rehabilitation Science, Graduate School of Inje University, Gimhae, 50834, Republic of Korea; Biohealth Products Research Center (BPRC), Inje University, Gimhae, 50834, Republic of Korea; Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, 50834, Republic of Korea; Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Gimhae, 50834, Republic of Korea; Department of Medicine, Division of Hematology/Oncology, Harvard Medical School-Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. Electronic address:

Endogenous melatonin levels are inversely associated with age and cognitive deficits. Although melatonin can improve psychopathological behavior disturbances in clinical trials, whether melatonin may also enhance cognitive function remains elusive. This study examined cognitive outcomes from randomized trials of melatonin treatment for Alzheimer's disease (AD), insomnia, and healthy-subjects. Read More

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Pain reduction induced by tapentadol in patients with musculoskeletal chronic pain fosters better sleep quality.

Drugs Context 2021 19;10. Epub 2021 Apr 19.

Anesthesia, Intensive Care Nord and Pain Management Unit, Bellaria Hospital, Bologna, Italy.

Background: Poor sleep may predict the increase and intensification of pain over time with increased insomnia symptoms being both a predictor and an indicator of worse pain outcomes and physical functioning status over time. However, the impact of different analgesic therapies on quality of life, functional recovery and sleep has been poorly assessed to date, whereas these evaluations may greatly help clinicians in the selection of treatment when dealing with patients with chronic pain (CP).

Methods: To explore whether tapentadol-induced pain relief may drive improved sleep quality, we carried out a pooled analysis of real-world data collected from 487 patients with CP (mean age, 68. Read More

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A Case of Major Depression with Burning Mouth Syndrome and Tinnitus Successfully Treated with Vortioxetine.

Int Med Case Rep J 2021 28;14:271-273. Epub 2021 Apr 28.

Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, 8078555, Japan.

We reported a case involving a patient diagnosed with major depression with associated burning mouth syndrome (BMS) and tinnitus who was successfully treated with vortioxetine. The case was 57-year-old Japanese woman diagnosed with major depression according to DSM-5. She experienced increased levels of stress when performing daily duties. Read More

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Clinical features of Barré-Lièou syndrome and efficacy of trazodone for its treatment: A retrospective single center study.

Drug Discov Ther 2021 May 29;15(2):108-111. Epub 2021 Apr 29.

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino City, Japan.

Barré-Lièou syndrome (BLS) is a manifestation of various autonomic and secondary symptoms including muscle stiffness, tinnitus, dizziness, and pain in various body parts. Although considered to be caused by hyperactivation of the autonomic nervous system due to trauma, there is currently no firmly established etiology or evidence on the treatment and clinical features of BLS. We retrospectively examined the clinical features of BLS and evaluated the efficacy of trazodone (TZD) for its treatment. Read More

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Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018.

Br J Gen Pract 2021 May 4. Epub 2021 May 4.

The University of Adelaide Faculty of Health and Medical Sciences, General Practice, Adelaide Medical School, Adelaide, Australia.

Background: Despite an increase in the prevalence of sleep problems, few studies have investigated changes in the prescribing of drugs often used for managing insomnia.

Aim: To explore changes in the pattern of benzodiazepine (BZD), z-drugs (zolpidem, zopiclone) and non-BZD prescriptions.

Design And Setting: Open cohort study including 1,773,525 patients (55,903,294 consultations) regularly attending 404 Australian general practices from 2011-2018 (MedicineInsight). Read More

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The Effect of Beat Frequency Vibration on Sleep Latency and Neural Complexity: A Pilot Study.

IEEE Trans Neural Syst Rehabil Eng 2021 13;29:872-883. Epub 2021 May 13.

Insomnia affects millions of people worldwide, and non-pharmacological treatment options are limited. A bed excited with multiple vibration sources was used to explore beat frequency vibration (BFV) as a non-pharmacological treatment for insomnia. A repeated measures design pilot study of 14 participants with mild-moderate insomnia symptom severity (self-reported on the Insomnia Severity Index) was conducted to determine the effects of BFV, and traditional standing wave vibration (SWV) on sleep latency and sleep electrocortical activity. Read More

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[Treatment of insomnia, with what to start ?]

Rev Med Suisse 2021 May;17(737):890-897

Pharmacien·ne·s et pharmacologues cliniques, Unité de pharmacogénétique et de psychopharmacologie clinique, Centre de neurosciences psychiatriques, Département de psychiatrie, CHUV et Université de Lausanne, Site de Céry, 1008 Prilly.

Confronted with a complaint of insomnia, several points must be considered before prescribing a specific treatment. In particular, it is necessary to optimize the management of somatic and psychiatric comorbidities that can affect sleep and to review the intake of sleep-disrupting substances and drugs. The current guidelines for insomnia rank treatment options based on the quality of the evidence. Read More

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The Smarter Sleep educational interventions: an initiative to reduce hypnotic prescribing in in-patient psychiatric care.

BJPsych Bull 2021 May 5:1-9. Epub 2021 May 5.

Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Aims And Method: In-patients on mental health wards are commonly prescribed hypnotics for the long-term management of disturbed sleep. Specific sleep disorders remain underdiagnosed and effective behavioural interventions are underused. We developed a suite of three educational interventions (a video, poster and handbook) about sleep, sleep disorders, the safe prescribing of hypnotics and use of psychological strategies (sleep hygiene and cognitive-behavioural therapy for insomnia, CBTi) using co-design and multiprofessional stakeholder involvement. Read More

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Sleep disorders among nurses and other health care workers in Poland during the COVID-19 pandemic.

Appl Nurs Res 2021 06 11;59:151412. Epub 2021 Feb 11.

Polish Association of Anaesthesiology and Intensive Care Nurses, Poznań, Poland; Institute of Health Sciences, College of Medical Sciences of the University of Rzeszow, Poland St. Warzywna 1A, 35-310 Rzeszow, Poland.

Background: The profession of nurses involves exposure to harmful agents. Despite numerous international studies on the occurrence of sleep disorders in nurses, most studies lacked an assessment of the dependence on the occurrence of the situation causing fear and anxiety which is a highly contagious.

Aim: Determining the relationship between the occurrence of sleep disorders and socio-demographic variables of medical personnel during the COVID-19 epidemic. Read More

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Change in Dysfunctional Sleep-Related Beliefs is Associated with Changes in Sleep and Other Health Outcomes Among Older Veterans With Insomnia: Findings From a Randomized Controlled Trial.

Ann Behav Med 2021 May 4. Epub 2021 May 4.

Geriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, CAUSA.

Background: Cognitive behavioral therapy for insomnia (CBTI) targets changing dysfunctional sleep-related beliefs. The impact of these changes on daytime functioning in older adults is unknown.

Purpose: We examined whether changes in sleep-related beliefs from pre- to post-CBTI predicted changes in sleep and other outcomes in older adults. Read More

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An investigation and replication of sleep-related cognitions, acceptance and behaviours as predictors of short- and long-term outcome in cognitive behavioural therapy for insomnia.

J Sleep Res 2021 May 3:e13376. Epub 2021 May 3.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, M58, Huddinge Hospital, Stockholm, Sweden.

The objectives were to investigate the potential for sleep-related behaviours, acceptance and cognitions to predict outcome (insomnia severity) of cognitive behavioural therapy for insomnia (CBT-I). Baseline and outcome data from four randomised controlled trials (n = 276) were used. Predictors were the Dysfunctional Beliefs and Attitudes about Sleep-10 (DBAS-10), Sleep-Related Behaviours Questionnaire (SRBQ), and Sleep Problems Acceptance Questionnaire (SPAQ), and empirically derived factors from a factor analysis combining all items at baseline (n = 835). Read More

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GABA receptor β -subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep.

Eur J Neurosci 2021 May 3. Epub 2021 May 3.

Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

γ-Aminobutyric acid (GABA) acting through heteropentameric GABA receptors plays a pivotal role in the sleep-promoting circuitry. Whereas the role of the different GABA receptor α-subunits in sleep regulation and in mediating the effect of benzodiazepines for treatment of insomnia is well-described, the β-subunits are less studied. Here we report the first study characterizing sleep in mice lacking the GABA receptor β -subunit (β mice). Read More

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Sleep disorders and related factors among frontline medical staff supporting Wuhan during the COVID-19 outbreak.

Bull Menninger Clin 2021 May 3:1-17. Epub 2021 May 3.

Xiamen Xianyue Hospital, Xiamen, Fujian, China.

Sleep problems among frontline medical staff during the COVID-19 epidemic require attention. A total of 249 frontline medical staff who were recruited to support Wuhan completed this cross-sectional study. A web-based questionnaire about insomnia, depression, anxiety, and fatigue was used to assess mental health status. Read More

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Evaluation of the Etiology, Clinical Presentation, Findings and Prophylaxis of Children with Headache.

Betul Kilic

Sisli Etfal Hastan Tip Bul 2021 17;55(1):128-133. Epub 2021 Mar 17.

Department of Pediatric Neurology, University of Health Sciences Turkey Faculty of Medicine, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Objectives: A headache is prevalent in childhood and constitutes a significant part of outpatient applications. This study aimed to evaluate the results of etiology, clinical features, examination results, prophylactic treatment and follow-up in patients with a headache.

Methods: Between January 2017 and December 2018, the files of the patients with the complaint of headache were reviewed retrospectively in this study. Read More

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Health-Related Quality of Life of Patients Receiving Cancer Treatment in Nepal: A Hospital-based Cross-Sectional Study.

J Nepal Health Res Counc 2021 Apr 23;19(1):26-31. Epub 2021 Apr 23.

Central Department of Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Background: Information on health-related quality of life of the patients enables healthcare providers to understand patients' concerns and guides to introduce appropriate treatment care. This study assessed the health-related quality of life of the cancer patients attending a tertiary hospital in Nepal.

Methods: A cross-sectional study was conducted among 294 cancer patients receiving treatment service from Bhaktapur Cancer Hospital between November 2016 and February 2017. Read More

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Physical activity and sleep: An updated umbrella review of the 2018 Physical Activity Guidelines Advisory Committee report.

Sleep Med Rev 2021 Apr 9;58:101489. Epub 2021 Apr 9.

Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.

Physical activity (PA) is widely considered to improve sleep, but a comprehensive review of the research on this topic has not been performed. In this umbrella review, conducted initially for the 2018 Physical Activity Guidelines for Americans Advisory Committee and updated to reflect more recent research, we examined whether PA enhances sleep outcomes across the lifespan as well as among individuals with sleep disorders. Systematic reviews and meta-analyses were utilized to assess the evidence. Read More

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Efficacy results of pimavanserin from a multi-center, open-label extension study in Parkinson's disease psychosis patients.

Parkinsonism Relat Disord 2021 Apr 28;87:25-31. Epub 2021 Apr 28.

ACADIA Pharmaceuticals Inc., San Diego, CA, USA.

Introduction: Pimavanserin, a selective 5-HT inverse agonist/antagonist, was approved for hallucinations and delusions associated with Parkinson's disease psychosis (PDP). We present durability of response with pimavanserin in patients with PDP for an additional 4 weeks of treatment.

Methods: This was an open-label extension (OLE) study in patients previously completing one of three double-blind, placebo-controlled (Core) studies. Read More

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