SAGE Open Med Case Rep 2021 21;9:2050313X211025145. Epub 2021 Jun 21.
Division of Nephrology and Hypertension and Kidney Transplantation, Department of Medicine, University of California, Irvine, Irvine, CA, USA.
Non-steroidal anti-inflammatory drugs are not only potent analgesics and antipyretics but also nephrotoxins, and may cause electrolyte disarray. In addition to the commonly expected effects, including hyperkalemia, hyponatremia, acute renal injury, renal cortical necrosis, and volume retention, glomerular disease with or without nephrotic syndrome or nephritis can occur as well including after years of seemingly safe administration. Minimal change disease, secondary membranous glomerulonephritis, and acute interstitial nephritis are all reported glomerular lesions seen with non-steroidal anti-inflammatory use. Read More