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Hyaluronan-fullerene/AIEgen nanogel as CD44-targeted delivery of tirapazamine for synergistic photodynamic-hypoxia activated therapy.

Nanotechnology 2021 Jul 29. Epub 2021 Jul 29.

Northwest A&F University, Northwest A&F University, Yangling, Yangling, 712100, CHINA.

The therapeutic effect of oxygen-concentration-dependent photodynamic therapy (PDT) can be diminished in the hypoxic environment of solid tumours, the effective solution to this problem is utilising hypoxic-activated bioreduction therapy (BRT). In this research, a biocompatible HA-C60/TPENH2 nanogel which can specifically bind to CD44 receptor was developed for highly efficient PDT-BRT synergistic therapy. The nanogel was degradable in acidic microenvironments of tumours and facilitated the release of biological reduction prodrug tirapazamine (TPZ). Read More

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Fabrication of highly permeable and anti-fouling performance of Poly(ether ether sulfone) nanofiltration membranes modified with zinc oxide nanoparticles.

Chemosphere 2021 Jul 21;286(Pt 1):131616. Epub 2021 Jul 21.

Integrated Bioprocessing Laboratory, School of Bioengineering, SRM Institute of Science and Technology (SRM IST), Kattankulathur, Tamil Nadu, 603 203, India. Electronic address:

Membrane fouling is one of the challenging bottleneck problems in waste water treatment by membrane process. The present study constructed a nanofiltration membrane based on the zinc oxide nanoparticle (n-ZnO) integrated Poly(ether ether sulfone) (PEES) membranes. The developed membranes were characterized by X-ray diffraction (XRD), attenuated total reflectance - fourier transform infrared spectroscopy (AT-FTIR), atomic force microscopy (AFM) and scanning electron microscope (SEM) coupled with energy dispersive X-ray (EDX) analysis. Read More

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Highly sensitive electrochemical immunosensor using a protein-polyvinylidene fluoride nanocomposite for human thyroglobulin.

Bioelectrochemistry 2021 Jul 16;142:107888. Epub 2021 Jul 16.

LABEL, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas 69067-005, Brazil. Electronic address:

The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods. This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs). The functionalized polymer matrices were characterized by UV-Vis, FTIR, XPS, SEM, dynamic light scattering, and free surface energy. Read More

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Interleukin 27 as an inducer of antiviral response against chikungunya virus infection in human macrophages.

Cell Immunol 2021 Jul 21;367:104411. Epub 2021 Jul 21.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Chikungunya virus (CHIKV) is known to have a wide range of tropism in human cell types throughout infection, including keratinocytes, fibroblasts, endothelial cells, monocytes, and macrophages. We reported that human monocytes-derived macrophages (MDMs) are permissive to CHIKV infection in vitro. We found that the peak of CHIKV replication was at 24 hpi; however, at 48 hpi, a significant reduction in viral titer was observed that correlated with high expression levels of genes encoding antiviral proteins (AVPs) in an IFN-independent manner. Read More

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Photoinhibition and Photocatalytic Response of Surfactant Mediated Pt/ZnO Nanocomposite.

Photodiagnosis Photodyn Ther 2021 Jul 26:102458. Epub 2021 Jul 26.

Institute of Chemical Sciences, Gomal University, D. I. Khan, KP, Pakistan.

Water pollution and bacterial resistance to the available drugs are the universal problems. Several drugs and protocols have been employed to deal with these microbes and pollutants but these customary chemicals have many limitations. It is very essential to produce new methods and materials to deal with these deleterious microbes. Read More

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Light-induced in situ transmission electron microscopy - novel approach for antimicrobial photodynamic therapy imaging.

Photodiagnosis Photodyn Ther 2021 Jul 26:102463. Epub 2021 Jul 26.

Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.

The novel approach for imaging of antimicrobial photodynamic therapy processes presented in this work is based on transmission electron microscopy methods. With the use of liquid cell, illumination system, and lowered electron dose the successful light-induced in-situ observations on Staphylococcus aureus encapsulated with methylene blue were performed. Results showed that with specified imaging parameters it is possible to conduct reliable research on bacteria in electron microscope despite the unfavorable damaging effect of the highly energetic electron beam used for imaging. Read More

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Clinical and laboratory features of Strongyloides stercoralis infection at diagnosis and after treatment: a systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jul 26. Epub 2021 Jul 26.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: The clinical and laboratory characterization of Strongyloides stercoralis infection at diagnosis and after treatment is still poorly defined.

Objectives: Primary objective was to describe pattern and frequency of clinical and laboratory characteristics associated to S. stercoralis infection. Read More

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G6PD inhibits ferroptosis in hepatocellular carcinoma by targeting cytochrome P450 oxidoreductase.

Cell Signal 2021 Jul 26:110098. Epub 2021 Jul 26.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China. Electronic address:

Ferroptosis is an important cell necrosis and has been a focus in cancer related research.Increcsing studies have focused on the phenotype and function of ferroptosis in tumorigenesis, but the underlying mechanism remains poorly understood. Here, we used bioinformatics approaches to identify differentially expressed genes associated with HCC and ferroptosis. Read More

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Chitosan derivatives: A suggestive evaluation for novel inhibitor discovery against wild type and variants of SARS-CoV-2 virus.

Int J Biol Macromol 2021 Jul 26. Epub 2021 Jul 26.

Department of Biotechnology, National Institute of Technology (NIT), Raipur, Chhattisgarh, India. Electronic address:

With increasing global cases and mortality rates due to COVID-19 infection, finding effective therapeutic interventions has become a top priority. Marine resources are not explored much and to be taken into consideration for exploring antiviral potential. Chitosan (carbohydrate polymer) is one such bioactive glycan found ubiquitously in marine organisms. Read More

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ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation.

Cancer Lett 2021 Jul 26. Epub 2021 Jul 26.

The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China; Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc., Changzhou, China; School of Biopharmacy, China Pharmaceutical University, Nanjing, China. Electronic address:

Melanoma is a highly metastatic cancer that requires effective and targeted curative therapy. Annexin A10 (ANXA10), a member of the annexin family, is a calcium- and phospholipid-binding protein. Considerable evidence indicates that ANXA10 is involved in tumour progression, but little is known about its role in melanoma development. Read More

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Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders.

Biomacromolecules 2021 Jul 29. Epub 2021 Jul 29.

Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States.

Over two million people die of liver disorders every year globally. Hepatocytes are the key cells affected in several acute and chronic liver diseases. The current clinical outcomes of liver-targeted nanoparticles are limited, necessitating the need to develop smart hepatocyte-targeted drug delivery systems. Read More

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Dramatic response to alectinib in a patient with ALK-rearranged squamous cell lung cancer.

Thorac Cancer 2021 Jul 29. Epub 2021 Jul 29.

Division of Respiratory Medicine, Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.

Lung cancers with anaplastic lymphoma kinase (ALK) rearrangements are highly sensitive to treatment with ALK tyrosine kinase inhibitors (TKIs). Due to the very low rate of patients with squamous cell carcinoma enrolled in clinical trials, the efficacy of ALK inhibitors in patients with ALK-rearranged squamous cell carcinoma in the lung remains unclear. Herein, we present the case of a 70-year-old female patient with squamous cell lung cancer harboring the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene. Read More

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Year in Review 2020: Multisystemic impact of cystic fibrosis.

Pediatr Pulmonol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatrics, Division of Pulmonary Medicine, Tulane University School of Medicine, Children's Hospital of New Orleans, New Orleans, Louisiana, USA.

Clinical care in cystic fibrosis (CF) has continued to advance over the last several years, particularly with the widespread eligibility and use of highly effective modulator therapy. Improved outcomes and longevity of persons with CF (PwCF) have increased recognition of the multisystem impact of the disease on the daily lives of PwCF. This review will cover a broad array of topics, from diagnosis to multisystem effects related to mental health, endocrine, palliative care, reproductive health, otolaryngology, and cardiac issues. Read More

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Lactate based Scoring System in the diagnosis of necrotizing fasciitis.

J Burn Care Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Plastic, Reconstructive, Hand and Burn Surgery, Cologne Merheim Medical Center, University of Witten-Herdecke, Cologne, Germany.

Introduction: Necrotizing fasciitis (NF) is a rare and quickly progressing infection and leads to 100% mortality if untreated. Quick diagnosis and an early and radical surgical treatment are essential for stopping bacterial progression. Unfortunately, the absence of clear clinical signs makes the diagnosis often challenging. Read More

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Chemotherapy and Targeted Therapy for Patients With Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor-Negative: ASCO Guideline Update.

J Clin Oncol 2021 Jul 29:JCO2101374. Epub 2021 Jul 29.

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

Purpose: This guideline updates recommendations of the ASCO guideline on chemotherapy and targeted therapy for patients with human epidermal growth factor receptor 2-negative metastatic breast cancer (MBC) that is either endocrine-pretreated or hormone receptor (HR)-negative.

Methods: An Expert Panel conducted a targeted systematic literature review guided by a signals approach to identify new, potentially practice-changing data that might translate into revised guideline recommendations.

Results: The Expert Panel reviewed abstracts from the literature review and retained 14 articles. Read More

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Intuitive repositioning of an anti-depressant drug in combination with tivozanib: precision medicine for breast cancer therapy.

Mol Cell Biochem 2021 Jul 29. Epub 2021 Jul 29.

Precision NeuroOncology & NeuroVascular Disease Modeling Group, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi-NCR, 201314, India.

Despite the existing therapies and lack of receptors such as HER-2, estrogen receptor and progesterone receptor, triple-negative breast cancer is one of the most aggressive subtypes of breast cancer. TNBCs are known for their highly aggressive metastatic behavior and typically migrate to brain and bone for secondary site propagation. Many diseases share similar molecular pathology exposing new avenues in molecular signaling for engendering innovative therapies. Read More

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Probiotics in the management of Giardia duodenalis: an update on potential mechanisms and outcomes.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jul 29. Epub 2021 Jul 29.

Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Giardia duodenalis is a common cause of infection in children and travelers. The most frequent symptom is diarrhea in these patients. G. Read More

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Water recovery and on-site reuse of laundry wastewater by a facile and cost-effective system: Combined biological and advanced oxidation process.

Sci Total Environ 2021 May 29;789:148068. Epub 2021 May 29.

Department of Environmental Health Engineering, Maragheh University of Medical Sciences, Maragheh, Iran. Electronic address:

Combined biological and physicochemical process was selected for treatment of laundry wastewater. The results show that after microbial adaptation, almost 91% of COD was removed at food to microorganism (F/M) ratio of 0.12 gBOD/gMLSS·d. Read More

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Yoga for hypertensive patients: a study on barriers and facilitators of its implementation in primary care.

Glob Health Action 2021 Jan;14(1):1952753

Institute for Health and Sport, Victoria University, Melbourne, Australia.

Background: International guidelines for hypertension treatment recommend the use of yoga, particularly among low-risk patients. However, evidence is lacking on the implementation potential of health-worker-led yoga interventions in low-resource, primary care settings.

Objective: To assess barriers to and facilitators of the implementation of a yoga intervention for hypertensive patients in primary care in Nepal. Read More

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January 2021

An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development.

Expert Opin Pharmacother 2021 Jul 29:1-13. Epub 2021 Jul 29.

Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain.

: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that may affect 3 in 1,000 people within the general population. The therapeutic scenario is complex, and no therapy has proved to be able to modify the natural course of the disease, nor to prevent the most severe systemic complications.: Recently, the EULAR 2020 Recommendations for pSS have underlined the low level of evidence supporting efficacious therapeutic approaches, lacking a definition of specific treatment targets and being far from the 'disease modification' concept that is frequently used in other diseases. Read More

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A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens.

Environ Health Perspect 2021 Jul 29;129(7):77006. Epub 2021 Jul 29.

Boston University Superfund Research Program, Boston University, Massachusetts, USA.

Background: Chemicals in disparate structural classes activate specific subsets of the transcriptional programs of peroxisome proliferator-activated receptor- () to generate adipocytes with distinct phenotypes.

Objectives: Our objectives were to ) establish a novel classification method to predict ligands and modifying chemicals; and ) create a taxonomy to group chemicals on the basis of their effects on transcriptome and downstream metabolic functions. We tested the hypothesis that environmental adipogens highly ranked by the taxonomy, but segregated from therapeutic ligands, would induce white but not brite adipogenesis. Read More

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Rapid, Simple, and Inexpensive Spatial Patterning of Wettability in Microfluidic Devices for Double Emulsion Generation.

Anal Chem 2021 Jul 29. Epub 2021 Jul 29.

School of Engineering, Macquarie University, Balaclava Road, North Ryde, New South Wales 2109, Australia.

Water-in-oil-in-water (w/o/w) double emulsion (DE) encapsulation has been widely used as a promising platform technology for various applications in the fields of food, cosmetics, pharmacy, chemical engineering, materials science, and synthetic biology. Unfortunately, DEs formed by conventional emulsion generation approaches in most cases are highly polydisperse, making them less desirable for quantitative assays, controlled biomaterial synthesis, and entrapped ingredient release. Microfluidic devices can generate monodisperse DEs with controllable size, morphology, and production rate, but these generally require multistep fabrication processes and use of different solvents or bulky external instrumentation to pattern channel wettability. Read More

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Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide.

Clin Transl Med 2021 Jul;11(7):e495

Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Castration-resistant prostate cancer (CRPC) is the latest stage of PCa, and there is almost no effective treatment available for the patients with CRPC when next-generation androgen deprivation therapy drugs, such as enzalutamide (ENZ), fail. The androgen receptor (AR) plays key roles in PCa and CRPC progression and drug resistance. Histone acetyltransferase 1 (HAT1) has recently been reported to be highly expressed in some tumors, such as lung carcinoma. Read More

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Nanoparticulation of Prodrug into Medicines for Cancer Therapy.

Adv Sci (Weinh) 2021 Jul 29:e2101454. Epub 2021 Jul 29.

Frontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, China.

This article provides a broad spectrum about the nanoprodrug fabrication advances co-driven by prodrug and nanotechnology development to potentiate cancer treatment. The nanoprodrug inherits the features of both prodrug concept and nanomedicine know-how, attempts to solve underexploited challenge in cancer treatment cooperatively. Prodrugs can release bioactive drugs on-demand at specific sites to reduce systemic toxicity, this is done by using the special properties of the tumor microenvironment, such as pH value, glutathione concentration, and specific overexpressed enzymes; or by using exogenous stimulation, such as light, heat, and ultrasound. Read More

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Gaseous ozone to preserve quality and enhance microbial safety of fresh produce: Recent developments and research needs.

Authors:
Xuetong Fan

Compr Rev Food Sci Food Saf 2021 Jul 29. Epub 2021 Jul 29.

Eastern Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, Wyndmoor, Pennsylvania, USA.

Fresh fruits and vegetables are highly perishable and are subject to large postharvest losses due to physiological (senescence), pathologic (decay), and physical (mechanical damage) factors. In addition, contamination of fresh produce with foodborne human pathogens has become a concern. Gaseous ozone has multiple benefits including destruction of ethylene, inactivation of foodborne and spoilage microorganisms, and degradation of chemical residues. Read More

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The antiproliferative activity of ferrocene derivatives against drug-resistant cancer cell lines: A mini review.

Authors:
Li Li Lin Ma Jian Sun

Curr Top Med Chem 2021 Jul 27. Epub 2021 Jul 27.

Agro-food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China.

Cancer, a highly heterogeneous disease at intra/inter patient levels, remains a serious health problem contributing to significant morbidity and mortality worldwide. Despite great progress in clinical treatment, the concerns impeding the success of conventional cancer chemotherapy is descending efficacy of anticancer agents due to the development of drug resistance especially multiple drug resistance (MDR). Ferrocene derivatives have a different mode of action to the platinum anticancer drugs, and the ferrocene-phenol hybrid ferrocifen exhibits potential activity against drug-resistant cancers. Read More

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[From Passive Application to Active Design Restructuring and Reshaping of Core Specialty Knowledge Systems of Biomedical Engineering (Biomedical Materials Track) Undergraduate Education].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):566-569

College of Biomedical Engineering, Sichuan University, Chengdu 610064, China.

Biomedical engineering (BME) (biomedical materials track) is a typical field of interdisciplinary integration. Its specialty education simultaneously undertakes the duo reformation responsibilities for the new engineering education and the new medical education due to its unique strengths in interdisciplinary nature, comprehensive scope of knowledge, and status of being on the cutting edge of technology. We made an analysis, in this paper, of the opportunities and challenges faced by BME (biomedical materials track) specialty education on the basis of the trends and frontiers of development in biomedical materials in the world. Read More

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[Reflections on the Application of Critical Care Ultrasound in Viral Pneumonia Patients with Circulatory Dysfunction-New Classification and Precision Treatment Based on Ciritical Care Ultrasound].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):555-560

Emergency Department and Intensive Care Unit, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Viruses are among the main pathogens of pulmonary infection and tend to cause pandemics of viral pneumonia. Severe viral pneumonia tends to be accompanied by acute respiratory distress syndrome (ARDS) manifestations, displaying highly specific clinical symptoms that are most prominently expressed in the circulatory system. Shock occurred rarely, it occured at a rather late stage in this outbreak of viral pneumonia. Read More

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Happy Talk: A pilot effectiveness study of a targeted-selective speech-language and communication intervention for children from areas of social disadvantage.

Int J Lang Commun Disord 2021 Jul 28. Epub 2021 Jul 28.

Newcastle University, Newcastle upon Tyne, Newcastle, UK.

Background: Despite the public health implications of language difficulties associated with social disadvantage, there is a dearth of effectiveness studies investigating the effects of targeted speech and language programmes in this area.

Aims: To determine the effects of a targeted selective community-based child language intervention programme (Happy Talk), which simultaneously engaged with parents and early childhood educators, in the Republic of Ireland.

Methods & Procedures: A mixed methods methodology was applied with quantitative outcome and qualitative process data collected. Read More

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