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Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019), a Dutch population based study.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Radboud university medical centre, Radboud Institute for Health Sciences, Department of Surgery, Nijmegen, The Netherlands.

Aim: Anastomotic leakage (AL) after colon cancer (CC) and rectal cancer (RC) surgery often requires reintervention. Prevalence and morbidity may change over time with evolutions in treatment strategies and changes in patient characteristics. This nationwide study aimed to evaluate changes in the incidence, risk factors and mortality from AL during the past nine years. Read More

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September 2021

The anatomy of agency: Improving academic performance in first year university students.

Anat Sci Educ 2021 Sep 18. Epub 2021 Sep 18.

The School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.

The transition from secondary to tertiary education can be challenging, as students must adapt to independent learning. For students in the allied health and nursing disciplines, this transition may coincide with compulsory first year courses in anatomy, which are traditionally difficult to master. Students' agency - their capacity to make intentional choices to alter the path of their learning - may play a role in their successful completion of first year anatomy courses. Read More

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September 2021

Pelvic inflammatory disease is associated with ovarian cancer development in women with endometriosis: A cohort study in Taiwan.

Int J Gynaecol Obstet 2021 Sep 18. Epub 2021 Sep 18.

Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Tzyou, Taiwan.

Objective: Endometriosis and pelvic inflammatory disease are considered to be risk factors for ovarian cancer, as dysbiosis likely contributes to ovarian cancer development via chronic inflammation and immune response alteration. Therefore, we hypothesized that pelvic inflammatory disease predisposes to ovarian cancer development in women with endometriosis.

Methods: We selected patients who were diagnosed with endometriosis or pelvic inflammatory disease between January 1, 2000, and December 31, 2015 in a 2-million longitudinal health and welfare database in Taiwan, with cancer and death registries. Read More

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September 2021

Recent improvement in survival outcomes and reappraisal of prognostic factors in pediatric living donor liver transplantation.

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Asan Medical Center Children's Hospital, University Ulsan College of Medicine, Seoul, Korea.

Background: Living donor liver transplantation (LDLT) is a significant advancement for the treatment of children with end-stage liver disease given the shortage of deceased donors. The ultimate goal of pediatric LT is to achieve complete donor safety and zero recipient mortality.

Methods: We conducted a retrospective, single center assessment of the outcomes as well as the clinical factors that may influence graft and patient survival after primary LDLTs conducted between 1994 and 2020. Read More

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September 2021

Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma.

Eur J Cancer 2021 Sep 15;157:250-258. Epub 2021 Sep 15.

University of Brescia, Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, ASST-Spedali Civili, Brescia, Lombardia, Italy. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) has an overall favourable outcome, except for patients with an advanced stage disease. The programmed death protein-1 (PD-1) inhibitor cemiplimab has been approved for use in advanced cSCC. We report clinical outcomes from the named patient programme-compassionate use of cemiplimab for patients with advanced cSCC in Italy. Read More

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September 2021

Postsurgical status of articular cartilage after arthroscopic posterior cruciate ligament reconstruction in patients with or without concomitant meniscal pathology.

Clin Imaging 2021 Sep 8;80:406-412. Epub 2021 Sep 8.

Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Several factors present at the time of posterior cruciate ligament reconstruction (PCLR) may cause the subsequent progression of articular cartilage lesions. This study aimed to evaluate postsurgical articular cartilage lesions which can be seen on MRI in patients who underwent arthroscopic PCLR with or without concomitant meniscal pathology.

Material And Methods: A total of sixty-five patients (mean age 35. Read More

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September 2021

Review of prophylactic swallowing interventions for head and neck cancer.

Int J Nurs Stud 2021 Aug 27;123:104074. Epub 2021 Aug 27.

The First Hospital of Jilin University, No.71 Xinmin street, Changchun, Jilin 130021, China. Electronic address:

Background: Head and neck cancer treatment destroys nerves and/or organs associated with swallowing. Previous studies have investigated the efficacy of exercises for muscles used in swallowing before treatment in reducing disuse atrophy and delaying the occurrence of muscle fibrosis. However, the rehabilitation effects of training and the optimal intervention strategy are unknown. Read More

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Coordination of nitrogen uptake and assimilation favours the growth and competitiveness of moso bamboo over native tree species in high-NH environments.

J Plant Physiol 2021 Sep 7;266:153508. Epub 2021 Sep 7.

College of Landscape and Art, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China; Jiangxi Provincial Key Laboratory for Bamboo Germplasm Resources and Utilization, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China. Electronic address:

Phenotypic plasticity and competitive strength are major mechanisms determining the success of invasive species and are influenced by abiotic factors. A rise in the ratio of ammonium (NH) to nitrate (NO) in soils is frequently associated with the invasion of bamboo into broad-leaved evergreen forests. However, the influence of soil nitrogen (N) chemistry on plant growth and interspecific competition in the context of invasion remains insufficiently studied. Read More

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September 2021

Heterotrophic nitrification and aerobic denitrification process: Promising but a long way to go in the wastewater treatment.

Sci Total Environ 2021 Sep 10;805:150212. Epub 2021 Sep 10.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

The traditional biological nitrogen removal (BNR) follows the conventional scheme of sequential nitrification and denitrification. In recent years, novel processes such as anaerobic ammonia oxidation (anammox), complete oxidation of ammonia to nitrate in one organism (comammox), heterotrophic nitrification and aerobic denitrification (HN-AD), and dissimilatory nitrate reduction to ammonium (DNRA) are gaining tremendous attention after the discovery of metabolically versatile bacteria. Among them, HN-AD offers several advantages because individual bacteria could achieve one-stage nitrogen removal under aerobic conditions in the presence of organic carbon. Read More

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September 2021

A case of two traumatic penetrations of a duodenal diverticulum caused by a kick to the upper abdomen.

Int J Surg Case Rep 2021 Sep 6;87:106388. Epub 2021 Sep 6.

Department of Surgery, Ureshino medical Center, 4279-3 Ureshino, Saga 843-0393, Japan.

Introduction And Importance: A duodenal diverticulum is a pseudodiverticulum that lacks a proper muscular layer. Cases of traumatic penetration or perforation of a duodenal diverticulum are relatively rare.

Case Presentation: A 67-year-old woman was injured when her roommate kicked her in the upper abdomen, and was transferred to our hospital 6 h after the injury with upper abdominal pain and lethargy. Read More

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September 2021

MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration.

Biomed Pharmacother 2021 Sep 15;143:112170. Epub 2021 Sep 15.

Second Provincial People's Hospital of Gansu, 1 Hezheng West Street, Lanzhou 730000, PR China; Affiliated Hospital of Northwest Minzu Univsity, Lanzhou 730000, PR China. Electronic address:

Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease, which is considered the main cause of low back pain. It seriously affects the quality of life of patients and consequently brings a heavy economic burden to their families and the society. Although IDD is considered a natural process in degenerative lesions, it is mainly caused by aging, trauma, genetic susceptibility and other factors. Read More

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September 2021

Long-term response and response patterns to antiepileptic drugs in patients with newly diagnosed epilepsy.

Epilepsy Behav 2021 Sep 15;124:108309. Epub 2021 Sep 15.

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address:

Objective: This study investigated the long-term response and response patterns to antiepileptic drugs (AEDs) in patients with newly diagnosed epilepsy.

Methods: Patients who had been newly diagnosed with epilepsy and had at least 3-year follow-up records were enrolled. Their long-term response and response patterns to AEDs were retrospectively analyzed. Read More

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September 2021

Sulfated alginate/polycaprolactone double-emulsion nanoparticles for enhanced delivery of heparin-binding growth factors in wound healing applications.

Colloids Surf B Biointerfaces 2021 Sep 15;208:112105. Epub 2021 Sep 15.

Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut 1107 2020, Lebanon. Electronic address:

Diabetic foot ulcers (DFUs) that are not effectively treated could lead to partial or complete lower limb amputations. The lack of connective tissue growth factor (CTGF) and insulin-like growth factor (IGF-I) in DFUs results in limited matrix deposition and poor tissue repair. To enhance growth factor (GF) availability in DFUs, heparin (HN)-mimetic alginate sulfate/polycaprolactone (AlgSulf/PCL) double emulsion nanoparticles (NPs) with high affinity and sustained release of CTGF and IGF-I were synthesized. Read More

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September 2021

The Application of Whole-Body Vibration Training in Knee Osteoarthritis.

Joint Bone Spine 2021 Sep 15:105276. Epub 2021 Sep 15.

School of Kinesiology, Shenyang Sport University, No.36 Jinqiansong East Road, Shenyang 110102, China. Electronic address:

With the gradual increase of the aging population in Chinese society, the incidence of knee osteoarthritis showed an increasing trend. However, there are very few practical solutions for it. As a novel neuromuscular training technique, whole-body vibration training has become a candidate for treating knee osteoarthritis. Read More

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September 2021

The relationship between kinesiophobia and health-related quality of life in patients with rheumatoid arthritis: A controlled cross-sectional study.

Joint Bone Spine 2021 Sep 15:105275. Epub 2021 Sep 15.

Department of Physical Medicine and Rehabilitation, Erzincan Binali Yildirim University Mengucek Gazi Training and Research Hospital, Erzincan, Turkey.

Objectives: To evaluate the kinesiophobia and kinesiophobia-related factors in patients with rheumatoid arthritis (RA) and provide a better perspective on the relationship between kinesiophobia and patients' health-related quality of life (HRQoL).

Methods: A total of 88 patients (67 females, 21 males) with RA and 93 healthy volunteers (67 females, 26 males) were included in the study between March 2020 and July 2020. Kinesiophobia was evaluated using the Tampa Scale of Kinesiophobia (TSK) and HRQoL was evaluated using the 36-item Short-Form Health Survey (SF-36). Read More

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September 2021

Multiple-type HPV infection predicting condyloma acuminatum recurrence after aminolevulinic acid photodynamic therapy.

Photodiagnosis Photodyn Ther 2021 Sep 15:102538. Epub 2021 Sep 15.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Background: Aminolevulinic acid photodynamic therapy (ALA-PDT) has been widely used in the treatment of condyloma acuminatum (CA), but there is a lack of reports on clinical factors related to CA relapse after photodynamic therapy.

Methods: The clinical data of patients with CA treated with ALA-PDT from April 2018 to December 2019 were retrospectively analyzed, including HPV type, follow-up time and recurrence within 6 months after treatment. The patients were classified into single-type HPV infection and multiple-type HPV infection groups. Read More

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September 2021

Prognostic impact of neoadjuvant chemotherapy in patients with synchronous colorectal liver metastasis: A propensity score matching comparative study.

Int J Surg 2021 Sep 15:106106. Epub 2021 Sep 15.

Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka-City 545-8585, Japan. Electronic address:

Background: Synchronous colorectal liver metastasis (SCRLM) is at an advanced tumor stage and requires multidisciplinary treatments. Neoadjuvant chemotherapy (NAC) is thought to be an effective treatment modality, but its prognostic impact is still unclear.

Materials And Methods: Patients with resectable SCRLM presented to eight university hospitals between 2007 and 2017 were retrospectively reviewed. Read More

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September 2021

A review of Liquid biopsy as a tool to assess Epigenetic, cfDNA and miRNA variability as Methotrexate response predictors in patients with Rheumatoid Arthritis.

Pharmacol Res 2021 Sep 15:105887. Epub 2021 Sep 15.

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease affecting 0.5-1% of adults worldwide. Achieving long term remission or low disease activity is possible through early diagnosis, rapid initiation of disease modifying anti-rheumatic drugs (DMARDs) and implementation of a treat to target approach. Read More

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September 2021

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved.

Neurochem Int 2021 Sep 15:105188. Epub 2021 Sep 15.

Laboratorio de Dolor en Cáncer, Instituto de Investigaciones en Medicina Traslacional CONICET - Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina; Facultad de Ciencias Biomédicas, Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina. Electronic address:

After different types of acute central nervous system insults, including stroke, subarachnoid haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a central role in the induction of cell death, neurodegeneration and functional deficits. Interestingly, secondary cell death presents an attractive target for clinical intervention because the temporal lag between injury and cell loss provides a potential window for effective treatment. While primary injuries are the direct result of the precipitating insult, secondary damage involves the activation of pathological cascades through which endogenous factors can exacerbate initial tissue damage. Read More

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September 2021

BMSCs-exosomes containing GDF-15 alleviated SH-SY5Y cell injury model of Alzheimer's disease via AKT/GSK-3β/β-catenin.

Brain Res Bull 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, P.R. China. Electronic address:

Background: Mesenchymal stem cells (MSCs) therapy has great potential for Alzheimer's disease (AD) treatment. Here, we investigated the roles of BMSCs-exosomes containing growth differentiation factor-15 (GDF-15) in regulating SH-SY5Y cell injury in AD.

Methods: The SH-SY5Y cell injury model was constructed by treating SH-SY5Y cells with 10μM Aβ. Read More

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September 2021

The emerging tale of microglia in psychiatric disorders.

Neurosci Biobehav Rev 2021 Sep 15. Epub 2021 Sep 15.

McGill Group for Suicide Studies, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada. Electronic address:

As the professional phagocytes of the brain, microglia orchestrate the immunological response and play an increasingly important role in maintaining homeostatic brain functions. Microglia are activated by pathological events or slight alterations in brain homeostasis. This activation is dependent on the context and type of stressor or pathology. Read More

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September 2021

Differential effects of ergometer-cycling and Whole-Body-Vibration training on serological BDNF and IGF-1 in the treatment of adolescent depression - is there an impact of BDNF-p.Val66Met variants?

Physiol Behav 2021 Sep 15:113596. Epub 2021 Sep 15.

Department of Child and Adolescent Psychiatry, Psychotherapy and Paediatric Neurology, Gemeinschaftskrankenhaus Herdecke & Chair of Child and Adolescent Psychiatry, Witten/Herdecke University, Witten, Germany.

Background: Pathogenesis and treatment of adolescent depression may be influenced by growth-factors, including brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). We investigated, if treatment response to two different add-on exercise-therapies in juvenile depression, differ in the changes of BDNF and IGF-1 serology. A subgroup analysis for genetic variations in BDNF p. Read More

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September 2021

Noncancerous Genitourinary Conditions as a Public Health Priority: Conceptualizing the Hidden Burden.

Urology 2021 Sep 15. Epub 2021 Sep 15.

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objective: To provide a conceptual framework to guide investigations into burdens of noncancerous genitourinary conditions (NCGUCs), which are extensive and poorly understood.

Methods: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) convened a workshop of diverse, interdisciplinary researchers and health professionals to identify known and hidden burdens of NCGUCs that must be measured to estimate the comprehensive burden. Following the meeting, a subgroup of attendees (authors of this article) continued to meet to conceptualize burden. Read More

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September 2021

Cancer in Cystic Fibrosis: A Narrative Review of Prevalence, Risk Factors, Screening and Treatment Challenges.

Chest 2021 Sep 15. Epub 2021 Sep 15.

Department of Surgery and Department of Family Medicine, New York Medical College, Valhalla, NY, USA.

Cystic fibrosis is a progressive monogenetic disorder that causes persistent pulmonary disease, but also affects other organ systems including the digestive tract. Recent advances in treatment and care of CF patients including the use of new and highly effective CFTR modulators, have led to a dramatic increase in survival; young patients with CF can now expect to live to or beyond middle age, where cancer is more frequent. CF patients are now known to face an increased risk of digestive tract cancer-particularly cancer of the colon. Read More

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September 2021

Surgical site infections in early onset scoliosis: what are long-term outcomes in patients with traditional growing rods?

Spine Deform 2021 Sep 18. Epub 2021 Sep 18.

Division of Pediatric Orthopaedic Surgery, Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Purpose: Deep surgical site infections (SSIs) are a common and potentially severe complication in early onset scoliosis (EOS) patients. We sought to identify the long-term outcomes following SSI, specific risk factors associated with recurrent infections, and if instrument retention is a prudent SSI management strategy in EOS.

Methods: We performed a retrospective review of all EOS patients who underwent traditional growing rod spine procedures from 2003 to 2017. Read More

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September 2021

The Risk Factors of Exacerbation in Interstitial Pneumonia With Autoimmune Features: A Single-Center Observational Cohort Study.

Rheumatol Ther 2021 Sep 18. Epub 2021 Sep 18.

Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, 2-1-1 Idaidori Yahaba-chou Shiwa-gun, Morioka, Iwate, 028-3694, Japan.

Objectives: To investigate the long-term outcomes, including risk factors, for exacerbation between monotherapy and combination therapy in patients with interstitial pneumonia with autoimmune features (IPAF).

Methods: We assessed 672 patients between April 2009 and March 2019 who were evaluated using high-resolution computed tomography (HRCT) of the chest. We applied the IPAF criteria. Read More

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September 2021

Selenomethionine Alleviates Intestinal Ischemia-Reperfusion Injury in Mice Through the Bax-Caspase Pathway.

Biol Trace Elem Res 2021 Sep 18. Epub 2021 Sep 18.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Tech Industrial Development Zone, Daqing, Heilongjiang, 163319, People's Republic of China.

Selenomethionine (SeMet) is known to alleviate ischemia-reperfusion (I/R) injury. However, its details of action have not been thoroughly elucidated in mice with intestinal I/R injury. In this study, intestinal I/R injury mice models were established, and ELISAs were performed to determine the levels of redox factors, including glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA), in mice intestinal tissues. Read More

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September 2021

Involuntary Psychiatric Hospitalization: How Patient Characteristics Affect Decision-Making.

Psychiatr Q 2021 Sep 18. Epub 2021 Sep 18.

Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Emergency department (ED) psychiatrists face the consequential decision to pursue involuntary inpatient psychiatric admission. Research on the relationship between patient characteristics and the decision to pursue involuntary psychiatric admission is limited. Using data from 2017 to 2018 at an urban Los Angeles hospital, we used generalized linear mixed effects models to compare patients who were involuntarily admitted to inpatient psychiatry to patients who were discharged from the ED. Read More

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September 2021

Injection and Non-Injection Drug Use Among Adults with Diagnosed HIV in the United States, 2015-2018.

AIDS Behav 2021 Sep 18. Epub 2021 Sep 18.

Division of HIV Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, US8-4, Atlanta, GA, 30329-4027, USA.

Understanding behavioral characteristics and health outcomes of people with HIV (PWH) who inject drugs and PWH who use drugs, but do not inject, can help inform public health interventions and improve HIV clinical outcomes. However, recent, nationally representative estimates are lacking. We used 2015-2018 Medical Monitoring Project data to examine health outcome differences among adults with diagnosed HIV who injected drugs or who only used non-injection drugs in the past year. Read More

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September 2021

Survival Among New Yorkers with HIV from 1981 to 2017: Inequities by Race/Ethnicity and Transmission Risk Persist into the Post-HAART Era.

AIDS Behav 2021 Sep 18. Epub 2021 Sep 18.

New York City Department of Health and Mental Hygiene, Bureau of HIV, New York, NY, USA.

Data on long-term survival among people with HIV (PWH) can inform the development of services for this population. An estimated 90,000 PWH live in New York City (NYC). Using HIV surveillance data, we conducted survival analysis of PWH diagnosed in NYC before and after introduction of highly active antiretroviral therapy (HAART) (pre-HAART cohort: 1981-1994; post-HAART cohort: 1995-2016). Read More

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September 2021