53,106 results match your criteria treatment expanded

Meta-computational techniques' for managing spare data: An application in off-pump heart surgery.

Comput Methods Programs Biomed 2021 Jul 5;208:106267. Epub 2021 Jul 5.

Department of Mathematics, College of Science Al-Zulfi, Majmaah University, PO Box 66, Al-Majmaah 11952, Saudi Arabia. Electronic address:

Background And Objectives: This research looked at the key considerations to remember when selecting a model for working with sparse data. In the presence of sparse evidence, it proposes ideal conditions for conducting meta-analysis.

Methods: Monte Carlo simulations were used to produce study results, and three forms of continuity correction were used in the research. Read More

View Article and Full-Text PDF

Sexually Transmitted Infections Treatment Guidelines, 2021.

MMWR Recomm Rep 2021 Jul 23;70(4):1-187. Epub 2021 Jul 23.

These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019. The information in this report updates the 2015 guidelines. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4) management of Mycoplasma genitalium; 5) human papillomavirus vaccine recommendations and counseling messages; 6) expanded risk factors for syphilis testing among pregnant women; 7) one-time testing for hepatitis C infection; 8) evaluation of men who have sex with men after sexual assault; and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. Read More

View Article and Full-Text PDF

Toward the Cure of Acute Lymphoblastic Leukemia in Children in China.

JCO Glob Oncol 2021 Jul;7:1176-1186

Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

This study explored results of therapy of children with acute lymphoblastic leukemia (ALL) in China, recent progress, and challenges. Included are a survey of therapy outcomes of ALL in Chinese children nationwide, comparison of these data with global ALL therapy outcomes, analyses of obstacles to improving outcomes, and suggestions of how progress can be achieved. Therapy outcomes at many Chinese pediatric cancer centers are approaching those of resource-rich countries. Read More

View Article and Full-Text PDF

Secondary Dysgammaglobulinemia in Children with Hematological Malignancies Treated with Targeted Therapies.

Paediatr Drugs 2021 Jul 22. Epub 2021 Jul 22.

Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, University Children's Hospital Münster, Münster, Germany.

Targeted therapies have emerged as innovative treatments for patients whose disease does not respond to conventional chemotherapy, and their use has widely expanded in the field of pediatric hematologic malignancies in the last decade. While they carry the promise of improved disease control and survival and are currently investigated in first-line treatment protocols for patients with poor prognostic markers, they are associated with a considerable incidence of specific toxicities, including cytokine-release syndrome, neurotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, endocrine adverse events, and infectious complications. Iatrogenic or secondary dysgammaglobulinemia is a main consequence of targeted therapies using monoclonal antibodies and other antibody-derived treatments that target specific antigens on lymphoid cells (blinatumomab, inotuzumab ozogamicin, rituximab), chimeric antigen receptor T cells, tyrosine kinase inhibitors (imatinib, dasatinib, nilotinib) and, to a lesser extent, checkpoint inhibitors (pembrolizumab, nivolumab). Read More

View Article and Full-Text PDF

Who holds a shared responsibility view of minimizing gambling harm? Results from a multiwave survey of casino gamblers.

Psychol Addict Behav 2021 Jul 22. Epub 2021 Jul 22.

International Gaming Institute.

Academics, gambling regulators, and the gambling industry increasingly espouse a shared responsibility view of preventing gambling harm, considering individual gamblers and external stakeholders (e.g., gambling industry employees, government regulators, and public health workers) to be jointly responsible for this task. Read More

View Article and Full-Text PDF

Accurate Removal of Trace 17β-Estradiol and Estrogenic Activity in Blended Systems under a Photoelectrocatalytic Circulating Flow.

Environ Sci Technol 2021 Jul 22. Epub 2021 Jul 22.

School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092, China.

Trace 17β-estradiol (E2) is persistent against advanced treatment when blended with higher concentrations of low-toxicity organics, thus wasting energy. A circulating-flow selective photoelectrocatalysis (CF-SPEC) system is established with a selective E2-TiO-NR photoanode, accurately reducing 1 μg L E2 to less than 0.1 ng L along with eliminating estrogenic activity even when blended with natural organic matter (NOM) at a thousand times higher concentration. Read More

View Article and Full-Text PDF

Interferential Electrical Stimulation Efficacy in the Management of Lower Urinary Tract Dysfunction in Children: A Review of the Literature.

Urol J 2021 Jul 22. Epub 2021 Jul 22.

Pediatric Urology and Regenerative Medicine Research Center, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lower urinary tract dysfunction (LUTD) is the most common problem of the referral children to the pediatric urology clinics. If this condition does not treat early in life, it will be a lifelong problem. During recent decades, electrical stimulation therapy has been expanded and extensively used for the treatment of LUTD in both adults and children. Read More

View Article and Full-Text PDF

Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application.

Front Cell Dev Biol 2021 5;9:681087. Epub 2021 Jul 5.

Sunnybrook Research Institute, Biological Sciences Platform, Toronto, ON, Canada.

Direct neuronal reprogramming is an innovative new technology that involves the conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent state. The capacity to make new neurons in the brain, which previously was not achievable, has created great excitement in the field as it has opened the door for the potential treatment of incurable neurodegenerative diseases and brain injuries such as stroke. These neurological disorders are associated with frank neuronal loss, and as new neurons are not made in most of the adult brain, treatment options are limited. Read More

View Article and Full-Text PDF

Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.

Proc Natl Acad Sci U S A 2021 Jul;118(30)

Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, D-14195 Berlin, Germany;

Many bacteria harbor RNA-dependent nucleoside-triphosphatases of the DEAH/RHA family, whose molecular mechanisms and cellular functions are poorly understood. Here, we show that the DEAH/RHA protein, HrpA, is an ATP-dependent 3 to 5' RNA helicase and that the RNA helicase activity of HrpA influences bacterial survival under antibiotics treatment. Limited proteolysis, crystal structure analysis, and functional assays showed that HrpA contains an N-terminal DEAH/RHA helicase cassette preceded by a unique N-terminal domain and followed by a large C-terminal region that modulates the helicase activity. Read More

View Article and Full-Text PDF

Cohort profile: an observational longitudinal data collection of health aspects in a cohort of female cancer survivors with a history of pelvic radiotherapy-a population-based cohort in the western region of Sweden.

BMJ Open 2021 Jul 21;11(7):e049479. Epub 2021 Jul 21.

Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Science, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Purpose: The study 'Health among women after pelvic radiotherapy' was conducted in response to the need for more advanced and longitudinal data concerning long-term radiotherapy-induced late effects and chronic states among female cancer survivors. The objective of this paper is to detail the cohort profile and the study procedure in order to provide a sound basis for future analyses of the study cohort.

Participants: Since 2011, and still currently ongoing, participants have been recruited from a population-based study cohort including all female patients with cancer, over 18 years of age, treated with pelvic radiotherapy with curative intent at Sahlgrenska University Hospital in Gothenburg, in the western region of Sweden, which covers 1. Read More

View Article and Full-Text PDF

"The system has to be health literate, too" - perspectives among healthcare professionals on health literacy in transcultural treatment settings.

BMC Health Serv Res 2021 Jul 21;21(1):716. Epub 2021 Jul 21.

Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health (CERES), University of Cologne and Research Unit Ethics, Faculty of Medicine and University Hospital Cologne, 50931, Cologne, Germany.

Background: Effective communication is a central aspect of organizational health literacy. Healthcare professionals are expected to ensure an effective and satisfactory flow of information and to support their patients in accessing, understanding, appraising, and applying health information. This qualitative study aimed to examine the health literacy-related challenges, needs, and applied solutions of healthcare professionals when engaging with persons with a migrant background. Read More

View Article and Full-Text PDF

Relevant factors of self-care in children and adolescents with spastic cerebral palsy.

PLoS One 2021 21;16(7):e0254899. Epub 2021 Jul 21.

Faculty of Health Sciences, Department of Physical Therapy, Tokyo Metropolitan University, Arakawa-ku, Tokyo, JP.

Objective: Manual ability is considered one of the factors that can predict functional independence in activities of daily living. For evaluating personal tasks such as self-care, the Pediatric Evaluation of Disability Inventory (PEDI) comprises/introduces/offers a set of useful measures that assist in enhancing the capability for self-care among children and adolescents with cerebral palsy (CP). The aim of this study was to investigate the relevant factors of self-care capability and performance in children and adolescents with spastic CP. Read More

View Article and Full-Text PDF

Home infusions of natalizumab for people with multiple sclerosis: a pilot randomised crossover trial.

Ann Clin Transl Neurol 2021 Jul 21. Epub 2021 Jul 21.

Neurology & Stroke Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objective: The delivery of healthcare at home has expanded to intravenous infusions of monoclonal antibodies. A recently developed model of care for home infusions of natalizumab for people with relapsing-remitting multiple sclerosis was evaluated. This pilot study of home infusions of natalizumab and usual care (attendance in a hospital out-patients' clinic) compared safety, feasibility, patient satisfaction, effectiveness and costs. Read More

View Article and Full-Text PDF

Oncology Expanded Access and FDA's Project Facilitate.

Oncologist 2021 Jul 19. Epub 2021 Jul 19.

Oncology Center of Excellence, U.S. Food and Drug Administration.

The Oncology Center of Excellence at the Food and Drug Administration (FDA) launched Project Facilitate on May 31, 2019, to assist oncology healthcare providers with Expanded Access requests for investigational drugs. Expanded Access, sometimes called "compassionate use" is a regulatory pathway for physicians caring for patients who have a life-threatening condition or a serious disease to gain access to an investigational drug for treatment when no comparable or satisfactory alternative treatment options are available [1]. Herein we describe the Project Facilitate program and the process for requesting Expanded Access to an investigational drug. Read More

View Article and Full-Text PDF

Accuracy of the Standardized Early Fetal Heart Assessment in Excluding Major Congenital Heart Defects in High-Risk Population: A Single-Center Experience.

J Ultrasound Med 2021 Jul 20. Epub 2021 Jul 20.

Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Objective: To evaluate the ability of standardized early fetal heart assessment (EFHA) that includes the 4-chamber, outflow tract relationship (OTR), transverse arches views (TAV) of the great arteries in excluding major congenital heart defects (CHDs) in high-risk populations.

Methods: This retrospective study included high-risk pregnancies for CHDs undergoing EFHA at 11-14 weeks of gestation. Risk factors for CHDs were diabetes mellitus, a family history of CHDs, a history of a CHD use of teratogenic medications, seizure disorder, assisted reproductive treatment-conceived pregnancy, presence of at least one of the ultrasound markers: enlarged nuchal translucency (>95th percentile), tricuspid regurgitation, and reversed a-wave in the ductus venosus, presence of an extracardiac or a suspected cardiac anomaly, a high-risk first trimester combined screen result, and multiple pregnancies. Read More

View Article and Full-Text PDF

Primary care mental health services in Qatar.

BJPsych Int 2021 Feb;18(1):15-18

Senior Consultant Psychiatrist, Chairman, Mental Health Services, Hamad Medical Corporation and Qatar University, Doha, Qatar.

With rapid growth and development in recent decades, the State of Qatar has been redefining strategies and policies towards building a world-class healthcare system. Mental health has emerged as a priority area for development. As a result, mental health services in the region are being redefined and expanded, and this was realised with the launching of the ambitious National Mental Health Strategy in 2013. Read More

View Article and Full-Text PDF
February 2021

Identification of Human SARS-CoV-2 Monoclonal Antibodies from Convalescent Patients Using EBV Immortalization.

Antibodies (Basel) 2021 Jul 5;10(3). Epub 2021 Jul 5.

Center of Cellular Therapy "G. Lanzani", Division of Hematology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.

We report the isolation of two human IgG1k monoclonal antibodies (mAbs) directed against the SARS-CoV-2 spike protein. These mAbs were isolated from two donors who had recovered from COVID-19 infection during the first pandemic peak in the Lombardy region of Italy, the first European and initially most affected region in March 2020. We used the method of EBV immortalization of purified memory B cells and supernatant screening with a spike S1/2 assay for mAb isolation. Read More

View Article and Full-Text PDF

3D Tumor Models for Breast Cancer: Whither We Are and What We Need.

ACS Biomater Sci Eng 2021 Jul 21. Epub 2021 Jul 21.

Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore-560012, India.

Three-dimensional (3D) models have led to a paradigm shift in disease modeling , particularly for cancer. The past decade has seen a phenomenal increase in the development of 3D models for various types of cancers with a focus on studying stemness, invasive behavior, angiogenesis, and chemoresistance of cancer cells, as well as contributions of its stroma, which has expanded our understanding of these processes. Cancer biology is moving into exploring the emerging hallmarks of cancer, such as inflammation, immune evasion, and reprogramming of energy metabolism. Read More

View Article and Full-Text PDF

[Endemic status of schistosomiasis in People's Republic of China in 2020].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Jun;33(3):225-233

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China.

This report presented the endemic status of schistosomiasis in the People's Republic of China at a national level in 2020, and analyzed the data collected from the national schistosomiasis prevention and control system and national schistosomiasis surveillance sites. Among the 12 provinces (municipality and autonomous region) endemic for schistosomiasis in China, Shanghai Municipality, Zhejiang Province, Fujian Province, Guangdong Province and Guangxi Zhuang Autonomous Region continued to consolidate the achievements of schistosomiasis elimination, and Sichuan and Jiangsu provinces maintained the criteria of transmission interruption, while Yunnan, Hubei, Anhui, Jiangxi and Hunan provinces maintained the criteria of transmission control by the end of 2020. A total of 450 counties (cites, districts) were found to be endemic for schistosomiasis in China, with 28 376 endemic villages covering 71 370 400 people at risk of infections. Read More

View Article and Full-Text PDF

Knockdown of miR-15b partially reverses the cisplatin resistance of NSCLC through the GSK-3β/MCL-1 pathway.

Adv Clin Exp Med 2021 Jul 20. Epub 2021 Jul 20.

Department of Anesthesia, Nanhua University, Hengyang, China.

Background: Induction of acquired drug resistance occurs frequently with cisplatin-based therapy for non-small cell lung cancer (NSCLC). As recent studies have demonstrated that deregulation of microRNAs (miRNAs) is associated with drug resistance in cancers, correcting the deregulation of miRNAs represents a promising strategy to reverse acquired resistance in NSCLC.

Objectives: This study investigated the functional role of miR-15b in cisplatin resistance in NSCLC. Read More

View Article and Full-Text PDF

Candidate reference measurement procedure based on HPAEC-PAD for the development of certified reference materials for monosaccharides in serum.

Anal Bioanal Chem 2021 Jul 20. Epub 2021 Jul 20.

Biometrology Group, Division of Chemical and Biological Metrology, Korea Research Institute of Standards and Science, 267 Gajeong-ro, Yuseong-Gu, Daejeon, 34113, Republic of Korea.

To achieve the measurement reliability of monosaccharides used as diagnostic markers in clinical fields, it is essential to establish certified reference materials (CRMs). The purpose of this study is to develop a serum CRM by adopting high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD) as a new candidate reference measurement procedure for the measurement of glucose and galactose, common diagnostic markers of diabetes and galactosemia, respectively. Using various monosaccharides as internal standards, the accuracy of the HPAEC-PAD method was tested by measuring glucose CRM following treatment with three different deproteinization methods: ultrafiltration, protein precipitation by trichloroacetic acid (TCA), and protein precipitation by acetonitrile. Read More

View Article and Full-Text PDF

Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection.

JAC Antimicrob Resist 2021 Sep 16;3(3):dlab092. Epub 2021 Jul 16.

Antimicrobial Development Specialists LLC, Nyack, NY, USA.

Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the early 1980s, they have spread worldwide and an are now endemic in Enterobacterales isolated from both hospital-associated and community-acquired infections. As a result, they are a global public health concern. Read More

View Article and Full-Text PDF
September 2021

Characterization of neoantigen-specific T cells in cancer resistant to immune checkpoint therapies.

Proc Natl Acad Sci U S A 2021 Jul;118(30)

Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;

Neoantigen-specific T cells are strongly implicated as being critical for effective immune checkpoint blockade treatment (ICB) (e.g., anti-PD-1 and anti-CTLA-4) and are being targeted for vaccination-based therapies. Read More

View Article and Full-Text PDF

The Dosimetric Outcome of a Rotational Planning Target Volume in Patients With Oropharyngeal Cancers.

Dysphagia 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiation Oncology, Indiana University, 535 Barnhill Drive, RT041, Indianapolis, IN, 46202, USA.

An isotropic expanded Planning Target Volume (PTV) neglects patient's off-axis rotation. This study designs a rotational PTV that is used instead of the standard 3-mm Clinical Target Volume (CTV) expanded PTV in oropharyngeal cancers with the goal to reduce pharyngeal constrictor muscle (PCM) mean dose. 10 patients were retrospectively evaluated. Read More

View Article and Full-Text PDF

Surgical Complications After Reverse Total Shoulder Arthroplasty and Total Shoulder Arthroplasty in the United States.

J Am Acad Orthop Surg Glob Res Rev 2021 07 20;5(7). Epub 2021 Jul 20.

From the Department of Orthopaedic Surgery, University of California, San Francisco, CA.

Introduction: Shoulder arthroplasty has become popular in the treatment of degenerative shoulder conditions in the United States. Shoulder arthroplasty usage has expanded to younger patients with increased surgical indications.

Methods: Reverse total shoulder arthroplasty (RTSA) and TSA patient records with the 1-year follow-up between 2015 and 2018 were queried from the nationwide PearlDiver Mariner Shoulder Database using International Classification of Disease-10 codes. Read More

View Article and Full-Text PDF

Expansion of cytotoxic natural killer cells in multiple myeloma patients using K562 cells expressing OX40 ligand and membrane-bound IL-18 and IL-21.

Cancer Immunol Immunother 2021 Jul 20. Epub 2021 Jul 20.

Research Center for Cancer Immunotherapy, Gwangju, South Korea.

Background: Natural killer (NK) cell-based immunotherapy is a promising treatment approach for multiple myeloma (MM), but obtaining a sufficient number of activated NK cells remains challenging. Here, we report an improved method to generate ex vivo expanded NK (eNK) cells from MM patients based on genetic engineering of K562 cells to express OX40 ligand and membrane-bound (mb) IL-18 and IL-21.

Methods: K562-OX40L-mbIL-18/-21 cells were generated by transducing K562-OX40L cells with a lentiviral vector encoding mbIL-18 and mbIL-21, and these were used as feeder cells to expand NK cells from peripheral blood mononuclear cells of healthy donors (HDs) and MM patients in the presence of IL-2/IL-15. Read More

View Article and Full-Text PDF

PERK mediates resistance to BRAF inhibition in melanoma with impaired PTEN.

NPJ Precis Oncol 2021 Jul 19;5(1):68. Epub 2021 Jul 19.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Targeting mutant BRAF in patients with melanomas harboring this oncogene has been highly successful as a first-line treatment, but other mutations may affect its efficacy and alter the route of acquired resistance resulting in recurrence and poor prognosis. As an evolving strategy, melanoma treatment needs to be expanded to include targets based on newly discovered emerging molecules and pathways. We here show that PERK plays a critical role in BRAF inhibitor-acquired resistance in melanoma with impaired PTEN. Read More

View Article and Full-Text PDF

Role of Matrix-Associated Autologous Chondrocyte Implantation with Spheroids in the Treatment of Large Chondral Defects in the Knee: A Systematic Review.

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

Department of Orthopaedic Surgery, Faculty of Medicine, UPEC (University Paris-Est, Créteil), 94000 Créteil, France.

Autologous chondrocyte implantation (ACI) is a cell therapy for the treatment of focal cartilage defects. The ACI product that is currently approved for use in the European Union (EU) consists of spheroids of autologous matrix-associated chondrocytes. These spheroids are spherical aggregates of ex vivo expanded human autologous chondrocytes and their self-synthesized extracellular matrix. Read More

View Article and Full-Text PDF

Mediator Effect of Affinity for E-Learning on Mental Health: Buffering Strategy for the Resilience of University Students.

Int J Environ Res Public Health 2021 Jul 2;18(13). Epub 2021 Jul 2.

Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

The pandemic affected the quality of life and wellness of the population, changing living habits through restriction measures. This study aimed to analyze the psychological impact of the fear of the COVID-19 pandemic and the adoption of e-learning for university students. The study was articulated in two research applications: the first application was a rapid review on the psychological effects of the pandemic on the emotional dimension of undergraduate students; the second application was an observational study on the effect of e-learning adoption in the pandemic emergency. Read More

View Article and Full-Text PDF