547,634 results match your criteria treatment difference


Five-Session Dual-Transcranial Direct Current Stimulation With Task-Specific Training Does Not Improve Gait and Lower Limb Performance Over Training Alone in Subacute Stroke: A Pilot Randomized Controlled Trial.

Neuromodulation 2021 Sep 21. Epub 2021 Sep 21.

Neuro Electrical Stimulation laboratory (NeuE), Faculty of Physical Therapy, Mahidol University, Salaya, Nakhon Pathom, Thailand.

Objective: To determine the effect of five-session dual-transcranial direct current stimulation (dual-tDCS) combined with task-specific training on gait and lower limb motor performance in individuals with subacute stroke.

Materials And Methods: Twenty-five participants who had a stroke in the subacute phase with mild motor impairment were recruited, randomized, and allocated into two groups. The active group (n = 13) received dual-tDCS with anodal over the lesioned hemisphere M1 and cathodal over the nonlesioned hemisphere, at 2 mA for 20 min before training for five consecutive days, while the sham group (n = 12) received sham mode before training. Read More

View Article and Full-Text PDF
September 2021

Perioperative hyperbaric oxygen treatment and postoperative complications following secondary breast reconstruction after radiotherapy: a case-control study of 45 patients.

Diving Hyperb Med 2021 Sep;51(3):288-294

Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Introduction: Radiotherapy reduces the risk of locoregional recurrence of breast cancer. As a side-effect, tissue can become hypocellular, hypovascular, and hypoxic and late radiation tissue injury can develop months or years later. Radiotherapy increases the risk of complications following secondary breast reconstruction. Read More

View Article and Full-Text PDF
September 2021

Comparison of venous, capillary and interstitial blood glucose data measured during hyperbaric oxygen treatment from patients with diabetes mellitus.

Diving Hyperb Med 2021 Sep;51(3):240-247

School of Nursing and Midwifery, La Trobe University, Melbourne, Victoria, Australia.

Introduction: Patients undergoing hyperbaric oxygen treatments (HBOT) have been shown to experience a reduction in blood glucose (BG) levels during a treatment. This necessitates frequent assessment of BG levels. Continuous glucose monitoring (CGM) may represent an alternative to the current finger prick monitoring method in-chamber, however, continuous sensor glucose (SG) data has not been validated in situ. Read More

View Article and Full-Text PDF
September 2021

Haploidentical vs. sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

University of Virginia, Charlottesville, Virginia, United States.

The role of haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariate analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) between haploidentical HCT using PTCy and HLA-matched sibling donor (MSD), 8/8 HLA-matched unrelated donor (MUD) , 7/8 HLA-matched UD, or umbilical cord blood (UCB) HCT. Read More

View Article and Full-Text PDF
September 2021

Anti-interleukin-5 in the Management of Eosinophilic Asthma: A Review of Effectiveness, Safety, and Budgetary Impact From the Perspective of the Brazilian Health System.

Value Health Reg Issues 2021 Sep 18;26:169-181. Epub 2021 Sep 18.

Universidade Federal de Mato Grosso - UFMT/Universidade de Várzea Grande-MT, Cuiabá-MT, Brasil.

Objectives: To evaluate the efficacy and safety of anti-interleukin-5 class therapy agents in the treatment of eosinophilic asthma and the financial impact of these drugs on the Brazilian and Mato Grosso public health systems.

Methods: The literature review in important databases was guided by a structured research question including patient or population, intervention, comparator, outcome and type of study. The retrieved studies went through a screening, selection, data extraction, and methodological quality assessment process. Read More

View Article and Full-Text PDF
September 2021

Effect of exercise training on body composition in patients with obstructive sleep apnea: a systematic review and meta-analysis.

Sleep Med 2021 Sep 3;87:105-113. Epub 2021 Sep 3.

Sleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE), University of Pernambuco, (UPE), Recife, Pernambuco, Brazil; Department of Health Sciences, University of Pernambuco, (UPE), Recife, Pernambuco, Brazil.

Reduction in adiposity is considered a cornerstone in the treatment of obstructive sleep apnea (OSA). Exercise training is one of the interventions used in the treatment of OSA. However, it remains unclear whether exercise training alleviates OSA by improving body composition. Read More

View Article and Full-Text PDF
September 2021

Do all patients with locoregionally advanced nasopharyngeal carcinoma benefit from the maintenance chemotherapy using S-1/capecitabine?

Oral Oncol 2021 Sep 18;122:105539. Epub 2021 Sep 18.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou 510060, PR China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China. Electronic address:

Background: The goal of this study was to explore the benefits of S-1/capecitabine as maintenance therapy in locoregionally advanced nasopharyngeal carcinoma (NPC) patients with different risks of treatment failure.

Methods: A total of 2205 eligible, locoregionally advanced NPC patients were recruited for this retrospective study. Multivariate Cox regression analysis was performed to identify optimal predictors of overall survival (OS) and distant metastasis-free survival (DMFS) for constructing the nomograms. Read More

View Article and Full-Text PDF
September 2021

Safety of malleolar osteotomies in surgery for osteochondral lesions of the talus.

Orthop Traumatol Surg Res 2021 Sep 18:103070. Epub 2021 Sep 18.

Hopital Central, 29 avenue du maréchal de Lattre de Tassigny, 54000 Nancy, France.

The talus is a central bone in the hindfoot that is difficult to access surgically. Performing a medial or lateral malleolar osteotomy in the management of an osteochondral lesion of the talus (OLT) is a feared procedure amongst surgeons and their patients. The objective of this study was to assess the complications inherent to malleolar osteotomies in the treatment of OLTs. Read More

View Article and Full-Text PDF
September 2021

Human papillomavirus detected in sperm of Japanese infertile males affects reproductive parameters: HPV detection in spermatozoa of infertile men.

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Objectives: The effects of human papillomavirus (HPV) infection on male reproductive parameters are currently a matter of controversy. In order to clarify the issue in Japanese infertile men, we examined HPV prevalence and localization in semen, sperm parameters, and seminal sample reactive oxygen species (ROS) activity among 216 Japanese infertile men.

Methods: DNA was extracted from liquid-based cytological semen samples. Read More

View Article and Full-Text PDF
September 2021

Comparative Study of Survival among Small Cell Lung Cancer Patients in the U.S. Military Health System and Those in the Surveillance, Epidemiology, and End Results (SEER) Program.

Ann Epidemiol 2021 Sep 18. Epub 2021 Sep 18.

John P. Murtha Cancer Center Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland. Electronic address:

Purpose: The U.S. military health system (MHS) provides universal health care access to beneficiaries. Read More

View Article and Full-Text PDF
September 2021

Delineating the complex mechanistic interplay between NF-κβ driven mTOR depedent autophagy and monocyte to macrophage differentiation: A functional perspective.

Cell Signal 2021 Sep 18:110150. Epub 2021 Sep 18.

School of Biological Sciences, Indian Association for the Cultivation of Science, Kolkata 700032, India. Electronic address:

Autophagy is an extremely essential cellular process aimed to clear redundant and damaged materials, namely organelles, protein aggregates, invading pathogens, etc. through the formation of autophagosomes which are ultimately targeted to lysosomal degradation. In this study, we demonstrated that mTOR dependent classical autophagy is ubiquitously triggered in differentiating monocytes. Read More

View Article and Full-Text PDF
September 2021

Do Medical Insurance Companies Reimburse Telemedicine Office Visits the Same as In-Person Office Visits in an Academic Oral and Maxillofacial Surgeon Setting?

J Oral Maxillofac Surg 2021 Aug 16. Epub 2021 Aug 16.

Assistant Professor and Section Chief of Oral and Maxillofacial Surgery, Philadelphia Veterans Affairs Medical Center, Penn Presbyterian Medical Center, University of Pennsylvania School of Dental Medicine, Philadelphia, PA. Electronic address:

Purpose: Telemedicine use has grown exponentially during the last decade but a barrier to widespread adoption remains reimbursement rates for providers. The aim of this study is to compare reimbursement rates of telemedicine and in-person visits in an academic oral and maxillofacial surgery practice.

Methods: The investigators implemented a retrospective cohort study. Read More

View Article and Full-Text PDF

Identification of colon tumor marker NKD1 via integrated bioinformatics analysis and experimental validation.

Cancer Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Oncology, Wujin Hospital Affiliated with Jiangsu University, Jiangsu Province, China.

Background: Colorectal cancer is an important death-related disease in the worldwide. However, specific colon cancer tumor markers currently used for diagnosis and treatment are few. The purpose of this study is to screen the potential colon cancer markers by bioinformatics and verify the results with experiments. Read More

View Article and Full-Text PDF
September 2021

Characteristics, prognosis, risk factors, and management of recently diagnosed ductal carcinoma in situ with microinvasion.

Cancer Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Ductal carcinoma in situ with microinvasion (DCISM) represents ~1% of all breast cancer cases and is arguably a more aggressive subtype of ductal carcinoma in situ (DCIS). Lacking studies with a large population, the survival outcomes of DCISM are still poorly understood and the treatment recommendations remain controversial. This study aims to investigate the long-term outcome of patients with DCISM, potential risk factors for their prognosis, and the difference of survival between patients treated with breast-conserving surgery plus radiotherapy (BCT + RT) and mastectomy only. Read More

View Article and Full-Text PDF
September 2021

Outcomes of surgery for extensive infective endocarditis.

J Card Surg 2021 Sep 21. Epub 2021 Sep 21.

Department of Cardiac Surgery, Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Objective: Extensive infective endocarditis (EIE) involving the valve annulus or the intervalvular fibrous body (IFB) is a treatment challenge. We sought to clarify the outcomes of patients undergoing surgery for EIE.

Methods: We retrospectively reviewed all 197 consecutive patients who underwent an operation for infective endocarditis (IE) between 2005 and 2016 in the Helsinki University Hospital. Read More

View Article and Full-Text PDF
September 2021

Infection Control in Adult Periodontal Patients Using Ultrasonic Debridement and Erythritol Powder: A Randomized, Controlled, Split-Mouth Clinical Study.

Int J Periodontics Restorative Dent 2021 Sep-Oct;41(5):675-681

Ten patients with a diagnosis of generalized chronic periodontitis underwent nonsurgical periodontal therapy performed with the exclusive use of ultrasonic instrumentation and air polishing with erythritol powder. For each patient, four pockets with probing depths (PDs) of 4 to 10 mm were selected as experimental sites, and air polishing was performed either before (Group A) or after (Group B) ultrasonic scaling. PDs and clinical attachment levels significantly improved over a 12-month observation period. Read More

View Article and Full-Text PDF
September 2021

Treatment of Teeth with an Insufficient Clinical Crown. Part 2: Treatment Cost and Time and Patient Outcomes.

Int J Periodontics Restorative Dent 2021 Sep-Oct;41(5):637-645

This study involves a group of 168 teeth in 126 patients treated with crown lengthening and tooth reconstruction (experimental group), and a group of 75 teeth from 62 patients that were judged irrational to treat, extracted, and replaced (control group). In the control group, 13 teeth in 12 patients were not replaced; 37 were replaced with an implant-supported crown, 14 with a tooth-supported partial denture, 2 with a Maryland partial denture; and 9 patients requested a removable prosthesis. In the experimental group, 44 teeth in 37 patients received a conservative restoration (24 direct and 20 indirect), while 124 teeth in 94 patients received a full crown. Read More

View Article and Full-Text PDF
September 2021

25 years of ERβ: a personal journey.

J Mol Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

J Gustafsson, Biology and Biochemistry, Center for NRs and cell signaling, Houston, 77002-1014, United States.

After the discovery of ERβ, a novel role for DHT in estrogen signaling was revealed. Instead of just being a better androgen, DHT was found to be a precursor of the ERβ agonist 5α-androstane-3β, 17β-diol (3βAdiol), the second estrogen in the body which did not require aromatase for its synthesis. ERβ was found to oppose androgen signaling and thus a potential target for treatment of prostate cancer. Read More

View Article and Full-Text PDF
September 2021

Human Papillomavirus-Negative Oropharyngeal Cancer Survival Outcomes Based on Primary Treatment: National Cancer Database Analysis.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211047169. Epub 2021 Sep 21.

Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.

Objective: To compare survival outcomes between primary surgery and primary radiation therapy (RT) in patients with human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC).

Study Design: A retrospective observational cohort study.

Setting: National Cancer Database. Read More

View Article and Full-Text PDF
September 2021

Effect of Medical Therapy in Allergic Rhinitis: A Systematic Review and Meta-Analysis.

Am J Rhinol Allergy 2021 Sep 21:19458924211041438. Epub 2021 Sep 21.

2345Medical University of South Carolina, Charleston, SC, USA.

Background: Intranasal corticosteroids (INCS), oral antihistamines (POAH), and allergen-specific immunotherapy (ASIT) are widely used in the treatment of allergic rhinitis (AR); however, appraisal of treatment effect has been heterogenous, and few studies have interpreted these outcomes in context with measures of nasal airflow.

Objective: To provide a systematic review and meta-analysis of randomized placebo-controlled trials for common therapy classes for AR to assess standardized treatment effect on validated patient-reported outcomes and physiologic measures of airflow.

Methods: A systematic search was performed in PubMed, Scopus, OVID, and Cochrane library databases to identify randomized controlled trials meeting inclusion criteria. Read More

View Article and Full-Text PDF
September 2021

Intraoperative fluid management and kidney transplantation outcomes: A retrospective cohort study.

Clin Transplant 2021 Sep 21:e14489. Epub 2021 Sep 21.

Division of Transplant and Hepatobiliary Surgery, Scottsdale, Arizona, USA.

Background: Patients undergoing kidney transplantation traditionally receive liberal amounts of fluid during surgery. However, excessive fluids can lead to fluid overload and ileus. In this retrospective cohort study, we compared the effect of restrictive versus liberal fluid therapy on kidney transplantation outcomes. Read More

View Article and Full-Text PDF
September 2021

Real-World Outcomes and Costs Following 6 Months of Treatment with the Long-Acting Injectable (LAI) Aripiprazole Lauroxil for the Treatment of Schizophrenia.

CNS Drugs 2021 Sep 21. Epub 2021 Sep 21.

Alkermes, Waltham, MA, USA.

Background: Continuous antipsychotic therapy is recommended as part of long-term maintenance treatment of schizophrenia, and gaps in antipsychotic treatment have been associated with increased risks of relapse and rehospitalization. Because the use of long-acting injectable (LAI) antipsychotics may reduce the likelihood of undetected medication gaps, initiating an LAI medication may affect resource utilization and costs. The LAI aripiprazole lauroxil (AL) was approved in the United States (US) in 2015 for the treatment of schizophrenia in adults. Read More

View Article and Full-Text PDF
September 2021

CT-Guided Coeliac Plexus Neurolysis in Patients with Intra-Abdominal Malignancy: A Retrospective Evaluation of 52 Palliative In-Patients.

Pain Ther 2021 Sep 21. Epub 2021 Sep 21.

Center for Interdisciplinary Pain Therapy, Oncology and Palliative Care, Klinikum Klagenfurt am Wörthersee, Feschnigstrasse 11, 9020, Klagenfurt am Wörthersee, Austria.

Introduction: Prevalence rates of chronic abdominal pain (CAP) and breakthrough cancer pain (BTcP) are high in patients with intra-abdominal malignancies. As part of a multimodal approach, CT-guided coeliac plexus blockade (CPB) and CT-guided coeliac plexus neurolysis (CPN) are commonly used pain management strategies. The aim of this study was to evaluate pain outcomes among patients with intra-abdominal malignancies who underwent CPB and/or CPN. Read More

View Article and Full-Text PDF
September 2021

A comparative study of anticoagulant/antiplatelet therapy among men undergoing robot-assisted radical prostatectomy: a prospective single institution study.

J Robot Surg 2021 Sep 21. Epub 2021 Sep 21.

Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy.

The present study aimed to assess the safety and efficacy of robot-assisted radical prostatectomy (RARP) in patients with prostate cancer (PCa) under anticoagulant (AC) and/or antiplatelet (AP) therapy, as compared to a control group, and to establish possible differences in postoperative-related morbidity. Data of all consecutive patients submitted to elective RARP for PCa from June 2017 to May 2020 at our institution were prospectively collected. Patients were divided according to the use of AC/AP therapy at surgery. Read More

View Article and Full-Text PDF
September 2021

In-hospital outcomes of self-expanding and balloon-expandable transcatheter heart valves in Germany.

Clin Res Cardiol 2021 Sep 21. Epub 2021 Sep 21.

Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University, Freiburg, Germany.

Introduction: The effect of valve type on outcomes in transfemoral transcatheter aortic valve replacement (TF-TAVR) has recently been subject of debate. We investigate outcomes of patients treated with balloon-expanding (BE) vs. self-expanding (SE) valves in in a cohort of all these procedures performed in Germany in 2018. Read More

View Article and Full-Text PDF
September 2021

Honey-based trap for Pseudomonas: a sustainable prototype for water disinfection.

Arch Microbiol 2021 Sep 21. Epub 2021 Sep 21.

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, 303007, India.

This paper introduces a novel prototype for the removal of Pseudomonas from water samples. Bacterial cells have the tendency to get attracted towards specific chemicals (chemotaxis); a 'honey-based trap' (henceforth, addressed as 'honey-trap') strip was conceptualized by integrating a combination of serine, pseudomonas-specific chemoattractant and honey to attract and inhibit the bacteria in situ. Honey, a natural antimicrobial agent, has garnered the attention as an effective inhibitor for Pseudomonal biofilms and wound infections. Read More

View Article and Full-Text PDF
September 2021

Correlation between the position of the glenoid fossa and condylar translational movement in skeletal Class III mandibular asymmetry patients.

Eur J Orthod 2021 Sep 21. Epub 2021 Sep 21.

Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.

Objectives: Understanding the mechanism of mandibular asymmetry (MA) is important to provide suggestions for occlusal treatment and to know the developmental process of masticatory dysfunction. To investigate the morphological and functional effects on MA, we evaluated the three-dimensional position of the glenoid fossa and its relationship to asymmetrical condylar translational movement.

Methods: In this retrospective study, 50 subjects who previously underwent computed tomography for surgical purposes were divided into MA and control groups according to a menton deviation of at least 4 mm from the mid-sagittal plane. Read More

View Article and Full-Text PDF
September 2021

An Analysis of the Impact of Timing and Technique on Outcomes after Surgery for Distal Radius Fractures: The Wrist and Radius Injury Surgical Trial Collaborative Study.

Plast Reconstr Surg 2021 Sep 20. Epub 2021 Sep 20.

From the Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School; and Department of Biostatistics, University of Michigan.

Background: Surgical treatment of closed distal radius fractures varies based on treatment, surgeon schedule, and patient preferences. The authors examined how timing and technique impact surgeon-perceived procedural difficulty and quality of reduction, outcomes, and complications.

Methods: This was a retrospective study of participants in the randomized, multicenter Wrist and Radius Injury Surgical Trial with isolated unstable distal radius fractures. Read More

View Article and Full-Text PDF
September 2021

The effect of COVID-19 on children with congenital talipes equinovarus in a tertiary service in the United Kingdom.

J Pediatr Orthop B 2021 Sep 17. Epub 2021 Sep 17.

Department of Orthopaedic Surgery, Bart's Health NHS Trust Department of Orthopaedics, Barts and the London School of Medicine and Dentistry, London, UK.

During the coronavirus disease 2019 (COVID-19) pandemic, many aspects of healthcare have been hindered. The primary aim of this study was to identify what the impact of COVID-19 was on the delivery of outpatient care for children with congenital talipes equinovarus deformity (CTEV) at a large tertiary hospital in the UK. This study reviewed the patients who commenced their Ponseti treatment between March and September 2020, representing the cohort who received hands-on care during the first wave of the COVID-19 pandemic. Read More

View Article and Full-Text PDF
September 2021