158,982 results match your criteria treatment diabetic


Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers.

Int J Pharm 2021 Jul 19:120903. Epub 2021 Jul 19.

School of Science, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent ME4 4TB, UK. Electronic address:

Recently developed medicated dressings target either bacterial or fungal infection only, which is not effective for the treatment of mixed infections common in diabetic foot ulcers (DFUs). This study aims to develop advanced bioactive alginate-based dressings (films and wafers) to deliver therapeutically relevant doses of ciprofloxacin (CIP) and fluconazole (FLU) to target mixed bacterial and fungal infections in DFUs. The alginate compatibility with the drugs was confirmed by SEM, XRD, FTIR and texture analysis, while the medicated wafers showed better fluid handling properties than the films in the presence of simulated wound fluid. Read More

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Design and evaluation of GLP-1 receptor G-protein biased agonist with prolonged efficacy on diabetes.

Life Sci 2021 Jul 19:119844. Epub 2021 Jul 19.

Peking University Third Hospital, Beijing 100191, PR China. Electronic address:

Aim: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as potent drug development target for treating diabetes and obesity. Here, we designed and evaluated novel long-acting GLP-1R G protein biased agonist with potent clinical application.

Main Methods: GLP-1R G-protein biased sequences were screened via a high-throughput autocrine-based strategy and then fused to Exendin (9-39). Read More

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Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.

Chem Biodivers 2021 Jul 22. Epub 2021 Jul 22.

Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Plant Resources in West China, 132 Lanhei Road, Heilongtan, Kunming 650201, Not Available, 650201, Kunming, CHINA.

A new neo -clerodane diterpenoid, salvihispin H ( 1 ), and six known ones ( 2 - 7 ) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic ( 1 H, 13 C, and 2D NMR, and HRESIMS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H ( 1 ) and salvifaricin ( 2 ) were evaluated in diabetic db/db mice. Read More

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Association of serum apolipoprotein B with retinal neurovascular structural alterations in patients with type 2 diabetes: an optical coherence tomography angiography study.

Acta Diabetol 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.

Purpose: To investigate the association of serum apoB concentrations with retinal neurovascular structural alterations in type 2 diabetes patients without clinically visible retinopathy.

Methods: Eyes with no clinically visible diabetic retinopathy (DR) from diabetic patients with or without dyslipidemia were included. Changes in retinal neural structures, including the ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (RNFL) thicknesses, and microvascular metrics, including macular vessel density (VD) and perfusion density (PD) of the superficial capillary plexus, were measured with optical coherence tomography angiography (OCTA). Read More

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Modifications of intravitreal injections in response to the COVID-19 pandemic.

J Chin Med Assoc 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

The Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented disruption to the normal operation of the healthcare system. On a worldwide scale, hospitals suspended non-urgent surgeries and outpatient visits to downsized clinical loadings to redistribute manpower to counteract the pandemic's impact. So far, there is no evidence-based guideline defining a clear line between urgent and non-urgent indications of intravitreal injections (IVI). Read More

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The Effect of Periodontal Disease on Metabolic Control in Patients With Diabetes Mellitus in South Africa: Protocol for a Systematic Review.

JMIR Res Protoc 2021 Jul 22;10(7):e27471. Epub 2021 Jul 22.

Research Support Unit, University of the Western Cape, Cape Town, South Africa.

Background: The increase in the prevalence of type 2 diabetes mellitus (T2DM) and its associated complications is burdensome to the South African health system. Understanding the role of comorbid diseases, such as periodontal disease (PD), and their effect on metabolic control in patients with DM in South Africa will raise awareness about the importance of periodontal interventions among patients with DM in South Africa.

Objective: The review will aim to determine the effect of PD on the metabolic control of T2DM in a South African population. Read More

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Bexagliflozin for type 2 Diabetes: an overview of the data.

Expert Opin Pharmacother 2021 Jul 22. Epub 2021 Jul 22.

Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, Royal Perth Hospital Research Foundation, Faculty of Medicine, Dentistry & Health Sciences, The University of Western Australia, Perth Australia.

Introduction: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a relatively novel glucose-lowering drugs (GLDs) which additionally promote weight loss and blood pressure reduction amongst other beneficial effects.

Areas Covered: This review reflects on the extra-glycaemic effects of SGLT2 inhibitors and their impact on important clinical endpoints, and provides an overview of data relating to a newer member of the SGLT2 inhibitor class, bexagliflozin.

Expert Opinion: SGLT2 inhibitors, while consolidating glycaemic control as adjunctive therapy, indisputably effect cardio-renal benefits in the T2D population which is prevalently afflicted by heightened cardiovascular risk profiles and a disproportionately increased incidence of unfavourable cardiovascular and renal clinical outcomes. Read More

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Diagnostic Accuracy of Myocardial Perfusion Imaging in Obese Diabetic Patients.

Obes Surg 2021 Jul 22. Epub 2021 Jul 22.

Laboratory of Experimental Surgery and Surgical Research, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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KSI-301: antibody biopolymer conjugate in retinal disorders.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211027708. Epub 2021 Jul 12.

Retina Services, JB Eye Care & Retina Centre, Salem, India.

KSI-301 is a new intravitreal anti-vascular endothelial growth factor (VEGF) antibody biopolymer conjugate under investigation for the treatment of age-related macular degeneration (AMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). Preclinical and early clinical trials so far have shown promising results in retinal vascular diseases. When using anti-VEGF agents for treatment of retinal disorders, the frequency of injections and follow-up visits has increased the treatment burden, greatly affecting the treatment outcome. Read More

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Hypoglycemic, hypolipidemic and hepato-protective effect of bee bread in streptozotocin-induced diabetic rats.

Avicenna J Phytomed 2021 Jul-Aug;11(4):343-352

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of life (SNAMOPEQ), Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Objective: This study aims to shed a new light on pharmacological effects of bee bread as a product of the hive through examination of the effect of itsethyl acetate extract onhyperglycemia, dyslipidemia, and liver dysfunction induced by streptozotocin.

Materials And Methods: The bee bread ethyl acetate extract was analyzed for total phenolics, flavonoids, and the antioxidant activities using total antioxidant capacity, 2, 2- diphenyl-1-picrylhydrazyl (DPPH), 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and reducing power assays. study was carried out on thirty-six rats divided into control or diabetic rats, received daily for 15 days distilled water (10 ml/kg), or ethyl acetate extract of bee bread (100 mg/kg), or glibenclamide (2. Read More

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October 2019

Noninvasive exploration of Cardiac Autonomic Neuropathy by heart rate and blood pressure variability analysis in Type 2 Diabetic patients.

Pak J Med Sci 2021 Jul-Aug;37(4):1020-1024

Ambreen Shakir, MBBS. Ex-lecturer Physiology, Bahria Medical, and Dental College, Bahria University, Karachi, Pakistan.

Objectives: To determine the prevalence of asymptomatic cardiac autonomic neuropathy and its association with risk factors among patients with Type-2 diabetes mellitus (T2DM).

Methods: The present case-control study was conducted at Department of Medicine, Civil Hospital, Dow University of Health Sciences (DUHS), Karachi, Pakistan during the period September` 2016 to May` 2017. After taking informed consent, subjects from both genders, 72 healthy controls and 72 clinically diagnosed T2DM diabetic patients, age between 30-65 years were selected by non-probability sampling technique. Read More

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September 2020

Diabetic Retinopathy in the Aging Population: A Perspective of Pathogenesis and Treatment.

Clin Interv Aging 2021 15;16:1367-1378. Epub 2021 Jul 15.

Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.

The elderly population in the United States is projected to almost double by the year 2050. In addition, the numbers of diabetics are rising, along with its most common complication, diabetic retinopathy (DR). To effectively treat DR within the elderly population, it is essential first to consider the retinal changes that occur due to aging, such as decreased blood flow, retinal thinning, and microglial changes, and understand that these changes can render the retina more vulnerable to oxidative and ischemic damage. Read More

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AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism.

Oncogene 2021 Jul 21. Epub 2021 Jul 21.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Epidemiologic studies in diabetic patients as well as research in model organisms have indicated the potential of metformin as a drug candidate for the treatment of various types of cancer, including breast cancer. To date most of the anti-cancer properties of metformin have, in large part, been attributed either to the inhibition of mitochondrial NADH oxidase complex (Complex I in the electron transport chain) or the activation of AMP-activated kinase (AMPK). However, it is becoming increasingly clear that AMPK activation may be critical to alleviate metabolic and energetic stresses associated with tumor progression suggesting that it may, in fact, attenuate the toxicity of metformin instead of promoting it. Read More

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Hyperkalemia in diabetes: newer insights into mechanism and treatment.

Postgrad Med J 2021 Jul 21. Epub 2021 Jul 21.

Nephrology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

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Is Mucormycosis an inevitable complication of Covid-19 in India?

Braz J Infect Dis 2021 Jul 5:101597. Epub 2021 Jul 5.

Junior Research Fellow, Central Council for Research in Siddha (Ministry of AYUSH), Siddha Central Research Institute, Department of Pharmacology, Arumbakkam, Chennai, amilnadu, India.

Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. Read More

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Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy.

Arch Biochem Biophys 2021 Jul 18:108995. Epub 2021 Jul 18.

Molecular Endocrinology and Stem Cell Research Laboratory, Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, 390021, India. Electronic address:

Failing pancreas and subsequent loss of pancreatic β cells worsen diabetic conditions which are further alleviated by the mounting up of glucose levels. Inhibition of sodium glucose cotransporter 2 (SGLT2) in the kidney responsible for glucose reabsorption strikingly reduces blood glucose levels. Bioactive swertisin showed a promising glucose-lowering effect. Read More

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Spin Infrequently Occurs in Abstracts of Systematic Reviews For The Pharmacological Treatment of Type 2 Diabetes Mellitus.

Diabet Med 2021 Jul 21:e14653. Epub 2021 Jul 21.

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, United States.

Aims: Currently, there is a growing body of research demonstrating that spin - the misinterpretation and distortion of a study's findings - is common in different fields of medicine. To our knowledge, no study has investigated its presence in systematic reviews focused on diabetic therapies.

Methods: We performed a cross-sectional study by searching MEDLINE and Embase for systematic reviews focused on pharmacologic treatments for type 2 diabetes mellitus. Read More

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Diabetic Peripheral Neuropathy and Depression: Dancing with Wolves? - Mini-Review and Commentary on Alghafri et al. "Screening for depressive symptoms amongst patients with diabetic peripheral neuropathy".

Rev Diabet Stud 2021 10;17(1):17-20. Epub 2021 May 10.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

The co-existence of diabetic peripheral neuropathy (DPN) and depression in subjects with diabetes is being increasingly recognized. The interaction of these two serious comorbidities may increase morbidity and mortality. An emerging thought is that persisting depression, along with stroke and cognitive dysfunction, may represent a cluster of potential microvascular injuries affecting the brain, which shares a common risk factor with DPN. Read More

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Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells.

Gels 2021 Jul 16;7(3). Epub 2021 Jul 16.

Department of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA.

(1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as "active moiety carriers" was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or controlled release activity. The nano-based neuroprotective strategy is explored as an imperative treatment for diabetic neuropathy (DN). Avanafil (AV), that selectively inhibits the degradation of cGMP-specific phosphodiesterase, thereby increasing the levels of cGMP, makes a decisive mediator for cytoprotection. Read More

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Optimising type 1 diabetes after multiple daily injections and capillary blood monitoring: Pump or Sensor First? A meta-analysis using pooled differences in outcome measures.

Diabetes Obes Metab 2021 Jul 19. Epub 2021 Jul 19.

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Aims/hypothesis: Most people living with type 1 diabetes self-manage using multiple dose injection insulin (MDI) regimens and self-monitoring of blood glucose (SMBG). Continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) are adjuncts to education and support self-management optimisation. The aim of this systematic review and meta-analysis was to assess which first line technology is most effective. Read More

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Sexual dysfunction in dialytic patients. A prospective cross-sectional observational study in two hemodialysis centers.

Arch Ital Urol Androl 2021 Jun 28;93(2):215-220. Epub 2021 Jun 28.

Department of Surgical, Oncological and Oral Sciences, Section of Urology, University of Palermo.

Objectives: Incidence and prevalence of patients in dialytic therapy increased considerably in recent years. The onset of new issues, once overshadowed, linked to a lower quality of life like sexual dysfunction became increasingly common. The first study in this area, dating back to the 1970s, shows the high prevalence of sexual dysfunction among patients in dialytic therapy of both sexes. Read More

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Functional hydrogels for diabetic wound management.

APL Bioeng 2021 Sep 9;5(3):031503. Epub 2021 Jul 9.

Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.

Diabetic wounds often have a slow healing process and become easily infected owing to hyperglycemia in wound beds. Once planktonic bacterial cells develop into biofilms, the diabetic wound becomes more resistant to treatment. Although it remains challenging to accelerate healing in a diabetic wound due to complex pathology, including bacterial infection, high reactive oxygen species, chronic inflammation, and impaired angiogenesis, the development of multifunctional hydrogels is a promising strategy. Read More

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September 2021

PGC-1α attenuates the oxidative stress-induced impaired osteogenesis and angiogenesis regulation effects of mesenchymal stem cells in the presence of diabetic serum.

Biochem Biophys Rep 2021 Sep 8;27:101070. Epub 2021 Jul 8.

Department of Orthopedic Surgery, Liangxiang Hospital of Beijing Fangshan District, and Liangxiang Teaching Hospital of Capital Medical University, No.45, Gongchen Ave., Liangxiang, Fangshan Dist., Beijing, 102488, China.

Oxidative stress is believed to induce dysfunction of the bone remodeling process and be associated with progressive loss of bone mass. The peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master controller during mitochondrial biogenesis and the antioxidant response. We postulated that PGC-1α could function as a cyto-protective effector in mesenchymal stem cells (MSCs) under oxidative stress conditions. Read More

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September 2021

Antidiabetic efficacy of a honey-royal jelly mixture: Biochemical study in rats.

Int J Health Sci (Qassim) 2021 Jul-Aug;15(4):4-9

Department of Family Medicine, College of Medicine, Qassim University, Buraydah, Saudi Arabia.

Objectives: The current tools for the management of diabetes mellitus (DM) do not prevent its development or complications, so investigations into promising new treatments, for example, honey-royal jelly (H-RJ) mixtures, are needed. This study was conducted to evaluate the effect of royal jelly on DM by measuring the biochemical parameters (fasting blood glucose and glycated hemoglobin [HbA1c]) accompanying streptozotocin (i.p. Read More

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Severe Pulmonary s Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan.

Int Med Case Rep J 2021 12;14:465-470. Epub 2021 Jul 12.

Division of Infectious Diseases and Infection Control, Faculty of Medicine.

Background: frequently causes severe infections, yet its pathophysiological features and treatment regimens have not been established.

Case Report: We present five cases of severe pneumonia due to infection in Japan. All cases were diabetic patients, with possible acceleration to pneumonia due to co-infection with other microorganisms. Read More

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Low-Intensity Shockwave Therapy (LI-ESWT) in Diabetic Kidney Disease: Results from an Open-Label Interventional Clinical Trial.

Int J Nephrol Renovasc Dis 2021 13;14:255-266. Epub 2021 Jul 13.

Department of Urology, Odense University Hospital, Odense, Denmark.

Purpose: Treatment with low-intensity shockwave therapy (LI-ESWT) is associated with angiogenesis and is suggested as a treatment for different types of vascular diseases. It was hypothesized that LI-ESWT improves the renal filtration barrier and halts the progression of GFR decline in diabetic kidney disease (DKD) potentially through VEGF and NO formation. We present the first data on LI-ESWT in human DKD. Read More

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A Call to Action by the Italian Mesotherapy Society on Scientific Research.

Drug Des Devel Ther 2021 12;15:3041-3047. Epub 2021 Jul 12.

Department of Vascular Surgery, Limb Salvage and Diabetic Foot, IDI-IRCCS, Rome, Italy.

Mesotherapy (local intradermal therapy, LIT) is a technique used to slowly spread drugs in tissues underlying the site of injection to prolong the pharmacological effect with respect to intramuscular injection. Recommendations for proper medical use of this technique have been made for pain medicine and rehabilitation, chronic venous disease, sport medicine, musculoskeletal disorders, several dermatological conditions, skin ageing, and immune-prophylaxis. Although mesotherapy is considered a valid technique, unresolved questions remain, which should be answered to standardize methodology and dosing regimen as well as to define the right indications in clinical practice. Read More

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Aflibercept versus Ranibizumab as a Second Line Therapy After Bevacizumab for Diabetic Macular Edema.

Clin Ophthalmol 2021 13;15:2975-2980. Epub 2021 Jul 13.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To compare the visual and anatomic outcomes of aflibercept versus ranibizumab as a second line treatment for persistent diabetic macular edema (DME) after initial bevacizumab injections.

Methods: In this retrospective cohort study, patients with center-involved DME of ≥ 300 μm thickness after bevacizumab intravitreal injections in 2015-2019 were included. Those treated with ranibizumab (R) and aflibercept (A) were grouped as group R and group A, respectively. Read More

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A method for constructing GLP-1 overexpression intestinal organoids.

Yi Chuan 2021 Jul;43(7):694-703

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.

As a potent insulinotrophic hormone, glucagon-like peptide 1 (GLP-1) is mainly secreted by intestinal L cells, which can effectively promote the release of insulin and thus reduce blood glucose. Therefore, GLP-1 and its analogs have a good prospect in the treatment of type 2 diabetes. In this study, we constructed mouse intestinal organoids that overexpress GLP-1 by optimizing the GLP-1 lentivirus infection method. Read More

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Improving frequency of urinary albumin testing in type 2 diabetes in primary care - An analysis of cross-sectional studies in Denmark.

Prim Care Diabetes 2021 Jul 17. Epub 2021 Jul 17.

Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.

Background: To ensure high quality standards in chronic care of type 2 diabetes, it is paramount to ensure regular measurement of clinical risk factors. For prevention of diabetic kidney disease, testing for albuminuria and kidney function is vital. The majority of individuals with type 2 diabetes in Denmark are treated in general practice, and given the recent development of kidney-protective treatments, a renewed focus on renal risk factors is important. Read More

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