81,410 results match your criteria treatment cycles

Copanlisib plus rituximab versus placebo plus rituximab in patients with relapsed indolent non-Hodgkin lymphoma (CHRONOS-3): a double-blind, randomised, placebo-controlled, phase 3 trial.

Lancet Oncol 2021 Apr 9. Epub 2021 Apr 9.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", and Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy.

Background: Copanlisib, an intravenous pan-class I PI3K inhibitor, showed efficacy and safety as monotherapy in patients with relapsed or refractory indolent non-Hodgkin lymphoma who had received at least two therapies. The CHRONOS-3 study aimed to assess the efficacy and safety of copanlisib plus rituximab in patients with relapsed indolent non-Hodgkin lymphoma.

Methods: CHRONOS-3 was a multicentre, double-blind, randomised, placebo-controlled, phase 3 study in 186 academic medical centres across Asia, Australia, Europe, New Zealand, North America, Russia, South Africa, and South America. Read More

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The Activity of Crizotinib in Chemo-Refractory MET-Amplified Esophageal and Gastric Adenocarcinomas: Results from the AcSé-Crizotinib Program.

Target Oncol 2021 Apr 13. Epub 2021 Apr 13.

Gustave Roussy, Villejuif, France.

Background: The AcSé-crizotinib program provides extensive screening of crizotinib-targeted genomic alteration in several malignancies. We here report the results in patients with esogastric MET-amplified adenocarcinomas.

Objective: The objective of the study was to evaluate the efficacy and tolerability of crizotinib in patients with pretreated esogastric MET-amplified adenocarcinoma who have no alternative treatment options. Read More

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Effect of different surface treatment on the repair bond strength of feldspathic porcelain.

Dent Med Probl 2021 Jan-Mar;58(1):107-113

Department of Restorative Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Considering the use of silane-containing universal adhesives to enhance the repair bond strength of porcelain restorations, a question arises whether the application of these adhesives eliminates the need for a separate application of silane or not.

Objectives: This study aimed to assess the effect of various kinds of surface treatment, including hydrofluoric acid (HF) etching, the application of bis-silane and the use of universal adhesives, on the repair bond strength of feldspathic porcelain.

Material And Methods: In this experimental in vitro study, 70 porcelain disks were fabricated and divided into 7 groups (n = 10) for the following types of surface treatment: C (control group) - HF etching + silane + Porcelain Bond; HSB - HF etching + Single Bond; HSSB - HF etching + silane + Single Bond; HAB - HF etching + All Bond; HSAB - HF etching + silane + All Bond; HFB - HF etching + FuturaBond®; and HSFB - HF etching + silane + FuturaBond. Read More

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Comparison of the Effect of Holder Pasteurization and High-Pressure Processing on Human Milk Bacterial Load and Bioactive Factors Preservation.

J Pediatr Gastroenterol Nutr 2021 May;72(5):756-762

Medical Affairs and Innovation, Héma-Québec, Québec, QC, Canada.

Objectives: This project aims at comparing the impact of Holder pasteurization (HoP) and high-pressure processing (HPP) on bacterial load and retention of immunological components in human milk.

Methods: Human milk samples discarded by the Public Mothers' milk bank (Montreal, Canada) for bacterial purpose were pooled (n = 6) and pasteurized either by heating in a water bath (62.5°C, 30 minutes) or by HPP treatment (425 MPa, four cycles of 6 minutes, initial milk temperature of 4°C or 37°C). Read More

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Angiogenesis imaging study using interim [F] RGD-K5 PET/CT in patients with lymphoma undergoing chemotherapy: preliminary evidence.

EJNMMI Res 2021 Apr 12;11(1):37. Epub 2021 Apr 12.

Department of Nuclear Medicine, Henri Becquerel Cancer Center, Rouen University Hospital & QuantIF-LITIS, University of Rouen, 1 rue d'amiens, 76000, Rouen, France.

Background: Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography-computed tomography (PET) on patients presenting with lymphoma. Nineteen patients at Rouen's Henri Becquerel Cancer Centre were prospectively included. Fluorodeoxyglucose (FDG) and RGD-K5 PET were performed before (C0) and after (C2) two cycles of chemotherapy. Read More

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Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy.

Support Care Cancer 2021 Apr 12. Epub 2021 Apr 12.

Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, sala 503, CEP: 90035-003 Santana, Porto Alegre, RS, Brazil.

Purpose: To investigate the incidence and risk factors for oral mucositis (OM) in patients with childhood cancer undergoing chemotherapy.

Methods: Eight hundred and twenty-nine cycles of chemotherapy were evaluated in 112 patients with childhood cancer undergoing chemotherapy. Chemotherapy protocol, hematological, hepatic, and renal function parameters were collected and compared to presence and severity of OM, as graded by the World Health Organization (WHO) scale. Read More

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A phase 1 study of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor in Chinese patients with advanced breast cancer.

Biomark Res 2021 Apr 12;9(1):24. Epub 2021 Apr 12.

Jiangsu Hengrui Medicine Co. Ltd, Shanghai, China.

Background: Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study was conducted to evaluate the tolerability, pharmacokinetics, safety, and preliminary antitumor activity of dalpiciclib in patients with advanced breast cancer (ABC).

Methods: In this open-label, phase 1 study, Chinese patients who had failed standard therapy were enrolled to receive oral dalpiciclib in 3 + 3 dose-escalation pattern at doses of 25-175 mg. Read More

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Chidamide induces long-term remission in rare subcutaneous panniculitis-like T-cell lymphoma: An unusual case report and literature review.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211009342

Department of Central Laboratory, The First Hospital of Lanzhou University, Lanzhou, China.

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma composed of CD8 cytotoxic T-cell that is primarily localized in the subcutaneous tissue. No standard treatments are currently available for SPTCL due to its rarity. Chemotherapy, radiotherapy, immunosuppressive agents, and hematopoietic stem cell transplantation (HSCT) have been used frequently, however, the effects of these treatment approaches remain controversial. Read More

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Comparison of Laparoscopic and Open Surgery in the Treatment of Renal Hydatid Cysts.

J Laparoendosc Adv Surg Tech A 2021 Apr 12. Epub 2021 Apr 12.

Department of Urology, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey.

To compare the efficacy, safety, and long-term results of laparoscopic and open approaches in patients undergoing surgery for renal hydatid cyst. The files of 36 patients who were surgically treated in our clinic and with diagnosis of renal cyst hydatid confirmed pathologically were reviewed. According to the surgical technique applied, the patients were divided into two groups as open (group 1) or laparoscopic (group 2) partial pericystectomy. Read More

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Peri-implantitis-like mronj: Clinical considerations and histological evaluation with confocal laser scanning microscope.

Oral Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, Aldo Moro University of Bari, Italy.

Objective: In the recent years, an increasing number of peri-implant Medication-related Osteonecrosis of the Jaw (PI-MRONJ) has been reported in literature, both in oncologic and osteoporotic patients. The aim of this study is to describe 19 cases of patients previously diagnosed as affected by peri-implantitis, who were treated for PI-MRONJ, with consideration on clinical and histopathological features.

Materials And Methods: Patients included were affected by postmenopausal osteoporosis and were administered with different antiresorptive drugs. Read More

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Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI).

Cochrane Database Syst Rev 2021 Apr 12;4:CD005289. Epub 2021 Apr 12.

Division of Applied Health Sciences, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, UK.

Background: Monitoring of in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) is necessary to detect as well as reduce the incidence and severity of ovarian hyperstimulation syndrome (OHSS) whilst achieving the optimal ovarian response needed for assisted reproduction treatment. Traditional monitoring of ovarian hyperstimulation during in vitro fertilisation IVF and ICSI treatment has included transvaginal ultrasonography (TVUS) plus serum estradiol levels. The need for combined monitoring (using TVUS and serum estradiol) during ovarian stimulation in assisted reproduction is controversial. Read More

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Factors affecting the choice of drospirenone as the component of combined contraceptive pill in daily clinical practice: the results of nation-wide survey.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Women's Health Chair, School of Health Science in Katowice, Medical University of Silesia, Katowice, Poland.

Objectives: The aim of the multicenter, open-label, post-marketing, observational survey was to assess doctors' preferences in choosing the progestogen component of the combined contraceptive pill (CCP) and factors affecting this choice in daily clinical practice as well as non-contraceptive reasons use of CCP containing drospirenone (CCPD) and patients' tolerance and satisfaction with the treatment.

Material And Methods: This multicenter, open-label, post-marketing, survey was performed nation-wide with the participation of 222 doctors involving and 10,345 patients treated with CCPD. The study questionnaire included questions concerning factors affecting the choice of drospirenone as a component of CCP and assessing prescription pattern of the drug as well as tolerance and satisfaction with the use of CCPD. Read More

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Double plating is associated with higher fixation strength than single plating in osteoporotic fractures of the scapular spine: a biomechanical study.

Arch Orthop Trauma Surg 2021 Apr 12. Epub 2021 Apr 12.

Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Waldeyer Str. 1, 48149, Muenster, Germany.

Introduction: The number of atraumatic stress fractures of the scapular spine associated with reverse shoulder arthroplasty is increasing. At present, there is no consensus regarding the optimal treatment strategy. Due to the already weakened bone, fractures of the scapular spine require a high fixation stability. Read More

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Surgical Decision Making in Pancreatic Ductal Adenocarcinoma: Modeling Prognosis Following Pancreatectomy in the Era of Induction and Neoadjuvant Chemotherapy.

Ann Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Department of Surgery, New York University School of Medicine and NYU-Langone Medical Center, New York, New York, United States of America.

Objective: To develop a predictive model of oncologic outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) undergoing resection after neoadjuvant or induction chemotherapy use.

Background: Early recurrence following surgical resection for PDAC is common. The use of neoadjuvant chemotherapy prior to resection may increase the likelihood of long-term systemic disease control. Read More

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Stereotactic Radiosurgery with Whole Brain Radiotherapy Combined with Bevacizumab in the Treatment of Brain Metastases from NSCLC.

Int J Neurosci 2021 Apr 10:1-12. Epub 2021 Apr 10.

Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Non-small cell lung cancer (NSCLC) patients who experience brain metastases are usually associated with poor prognostic outcomes. Whole-brain radiotherapy (WBRT) is one of the standard treatment strategies for NSCLC. It is interesting to combine angiogenesis inhibitors such as bevacizumab with radiation therapy. Read More

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Enzyme polymer engineered structure strategy to enhance cross-linked enzyme aggregate stability: a step forward in laccase exploitation for cannabidiol removal from wastewater.

Environ Sci Pollut Res Int 2021 Apr 12. Epub 2021 Apr 12.

Université de Sherbrooke Water Research Group, Department of Civil and Building Engineering, Université de Sherbrooke, 2500 boul. de l'Université, Sherbrooke, Québec, J1K 2R1, Canada.

Despite all its advantages and potential, cross-linking enzyme aggregate (CLEA) technology is still not applied at an industrial scale for enzyme insolubilization for bioremediation purposes. In this study, the enzyme polymer engineered structure (EPES) method was used to enhance CLEA stability and reuse. A crude laccase from Trametes hirsuta was successfully insolubilized to form EPES-CLEAs. Read More

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The exact synchronization timing between the cleavage embryo stage and duration of progesterone therapy-improved pregnancy rates in frozen embryo transfer cycles: A cross-sectional study.

Int J Reprod Biomed 2021 Mar 21;19(3):227-234. Epub 2021 Mar 21.

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Synchronization between the embryonic stage and the uterine endometrial lining is important in the outcomes of the vitrified-warmed embryo transfer (ET) cycles.

Objective: The aim was to investigate the effect of the exact synchronization between the cleavage stage of embryos and the duration of progesterone administration on the improvement of clinical outcomes in frozen embryo transfer (FET) cycles.

Materials And Methods: 312 FET cycles were categorized into two groups: (A) day-3 ET after three days of progesterone administration (n = 177) and (B) day-2 or -4 ET after three days of progesterone administration (n = 135). Read More

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Integrated Utilization Strategy for Soybean Oil Deodorizer Distillate: Synergically Synthesizing Biodiesel and Recovering Bioactive Compounds by a Combined Enzymatic Process and Molecular Distillation.

ACS Omega 2021 Apr 27;6(13):9141-9152. Epub 2021 Mar 27.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China.

Soybean oil deodorizer distillate (SODD) is well recognized as a good source of both biodiesel and high-value bioactive compounds of tocopherols, squalene, and phytosterols. To achieve a one-step synthesis of biodiesel and recovery of bioactive compounds from SODD, four commercial immobilized enzymes (Novozym 435, Lipozyme TLIM, Lipozyme RMIM, and Lipozyme RM) and one self-prepared immobilized lipase MAS1-H108A were compared. The results showed that immobilized lipase MAS1-H108A due to the better methanol tolerance and higher catalytic activity gave the highest biodiesel yield of 97. Read More

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Efficacy and safety of pemetrexed maintenance chemotherapy for advanced non-small cell lung cancer in a real-world setting.

J Thorac Dis 2021 Mar;13(3):1813-1821

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Medical Oncology, Peking University Cancer Hospital & Institute, Beijing, China.

Background: Pemetrexed maintenance therapy offers a survival benefit in patients with nonprogressive advanced nonsquamous non-small cell lung cancer (NSCLC) with good tolerability. This study was designed to analyze the efficacy and safety of pemetrexed maintenance chemotherapy in advanced nonsquamous NSCLC patients in a real-world setting.

Methods: The response rate (RR) and adverse events in 71 nonsquamous NSCLC patients treated with pemetrexed-based chemotherapy were observed until disease progression or unacceptable toxicities. Read More

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Neoadjuvant pembrolizumab with chemotherapy for the treatment of stage IIB-IIIB resectable lung squamous cell carcinoma.

J Thorac Dis 2021 Mar;13(3):1760-1768

Department of Thoracic Surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Background: Researches on programmed cell death (PD-1) as neoadjuvant immunotherapy for resectable non-small cell lung cancer is underway, which brings hope for individuals with the disease. However, a study dedicated to lung squamous cell carcinoma (LUSC) specifically has yet to be conducted. Now, data from our pilot prospective research neoadjuvant study provide new insights in the field of neoadjuvant regimen for LUSC. Read More

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Intracellular Nampt impairs esophageal squamous cell carcinoma neo-adjuvant chemotherapy response independent of eNampt.

Am J Transl Res 2021 15;13(3):1411-1421. Epub 2021 Mar 15.

Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi, China.

Nampt consists of iNampt and eNampt, might contribute to modulating obesity-related malignancies and impairing response to chemotherapy in a range of cancers. This study explored the role of Nampt and adiposity in the progression and response to neo-adjuvant chemotherapy of esophageal squamous cell carcinoma (ESCC). Patients with ESCC were treated with 2 cycles of neo-adjuvant chemotherapy, then evaluated for surgery. Read More

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Genetic Polymorphism Drives Susceptibility Between Bacteria and Bacteriophages.

Front Microbiol 2021 24;12:627897. Epub 2021 Mar 24.

Key Laboratory of Emerging Pathogens and Biosafety, Centre for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Phage therapy has attracted much attention for the treatment of antibiotic-resistant bacteria in recent years. However, it is common for bacteria to obtain resistance capability in short time after interaction with a lytic phage, as observed in phage therapy and co-culture of host and phage in a lab. In order to understand the mechanisms behind resistance, AB91118 and its lytic phage LQ7 were studied as a model system. Read More

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Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer.

Nutr Cancer 2021 Apr 12:1-10. Epub 2021 Apr 12.

Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.

Ulcerative colitis patients have an increased risk of developing colorectal cancer (CRC). The aim of the current study was to determine whether Emu Oil (EO) could reduce the severity of colitis, thereby inhibiting colitis-associated CRC (CA-CRC) development. Female C57BL/6 mice ( = 8/group) were injected (i. Read More

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Nitrogen process in stormwater bioretention: the impact of alternate drying and rewetting on nitrogen migration and transformation.

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

School of River and Ocean Engineering, Chongqing Jiaotong University, Chongqing, 400074, China.

Nitrogen migration and transformation in the stormwater bioretention system were studied in laboratory experiments, in which the effects of drying-rewetting were particularly investigated. The occurrence and distribution of nitrogen in the plants, the soil, and the pore water were explored under different drying-rewetting cycles. The results clearly showed that bioretention system could remove nitrogen efficiently in all drying-rewetting cycles. Read More

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Tumor flare of brain metastases upon dose interruption of sunitinib in a patient with metastatic renal cell carcinoma.

Cancer Treat Res Commun 2021 Mar 31;27:100367. Epub 2021 Mar 31.

University of Colorado Anschutz Medical Campus, Department of Medicine, Division of Medical Oncology. Electronic address:

Brain metastases from renal cell carcinoma are associated with poor prognosis. Sunitinib is a multi-targeted tyrosine kinase inhibitor used for the treatment of metastatic renal cell carcinoma. It is taken orally on a traditional dosing schedule of 4-week on/2-week off cycles or an alternate dosing schedule of 2-week on/1-week off cycles. Read More

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Fabrication of MXene/PEI functionalized sodium alginate aerogel and its excellent adsorption behavior for Cr(VI) and Congo Red from aqueous solution.

J Hazard Mater 2021 Apr 2;416:125777. Epub 2021 Apr 2.

College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, PR China; National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Chengdu 610065, PR China. Electronic address:

MXene/PEI modified sodium alginate aerogel (MPA) was facilely prepared by introducing polyethylenimine (PEI) and amino functionalized TiCT into sodium alginate (SA) aerogel matrix through cross-linking reactions. Abundant active groups of PEI coupled with in situ reduction ability of MXene dramatically promoted the removal of Cr(VI), realizing the adsorption capacity of 538.97 mg/g. Read More

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Effect of nanomolar concentrations of lanthanum on Desmodesmus quadricauda cultivated under environmentally relevant conditions.

Aquat Toxicol 2021 Mar 26;235:105818. Epub 2021 Mar 26.

Czech Academy of Sciences, Biology Centre, Institute of Plant Molecular Biology, Department of Plant Biophysics and Biochemistry, Branišovská 31/1160, 370 05 České Budějovice, Czech Republic; University of South Bohemia, Department of Experimental Plant Biology, Branišovská 31/1160, 370 05 České Budějovice, Czech Republic. Electronic address:

Toxicity of lanthanides is generally regarded as low, and they even have been suggested to be beneficial at low concentrations. This research was conducted to investigate effects of Lanthanum (La) on Desmodesmus quadricauda, a freshwater green microalga. The algal cultures were treated with nanomolar La concentrations under controlled environmentally relevant conditions. Read More

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Magnetic field-influenced nanofiltration membrane blended by CS-EDTA-mGO as multi-functionality green modifier to enhance nanofiltration performance, efficient removal of NaSO/Pb/RR195 and cyclic wastewater treatment.

Chemosphere 2021 Mar 28;278:130379. Epub 2021 Mar 28.

Department of Environmental Planning and Management, School of Environment, College of Engineering, University of Tehran, Tehran, Iran.

Magnetic field-influenced nanofiltration membrane by blending of magnetic multi-functionality green modifier (CS-EDTA-mGO) was fabricated via phase inversion processes. Migration of superparamagnetic nanofiller particles into top surface layer of M6 NF-membrane by incorporating external magnetic-filed during casting phase improved the hydrophilicity, as well as formation of large pores diameters (1.57 nm) which offer a flux enhancement (84. Read More

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Effectiveness and Safety of Moxibustion Robots on Primary Dysmenorrhea: A Randomized Controlled Pilot Trial.

Chin J Integr Med 2021 Apr 10. Epub 2021 Apr 10.

Department of Acupuncture and Rehabilitation, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Objective: To conduct a pilot trial to explore the effectiveness and safety of moxibustion robots in treating primary dysmenorrhea (PD) and evaluate its feasibility in clinic.

Methods: A total of 70 participants with PD were allocated to either moxibustion robot (MR) group (35 cases) or manual moxibustion (MM) group (35 cases) using computer-generated randomization. One acupoint Guanyuan (CV 4) was selected to receive moxa heat stimulation. Read More

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Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor.

J Immunother Cancer 2021 Apr;9(4)

Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA

Background: PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. We hypothesized that Gal-3 blockade with belapectin (GR-MD-02) plus anti-PD-1 (pembrolizumab) would enhance tumor response in patients with metastatic melanoma (MM) and head and neck squamous cell carcinoma (HNSCC).

Methods: We performed a phase I dose escalation study of belapectin+pembrolizumab in patients with advanced MM or HNSCC (NCT02575404). Read More

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