43,463 results match your criteria treatment bipolar


Association between visceral adipose tissue and major depressive disorder across the lifespan: a Scoping Review.

Bipolar Disord 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Objectives: Increasing evidence supports a bidirectional relationship between major depressive disorder (MDD) and obesity, but the role of visceral adipose tissue (VAT) as a measure of obesity in relation to MDD is not well understood. Here we review literature investigating the link between MDD and VAT in terms of biomarkers, sex differences, and aging.

Methods: PubMed, EMBASE, PsycINFO, and CINAHL searches were conducted on December 11, 2020. Read More

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September 2021

Commentary: Ketamine for Treatment-Resistant bipolar depression - need for more data!

Bipolar Disord 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota, USA.

Treatment-resistant bipolar depression (TRBD) is a significant but less well-defined and quantified condition compared to treatment-resistant depression (TRD, unipolarity implied). Ketamine, a novel glutamatergic anesthetic agent repurposed as a rapid-acting antidepressant, is considered a third-line treatment with Level 3 evidence for acute bipolar I and II depression. While there are numerous studies of the efficacy, safety, and tolerability of off-label intravenous (IV) racemic ketamine and its FDA-approved enantiomer intranasal esketamine for TRD the evidence base of ketamine for TRBD is much less. Read More

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September 2021

New-Onset Psychosis Following COVID-19 Infection.

Cureus 2021 Sep 12;13(9):e17904. Epub 2021 Sep 12.

Department of Psychiatry, Brookdale University Hospital Medical Center, Brooklyn, USA.

Previous studies have suggested that some individuals experience neuropsychiatric symptoms following coronavirus disease 2019 (COVID-19) infection. We describe a case of new-onset psychosis following COVID-19 infection in a 55-year-old female with no prior psychiatric history. The patient started exhibiting symptoms of COVID-19 infection three weeks prior and was treated in the hospital with 4 L oxygen, dexamethasone 6 mg, and remdesivir therapy for seven days. Read More

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September 2021

Rs1h exon 3-del rat model of X-linked retinoschisis with early onset and rapid phenotype is rescued by RS1 supplementation.

Gene Ther 2021 Sep 22. Epub 2021 Sep 22.

National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Animal models of X-linked juvenile retinoschisis (XLRS) are valuable tools for understanding basic biochemical function of retinoschisin (RS1) protein and to investigate outcomes of preclinical efficacy and toxicity studies. In order to work with an eye larger than mouse, we generated and characterized an Rs1h knockout rat model created by removing exon 3. This rat model expresses no normal RS1 protein. Read More

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September 2021

Efficacy and safety of bipolar androgen therapy in mCRPC after progression on abiraterone or enzalutamide: A systematic review.

Urol Oncol 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology, Institute of Urology, Center of Biomedical big data and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Purpose: To further determine the efficacy and safety of bipolar androgen therapy (BAT) on patients with metastatic castration-resistant prostate cancer (mCRPC) after progression on abiraterone (ABI) or enzalutamide (ENZA).

Materials And Methods: We systematically searched the Pubmed, Web of Science and ClinicalTrials.gov up to June 2021. Read More

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September 2021

Treatment of bipolar disorders in older adults: a review.

Ann Gen Psychiatry 2021 Sep 21;20(1):45. Epub 2021 Sep 21.

Bereich Forschung & Wissenschaft, LWL-Klinik, Marsbruchstr. 179, 44287, Dortmund, Germany.

Background: Old age bipolar disorder has been an orphan of psychiatric research for a long time despite the fact that bipolar disorder (BD)-I and II together may affect 0.5-1.0% of the elderly. Read More

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September 2021

How to prevent surgical site infection in vascular surgery: A review of the evidence.

Ann Vasc Surg 2021 Sep 17. Epub 2021 Sep 17.

School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Western Australia, Australia. The University of Western Australia, Mailbox Drop Point 509, 35 Stirling Hwy, Nedlands, WA 6009; Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Western Australia, Australia. Level 6, G Block, QEII Medical Centre, Hospital Avenue, Nedlands, WA 6009; Curtin Medical School, Curtin University, Western Australia, Australia. Faculty of Health Sciences, Level 4 Building 400, Curtin University, GPO Box U1987, Perth, Western Australia 6845; Heart and Vascular Research Institute, Harry Perkins Institute for Medical Research, Western Australia, Australia. Heart and Vascular Research Institute, Level 2 Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, Western Australia, Australia 6009.

Objective: This review aims to identify and review the current evidence for preventing postoperative surgical site infections in abdominal aortic aneurysm surgery or infrainguinal arterial surgery.

Methods: Extended literature review of clinical trials that examined the prevention of postoperative surgical site infections in abdominal aortic aneurysm or infrainguinal arterial surgery. Searches were conducted on Ovid MEDLINE (1950 - 13 March 2020) using key terms for vascular surgery, surgical site infections and specific preventative techniques. Read More

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September 2021

Lamotrigine for Treating Anger in Veterans With Posttraumatic Stress Disorder.

Clin Neuropharmacol 2021 Sep-Oct 01;44(5):184-185

Phoenix VA Health Care System, Phoenix, AZ.

Abstract: Lamotrigine is an antiepileptic drug that was Food and Drug Administration approved in 2003 for use in the maintenance treatment of bipolar I disorder to delay the time to recurrence of new mood episodes. The mechanism by which lamotrigine achieves its therapeutic effect in the treatment of bipolar disorder is unknown. Here, we report on 2 Veterans with combat-related posttraumatic stress disorder (PTSD) endorsing significant anger, aggression, and agitation, who were treated with selective serotonin reuptake inhibitors, but whose residual symptoms of anger and aggression were ultimately successfully managed with lamotrigine augmentation. Read More

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September 2021

Comparison between ultrasound-guided monopolar and bipolar pulsed radiofrequency treatment for refractory chronic cervical radicular pain: A randomized trial.

J Back Musculoskelet Rehabil 2021 Sep 13. Epub 2021 Sep 13.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Korea.

Background: Many patients complain of chronic cervical radicular pain, and pulsed radiofrequency (PRF) is known to have a positive effect for alleviating neuropathic pain.

Objectives: In the present study, we used ultrasound (US) guidance and compared the effects of monopolar PRF with those of bipolar PRF in patients with chronic cervical radicular pain refractory to repeated transforaminal epidural steroid injections.

Methods: Sixty-six patients with chronic cervical radicular pain were included in this study. Read More

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September 2021

Asenapine: an atypical antipsychotic with atypical formulations.

Ther Adv Psychopharmacol 2021 11;11:20451253211035269. Epub 2021 Sep 11.

New York Medical College, Valhalla, NY, USA.

Asenapine is a second-generation (atypical) antipsychotic medication not available in a pill that can be swallowed; rather, it is commercialized in sublingual and transdermal formulations. This is a consequence of extensive first-pass metabolism if ingested. The sublingual formulation is approved in many jurisdictions for the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder and is available generically. Read More

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September 2021

Effective Antidepressant Chronotherapeutics (Sleep Deprivation and Light Therapy) Normalize the IL-1β:IL-1ra Ratio in Bipolar Depression.

Front Physiol 2021 1;12:740686. Epub 2021 Sep 1.

Vita-Salute San Raffaele University, Milan, Italy.

Background: Mood disorders associate with peripheral markers of low-grade inflammation, among which circulating levels of interleukin-1β (IL-1β) consistently predict diagnosis and poor outcomes. Antidepressant chronotherapeutics (total sleep deprivation and light therapy, TSD+LT) prompts response in drug-resistant bipolar depression, but its effect on peripheral inflammation were never assessed. Here we explored the effects of TSD+LT on IL-1β signaling. Read More

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September 2021

Molecular and Clinical Characterization of Patients With Metastatic Castration Resistant Prostate Cancer Achieving Deep Responses to Bipolar Androgen Therapy.

Clin Genitourin Cancer 2021 Aug 16. Epub 2021 Aug 16.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD.

Background: Bipolar androgen therapy (BAT) is an emerging treatment strategy for men with metastatic castration resistant prostate cancer (mCRPC) whereby serum testosterone is cycled from supraphysiologic to near-castrate levels each month. BAT has been shown to induce clinical responses in a significant proportion of patients, some of which are extreme. We explored the clinical and molecular characteristics of patients with mCRPC who achieved deep responses to BAT. Read More

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Do adolescents and young adults accessing the Emergency Room with substance use receive poor therapeutic indications at discharge? An observational retrospective study.

Int J Clin Pract 2021 Sep 19:e14890. Epub 2021 Sep 19.

Department of Mental Health, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, University of Milan, Milan, Italy.

Purpose: Emergency Rooms (ERs) are usually the first point of contact with mental health services for adolescents with Substance Use Disorders (SUDs). However, only a minority of them receives proper treatment and follow-up indications, increasing the risk of relapses and poor prognosis. In this perspective, we sought to characterize and compare sociodemographic and clinical characteristics of adolescents with vs without SUDs accessing the ER, assessing potential differences in terms of discharge instructions. Read More

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September 2021

Trace amine-associated receptor 1 (TAAR1): Potential Application in Mood Disorders: A Systematic Review.

Neurosci Biobehav Rev 2021 Sep 16. Epub 2021 Sep 16.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada. Electronic address:

There is a need for innovation with respect to therapeutics in psychiatry. Available evidence indicates that the trace amine-associated receptor 1 (TAAR1) agonist SEP-363856 is promising, as it improves measures of cognitive and reward function in schizophrenia. Hedonic and cognitive impairments are transdiagnostic and constitute major burdens in mood disorders. Read More

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September 2021

Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model.

Bipolar Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Epidemiology, University of California Irvine, Irvine, 92697, CA, USA.

Objective: The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. Compared to blood, saliva collection is easier, non-invasive, requires less processing, and can be done without the need for trained personnel. This study investigated the utility of longitudinal salivary lithium level monitoring. Read More

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September 2021

The emerging tale of microglia in psychiatric disorders.

Neurosci Biobehav Rev 2021 Sep 15;131:1-29. Epub 2021 Sep 15.

McGill Group for Suicide Studies, Douglas Mental Health University Institute, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada. Electronic address:

As the professional phagocytes of the brain, microglia orchestrate the immunological response and play an increasingly important role in maintaining homeostatic brain functions. Microglia are activated by pathological events or slight alterations in brain homeostasis. This activation is dependent on the context and type of stressor or pathology. Read More

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September 2021

Involuntary Psychiatric Hospitalization: How Patient Characteristics Affect Decision-Making.

Psychiatr Q 2021 Sep 18. Epub 2021 Sep 18.

Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Emergency department (ED) psychiatrists face the consequential decision to pursue involuntary inpatient psychiatric admission. Research on the relationship between patient characteristics and the decision to pursue involuntary psychiatric admission is limited. Using data from 2017 to 2018 at an urban Los Angeles hospital, we used generalized linear mixed effects models to compare patients who were involuntarily admitted to inpatient psychiatry to patients who were discharged from the ED. Read More

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September 2021

TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.

Mol Psychiatry 2021 Sep 17. Epub 2021 Sep 17.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the effect of body mass index (BMI), which identified a genome-wide significant single-nucleotide polymorphism (SNP) in the gene encoding the transcription factor 7 like 2 (TCF7L2). However, the molecular function of TCF7L2 in the central nervous system (CNS) and its possible role in the BD and BMI interaction remained unclear. Read More

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September 2021

Harnessing the potential of nanostructured formulations to mimic the food effect of lurasidone.

Int J Pharm 2021 Sep 14:121098. Epub 2021 Sep 14.

UniSA Clinical and Health Sciences, University of South Australia, Adelaide, South Australia 5000, Australia; ARC Centre for Excellence in Bio-Nano Science and Technology, Adelaide, South Australia 5000, Australia. Electronic address:

Lurasidone is an important antipsychotic drug indicated for the treatment of schizophrenia and bipolar disorder, with an oral bioavailability of 9-19% owing to its poor aqueous solubility. Additionally, lurasidone exhibits a 2-fold positive food effect, such that patients must administer their medication with a meal, leading to significant non-compliance. The aim of this research was to evaluate the in vitro and in vivo performance of lurasidone when engineered as nanostructured systems. Read More

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September 2021

Effect of Lithium Drug on Binding Affinities of Glycogen Synthase Kinase-3 β to Its Network Partners: A New Computational Approach.

J Chem Inf Model 2021 Sep 17. Epub 2021 Sep 17.

Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran.

Finding new methods to study the effect of small molecules on protein interaction networks provides us with invaluable tools in the fields of pharmacodynamics and drug design. Lithium is an antimanic drug that has been used for the treatment of bipolar disorder for more than 60 years. Here, we utilized a new approach to study the effect of lithium as a drug on the protein interaction network of GSK-3β as a hub protein and computed the affinities of GSK-3β to its partners in the presence of lithium or sodium ions. Read More

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September 2021

Combined treatment of myo-inositol and d-chiro-inositol (80:1) as a therapeutic approach to restore inositol eumetabolism in patients with bipolar disorder taking lithium and valproic acid.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5483-5489

Department of Neuroscience, Section of Psychiatry, Catholic University of the Sacred Heart of Rome, Rome, Italy.

Objective: Patients with bipolar disorder (BD) experience a poor quality of life (QoL) and a weak adherence to the therapy due to the various side effects occurring during the pharmacological therapy. To date clinicians have no tools to intervene on such effects, considering them as an unavoidable part of the therapy. This review paves the way for a step forward in the management of patients with BD bridging the therapeutic gap in clinical practice. Read More

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September 2021

Racial and ethnic disparities in emergency department restraint use: A multicenter retrospective analysis.

Acad Emerg Med 2021 09;28(9):957-965

Department of Emergency Medicine, Center for Social Justice and Health Equity, Massachusetts General Hospital, Boston, Massachusetts, USA.

Background: Research regarding disparities in physical restraint use in the emergency department (ED) is limited. We evaluated the role of race, ethnicity, and preferred language on the application of physical restraint among ED patients held under a Massachusetts section 12(a) order for mandatory psychiatric evaluation.

Methods: We identified all ED patient encounters with a section 12(a) order across a large integrated 11-hospital health system from January 2018 through December 2019. Read More

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September 2021

The Role of the UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder.

Front Cell Neurosci 2021 31;15:735622. Epub 2021 Aug 31.

Department of Biological Sciences, Wayne State University, Detroit, MI, United States.

Bipolar disorder (BD) is a mood disorder that affects millions worldwide and is associated with severe mood swings between mania and depression. The mood stabilizers valproate (VPA) and lithium (Li) are among the main drugs that are used to treat BD patients. However, these drugs are not effective for all patients and cause serious side effects. Read More

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An Evidence-Based Review of OLZ/SAM for Treatment of Adults with Schizophrenia or Bipolar I Disorder.

Neuropsychiatr Dis Treat 2021 9;17:2885-2904. Epub 2021 Sep 9.

Alkermes Pharma Ireland Limited, Dublin, Ireland.

Olanzapine effectively treats schizophrenia and bipolar I disorder (BD-I); however, its use is limited by the risk of significant weight gain and metabolic effects. OLZ/SAM, a combination of olanzapine and samidorphan, was recently approved in the United States for the treatment of adults with schizophrenia or BD-I. OLZ/SAM provides the efficacy of olanzapine while mitigating olanzapine-associated weight gain through opioid-receptor blockade. Read More

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September 2021

Stress exposure and well-being: correlates of meeting criteria for bipolar disorder, borderline personality disorder, or both.

Soc Psychiatry Psychiatr Epidemiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Sociology, University of Nevada, Reno, NV, USA.

Purpose: Bipolar and borderline personality disorders share similar features, are challenging to differentiate and sometimes co-occur in the same individual. This paper compares people with bipolar, borderline, both or neither, analyzing sociodemographic characteristics, lifetime exposure to stressors, and emotional, social, and physical wellbeing to illuminate differences in life experiences associated with expressing symptoms consistent with bipolar, borderline, or both.

Methods: Data were analyzed from the 2012-13 National Epidemiological Survey on Alcohol and Related Conditions (NESARC-III), N = 36,309. Read More

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September 2021