258,285 results match your criteria treatment basis


Personalised urethra pessaries prepared by material extrusion-based additive manufacturing.

Int J Pharm 2021 Sep 18:121112. Epub 2021 Sep 18.

Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.

Material extrusion-based additive manufacturing, commonly referred to as 3D-printing, is regarded as the key technology to pave the way for personalised medical treatment. This study explores the technique's potential in customising vaginal inserts with complex structures, so-called urethra pessaries. A novel, flawlessly 3D-printable and biocompatible polyester-based thermoplastic elastomer serves as the feedstock. Read More

View Article and Full-Text PDF
September 2021

Clinical characterization of Lassa fever: A systematic review of clinical reports and research to inform clinical trial design.

PLoS Negl Trop Dis 2021 Sep 21;15(9):e0009788. Epub 2021 Sep 21.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Background: Research is urgently needed to reduce the morbidity and mortality of Lassa fever (LF), including clinical trials to test new therapies and to verify the efficacy and safety of the only current treatment recommendation, ribavirin, which has a weak clinical evidence base. To help establish a basis for the development of an adaptable, standardised clinical trial methodology, we conducted a systematic review to identify the clinical characteristics and outcomes of LF and describe how LF has historically been defined and assessed in the scientific literature.

Methodology: Primary clinical studies and reports of patients with suspected and confirmed diagnosis of LF published in the peer-reviewed literature before 15 April 2021 were included. Read More

View Article and Full-Text PDF
September 2021

Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/ axis.

Bioengineered 2021 Dec;12(1):6748-6758

Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Genetic Testing, Xiamen, Fujian, China.

Polycystic ovary syndrome (PCOS) is an endocrine disease that affects the health of many women. Circular RNAs (circRNAs) are associated with the occurrence and progression of PCOS. This study aimed to explore the function of circ_RANBP9 in PCOS. Read More

View Article and Full-Text PDF
December 2021

Human Papillomavirus-Negative Oropharyngeal Cancer Survival Outcomes Based on Primary Treatment: National Cancer Database Analysis.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211047169. Epub 2021 Sep 21.

Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.

Objective: To compare survival outcomes between primary surgery and primary radiation therapy (RT) in patients with human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC).

Study Design: A retrospective observational cohort study.

Setting: National Cancer Database. Read More

View Article and Full-Text PDF
September 2021

Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective.

J Oncol Pharm Pract 2021 Sep 21:10781552211035695. Epub 2021 Sep 21.

Groupement Hospitalier Sud, Clinical Oncology Pharmacy Department, 26900Hospices Civils de Lyon, France.

Background: Cancer patients are being exposed to antineoplastic drugs more frequently and for longer periods, resulting in a higher risk of hypersensitivity reactions. The aim of this study was to assess the pharmaceutical time and direct cost of drug allergy explorations following immediate hypersensitivity reactions to antineoplastic agents.

Methods: A micro-costing method was used to collect data on consumption of human and material resources for allergy exploration preparations. Read More

View Article and Full-Text PDF
September 2021

Noncovalent Interactions with PAMAM and PPI Dendrimers Promote the Cellular Uptake and Photodynamic Activity of Rose Bengal: The Role of the Dendrimer Structure.

J Med Chem 2021 Sep 21. Epub 2021 Sep 21.

Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska St., 90-236 Lodz, Poland.

Rose bengal is an anionic dye considered as a potential photosensitizer for anticancer photodynamic therapy. The clinical utility of rose bengal is hampered by its short half-life, limited transmembrane transport, aggregation, and self-quenching; consequently, efficient drug carriers that overcome these obstacles are urgently required. In this study, we performed multilevel and characterization of interactions between rose bengal and cationic poly(amidoamine) (PAMAM) and poly(propyleneimine) (PPI) dendrimers of the third and fourth generation and assessed the ability of the resultant complexes to modulate the photosensitizing properties of the drug. Read More

View Article and Full-Text PDF
September 2021

Lower limb amputation for chronic pain and/or functional impairment.

J Rehabil Med 2021 Sep 21. Epub 2021 Sep 21.

UZ Leuven Campus Pellenberg, Weligerveld 1, 3212 Pellenberg, Belgium. E-mail:

Objective: To evaluate the impact of a lower limb amputation for chronic pain and/or functional impairment on pain and participation in daily living activities and to assess the use of prostheses. To improve decision-making for this controversial treatment.

Design: Survey. Read More

View Article and Full-Text PDF
September 2021

Knockdown of Uridine Diphosphate Glucosyltransferase 86Dg Enhances Susceptibility of Tribolium castaneum (Coleoptera: Tenebrionidae) to Artemisia vulgaris (Asterales: Asteraceae) Essential Oil.

J Econ Entomol 2021 Sep 21. Epub 2021 Sep 21.

College of Biology and Food Engineering, Anyang Institute of Technology, Anyang, Henan, China.

Uridine diphosphate glucosyltransferases (UGTs), which are phase II detoxification enzymes, are found in various organisms. These enzymes play an important role in the detoxification mechanisms of plant allelopathy and in insects. Artemisia vulgaris L. Read More

View Article and Full-Text PDF
September 2021

Psychoeducational Social Anxiety Mobile Apps: Systematic Search in App Stores, Content Analysis, and Evaluation.

JMIR Mhealth Uhealth 2021 Sep 21;9(9):e26603. Epub 2021 Sep 21.

School of Medicine, Western Sydney University, Blacktown, New South Wales, Australia.

Background: The wide use of mobile health apps has created new possibilities in social anxiety education and treatment. However, the content and quality of social anxiety apps have been quite unclear, which makes it difficult for people to choose appropriate apps to use on smartphones and tablets.

Objective: This study aims to identify the psychoeducational social anxiety apps in the two most popular Australian app stores, report the descriptive and technical information provided in apps exclusively for social anxiety, evaluate app quality, and identify whether any apps would be appropriate for people with social anxiety or others who know someone with social anxiety. Read More

View Article and Full-Text PDF
September 2021

Budget Impact of the Flash Continuous Glucose Monitoring System in Medicaid Diabetes Beneficiaries Treated with Intensive Insulin Therapy.

Diabetes Technol Ther 2021 Sep;23(S3):S36-S44

Abbott Diabetes Care, Alameda, California, USA.

We assessed the economic impact of using the newest flash continuous glucose monitoring (CGM) among Medicaid beneficiaries with diabetes treated with intensive insulin therapy (IIT). A budget impact analysis was created to assess the impact of increasing the proportion of Medicaid beneficiaries with diabetes on IIT, who use flash CGM by 10%. The analysis included glucose monitoring device costs, cost savings due to reductions in glycated hemoglobin, severe hypoglycemia events, and hyperglycemic emergencies such as diabetic ketoacidosis. Read More

View Article and Full-Text PDF
September 2021

Upregulation of AQP4 Improves Blood-Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage.

Neurotherapeutics 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

In intracerebral hemorrhage (ICH), delayed secondary neural damages largely occur from perihematomal edema (PHE) resulting from the disruption of the blood-brain barrier (BBB). PHE is often considered the principal cause of morbidity and mortality in patients with ICH. Nevertheless, the main cellular mechanism as well as the specific BBB component involved in the formation of PHE after ICH remains elusive. Read More

View Article and Full-Text PDF
September 2021

Clinical Observation on the Improvement of Serum Sex Hormone and Ovarian Function in Premature Ovarian Failure Patients with Deficiency-Cold Syndrome by Combining Wenjing Decoction with Tiaobu Chongren Acupuncture and Moxibustion.

Evid Based Complement Alternat Med 2021 11;2021:3926822. Epub 2021 Sep 11.

Chongqing Red Cross Hospital (Jiangbei District People's Hospital), No. 1, Jialing Village 1, Huaxin Street, Jiangbei District, Chongqing 400020, China.

Objective: To explore the effect of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on serum sex hormones and ovarian function recovery in premature ovarian failure (POF) patients with deficiency-cold syndrome.

Methods: From February 2018 to October 2019, 119 POI patients with deficiency-cold syndrome who met the selection criteria were randomly divided into the control group ( = 59) and the observation group ( = 60). The control group was treated with hormone replacement therapy, and the observation group was treated with Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on the basis of the control group. Read More

View Article and Full-Text PDF
September 2021

Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP.

Nat Rev Neurol 2021 Sep 20. Epub 2021 Sep 20.

Department of Medicine, Institute of Clinical Sciences Lund, Lund University, Lund, Sweden.

Migraine is ranked as the second highest cause of disability worldwide and the first among women aged 15-49 years. Overall, the incidence of migraine is threefold higher among women than men, though the frequency and severity of attacks varies during puberty, the menstrual cycle, pregnancy, the postpartum period and menopause. Reproductive hormones are clearly a key influence in the susceptibility of women to migraine. Read More

View Article and Full-Text PDF
September 2021

Human genetic basis of coronavirus disease 2019.

Signal Transduct Target Ther 2021 09 20;6(1):344. Epub 2021 Sep 20.

Health Management Center, the Third Xiangya Hospital, Central South University, Changsha, China.

Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable morbidity and mortality worldwide. COVID-19 incidence, severity, and mortality rates differ greatly between populations, genders, ABO blood groups, human leukocyte antigen (HLA) genotypes, ethnic groups, and geographic backgrounds. This highly heterogeneous SARS-CoV-2 infection is multifactorial. Read More

View Article and Full-Text PDF
September 2021

Multifunctional Biomedical Applications of Nitrogen and Sulfur Co-Doped Carbon Dots.

J Biomed Nanotechnol 2021 Aug;17(8):1598-1611

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, P. R. China; National Demonstration Center for Experimental Ethnopharmacology Education (South-Central University for Nationalities), Wuhan 430065, China.

Multifunctional carbon dots have drawn considerable attention due to their potential biomedical application value. We report the preparation of blue-green fluorescence-emitting, multifunctional, nitrogen-and-sulfur co-doped carbon dots (N, S-CDs) synthesized via a one-step process using 1-thioglycerol as a sulfur source, glucose and citric acid as carbon sources, and polyethyleneimine as a nitrogen source. Because of abundant amino and sulfur content, the CDs exhibited high sensibility and selectivity for detecting Cu (detection limit: 0. Read More

View Article and Full-Text PDF

Exploration of the profile-effect relationship of Siraitia grosvenorii aqueous extracts related to their laxative effect on the basis of gray correlation analysis.

BMC Complement Med Ther 2021 Sep 20;21(1):235. Epub 2021 Sep 20.

NHC Key Laboratory of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, 200032, PR China.

Background: Siraitia grosvenorii (binomial name Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Read More

View Article and Full-Text PDF
September 2021

Any Role of High-Dose Vitamin C for Septic Shock in 2021?

Semin Respir Crit Care Med 2021 10 20;42(5):672-682. Epub 2021 Sep 20.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, Georgia.

While the use of vitamin C as a therapeutic agent has been investigated since the 1950s, there has been substantial recent interest in the role of vitamin C supplementation in critical illness and particularly, sepsis and septic shock. Humans cannot synthesize vitamin C and rely on exogenous intake to maintain a plasma concentration of approximately 70 to 80 μmol/L. Vitamin C, in healthy humans, is involved with antioxidant function, wound healing, endothelial function, and catecholamine synthesis. Read More

View Article and Full-Text PDF
October 2021

Mechanisms of Pharmacoresistance in Hepatocellular Carcinoma: New Drugs but Old Problems.

Semin Liver Dis 2021 Sep 20. Epub 2021 Sep 20.

Experimental Hepatology and Drug Targeting (HEVEPHARM), University of Salamanca, IBSAL, Salamanca, Spain.

Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis when diagnosed at advanced stages in which curative treatments are no longer applicable. A small group of these patients may still benefit from transarterial chemoembolization. The only therapeutic option for most patients with advanced HCC is systemic pharmacological treatments based on tyrosine kinase inhibitors (TKIs) and immunotherapy. Read More

View Article and Full-Text PDF
September 2021

Isatidis Radix and Isatidis Folium: A systematic review on ethnopharmacology, phytochemistry and pharmacology.

J Ethnopharmacol 2021 Sep 17:114648. Epub 2021 Sep 17.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China. Electronic address:

Ethnopharmacological Relevance: Isatidis Radix (called Banlangen, BLG in Chinese) and Isatidis Folium (called Daqingye, DQY in Chinese) are common traditional edible-medicinal herbs in detoxifying for thousands of years, have been traditionally applied in traditional Chinese medicine for centuries. Both of them are bitter in taste, coolness in nature, acting on the heart and stomach channels. They are often used to treat influenza and other viral infectious diseases in clinic, as well as could treat fever, dizziness, and cough and sore throat caused by lung heat. Read More

View Article and Full-Text PDF
September 2021

Evaluation of neutrophil functional activity for rhinosinusitis diagnosis.

Klin Lab Diagn 2021 Sep;66(9):552-557

Penza Institute for Further Training of Physicians - Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuing Professional Education» of the Ministry of Healthcare of the Russian Federation.

Bacterial rhinosinusitis (BRS) is a complicated form of rhinosinusitis, characterized by its acute course and tendency to chronicity. A significant role in pathogenetic mechanisms of HRS is played by functional state of neutrophils responsible for inflammation development at HRS. Investigation of neutrophils metabolic activity on external stimuli by chemiluminescence method in patients with acute and chronic forms of the disease will enable to develop method of differential diagnostics of BRS forms. Read More

View Article and Full-Text PDF
September 2021

Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity.

J Eur Acad Dermatol Venereol 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology, Hôpital Saint Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.

Importance: Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of hereditary epidermolysis bullosa, with a poorly understood pathogenesis and no satisfactory treatment.

Objective: To assess the clinical and biological features, genetic basis and therapeutic management in order to better characterize this rare genodermatosis.

Design: We have conducted a retrospective study, reviewing the clinical presentation, genetic diagnosis, biological analyses and management of patients with dystrophic epidermolysis bullosa pruriginosa. Read More

View Article and Full-Text PDF
September 2021

Elevated Circulating Levels of Glycoprotein Non-Metastatic Melanoma Protein B as a Predictor of Gestational Diabetes Mellitus.

Clin Lab 2021 Sep;67(9)

Background: The current study aims to investigate the differences of glycoprotein non-metastatic melanoma protein B (GPNMB) levels between gestational diabetes mellitus (GDM) women and normal blood glucose women during pregnancy to provide the basis for early intervention and treatment of GDM.

Methods: The level of GPNMB was detected using an enzyme-linked immunosorbent assay (ELISA). Pearson's correlation assay was performed to analyze the correlation between serum GPNMB and fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c). Read More

View Article and Full-Text PDF
September 2021

3D and 4D Tumorigenesis Model for the Quantitative Analysis of Cancer Cell Behavior and Screening for Anticancer Drugs.

Methods Mol Biol 2022 ;2364:299-318

Developmental Studies Hybridoma Bank and W.M. Keck Dynamic Image Analysis Facility, Department of Biology, The University of Iowa, Iowa City, IA, USA.

Cancer cells from cell lines and tumor biopsy tissue undergo aggregation and aggregate coalescence when dispersed in a 3D Matrigel™ matrix. Coalescence is a dynamic process mediated by a subset of cells within the population of cancer cells. In contrast, non-tumorigenic cells from normal cell lines and normal tissues do not aggregate or coalesce, nor do they possess the motile cell types that orchestrate coalescence of cancer cells. Read More

View Article and Full-Text PDF
January 2022

Quantitative proteomics analysis reveals novel insights into mechanisms of action of Disulfiram (DSF).

Proteomics Clin Appl 2021 Sep 20:e2100031. Epub 2021 Sep 20.

Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China.

Purpose: DSF has been proven safe and shows the promising anti-tumor effect in preclinical studies. However, the precise mechanism of DSF on tumor is rarely reported. This study aims to fully understand the mechanism of action of DSF with a systems perspective in anti-cancer effects. Read More

View Article and Full-Text PDF
September 2021

Immunopathological basis of immune-related adverse events induced by immune checkpoint blockade therapy.

Immunol Med 2021 Sep 19:1-11. Epub 2021 Sep 19.

Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Despite the considerable success of cancer immunotherapy with immune checkpoint inhibitors, their nonspecific release of the immunosuppressive mechanism is often associated with immune-related adverse events (irAEs). irAEs significantly disturb patients' quality of life and can even be life-threatening. Therefore, the appropriate management of irAEs is crucial for the development of further reliable cancer immunotherapies. Read More

View Article and Full-Text PDF
September 2021

Identification of hub genes in bladder cancer based on weighted gene co-expression network analysis from TCGA database.

Cancer Rep (Hoboken) 2021 Sep 20:e1557. Epub 2021 Sep 20.

College of Life Sciences, Xinyang Normal University, Xinyang, China.

Background: Muscular invasive bladder cancer (MIBC) is a common malignant tumor in the world. Because of their heterogeneity in prognosis and response to treatment, biomarkers that can predict survival or help make treatment decisions in patients with MIBC are essential for individualized treatment.

Aim: We aimed to integrate bioinformatics research methods to identify a set of effective biomarkers capable of predicting, diagnosing, and treating MIBC. Read More

View Article and Full-Text PDF
September 2021

Isolated aneurysms of the spinal circulation: a systematic review of the literature.

Neurosurg Rev 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 5-109, Baltimore, MD, 21287, USA.

Aneurysms arising in the spinal circulation are rare and underreported. The objective of this study was to systematically review the English literature on different aspects of isolated spinal aneurysms using the PubMed, Ovid MEDLINE, and Google Scholar databases. Eighty-two papers reporting 107 individual patient cases were included. Read More

View Article and Full-Text PDF
September 2021

Scope and challenges of machine learning-based diagnosis and prognosis in clinical dentistry: A literature review.

J Clin Transl Res 2021 Aug 30;7(4):523-539. Epub 2021 Jul 30.

Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil.

Background: Machine learning (ML) has emerged as a branch of artificial intelligence dealing with the analysis of large amounts of data. The applications of ML algorithms have also expanded to health care, including dentistry. Recent advances in this field point to future improvements in diagnostic techniques and the prognosis of various diseases of the teeth and other maxillofacial structures. Read More

View Article and Full-Text PDF

Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system.

Synth Syst Biotechnol 2021 Sep 9;6(3):231-241. Epub 2021 Sep 9.

Department of Biochemical Engineering, University College London, UK.

The development of Drug Delivery Systems (DDS) has led to increasingly efficient therapies for the treatment and detection of various diseases. DDS use a range of nanoscale delivery platforms produced from polymeric of inorganic materials, such as micelles, and metal and polymeric nanoparticles, but their variant chemical composition make alterations to their size, shape, or structures inherently complex. Genetically encoded protein nanocages are highly promising DDS candidates because of their modular composition, ease of recombinant production in a range of hosts, control over assembly and loading of cargo molecules and biodegradability. Read More

View Article and Full-Text PDF
September 2021

Patients' awareness about their own breast cancer characteristics.

World J Clin Cases 2021 Aug;9(24):7043-7052

Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China.

Background: Patients' knowledge about the characteristics of their own cancer could be an important factor for understanding treatment regimens and adhering to therapies. However, to date nothing is known about the awareness among Chinese breast cancer patients about the characteristics of their own tumors.

Aim: To investigate how much knowledge that Chinese breast cancer patients have about their tumor characteristics and the impact of health and education literacy on the acquisition of such information. Read More

View Article and Full-Text PDF