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LaSnO/g-CN nanocomposites: Rapid and green sonochemical fabrication and photo-degradation performance for removal of dye contaminations.

Ultrason Sonochem 2021 Jul 24;77:105678. Epub 2021 Jul 24.

Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P. O. Box.87317-51167, Iran. Electronic address:

The deficiency of drinking water sources has become a serious crisis for the future of the world that the photocatalytic process is one of the most favorable methods for removal of artificial dyes and poisonous organic impurities. In the present study, rapid ultrasonic treatment was performed to obtain LaSnO/Graphitic carbon nitrides (LSO/CN) nanocomposites with advanced photo-catalytic performance. Broccoli extract was utilized as a natural surfactant with active surface groups to control nucleation and growth of formed crystals with the creation of spatial barriers around the cations, and finally prevent nano-product agglomeration. Read More

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A novel pyrrole-imidazole polyamide targets Aurora kinase A and suppresses tumor growth in vivo.

Biochem Biophys Res Commun 2021 Jul 27;571:167-173. Epub 2021 Jul 27.

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address:

Aurora kinase A (Aurora A) plays a critical role in regulating cell mitotic progression and has been considered as a promising drug target for cancer therapy. To develop a novel molecule targeting Aurora A with high selectivity and efficacy, we designed and synthesized a pyrrole-imidazole polyamide (PIP) Hoechst conjugate, PIP-Ht, targeting to a cell-cycle regulated DNA sequence locating at the promoter of human Aurora A gene (AURKA). PIP-Ht potently suppressed AURKA promoter activities, mRNA expression and protein level, induced tumor cell cycle delay and inhibited tumor cell proliferation in vitro. Read More

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Efficient degradation of sulfamethazine via activation of percarbonate by chalcopyrite.

Water Res 2021 Jul 22;202:117451. Epub 2021 Jul 22.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.

In this work, the novel application of chalcopyrite (CuFeS) for sodium percarbonate (SPC) activation towards sulfamethazine (SMT) degradation was explored. Several key influencing factors like SPC concentration, CuFeS dosage, reaction temperature, pH value, anions, and humic acid (HA) were investigated. Experimental results indicated that SMT could be effectively degraded in the neutral reaction media by CuFeS/SPC process (86. Read More

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Radiomic models for lymph node metastasis prediction in cervical cancer: can we think beyond sentinel lymph node?

Transl Oncol 2021 Jul 27;14(10):101185. Epub 2021 Jul 27.

Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Dipartimento per la salute della Donna e del Bambino e della Salute Pubblica, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

Liu and colleagues performed a retrospective study to validate a computed tomography (CT) scan-based radiomic model to detect lymph node metastasis in cervical cancer. The proposed model incorporating the arterial and venous phase CT-scan features represented a non-invasive method exhibiting high sensitivity in the prediction of lymph node metastasis. It is well established that lymph node metastasis is one of the most significant prognostic factors in cervical cancer. Read More

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Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring.

Bone 2021 Jul 27:116133. Epub 2021 Jul 27.

Department of Orthopedic Surgery; Department of Advanced Therapy for Musculoskeletal Disorders II; Department of Musculoskeletal Reconstruction and Regeneration Surgery; Department of Orthopedic Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Electronic address:

Changes in bone metabolism occur in mothers during pregnancy or lactation that may decrease bone mass and result in fragility fractures after partum. However, use of drugs during pregnancy or lactation to counteract these effects is often prohibited or strongly discouraged. Therefore, approaches to protect mothers from fragility fractures have not been established. Read More

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Photothermal Therapy Mediated by Gold Nanocages Composed of Anti-PDL1 and Galunisertib for Improved Synergistic Immunotherapy in Colorectal Cancer.

Acta Biomater 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), International Research Center for Chemistry-Medicine Joint Innovation, College of Chemistry, Jilin University, Changchun, 130012, China.

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. The primary treatment for CRC is surgical resection, along with chemotherapy in more advanced or inoperable cases. There is a growing interest to complement both curative and palliative treatment with immunotherapies such as the programmed cell death-1 (PD-1) and PD-ligand 1 (PDL1) checkpoint inhibitors and transforming growth factor (TGF) β inhibitors. Read More

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Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential.

Stem Cell Reports 2021 Jul 16. Epub 2021 Jul 16.

InterAcademy Partnership, ICTP Campus, c/o TWAS, Trieste 34151, Italy.

Regenerative medicine has great potential. The pace of scientific advance is exciting and the medical opportunities for regeneration and repair may be transformative. However, concerns continue to grow, relating to problems caused both by unscrupulous private clinics offering unregulated therapies based on little or no evidence and by premature regulatory approval on the basis of insufficient scientific rationale and clinical evidence. Read More

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Deep Brain Stimulation Programming Strategies: Segmented Leads, Independent Current Sources and Future Technology.

Expert Rev Med Devices 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, University of Florida College of Medicine, P.O. Box 100236 Gainesville, FL 32610.

Introduction: Advances in neuromodulation and deep brain stimulation (DBS) technologies have facilitated opportunities for improved clinical benefit and side effect management. New technologies have however, added complexity to clinic-based DBS programming.

Areas Covered: In this article, we review basic basal ganglia physiology, proposed mechanisms of action and technical aspects of DBS. Read More

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From late fatherhood to prenatal screening of monogenic disorders: evidence and ethical concerns.

Hum Reprod Update 2021 Jul 30. Epub 2021 Jul 30.

Competence Centre on Health Technologies, Tartu, Estonia.

Background: With the help of ART, an advanced parental age is not considered to be a serious obstacle for reproduction anymore. However, significant health risks for future offspring hide behind the success of reproductive medicine for the treatment of reduced fertility associated with late parenthood. Although an advanced maternal age is a well-known risk factor for poor reproductive outcomes, understanding the impact of an advanced paternal age on offspring is yet to be elucidated. Read More

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Modified cellulose nanofibril aerogel: Tunable catalyst support for treatment of 4-Nitrophenol from wastewater.

Chemosphere 2021 Jul 8;285:131448. Epub 2021 Jul 8.

Department of Environmental Engineering, Chungbuk National University, Chungdae-ro 1, Seowon-Gu, Cheongju, Chungbuk, 28644, Republic of Korea. Electronic address:

4-Nitrophenol (4-NP) is a hazardous aromatic compound widely used for various industries. Catalytic reduction of 4-NP using metal nanoparticles (NPs) is a highly effective method to treat 4-NP from waste effluent. Even though lots of methods have investigated to prepare efficient metal NPs composites, the nano and/or micro size of composites makes it hard to recover after wastewater treatment, limiting its practical use. Read More

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Enhanced nutrient removal and facilitating granulation via intermittent aeration in simultaneous partial nitrification endogenous denitrification and phosphorus removal (SPNEDpr) process.

Chemosphere 2021 Jul 6;285:131443. Epub 2021 Jul 6.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing, 100124, PR China.

A novel simultaneous partial nitrification, endogenous denitrification and phosphorus removal (SPNEDpr) system was operated for 213 days in a sequencing batch reactor to treat real domestic sewage. The nutrient removal was achieved under an operation mode of intermittent aeration at unequal intervals with low oxygen concentrations. Through optimizing intermittent aeration conditions, the removal efficiencies of total inorganic nitrogen (TIN), POP and chemical oxygen demand (COD) reached 78. Read More

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Facile construction of dual heterojunction [email protected]/MXene hybrid with efficient and stable catalytic activity for phenol degradation with peroxymonosulfate under visible light irradiation.

J Hazard Mater 2021 Jul 18;420:126686. Epub 2021 Jul 18.

CSIRO Manufacturing, Private Bag 10, Clayton South, VIC 3169, Australia. Electronic address:

Photocatalysis and peroxymonosulfate (PMS) based advanced oxidation processes (AOP) are emerging technology for the degradation of refractory organic pollutant in the field of water treatment. Here we report a novel [email protected]/MXene (CTM) hybrid through a facile sonication-hydrothermal method for efficient degradation of phenol via an integrated PMS activation-photocatalysis process. Benefiting from the proper position and superior suitability of the band structure, a dual interfacial charge transport channel was constructed, boosting the separation of photo-generated charge carriers and generating sufficient potential difference for redox reaction. Read More

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Application of different redox mediators induced bio-promoters to accelerate the recovery of denitrification and denitrifying functional microorganisms inhibited by transient Cr(VI) shock.

J Hazard Mater 2021 Jul 17;420:126664. Epub 2021 Jul 17.

School of Environmental Science and Engineering, Tianjin University, Tianjin 300350, China.

The transient hexavalent chromium (Cr(VI)) shock may directly inhibit the denitrification process of municipal wastewater treatment plants (WWTPs), which is difficult to recover in a short time. This study developed four nontoxic bio-promoters (combination of L-cysteine, flavin adenine dinucleotide (FAD), biotin, cytokinin and different redox mediators) to quickly restore the denitrification performance after high-loading Cr(VI) suppressing. After feeding with 100 mg/L of Cr(VI) for 42 cycles (T, 4 h), the removal efficiency of nitrate was reduced by 85. Read More

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Landfill leachate treatment by persulphate related advanced oxidation technologies.

J Hazard Mater 2021 Jun 8;418:126355. Epub 2021 Jun 8.

School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.

Landfill leachate is produced from garbage decomposition with highly toxic and bio-refractory compounds, which poses serious harm to environmental security and human health. Thus, it is urgent to treat landfill leachate properly. Persulfate (PS) oxidation has attracted extensive attentions in terms of fast reaction speed, non-selectivity to target pollutants and thorough oxidation. Read More

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Nutrients removal by interactions between functional microorganisms in a continuous-flow two-sludge system (AAO-BCO): Effect of influent COD/N ratio.

Sci Total Environ 2021 Jun 22;793:148581. Epub 2021 Jun 22.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, PR China. Electronic address:

Denitrifying phosphorus removal (DPR) technology is one of the most effective approach to simultaneously realize nitrogen (N) and phosphorus (P) removal from low COD/N ratio wastewater. Identifying the interaction of denitrifying phosphate-accumulating organisms (DPAOs), denitrifying glycogen organisms (DGAOs) and denitrifying ordinary heterotrophic organisms (DOHOs) is critical for optimizing denitrification and anoxic P uptake efficiency in DPR processes. In this study, a novel DPR system of anaerobic anoxic oxic - biological contact oxidation (AAO-BCO) was employed to dispose actual sewage with various influent COD/N ratios (3. Read More

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Superior nitrogen removal and sludge reduction in a suspended sludge system with in-situ enriching anammox bacteria for real sewage treatment.

Sci Total Environ 2021 Jun 25;793:148669. Epub 2021 Jun 25.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, PR China. Electronic address:

Mainstream partial anammox provides a cost- and energy-efficient alternative for wastewater treatment. This study provided a new strategy to achieve mainstream partial anammox in a single-stage suspended sludge system. The novel method coupling external excess sludge fermentation with simultaneous partial nitritation-anammox-denitrification process (SF-SPNAD) was established for 202 days in an anaerobic-aerobic-anoxic sequencing batch reactor (AOA-SBR) with real sewage and actual sludge fermentation products. Read More

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The characteristic of N-nitrosodimethylamine precursor release from algal organic matter and degradation performance of UV/HO/O technology.

Sci Total Environ 2021 Jun 28;795:148739. Epub 2021 Jun 28.

Shandong Province Water Supply and Drainage Monitoring Center, 250101 Jinan, China.

Seasonal cyanobacterial blooms in eutrophic water releases algal organic matter (AOM), which contains large amount of dissolved organic nitrogen (DON) and is difficult to be removed effectively by conventional treatment processes (e.g., coagulation and sand filtration) because of its high hydrophilicity. Read More

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Evaluation of Fenton and modified Fenton oxidation coupled with membrane distillation for produced water treatment: Benefits, challenges, and effluent toxicity.

Sci Total Environ 2021 Jul 15;796:148953. Epub 2021 Jul 15.

Department of Environment, Land and Infrastructure Engineering (DIATI), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy. Electronic address:

Membrane distillation is a promising technology to desalinate hypersaline produced waters. However, the organic content can foul and wet the membrane, while some fractions may pass into the distillate and impair its quality. In this study, the applicability of the traditional Fenton process was investigated and preliminarily optimized as a pre-treatment of a synthetic hypersaline produced water for the following step of membrane distillation. Read More

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Synthesis of a novel glibenclamide-pioglitazone hybrid compound and its effects on glucose homeostasis in normal and insulin-resistant rats.

Bioorg Chem 2021 Jul 7;114:105157. Epub 2021 Jul 7.

Universidade Federal de Santa Catarina, Departamento de Bioquímica - Centro de Ciências Biológicas, Campus Universitário, Trindade, CEP: 88040-900 - Florianópolis, SC, Brazil. Electronic address:

A new library of hybrid compounds that combine the functional parts of glibenclamide and pioglitazone was designed and developed. Compounds were screened for their antihyperglycemic effects on the glucose tolerance curve. This approach provided a single molecule that optimizes the pharmacological activities of two drugs used for the treatment of diabetes mellitus type 2 (DM2) and that have distinct biological activities, potentially minimizing the adverse effects of the original drugs. Read More

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SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study.

Mult Scler 2021 Jul 30:13524585211035318. Epub 2021 Jul 30.

Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy/Unit of Neurology, IRCCS Neuromed, Isernia, Italy.

Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available.

Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Read More

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Using knockoffs for controlled predictive biomarker identification.

Stat Med 2021 Jul 30. Epub 2021 Jul 30.

Advanced Methodology and Data Science, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.

One of the key challenges of personalized medicine is to identify which patients will respond positively to a given treatment. The area of subgroup identification focuses on this challenge, that is, identifying groups of patients that experience desirable characteristics, such as an enhanced treatment effect. A crucial first step towards the subgroup identification is to identify the baseline variables (eg, biomarkers) that influence the treatment effect, which are known as predictive variables. Read More

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Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy.

Int J Hematol 2021 Jul 30. Epub 2021 Jul 30.

Department of Healthcare Administration, Nagoya University, Nagoya, Japan.

The optimal treatment for Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) in first complete remission (CR1) has not been established in the high-intensity chemotherapy era. The outcomes of patients with Ph-negative ALL who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched related or unrelated donor in CR1 (HSCT-MRD group and HSCT-MUD group) were obtained from a Japanese registry database. Patients aged 16-24 years and 25-65 years were analyzed separately, and their outcomes were compared to those of patients who continued high-intensity chemotherapy in CR1 in studies (202U group and 202O group) by the Japan Adult Leukemia Study Group (JALSG). Read More

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Improving long-term intraocular pressure and visual outcomes in eyes with aniridic glaucoma.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 30. Epub 2021 Jul 30.

Department of Bio-Statistics, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To study the long-term intraocular pressure (IOP) and visual outcomes in treated aniridic glaucoma.

Methods: A retrospective chart review of patients with aniridia and glaucoma, with ≥ 2-year follow-up, was performed. Eyes in early glaucomatous stages were medically managed, while moderate-severe stage eyes underwent a trabeculectomy with mitomycin-c (MMC). Read More

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Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson's disease.

J Neurol 2021 Jul 30. Epub 2021 Jul 30.

Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, 10126, Turin, Italy.

Background: Parkinson's disease (PD) is increasingly recognized as a multidimensional disorder, characterized by several non-motor symptoms, including disturbances of sleep and cognition. Current studies on the relationship between sleep problems and neuropsychological functions, mainly conducted in early to moderate PD patients, outline mixed results. In this study, we analysed the relationship between subjectively reported sleep alterations and cognitive functions in a large cohort of 181 advanced PD patients. Read More

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The bigger picture of shared decision making: A service design perspective using the care path of locally advanced pancreatic cancer as a case.

Cancer Med 2021 Jul 30. Epub 2021 Jul 30.

Medical Decision Making, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Purpose: Solutions to improve the implementation of shared decision making (SDM) in oncology often focus on the consultation, with limited effects. In this study, we used a service design perspective on the care path of locally advanced pancreatic cancer (LAPC). We aimed to understand how experiences of patients, their significant others, and medical professionals over the entire care path accumulate to support their ability to participate in SDM. Read More

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A Paramedian Approach for Dorsal Root Ganglion Stimulation Placement Developed to Limit Lead Migration and Fracture.

Pain Pract 2021 Jul 30. Epub 2021 Jul 30.

The Spine & Pain Institute of New York, New York, NY, USA.

Introduction: Dorsal root ganglion stimulation (DRG-S), has demonstrated superiority in the treatment of complex regional pain syndrome and causalgia. Lead migration and fracture impact DRG-S therapeutic stability. Lead anchoring reduces DRG-S lead migration without increasing lead fracture. Read More

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Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer.

Cochrane Database Syst Rev 2021 Jul 30;7:CD005343. Epub 2021 Jul 30.

Department of Gynaecological Oncology, Musgrove Park Hospital, Taunton, UK.

Background: Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require a combination of surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. Read More

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New progress in drugs treatment of diabetic kidney disease.

Biomed Pharmacother 2021 Jul 19;141:111918. Epub 2021 Jul 19.

Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but also the leading cause of the end-stage renal disease (ESRD). The occurrence and development of DKD have always been a serious clinical problem that leads to the increase of morbidity and mortality and the severe damage to the quality of life of human beings. Controlling blood glucose, blood pressure, blood lipids, and improving lifestyle can help slow the progress of DKD. Read More

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Home-Based Electrical Stimulation to Accelerate Wound Healing-A Double-Blinded Randomized Control Trial.

J Diabetes Sci Technol 2021 Jul 30:19322968211035128. Epub 2021 Jul 30.

Michael E. DeBakey Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX, USA.

Background: Electrical stimulation (E-Stim) may offer a unique adjunctive treatment to heal complicated diabetic foot ulcers (DFU). Our primary goal is to examine the effectiveness of daily home-based E-Stim therapy to speed-up wound healing.

Methods: Patients with chronic DFUs and mild to severe peripheral arterial disease (PAD) were recruited and randomized to either control (CG) or intervention (IG) groups. Read More

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Tissue Engineering of Corneal Stroma via Melt Electrowriting.

J Tissue Eng Regen Med 2021 Jul 29. Epub 2021 Jul 29.

Ocular Surface Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

The cornea serves as the main refractive component of the eye with the corneal stroma constituting the thickest component in a stratified layered system of epithelia, stroma and endothelium. Current treatment options for patients suffering from corneal diseases are limited to transplantation of a human donor cornea (keratoplasty) or to implantation of an artificial cornea (keratoprosthesis). Nevertheless, donor shortage and failure of artificial corneas to integrate with local tissue constitute important problems that have not been yet circumvented. Read More

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