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Acute kidney injury caused by ammonium acid urate crystals in diabetic ketoacidosis at the onset of type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2021 Feb 26;2021. Epub 2021 Feb 26.

Department of Endocrinology, Chiba Children's Hospital, Chiba, Japan.

Summary: Ammonium acid urate (AAU) crystals are rare in industrialized countries. Furthermore, the number of children with diabetic ketoacidosis (DKA) who develop severe acute kidney injury (AKI) after hospitalization is small. We encountered two patients with AKI caused by AAU crystals during the recovery phase of DKA upon admission. Read More

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February 2021

Intravenous tPA Delays Door-To-Puncture Time in Acute Ischemic Stroke with Large Vessel Occlusion.

J Stroke Cerebrovasc Dis 2021 Apr 14;30(6):105732. Epub 2021 Apr 14.

Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. Electronic address:

Objective: Although intravenous thrombolysis (IVT) is recommended among acute ischemic stroke (AIS) patients secondary to large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT), time delays with bridging therapy (IVT prior to MT) and its potential benefit remains unclear. We compared the time delays and clinical outcomes among AIS SECONDARY TO LVO patients treated with bridging therapy or direct MT (dMT) at a comprehensive stroke center (CSC).

Methods: We performed a retrospective analysis of prospectively collected data of AIS secondary to LVO patients admitted between 2012 and 2017 at a large volume CSC. Read More

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Dl-3-n-butylphthalide pretreatment attenuates renal ischemia/reperfusion injury.

Biochem Biophys Res Commun 2021 Apr 14;557:166-173. Epub 2021 Apr 14.

Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address:

Background: Renal ischemia reperfusion injury (IRI) has become a growing concern in clinical practice with high morbidity and mortality rates. There is currently no effective prophylactic regimen available to prevent its occurrence and to improve its clinical prognosis. Dl-3-n-butylphthalide (NBP) has been used for stroke treatment in China for years. Read More

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Metabolic shifts modulate lung injury caused by infection with H1N1 influenza A virus.

Virology 2021 Apr 6;559:111-119. Epub 2021 Apr 6.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

Influenza A virus (IAV) infection alters lung epithelial cell metabolism in vitro by promoting a glycolytic shift. We hypothesized that this shift benefits the virus rather than the host and that inhibition of glycolysis would improve infection outcomes. A/WSN/33 IAV-inoculated C57BL/6 mice were treated daily from 1 day post-inoculation (d. Read More

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Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain.

Biomed Pharmacother 2021 Apr 14;139:111593. Epub 2021 Apr 14.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan; Stem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Basic Medicine, Fu Jen Catholic University, Taipei, Taiwan; Department of Life Science, Tunghai University, Taichung, Taiwan. Electronic address:

Background: Cerebral ischemic events, comprising of excitotoxicity, reactive oxygen production, and inflammation, adversely impact the metabolic-redox circuit in highly active neuronal metabolic profile which maintains energy-dependent brain activities. Therefore, we investigated neuro-regenerative potential of melatonin (Mel), a natural biomaterial secreted by pineal gland.

Methods: We specifically determined whether Mel could influence tunneling nanotubes (TNTs)-mediated transfer of functional mitochondria (Mito) which in turn may alter membrane potential, oxidative stress and apoptotic factors. Read More

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Indacaterol/glycopyrronium affects lung function and cardiovascular events in patients with chronic obstructive pulmonary diseases: A meta-analysis.

Heart Lung 2021 Apr 13;50(4):532-541. Epub 2021 Apr 13.

Division of Respiratory Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China. Electronic address:

Background: Bronchodilators are the cornerstone for treating patients with chronic obstructive pulmonary diseases (COPD), although some studies have shown that dual bronchodilators may exacerbate incidence of adverse cardiovascular events. Here, we evaluated the cardiopulmonary safety of indacaterol/glycopyrronium (IND/GLY) using a meta-analysis.

Methods: We searched PubMed, OVID, Cochrane Library and Web of Science databases, using "indacaterol/glycopyrronium", "indacaterol/glycopyrrolate", "IND/GLY", "QVA149", "chronic obstructive pulmonary diseases", "COPD", "chronic obstructive airway disease", "chronic obstructive lung disease" as key words. Read More

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Transjugular intrahepatic portosystemic shunt creation for the prevention of gastric variceal rebleeding in patients with hepatocellular carcinoma: a multicenter retrospective study.

J Vasc Interv Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Purpose: To evaluate the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) creation for the prevention of gastric variceal rebleeding in patients with Hepatocellular carcinoma (HCC).

Materials And Methods: This multicenter retrospective study included 126 cirrhotic patients (mean age, 54.1 ± 10. Read More

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Angioedema with severe acute abdominal pain: Think of hereditary angioedema.

Clin Res Hepatol Gastroenterol 2021 Apr 14:101702. Epub 2021 Apr 14.

Director, Division of Gastroenterology and Liver Disease, The George Washington University, 3131 I St NW, Washington, DC, United States.

Angioedema can be either mast cell- (histamine-) mediated or bradykinin-mediated. Treatment approaches for the two types are very different, making differential diagnosis critical. Severe acute abdominal pain caused by intestinal angioedema is commonly misdiagnosed, especially when associated with bradykinin-mediated angioedema. Read More

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Metabolome and lipidome derangements during a severe mast cell activation event in a patient with indolent systemic mastocytosis.

J Allergy Clin Immunol 2021 Apr 14. Epub 2021 Apr 14.

Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Background: The number of mast cells in various organs is manifold elevated in individuals with systemic mastocytosis. Degranulation can lead to life-threatening symptomatology. No data have been published about the alterations of the metabolome and lipidome during an attack. Read More

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Relationship between ambient temperature and severe acute poisoning by alcohol and drugs.

Alcohol 2021 Apr 14. Epub 2021 Apr 14.

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Asklepios Klinikum Harburg, Eißendorfer Pferdeweg 52, 21075 Hamburg, Germany. Electronic address:

Aim: To test the hypothesis that severe acute poisoning by alcohol and drugs is more frequent at higher rather than at lower ambient temperatures.

Method: This was a prospective observational study performed in a prehospital setting under marine west coast climate conditions. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Read More

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Transcervical Carotid Artery Revascularization: a Systematic Review and Meta-analysis of Outcomes.

J Vasc Surg 2021 Apr 14. Epub 2021 Apr 14.

First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.

Objective: Carotid artery stenosis is a determinant factor accused for cerebrovascular events, estimated to be the cause of 10-20% of all ischemic strokes. Trans-cervical carotid artery revascularization (TCAR) has been offered as an alternative to transfemoral carotid artery stenting and carotid endarterectomy.

Methods: A systematic review and meta-analysis of prospective and retrospective studies reporting on outcomes of patients undergoing TCAR for carotid stenosis was conducted. Read More

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In-hospital Outcomes and Long-term Survival of Women of Childbearing Age with Aortic Dissection: Results from a Single-Center Database.

J Vasc Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. Electronic address:

Objective: To define the outcomes and impact of pregnancy in a cohort of women of childbearing age with acute aortic dissection (AAD).

Methods: We reviewed our database of AAD to identify all eligible female patients. Women under the age of 45 were included. Read More

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Outcomes of Extremely Premature Infants Comparing Patent Ductus Arteriosus Management Approaches.

J Pediatr 2021 Apr 14. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, McGill University Health Centre; Department of Epidemiology, Biostatistics and Occupational Health, McGill University.

Objective: To evaluate the change in the proportion of deaths/bronchopulmonary dysplasia (BPD) among premature infants (<26 and 26-29 weeks) following a policy change to a strict non-intervention approach, compared with standard treatment.

Study Design: We examined 1249 infants (341 <26 weeks) at two comparable sites. Site #1 (control) continued medical treatment/ligation, and site #2 (exposed) changed to a non-intervention policy in late 2013. Read More

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Temporal trends and patient characteristics associated with 30-day hospital readmission rates after a first acute myocardial infarction.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Meyers Primary Care Institute, Worcester, MA 01655; Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, 01655.

Background: Limited data exists about relatively recent trends in the magnitude and characteristics of patients who are re-hospitalized after hospital admission for an acute myocardial infarction (AMI). This study examined trends in the frequency and socio-demographic and clinical characteristics of patients readmitted to the hospital within 30 days after an initial acute myocardial infarction.

Methods: We reviewed the medical records of 3,116 individuals who were hospitalized for a validated first acute myocardial infarction in six study periods between 2003 and 2015 at the three major medical centers in central Massachusetts. Read More

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Incidence, risk factors, treatment, and consequences of antibody-mediated kidney transplant rejection: A systematic review.

Clin Transplant 2021 Apr 17:e14320. Epub 2021 Apr 17.

Department of Medicine, Hennepin County Medical Center, Hennepin Healthcare, Minneapolis Minnesota.

Background: Antibody-mediated rejection (AMR) is a leading cause of kidney allograft failure, but its incidence, risk factors, and outcomes are not well understood.

Methods: We searched Ovid MEDLINE, Cochrane, EMBASE, and Scopus from January 2000-January 2020 to identify published cohorts of ≥ 500 incident adult or 75 pediatric kidney transplant recipients followed for ≥ 1 year posttransplant.

Results: At least two reviewers screened 5061 articles and abstracts; 28 met inclusion criteria. Read More

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[Two-stage contralateral combined microvascular and wide-lumen anastomosis inTwo-stage contralateral combined microvascular and wide-lumen anastomosis in a patient with acute ischemic stroke patient with acute ischemic stroke].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):68-74

Regional Clinical Hospital No. 2, Tyumen, Russia.

Common carotid artery (CCA) thrombosis is a rare cause of ischemic stroke. In available literature, we found no studies devoted to cerebral revascularization for CCA occlusion in acute period of ischemic stroke. Successful treatment of concomitant occlusion of CCA, internal (ICA) and external carotid arteries (ECA) with microvascular anastomoses is very interesting for various specialists. Read More

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January 2021

The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C).

Rheumatol Int 2021 Apr 17. Epub 2021 Apr 17.

Department of Pediatrics, Metropolitan Hospital, Piraeus, Greece.

Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C will need intensive care unit. Myocarditis and coronary artery ectasia/aneurysm are included between the main cardiovascular complications in MIS-C. Read More

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THE sGC STIMULATOR OLINCIGUAT ATTENUATES INFLAMMATION, VASO-OCCLUSION AND NEPHROPATHY IN MOUSE MODELS OF SICKLE CELL DISEASE.

Br J Pharmacol 2021 Apr 17. Epub 2021 Apr 17.

Cyclerion Therapeutics Inc., 301 Binney Street, Cambridge, MA, 02142, USA.

Background And Purpose: Reduced nitric oxide (NO) bioavailability, a hallmark of sickle cell disease (SCD), contributes to intravascular inflammation, vasoconstriction, vaso-occlusion, and organ damage observed in SCD patients. Soluble guanylyl cyclase (sGC) catalyzes synthesis of cyclic guanosine monophosphate (cGMP) in response to NO. cGMP amplifying agents, including NO donors and phosphodiesterase 9 inhibitors, alleviate tumor necrosis factor alpha (TNFα)-induced inflammation in wild-type C57BL/6 mice and in "humanized" mouse models of SCD. Read More

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Evaluation of the acute toxicity of Thymus linearis ethanol extract and its effect on the hemato-biochemical and behavioural response of the Golden mahseer, Tor putitora (Hamilton, 1923).

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

ICAR-Directorate of Coldwater Fisheries Research, Bhimtal, Uttarakhand, 263136, India.

The present investigation was conducted to estimate the acute toxicity of Thymus linearis plant extract, its effect on hemato-biochemical parameters and behavioural response in the golden mahseer (Tor putitora). The phytochemical composition present in T. linearis plant extrat were Alkaloids, Flavonoids, Phenols and Tannin. Read More

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The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.

Cell Mol Neurobiol 2021 Apr 16. Epub 2021 Apr 16.

Department of Pharmacology of the School of Medicine of Ribeirão Preto, University of São Paulo, Ave. Bandeirantes, São Paulo, Ribeirão Preto, 3900-14049-900, Brazil.

The renin-angiotensin system (RAS) is involved in cardiovascular and hydroelectrolytic control, being associated with the development of hypertension. The restraint stress (RS) model is an aversive situation, which promotes a sustained increase in blood pressure and heart rate, and stimulation of the hypothalamic-pituitary-adrenal axis. Stress leads to an increase of angiotensin-II contents both in the circulation and the central nervous system (CNS), as well as an increased expression of AT-1 receptors in CNS structures related to stress. Read More

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Focal seizures with impaired awareness as long-term neurological complication of COVID-19: a case report.

Neurol Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Neuroscience "Rita Levi Montalcini", University of Torino, Via Cherasco 15, 10126, Turin, Italy.

We report here the first case of a young individual otherwise healthy, who presented with frequent focal seizures with impaired awareness as a possible long-term complication of severe acute respiratory syndrome coronavirus-2 infection. Seizures were documented by electroencephalography and responded clinically and neuro-physiologically to antiseizure therapy. The patient underwent an extensive investigation including cerebrospinal fluid examination, conventional and quantitative brain magnetic resonance imaging, and 18-FDG positron emission tomography. Read More

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Effects of Different Ammonia Levels on Tribenuron Methyl Toxicity in Daphnia magna.

Arch Environ Contam Toxicol 2021 Apr 16. Epub 2021 Apr 16.

Department of Biology, Faculty of Science and Letters, Adıyaman University, 02040, Adıyaman, Turkey.

The present study investigates the toxicity of the herbicide tribenuron methyl (TBM) as an anthropogenic agent and ammonia as an abiotic factor on Daphnia magna at environmentally relevant concentrations. These stressors may coexist in surface waters in agricultural regions. To achieve this objective, D. Read More

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Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2021 Apr 16. Epub 2021 Apr 16.

Division of Medical Oncology, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Acute myeloid leukemia (AML) patients often undergo allogeneic hematopoietic cell transplantation (alloHCT) in first complete remission (CR). We examined the effect of depth of clinical response, including incomplete count recovery (CRi) and/or measurable residual disease (MRD), in patients from the Center for International Blood and Marrow Transplantation Research (CIBMTR) registry. We identified 2492 adult patients (1799 CR and 693 CRi) who underwent alloHCT between January 1, 2007 and December 31, 2015. Read More

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Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish.

Sci Rep 2021 Apr 16;11(1):8392. Epub 2021 Apr 16.

Department of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, 879-5593, Japan.

Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to sensitize the intracellular leucine concentration to the mammalian target of rapamycin complex 1 (mTORC1) activation. Biallelic mutation in the LARS gene causes infantile liver failure syndrome type 1 (ILFS1), which is characterized by acute liver failure, anaemia, and neurological disorders, including microcephaly and seizures. Read More

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Myalgia as a symptom at hospital admission by SARS-CoV-2 infection is associated to persistent musculoskeletal pain as long-term post-COVID sequelae: a case-control study.

Pain 2021 Apr 8. Epub 2021 Apr 8.

Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), Madrid. Spain. Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark Department of Neurology, Hospital Clínico San Carlos. Madrid, Spain Department of Public Health, Universidad Rey Juan Carlos (URJC), Madrid. Spain.

Abstract: This study investigated the association between COVID-related myalgia experienced by patients at hospital admission and the presence of post-COVID symptoms. A case-control study including patients hospitalised due to COVID-19 between February 20 and May 31, 2020 was conducted. Patients reporting myalgia and patients without myalgia at hospital admission were scheduled for a telephone interview 7 months after hospital discharge. Read More

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Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations.

Pain 2021 Apr 8. Epub 2021 Apr 8.

University of Rochester Medical Center, Rochester, NY, USA University of Washington, Seattle, WA, USA Stony Brook School of Medicine, Stony Brook, NY, USA Queens University, Kingston, Ontario, Canada (Formally) U.S. Food and Drug Administration, Silver Spring, MD, USA WCG Analgesic Solutions, Wayland, MA, USA John's Hopkins School of Medicine, Baltimore, MD, USA University of California San Francisco, San Francisco, CA, USA University of Pennsylvania, Philadelphia, PA, USA Indiana University School of Medicine, Indianapolis, IN, USA Brigham and Women's Hospital / Harvard Medical School, Boston, MA, USA Carolinas Pain Institute, Charlotte, NC, USA Innocoll, Athlone, Ireland American Chronic Pain Association, Rocklin, CA, USA Wake Forest School of Medicine, Winston-Salem, NC, USA Southern Illinois University Edwardsville, Edwardsville, IL, USA GW Pharmaceuticals, Carlsbad, CA, USA Biogen, Cambridge, MA, USA University at Buffalo, Buffalo, NY, USA McGill University, Montreal, Canada MCPHS University, Boston, MA National Institutes of Health, Bethesda, MD, USA U.S. Department of Veterans Affairs / George Washington University, Washington, DC, USA (Formally) Pacira , Parsippany, NY, USA SDG LLC, Cambridge, MA, USA Sarepta, Cambridge, MA, USA Pfizer, NYC, NY, USA University of Pittsburgh, Pittsburgh, PA, USA Flexion Therapeutics, Burlington, MA, USA.

Abstract: Randomized clinical trials have demonstrated the efficacy of opioid analgesics for the treatment of acute and chronic pain conditions, and for some patients, these medications may be the only effective treatment available. Unfortunately, opioid analgesics are also associated with major risks (e.g. Read More

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Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents.

Pain 2021 Apr 13. Epub 2021 Apr 13.

Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia, 5042, Australia Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia Discipline of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia Arena Pharmaceuticals, Inc, San Diego, CA, USA.

Abstract: Abdominal pain is a key symptom of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), for which there are inadequate therapeutic options. We tested whether olorinab-a highly selective, full agonist of the cannabinoid receptor 2 (CB2)-reduced visceral hypersensitivity in models of colitis and chronic visceral hypersensitivity (CVH). In rodents, colitis was induced by intrarectal administration of nitrobenzene sulfonic acid derivatives. Read More

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From acute to long-term alterations in pain processing and modulation after spinal cord injury: mechanisms related to chronification of central neuropathic pain.

Pain 2021 Apr 13. Epub 2021 Apr 13.

Department of Physical Therapy at Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University Department of Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer Department of Rehabilitation Sackler Faculty of Medicine, Tel Aviv University Barzilai Medical Center, Ashkelon.

Abstract: A severe and debilitating consequence of a spinal cord injury (SCI) is central neuropathic pain (CNP). Our aim was to investigate the processes leading to CNP emergence and chronification by analyzing causal relationship over time between spinothalamic function, pain excitability, and pain inhibition after SCI.This longitudinal follow-up study included 53 patients with acute SCI and 20 healthy controls. Read More

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CHK2 inhibition provides a strategy to suppress hematological toxicity from PARP inhibitors.

Mol Cancer Res 2021 Apr 16. Epub 2021 Apr 16.

Blood Cells and Blood Cancer, The Walter and Eliza Hall Institute

Cancer patients treated with poly (ADP-ribose) polymerase inhibitors (PARPi) experience various side effects, with hematological toxicity being most common. Short term treatment of mice with olaparib resulted in depletion of reticulocytes, B cell progenitors and immature thymocytes, whereas longer treatment induced broader myelosuppression. We performed a CRISPR/Cas9 screen that targeted DNA repair genes in Eµ-Myc pre-B lymphoma cell lines as a way to identify strategies to suppress hematological toxicity from PARPi. Read More

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