13,395 results match your criteria treatment 513


Early detection of MDR Mycobacterium tuberculosis mutations in Pakistan.

Sci Rep 2021 Aug 18;11(1):16736. Epub 2021 Aug 18.

Division of Molecular Virology and Infectious Diseases, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, 87-West Canal Bank Road, Thokar Niaz Baig, Lahore, Pakistan.

The result of improper treatment has led to the rise of Multidrug-resistant (MDR) strains. This concern still exists in Pakistan. In order to save energy, time and resources an early detection of resistant cases is imperative. Read More

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[Comparison of diagnostic performance of thyroid autoantibodies and high-resolution ultrasound in euthyroid Hashimoto's thyroiditis].

Zhonghua Yi Xue Za Zhi 2021 Aug;101(32):2537-2543

Department of Endocrinology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To compare the diagnostic performance of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and high-resolution ultrasound (HRUS) in euthyroid Hashimoto's thyroiditis (HT). From January 2016 to January 2019, patients with complete data of preoperative thyroid function, TPOAb, TgAb and HRUS who had undergone thyroid surgery treatment at the First Affiliated Hospital with Nanjing Medical University were reviewed. The diagnostic value of different diagnostic methods was compared using histopathology (HP) examination result as the gold standard. Read More

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[Treatment efficacy of dietary supplement Licofor for dry eye associated with meibomian gland dysfunction].

Zhonghua Yi Xue Za Zhi 2021 Aug;101(32):2508-2513

Eye Center of Xiangya Hospital, Central South University, Hunan Key Laboratory of Ophthalmology, Changsha 410008, China.

To evaluate the clinical efficacy of dietary supplement Licofor in the treatment of dry eye associated with meibomian gland dysfunction (MGD). This was a prospective, randomized controlled clinical trial. Sixty patients [25 males, 35 females, aged (42±13) years] who had dry eye associated with MGD were recruited in Xiangya Hospital of Central South University from December 2018 to October 2019. Read More

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Prevalence and modifiable risk factors of degenerative valvular heart disease among elderly population in southern China.

J Geriatr Cardiol 2021 Jul;18(7):523-533

Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China.

Objective: To investigate the prevalence and modifiable risk factors of degenerative valvular heart disease (DVHD) among elderly population in southern China.

Methods: A stratified multistage sampling method was used to recruit subjects. The contents of the survey included the questionnaire, laboratory examination, echocardiography, and other auxiliary examinations. Read More

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Association between post-hospital clinic and telephone follow-up provider visits with 30-day readmission risk in an integrated health system.

BMC Health Serv Res 2021 Aug 17;21(1):826. Epub 2021 Aug 17.

Department of Research and Evaluation, Kaiser Permanente Southern California, Research and Evaluation, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA.

Background: Follow-up visits with clinic providers after hospital discharge may not be feasible for some patients due to functional limitations, transportation challenges, need for physical distancing, or fear of exposure especially during the current COVID-19 pandemic.

Methods: The aim of the study was to determine the effects of post-hospital clinic (POSH) and telephone (TPOSH) follow-up provider visits versus no visit on 30-day readmission. We used a retrospective cohort design based on data from 1/1/2017 to 12/31/2019 on adult patients (n = 213,513) discharged home from 15 Kaiser Permanente Southern California hospitals. Read More

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SELP Asp603Asn and severe thrombosis in COVID-19 males.

J Hematol Oncol 2021 08 16;14(1):123. Epub 2021 Aug 16.

Medical Genetics Unit, University of Siena, Policlinico Le Scotte, Viale Bracci, 2, 53100, Siena, Italy.

Thromboembolism is a frequent cause of severity and mortality in COVID-19. However, the etiology of this phenomenon is not well understood. A cohort of 1186 subjects, from the GEN-COVID consortium, infected by SARS-CoV-2 with different severity was stratified by sex and adjusted by age. Read More

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Factors associated with testing for HIV and hepatitis C among behaviorally vulnerable men in Germany: a cross-sectional analysis upon enrollment into an observational cohort.

AIDS Res Ther 2021 08 16;18(1):52. Epub 2021 Aug 16.

Institute of Virology, Medical Faculty, University Bonn, Bonn, Germany.

Background: HIV and hepatitis C virus (HCV) have shared routes of transmission among men who have sex with men (MSM). Routine testing facilitates early diagnosis and treatment, thereby preventing morbidity and onward transmission. We evaluated factors associated with HIV and HCV testing in a behaviorally vulnerable cohort of predominantly MSM. Read More

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Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: A promising approach in cancer treatment.

Drug Discov Today 2021 Aug 12. Epub 2021 Aug 12.

Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Cancer is the second leading cause of death worldwide. Despite the availability of numerous therapeutic options, tumor heterogeneity and chemoresistance have limited the success of these treatments, and the development of effective anticancer therapies remains a major focus in oncology research. The serine/threonine-protein phosphatase 1 (PP1) and its complexes have been recognized as potential drug targets. Read More

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Not all flaps are created equal: Assessing the impact of active smoking in muscle-only versus perforator flaps for patients undergoing nonelective extremity-free tissue transfer-A case control study.

Microsurgery 2021 Sep 14;41(6):513-521. Epub 2021 Aug 14.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Long School of Medicine, UT Health San Antonio, San Antonio, Texas, USA.

Introduction: Active smoking is known to impair wound healing following free tissue transfer for reconstruction due to its vasoconstrictive effect on the microcirculation. The aim of this study was to evaluate the impact of flap selection on flap loss, in nonelective, traumatic extremity-free soft tissue transfer in active smokers.

Methods: All patients undergoing a free tissue transfer for acute trauma of the extremity at a level I trauma center from 2011 to 2017 were identified. Read More

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September 2021

Optimal Surgical Treatment for Type 2 Diabetes: Sleeve Gastrectomy or Gastric Bypass?

Adv Surg 2021 09 6;55:1-8. Epub 2021 Jul 6.

Department of Surgery, University of California - San Francisco, 513 Parnassus Avenue, HSW1601, San Francisco, CA 94143, USA. Electronic address:

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September 2021

Cancer-related cognitive impairment is associated with perturbations in inflammatory pathways.

Cytokine 2021 Aug 10;148:155653. Epub 2021 Aug 10.

School of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA 94143-0610, USA. Electronic address:

Cancer-related cognitive impairment (CRCI) is a significant problem for patients receiving chemotherapy. While a growing amount of pre-clinical and clinical evidence suggests that inflammatory mechanisms underlie CRCI, no clinical studies have evaluated for associations between CRCI and changes in gene expression. Therefore, the purpose of this study was to evaluate for differentially expressed genes and perturbed inflammatory pathways across two independent samples of patients with cancer who did and did not report CRCI. Read More

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Do people with mental health problems have lower adherence to precautionary measures in COVID-19 pandemic? A cross-sectional observational study in Hong Kong.

BMJ Open 2021 08 12;11(8):e046658. Epub 2021 Aug 12.

Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China

Objectives: Mental health problems are prevalent during the COVID-19 pandemic, but their effect on adherence to precautionary measures is not well understood. Given that psychological morbidities are associated with lower treatment adherence, and that precautionary measures are important in containing the spread of COVID-19, this study aims to determine if people with mental health problems have lower adherence to precautionary measures against COVID-19.

Design: We conducted a cross-sectional territory-wide online survey between 17 June and 31 July 2020 during the COVID-19 pandemic. Read More

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Molecular Pathology of Gastroesophageal Cancer.

Surg Pathol Clin 2021 Sep 8;14(3):443-453. Epub 2021 Jul 8.

Section of Hematology/Oncology, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Suite 7B, MS: BCM904, Houston, TX 77030, USA.

Upper gastroesophageal carcinomas consist of cancers arising from the esophagus and stomach. Squamous cell carcinomas and adenocarcinomas are seen in the esophagus and despite arising from the same organ have different biology. Gastric adenocarcinomas are categorized into 4 molecular subtypes: high Epstein-Barr virus load, microsatellite unstable cancers, chromosomal unstable (CIN) cancers, and genomically stable cancers. Read More

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September 2021

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.

Bone Joint Res 2021 Aug;10(8):498-513

Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited. Suramin is used to treat African sleeping sickness. Read More

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Effects of Dietary Patterns during Pregnancy on Preterm Birth: A Birth Cohort Study in Shanghai.

Nutrients 2021 Jul 10;13(7). Epub 2021 Jul 10.

Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.

The objective of this study was to analyse representative dietary patterns during pregnancy in Shanghai and explore the effects of dietary patterns during pregnancy on preterm birth. Data were derived from the 'Iodine Status in Pregnancy and Offspring Health Cohort' (ISPOHC) study. Multistage, stratified random sampling was used to select survey participants from 16 districts in Shanghai, which were divided into five sampling areas; 40-70 pregnant women were selected from each area. Read More

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Pre-clinical evidence that salinomycin is active against retinoblastoma via inducing mitochondrial dysfunction, oxidative damage and AMPK activation.

Authors:
Jing Li Yao Min

J Bioenerg Biomembr 2021 Oct 8;53(5):513-523. Epub 2021 Aug 8.

Department of Ophthalmology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street, Wuhan, 430014, Hubei, China.

The poor outcomes in retinoblastoma necessitate new treatments. Salinomycin is an attractive candidate, and has demonstrated selective anti-cancer properties in different cancer types. This work addressed the efficacy of salinomycin in retinoblastoma models and probe the associated mechanisms. Read More

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October 2021

Provider Bias in prescribing opioid analgesics: a study of electronic medical Records at a Hospital Emergency Department.

BMC Public Health 2021 08 6;21(1):1518. Epub 2021 Aug 6.

Department of Sociology, Duke Network Analysis, Duke University, Durham, NC, 27705, USA.

Background: Physicians do not prescribe opioid analgesics for pain treatment equally across groups, and such disparities may pose significant public health concerns. Although research suggests that institutional constraints and cultural stereotypes influence doctors' treatment of pain, prior quantitative evidence is mixed. The objective of this secondary analysis is therefore to clarify which institutional constraints and patient demographics bias provider prescribing of opioid analgesics. Read More

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Hydralazine and Panobinostat Attenuate Malignant Properties of Prostate Cancer Cell Lines.

Pharmaceuticals (Basel) 2021 Jul 13;14(7). Epub 2021 Jul 13.

Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/[email protected] (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto.CCC), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.

Among the well-established alterations contributing to prostate cancer (PCa) pathogenesis, epigenetics is an important player in its development and aggressive disease state. Moreover, since no curative therapies are available for advanced stage disease, there is an urgent need for novel therapeutic strategies targeting this subset of patients. Thus, we aimed to evaluate the combined antineoplastic effects of DNA methylation inhibitor hydralazine and histone deacetylase inhibitors panobinostat and valproic acid in several prostate cell lines. Read More

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Research Progress in Computational Fluid Dynamics Simulations of Membrane Distillation Processes: A Review.

Authors:
Long Chen Binxin Wu

Membranes (Basel) 2021 Jul 7;11(7). Epub 2021 Jul 7.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.

Membrane distillation (MD) can be used in drinking water treatment, such as seawater desalination, ultra-pure water production, chemical substances concentration, removal or recovery of volatile solutes in an aqueous solution, concentration of fruit juice or liquid food, and wastewater treatment. However, there is still much work to do to determine appropriate industrial implementation. MD processes refer to thermally driven transport of vapor through non-wetted porous hydrophobic membranes, which use the vapor pressure difference between the two sides of the membrane pores as the driving force. Read More

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Combined Radiomics Model for Prediction of Hematoma Progression and Clinical Outcome of Cerebral Contusions in Traumatic Brain Injury.

Neurocrit Care 2021 Aug 4. Epub 2021 Aug 4.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: Traumatic brain injury is a common and devastating injury that is the leading cause of neurological disability and death worldwide. Patients with cerebral lobe contusion received conservative treatment because of their mild manifestations, but delayed intracranial hematoma may increase and even become life-threatening. We explored the noninvasive method to predict the prognosis of progression and Glasgow Outcome Scale (GOS) by using a quantitative radiomics approach and statistical analysis. Read More

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Detection of ALK fusion transcripts in plasma of non-small cell lung cancer patients using a novel RT-PCR based assay.

Ann Transl Med 2021 Jun;9(11):922

University Côte d'Azur, Nice, France.

Background: Detection of genomic rearrangements, like anaplastic lymphoma kinase () fusions, is a pivotal requirement in non-small cell lung cancer (NSCLC) for the initiation of a targeted treatment. While tissue testing remains the gold standard, detection of these alterations using liquid biopsies is an unmet need. To enable the detection of rearrangements from circulating-free RNA (cfRNA) from NSCLC patients, we have evaluated a novel reverse transcription PCR (RT-PCR) based assay. Read More

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Iron phosphate mediated magnetite synthesis: a bioinspired approach.

Chem Sci 2021 Jul 10;12(27):9458-9465. Epub 2021 Jun 10.

Laboratory of Physical Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology P.O. Box 513 5600 MB Eindhoven The Netherlands

The biomineralization of intracellular magnetite in magnetotactic bacteria (MTB) is an area of active investigation. Previous work has provided evidence that magnetite biomineralization begins with the formation of an amorphous phosphate-rich ferric hydroxide precursor phase followed by the eventual formation of magnetite within specialized vesicles (magnetosomes) through redox chemical reactions. Although important progress has been made in elucidating the different steps and possible precursor phases involved in the biomineralization process, many questions still remain. Read More

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Comparison of the Effects of Ringer's Lactate and 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Need for Blood Transfusion After Off-Pump Coronary Artery Bypass Graft Cardiac Surgery.

Cureus 2021 Jun 30;13(6):e16049. Epub 2021 Jun 30.

Anesthesiology, Apollo Hospitals, Chennai, IND.

Background Infusion of crystalloids fluid replacement therapy tends to cause a greater expansion of intravascular volume. However, colloids can affect blood coagulation leading to greater blood loss and transfusion requirements. This study compared the intraoperative and postoperative blood loss with Ringer's lactate (RL) versus 6% hydroxyethyl starch (HES) 130/0. Read More

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Systematic review and meta-analysis: real-world data rates of deep remission with anti-TNFα in inflammatory bowel disease.

BMC Gastroenterol 2021 Aug 3;21(1):312. Epub 2021 Aug 3.

Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, HMR 101, Los Angeles, CA, 90033, USA.

Background: Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; however, real-world data (RWD) can provide information complementary to RCTs, specifically regarding treatment duration. In this systematic review with meta-analysis, we use real-world data (RWD) to determine rates of DR in IBD treated with anti-TNFα. Read More

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Gender disparities in transplantation.

Curr Opin Organ Transplant 2021 Oct;26(5):513-520

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Purpose Of Review: Transplantation is the life-saving therapy for patients suffering from end-organ failure, and as such, equitable access to transplantation (ATT) is of paramount importance. Unfortunately, gender/sex-based disparities exist, and despite the transplant community's awareness of this injustice, gender/sex-based disparities have persisted for more than two decades. Importantly, no legislation or allocation policy has addressed inequity in ATT that women disproportionately face. Read More

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October 2021

Acute chlorine poisoning caused by an accident at a swimming pool.

Toxicol Ind Health 2021 Sep 3;37(9):513-519. Epub 2021 Aug 3.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, 74639Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Chlorine is an irritant gas that is widely used in water purification. Several previous reports had reported accidents of inhalation injuries at swimming pools. However, there have been limited data on the detection of on-site chlorine concentration. Read More

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September 2021

Three-dimensional characterizations of two-photon excitation fluorescence images of elastic fibers affected by cutaneous scar duration.

Quant Imaging Med Surg 2021 Aug;11(8):3584-3594

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.

Background: The type or duration of a scar determines the choice of therapy available. Traditional detection methods can easily cause secondary trauma, so there is an urgent need for a non-invasive, rapid diagnostic approach.

Methods: A strategy for quantitative analysis of three-dimensional (3D) elastic fibers in human cutaneous scars was designed, which included 3D reconstruction, skeleton extraction, quantitative analysis, and random forest regression. Read More

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Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery.

Small 2021 Sep 1;17(37):e2103025. Epub 2021 Aug 1.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Successfully employing small interfering RNA (siRNA) therapeutics requires the use of nanotechnology for efficient intracellular delivery. Lipid nanoparticles (LNPs) have enabled the approval of various nucleic acid therapeutics. A major advantage of LNPs is the interchangeability of its building blocks and RNA payload, which allow it to be a highly modular system. Read More

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September 2021

New next-generation microwave thermosphere ablation for small hepatocellular carcinoma.

Clin Mol Hepatol 2021 Aug 2. Epub 2021 Aug 2.

Department of Hepatology, Wakayama Rosai Hospital, Wakayama, Japan.

Background/aims: In July 2017, the EmprintTM next-generation microwave ablation system using thermosphere technology (Covidien, Boulder, CO, USA) was approved for use in Japan. This system can produce a predictable spherical ablation zone at higher temperatures than radiofrequency ablation (RFA). The aim of the present study was to elucidate whether this new microwave thermosphere ablation (MTA) could safely improve outcome compared to RFA, which is the standard of care for small hepatocellular carcinoma (HCC). Read More

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1-Month Dual-Antiplatelet Therapy Followed by Aspirin Monotherapy After Polymer-Free Drug-Coated Stent Implantation: One-Month DAPT Trial.

JACC Cardiovasc Interv 2021 Aug 28;14(16):1801-1811. Epub 2021 Jul 28.

Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea. Electronic address:

Objectives: The aim of this study was to determine whether 1 month of dual-antiplatelet therapy (DAPT) followed by aspirin monotherapy after polymer-free drug-coated stent (PF-DCS) implantation is noninferior to 6 to 12 months of DAPT after biodegradable-polymer drug-eluting stent (BP-DES) implantation.

Background: It is necessary to determine the optimal minimal duration of DAPT followed by aspirin monotherapy after percutaneous coronary intervention (PCI).

Methods: In this trial, 3,020 patients with coronary artery disease considered for PCI for noncomplex lesions were randomized to 1-month DAPT after PF-DCS (n = 1,507) or 6- to 12-month DAPT after BP-DES (n = 1,513). Read More

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