808 results match your criteria treated subconjunctival


Protective roles of the TIR/BB-loop mimetic AS-1 in alkali-induced corneal neovascularization by inhibiting ERK phosphorylation.

Exp Eye Res 2021 Apr 9;207:108568. Epub 2021 Apr 9.

Center of Clinical Research, The Affiliated Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi, Jiangsu, 214023, People's Republic of China. Electronic address:

Hydrocinnamoyl-L-valylpyrrolidine (AS-1), a synthetic low-molecule mimetic of myeloid differentiation primary response gene 88 (MyD88), inhibits inflammation by disrupting the interaction between the interleukin-1 receptor (IL-1R) and MyD88. Here, we describe the effects of AS-1 on injury-induced increases in inflammation and neovascularization in mouse corneas. Mice were administered a subconjunctival injection of 8 μL AS-1 diluent before or after corneal alkali burn, followed by evaluation of corneal resurfacing and corneal neovascularization (CNV) by slit-lamp biomicroscopy and clinical assessment. Read More

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Subconjunctival injections of dimethyl fumarate inhibit lymphangiogenesis and allograft rejection in the rat cornea.

Int Immunopharmacol 2021 Apr 3;96:107580. Epub 2021 Apr 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Corneal lymphangiogenesis induced by macrophages played a critical role in corneal allograft rejection (CGR). However, there are few Food and Drug Administration (FDA)-approved drugs that target lymphangiogenesis. The aim of our study is to evaluate the effects of dimethyl fumarate (DMF) on corneal allograft survival in rats. Read More

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Evaluation of Clinical and Histological Outcomes of Adipose-Derived Mesenchymal Stem Cells in a Rabbit Corneal Alkali Burn Model.

Stem Cells Int 2021 7;2021:6610023. Epub 2021 Mar 7.

Laboratory of Experimental Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

To assess effects of adipose-derived mesenchymal stem cells (AMSCs) in corneal alkali injuries in an experimental animal model. Twenty white New Zealand rabbits were included in the study. The animal models were randomly divided into 2 groups. Read More

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An Atypical Presentation of Sympathetic Ophthalmia in an Intact Globe Following Mechanical Fall: A Case Report and Literature Review.

Vision (Basel) 2021 Feb 21;5(1). Epub 2021 Feb 21.

Department of Ophthalmology, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, UK.

Purpose: To describe an atypical case of sympathetic ophthalmia presenting after blunt trauma causing disinsertion of the iris in an intact globe.

Methods: Case report.

Results: A 71-year-old lady presented to the Emergency Department following a mechanical fall. Read More

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February 2021

Keratitis by Fungus After LASIK - A Case Report.

Int Med Case Rep J 2021 17;14:107-110. Epub 2021 Feb 17.

Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Purpose: To describe a rare case of an interface filamentous fungal keratitis and its successful clinical approach and management.

Patients And Methods: Retrospective case report. Analysis of the patient's clinical records. Read More

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February 2021

Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision.

BMC Ophthalmol 2021 Feb 8;21(1):75. Epub 2021 Feb 8.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Purpose: Infrared monitor-guided bleb revision (IRGBR), an alternative needling system, visualizes anterior-segment tissues around the bleb not visible during needle revision after trabeculectomy. This study determined the safety and efficiency of 5-fluorouracil (5-FU) as an adjunctive anti-metabolite in IRGBR.

Methods: We retrospectively analyzed 43 consecutive eyes (40 patients; 14 eyes, primary open-angle; 29 eyes, secondary glaucoma) treated with IRGBR for failing filtering blebs. Read More

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February 2021

A Case of Black Fungal Keratitis Caused by Biatriospora mackinnonii.

Cornea 2021 Jan 27. Epub 2021 Jan 27.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; National Center for Geriatrics and Gerontology, Aichi, Japan; and Medical Mycology Research Center, Chiba University, Chiba, Japan.

Purpose: To report a novel case of fungal keratitis caused by Biatriospora mackinnonii (Pyrenochaeta mackinnonii), a dematiaceous fungus (black fungus) that rarely causes dermatological infection, in a patient treated for ocular cicatricial pemphigoid.

Methods: An 81-year-old patient with ocular cicatricial pemphigoid was referred to our hospital because of persistent corneal epithelial defects in his left eye. On examination, a slightly elevated dark lesion in the middle of the erosion and hypopyon was observed in that eye, with smear examination of the obtained specimen revealed a filamentous fungal-like material. Read More

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January 2021

Capnocytophaga canimorsus blebitis: case report and review of literature.

BMC Ophthalmol 2021 Jan 26;21(1):59. Epub 2021 Jan 26.

Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, 92697, USA.

Background: Capnocytophaga canimorsus is a facultative anaerobic, slow-growing, capnophilic, Gram-negative bacillus, that is commonly found in the microflora of canine and feline oral cavities. Capnocytophaga infections are an emerging zoonotic disease that can cause fatal systemic infections in immunocompromised individuals. Localized ocular Capnocytophaga infections, including keratitis, blepharitis, and endophthalmitis, can lead to severe eye threatening situations. Read More

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January 2021

Coluber Constrictor Bite to the Eye: A Novel Case Report of a Wild Snake Bite to the Eye in North America and Review of Literature.

Cureus 2020 Dec 17;12(12):e12125. Epub 2020 Dec 17.

Ophthalmology, University of Florida, Gainesville, USA.

Snake bites involving the eye are an uncommon cause of ocular trauma; herein, we present one of the few known instances of a snake bite directly to the globe, specifically by the way of a , also known as the "Black Racer." In this case report, we describe a nine-year-old girl who presented immediately following a snake bite to the right eye. The patient's vision was unaffected despite visualized puncture wounds through the conjunctiva with associated near-total subconjunctival hemorrhage. Read More

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December 2020

Pigment Epithelium-Derived Factor Peptide Promotes Corneal Nerve Regeneration: An In Vivo and In Vitro Study.

Invest Ophthalmol Vis Sci 2021 Jan;62(1):23

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: To investigate the potential of a pigment epithelium-derived factor (PEDF) peptide 44-mer to promote nerve regeneration in a rabbit corneal nerve injury model to demonstrate its neurotrophic ability in cultivated mouse trigeminal neuron cells.

Methods: Subconjunctival or intrastromal injection of 44-mer on the cornea was performed in a rabbit model of corneal nerve injury created by corneal epithelial debridement. Immunocytochemical analysis (44-mer, anti-tubulin III, SMI312, CD11b, and α-SMA) and in vivo confocal microscopy were performed. Read More

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January 2021

Epigallocatechin-3-gallate increases autophagic activity attenuating TGF-β1-induced transformation of human Tenon's fibroblasts.

Exp Eye Res 2021 Mar 16;204:108447. Epub 2021 Jan 16.

Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences. Guangzhou, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

We previously found that epigallocatechin-3-gallate (EGCG) could inhibit the myofibroblast transformation of human Tenon's fibroblasts, however, the underlying mechanism remained unclear. We therefore investigated whether the autophagic regulation involved in the anti-fibrotic function of EGCG. The fibroblasts were subjected to transforming growth factor beta-1 (TGF-β1) induction followed by EGCG treatments. Read More

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Associated Ophthalmic Injuries in Patients With Fractures of the Midface.

Craniomaxillofac Trauma Reconstr 2020 Sep 28;13(3):168-173. Epub 2020 Apr 28.

Clinic for Oral and Maxillofacial Surgery, University Hospital Zurich, Switzerland.

Purpose: Concomitant ophthalmic injuries are common in patients with facial fractures, though frequency varies widely in the literature. Major ophthalmic injuries can have drastic consequences for patients, and permanent visual impairment cannot be prevented in all cases. This study analyzed the frequency and distribution pattern of associated ophthalmic injuries in patients who received operative treatment for fractures of the midface. Read More

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September 2020

Intraocular pressure-lowering effect of mycelia extract in a glaucoma rat model.

Int J Med Sci 2021 1;18(4):1007-1014. Epub 2021 Jan 1.

Department of Pharmacy and Master Program, Tajen University, Pingtung, Taiwan.

Glaucoma is a leading cause of irreversible blindness worldwide. This study evaluates the reduction of intraocular pressure (IOP) induced by mycelia extract in a steroid-induced rat model of glaucoma. mycelia is a well-known and valued traditional Chinese herbal medicine. Read More

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January 2021

Resolution of Refractory Corneal Neovascularization with Subconjunctival Bevacizumab.

Case Rep Ophthalmol 2020 Sep-Dec;11(3):652-657. Epub 2020 Dec 7.

Eye Surgery Associates, Orange, New South Wales, Australia.

Corneal neovascularization (CNV) has a variety of causes and threatens corneal clarity, thus optimal visual acuity. Conventional medical management includes topical steroids and matrix metalloproteinase inhibitors like doxycycline. Anti-vascular endothelial growth factor (anti-VEGF) agents have demonstrated promise but remain off-label for this indication. Read More

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December 2020

Novel combination therapy reduces subconjunctival fibrosis after glaucoma filtration surgery in the rabbit model.

Clin Exp Ophthalmol 2021 01 10;49(1):60-69. Epub 2021 Jan 10.

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Background: Glaucoma filtration surgery (GFS) is limited by subconjunctival, episcleral and scleral fibrosis sealing the trabeculectomy and scarring the filtering bleb. Mitomycin-C (MMC) is commonly applied intraoperatively to the subconjunctival and/or intrascleral space to reduce scarring and promotes GFS success but is associated with postoperative scleral melting and bleb leaks. IP-10 peptide (IP-10p), an ELR-negative CXC chemokine mimetic and inhibitor of fibroblast function, may be an alternative or adjunct to current postoperative GFS treatments. Read More

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January 2021

Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn.

Invest Ophthalmol Vis Sci 2020 Dec;61(14):22

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Purpose: This study aimed to investigate the therapeutic effects and underlying mechanisms of locally delivered regulatory T cells (Tregs) on acute corneal wound healing after alkali burn.

Methods: After corneal alkali burn, the mice were injected subconjunctivally with regulatory T cells (Tregs) isolated from syngeneic mice. The wound healing process was monitored by clinical manifestation, flow cytometry, and enzyme-linked immunosorbent assay (ELISA). Read More

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December 2020

Regenerative and Antioxidant Properties of Autologous Platelet-Rich Plasma Can Reserve the Aging Process of the Cornea in the Rat Model.

Authors:
Heba R Hashem

Oxid Med Cell Longev 2020 23;2020:4127959. Epub 2020 Nov 23.

Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Aging is a natural progressive decline in the biological function of cells. Age-related changes in the cornea can affect its ability to refract light or repair itself. Platelet-rich plasma (PRP) has a promising role in regenerative medicine and evidenced its efficacy in multiple fields, but in corneal aging has not yet been elucidated. Read More

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November 2020

Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model.

Sci Rep 2020 12 1;10(1):20936. Epub 2020 Dec 1.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-8566, Japan.

Inhibition of fibrosis is indispensable for maintaining filtering blebs after glaucoma filtration surgery (GFS). The purpose of this study was to investigate the ability of a pluripotent epigenetic regulator OBP-801 (OBP) to ameliorate extracellular matrix formation in a rabbit model of GFS. Rabbits that underwent GFS were treated with OBP. Read More

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December 2020

Comparative study of topical regimen for adenoviral kearoconjunctivitis by 0.1% fluorometholone with and without polyvinyl alcohol iodine.

Jpn J Ophthalmol 2021 Jan 26;65(1):107-114. Epub 2020 Nov 26.

Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1, Nishi-cho, Yonago-city, Tottori, 683-8504, Japan.

Purpose: The aim of this study was to compare the efficacy of the topical regimens of iodine/steroids vs. antibiotics/steroids in acute to subacute adenoviral keratoconjunctivitis.

Study Design: A prospective open-label study. Read More

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January 2021

Subconjunctival injection of tumor necrosis factor-α pre-stimulated bone marrow-derived mesenchymal stem cells enhances anti-inflammation and anti-fibrosis in ocular alkali burns.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 25;259(4):929-940. Epub 2020 Nov 25.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.

Purpose: To investigate the therapeutic effect of subconjunctival injection of tumor necrosis factor-α (TNF-α) pre-stimulated bone marrow-derived mesenchymal stem cells (BMMSCs) on ocular alkali burns in a rat model.

Methods: After applying a 6 mm filter paper soaking in 1 N NaOH on the cornea of rats, the suspension of TNF-α pre-stimulated BMMSCs, BMMSCs and PBS were given subconjunctivally and respectively. Corneal epithelial defect, corneal opacity, inflammation as well as PTGS2 and TSG-6 expression on day 7 and fibrosis on day 14 were compared. Read More

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Safety of intracameral cefuroxime in pars plana vitrectomy.

Eye (Lond) 2020 Nov 20. Epub 2020 Nov 20.

St. Thomas' Hospital, London, UK.

Background/objectives: Postoperative endophthalmitis is a rare, but serious complication of pars plana vitrectomy (PPV). Subconjunctival cefuroxime injection has been the traditional choice for post vitrectomy endophthalmitis prophylaxis. Its effectiveness and safety in this context are however poorly understood and cases of retinal toxicity have been reported. Read More

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November 2020

Spontaneous extrusion of a dexamethasone intravitreal implant (Ozurdex).

BMJ Case Rep 2020 Nov 3;13(11). Epub 2020 Nov 3.

Ophthalmology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

A 59-year-old man with diabetic macular oedema was treated with a dexamethasone intravitreal implant (Ozurdex) to his right eye. Immediately after injection, the implant was noted to have extruded into the perilimbal subconjunctival space. The remnants of the implant were expeditiously removed the following day to avoid corneal decompensation and permanent corneal oedema. Read More

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November 2020

[Anti-scarring effect of rapamycin following filtering surgery in rabbit eyes].

Nan Fang Yi Ke Da Xue Xue Bao 2020 Sep;40(9):1346-1352

Department of Emergency Medicine, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China.

Objective: To study the effect of rapamycin on scar formation in rabbit eyes following filtering operation and explore the possible mechanism.

Methods: Ninety-six healthy adult rabbits were subjected to trabeculectomy of the left eye and subsequently randomly divided into 4 groups (=24) for treatment with castor oil (control) or rapamycin (1%, 3%, or 5%) eye drops of the operated eyes 4 times a day. The morphology and function of the filtering blebs of the rabbits were compared at 7, 14, 21 and 28 days after the operation; at each of the time points, 6 rabbits from each group were euthanized for detection of expressions of proliferating cell nuclear antigen (PCNA) and α-smooth muscle actin (α-SMA) in the tissues in the surgical area using immunohistochemistry. Read More

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September 2020

Subconjunctival Acute Bilateral Hemorrhages Due to Kawasaki Disease in a Costa Rican Girl: An Unusual Clinical Manifestation of the Disease.

Cureus 2020 Sep 2;12(9):e10212. Epub 2020 Sep 2.

Pediatric Infectious Diseases, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera", San José, CRI.

Kawasaki disease is an acute systemic vasculitis and is the leading cause of acquired cardiac disease in children. Among the ocular manifestations in these patients, bilateral non-suppurative conjunctival injection and uveitis are the most common. We describe a six-year-old Costa Rican girl with acute Kawasaki disease who developed severe bilateral conjunctival injection with subsequent bilateral subconjunctival hemorrhages. Read More

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September 2020

Anti-fibrosis potential of pirarubicin via inducing apoptotic and autophagic cell death in rabbit conjunctiva.

Exp Eye Res 2020 11 5;200:108215. Epub 2020 Sep 5.

Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, 321006, China. Electronic address:

This study investigated the potential efficacy of pirarubicin (THP) in modulating rabbit conjunctival fibrosis both in vitro and in vivo and characterized the underlying mechanisms. Primary rabbit conjunctival fibroblasts (RCF) were cultured and treated with THP or mitomycin C (MMC) for 5 min, followed by assaying for cell viability, cell cycle distribution, apoptotic and autophagic pathways. The production of reactive oxygen species (ROS) and chemotaxis of macrophages by RCF were evaluated using 2',7'-dichlorofluorescein diacetate (DCFH-DA) labeling and transwell migration assay, respectively. Read More

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November 2020

Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn.

Int Immunopharmacol 2020 Nov 20;88:106902. Epub 2020 Aug 20.

Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China. Electronic address:

Objectives: To investigate the effects of neutrophil extracellular traps (NETs) on angiogenesis in vitro and in vivo and the regulatory role of mammalian target of rapamycin (mTOR) activity in it.

Methods: The regulatory role of mTOR in NETs formation was explored. In vitro, human neutrophils were pretreated with rapamycin. Read More

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November 2020

Potential of subconjunctival aflibercept in treating choroidal neovascularization.

Exp Eye Res 2020 10 12;199:108187. Epub 2020 Aug 12.

Nanyang Technological University-Northwestern Institute for Nanomedicine, School of Material Science & Engineering, Nanyang Technological University, Singapore; Singapore Eye Research Institute, Singapore; Tan Tock Seng Hospital, Singapore. Electronic address:

The study aimed to evaluate the intraocular pharmacokinetics and efficacy of aflibercept after subconjunctival injection in animal models for treating choroidal neovascularization (CNV) associated with Age-Related Macular Degeneration (AMD). New Zealand albino rabbits received aflibercept (2000 μg/50 μl) in one eye, and the other eye was used as control. At 7, 14, 21 and 28 days, the animals were sacrificed to dissect the ocular tissues, and serum was collected at 1hr, 3 h, 1, 7, 14, 21 and 28 days. Read More

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October 2020

Outcome of cataract surgery in eyes with uveitis.

Nepal J Ophthalmol 2019 Jul;11(22):152-157

Tilganga Institute of Ophthalmology Kathmandu.

Purpose: To assess the outcome of cataract surgery in patients with uveitis without the use of prophylactic high dose (> 5-10 mg/day) systemic steroid.

Method: A hospital based prospective study enrolling 64 eyes of 60 patients with uveitis and cataract from May 2013 to April 2014 having intraocular inflammation under control for at least 3 months preoperatively and underwent phacoemulsification with in bag placement of foldable acrylic intraocular lens (IOL).

Results: Twenty six male and 34 female were included with mean age of 47. Read More

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Ocular findings in patients with coronavirus disease 2019 (COVID-19) in an outbreak hospital.

J Med Virol 2021 02 21;93(2):1126-1132. Epub 2020 Aug 21.

Department of Ophthalmology, University of Health Scıences Gazi Yaşargil Education Research Hospital, Diyarbakır, Turkey.

Purpose: The aim of this study was to investigate the ocular findings observed in patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 and to present the relationship between ocular involvement, systemic findings, and laboratory results.

Material And Methods: This cross-sectional study was carried out between 1 May and 30 June 2020. The study included 359 patients diagnosed with COVID-19 and assessed by clinical evaluation, nasopharyngeal polymerase chain reaction, and lung computed tomography. Read More

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February 2021

A Curious Case of Dengue Fever: A Case Report of Unorthodox Manifestations.

Case Rep Med 2020 25;2020:1701082. Epub 2020 Jul 25.

Jinnah Post Graduate Medical Center, Karachi, Pakistan.

Dengue is the major cause of arthropod-borne viral disease in the world. It presents with high fever, headache, rash, myalgia, and arthralgia and it is a self-limiting illness. Severe dengue can occur in some cases resulting in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Read More

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