Exp Eye Res 2020 10 12;199:108187. Epub 2020 Aug 12.
Nanyang Technological University-Northwestern Institute for Nanomedicine, School of Material Science & Engineering, Nanyang Technological University, Singapore; Singapore Eye Research Institute, Singapore; Tan Tock Seng Hospital, Singapore. Electronic address:
The study aimed to evaluate the intraocular pharmacokinetics and efficacy of aflibercept after subconjunctival injection in animal models for treating choroidal neovascularization (CNV) associated with Age-Related Macular Degeneration (AMD). New Zealand albino rabbits received aflibercept (2000 μg/50 μl) in one eye, and the other eye was used as control. At 7, 14, 21 and 28 days, the animals were sacrificed to dissect the ocular tissues, and serum was collected at 1hr, 3 h, 1, 7, 14, 21 and 28 days. Read More