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Biomed Pharmacother 2021 Apr 13;139:111574. Epub 2021 Apr 13.

Division of Cardiovascular Sciences, Department of Medicine, The University of South Florida, Tampa, FL, United States. Electronic address:

The presistent increase of 12/15 lipoxygenase enzyme activity is correlated with uncontrolled inflammation, leading to organ dysfunction. ML351, a potent 12/15 lipoxygenase (12/15LOX) inhibitor, was reported to reduce infarct size and inflammation in a murine ischemic stroke model. In the presented work, we have applied three complementary experimental approaches, in-vitro, ex-vivo, and in-vivo, to determine whether pharmacological inhibition of 12/15LOX could dampen the inflammatory response in adult mice after Kdo2-Lipid A (KLA) as an endotoxin stimulator or post myocardial infarction (MI). Read More

Biomed Pharmacother 2021 Apr 13;139:111588. Epub 2021 Apr 13.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India. Electronic address:

Background: Cadmium is one of the most toxic heavy metals. The prolonged exposure of it can lead to severe alterations and damage in different tissues including blood, liver, kidney and brain. Eugenol, a phenolic compound, is present in various aromatic plants. Read More

Chemosphere 2021 Mar 31;279:130427. Epub 2021 Mar 31.

College of Land and Environment, Shenyang Agricultural University, Shenyang, 110866, PR China; Key Laboratory of Northeast Arable Land Conservation of Ministry of Agriculture, Shenyang Agricultural University, Shenyang, 110866, PR China.

This study aimed to investigate the bioremediation efficiency and bacterial regulation mechanism of biochar-immobilized bacterium (BM) in polycyclic aromatic hydrocarbon (PAH)-contaminated saline soil by conducting pot experiments. In BM treatment, PAH-degrading strain Sphingomonas sp. PJ2 was inoculated into biochar produced at 400 °C and 600 °C using the pine needles (BM400 and BM600). Read More

Biochim Biophys Acta Gen Subj 2021 Apr 13:129911. Epub 2021 Apr 13.

Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Science, Northeast Forestry University, Harbin 150040, China. Electronic address:

Background: Ellagic acid (EA) possesses prominent inhibitory activities against various cancers, including hepatocellular carcinoma (HCC). Our recent study demonstrated EA's activities in reducing HCC cell proliferation and tumor formation. However, the mechanisms of EA to exert its anticancer activities and its primary targets in cancer cells have not been systematically explored. Read More

Brain Res 2021 Apr 13:147480. Epub 2021 Apr 13.

Department of Psychobiology. School of Psychology, National University for Distance Learning (UNED), Madrid, Spain. Electronic address:

It has been suggested that cannabis consumption during adolescence may be an initial step to cocaine use in adulthood. Indeed, previous preclinical data show that adolescent exposure to cannabinoids (both natural and synthetic) potentiates cocaine self-administration in rats. Here we aimed at gaining a deeper understanding of the cellular activation patterns induced by cocaine as revealed by Fos imaging and how these patterns may change due to adolescent exposure to THC. Read More

Aging (Albany NY) 2021 Apr 16;13. Epub 2021 Apr 16.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Currently, the prevalence of obesity in aging populations is fast growing worldwide. Aging induced by D-galactose (D-gal) is proven to cause the worsening of cardiac dysfunction in pre-diabetic rats via deteriorating cardiac mitochondrial function. Hyperbaric oxygen therapy (HBOT) has been shown to attenuate D-gal-induced cognitive deterioration through decreased inflammation and apoptosis. Read More

Adv Exp Med Biol 2021 ;1308:579-588

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Anti-arrhythmic agents, like amiodarone, interfere at different stages of the ischemic stroke. However, amiodarone was accompanied with immunological pulmonary complications and adverse neurological effects. We hypothesize that magnesium sulfate in combination with amiodarone holds promise for stroke treatment. Read More

Adv Exp Med Biol 2021 ;1308:37-44

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Curcumin has been shown to have beneficial effects on pathogenic factors involved in the development of atherosclerosis. The aim of this study was to assess the effects of curcumin phytosomes on atherosclerosis induced by high-fat diet in rabbits. A total of 16 adult male New Zealand white rabbits (1. Read More

Evid Based Complement Alternat Med 2021 30;2021:6681729. Epub 2021 Mar 30.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Anti-inflammatory, antioxidant, and immunomodulatory effects of thymoquinone (TQ) have been shown. The effects of TQ on lipopolysaccharide- (LPS-) induced inflammation and pathological changes in rats' lung were investigated in this study. Four groups of rats included (1) control (saline treated); (2) LPS (treated with 1 mg/kg/day i. Read More

Front Pharmacol 2021 30;12:646088. Epub 2021 Mar 30.

Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Glutamate decarboxylase 67-kDa isoform (GAD67), which is encoded by the gene, is one of the key enzymes that produce GABA. The reduced expression of GAD67 has been linked to the pathophysiology of schizophrenia. Additionally, the excitatory glutamatergic system plays an important role in the development of this disorder. Read More

Mediators Inflamm 2021 30;2021:5597118. Epub 2021 Mar 30.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

Obesity is a well-known public health issue around the world. Sepsis is a lethal clinical syndrome that causes multiorgan failure. Obesity may aggravate inflammation in septic patients. Read More

Sci Rep 2021 Apr 15;11(1):8306. Epub 2021 Apr 15.

Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry (IUSD), 1121 W Michigan St, DS406, Indianapolis, IN, 46202, USA.

Root canal disinfection is of utmost importance in the success of the treatment, thus, a novel method for achieving root canal disinfection by electromagnetic waves, creating a synergistic reaction via electric and thermal energy, was created. To study electromagnetic stimulation (EMS) for the disinfection of root canal in vitro, single rooted teeth were instrumented with a 45.05 Wave One Gold reciprocating file. Read More

Transplantation 2021 Apr 9. Epub 2021 Apr 9.

RNA Systems Biology Laboratory (RSBL), Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil National Institute of Science and Technology for Vaccines (INCTV), Belo Horizonte, Minas Gerais, Brazil Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil Laboratório de Imunologia, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil Institute for Investigation in Immunology (INCT-iii), São Paulo, Brazil Laboratório de Imunologia Clínica e Alergia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Background: Brain death (BD) is associated with systemic inflammatory compromise, which might affect the quality of the transplanted organs. This study investigated the expression profile of cardiac microRNAs (miRNAs) after BD, and their relationship with the observed decline in myocardial function and with the changes induced by hypertonic saline solution (HSS) treatment.

Methods: Wistar rats were assigned to sham-operation (SHAM) or submitted to BD with and without the administration of HSS. Read More

Biosens Bioelectron 2021 Apr 6;183:113211. Epub 2021 Apr 6.

State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China. Electronic address:

Advances in trace protein detection contribute to the early diagnosis of diseases and exploration of stem cell development. The pre-coated interface proximity extension reaction (PIPER) assay enables target protein detection at trace levels and was developed based on protein biomarker recognition using sets of three specific antibodies and the extension of antibody-bound nucleic acid chains in proximity, accompanied by amplification and reading of protein signals via real-time quantitative polymerase chain reaction (qPCR). Noise generated in binding reactions and enzymatic steps was decreased by transferring the liquid-liquid reactions onto a liquid-solid interface in glutaraldehyde-treated tubes pre-coated with antibodies. Read More

J Pharm Pharmacol 2021 Apr 15. Epub 2021 Apr 15.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

Objectives: Lung cancer is one of the most frequent types of cancers that lead to death. Sildenafil is a potent inhibitor of phosphodiesterase-5 and showed potential anticancer effects, which has not yet been fully evaluated. Thus, this study aims to investigate the potential anticancer effect of sildenafil in urethane-induced lung cancer in BALB/c mice. Read More

Biomedicine (Taipei) 2020 1;10(3):25-32. Epub 2020 Sep 1.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: The most important side effects of Cyclophosphamide, as an anticancer broad-spectrum drug, are the negative effects on the reproduction and fertility because of oxidative stress. Considering the antioxidant properties of medicinal plants, especially those of the genus, this paper studied the effect of hydroalcoholic extract of L. on the pathology of testicular tissue in CP-treated mice. Read More

Stem Cells Int 2021 26;2021:6640424. Epub 2021 Mar 26.

Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.

Objective: Rotator cuff injury healing is problematic because the tendon-bone junction often forms cicatricial tissues, rather than fibrocartilage, which leads to mechanical impairment and is prone to redamage. Kartogenin (KGN) is a newly discovered small molecule compound which can induce cartilage formation through chondrogenesis of endogenous mesenchymal stem cells.

Methods: In this study, we used KGN with fibrin glue (FG) to repair the rotator cuff injury by promoting the formation of fibrocartilage at the tendon to bone interface. Read More

Diabetes Metab Syndr Obes 2021 6;14:1505-1517. Epub 2021 Apr 6.

Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Purpose: Optimal glycemic control is crucial for proper wound healing in patients with diabetes. However, it is not clear whether other antidiabetic drugs support wound healing in mechanisms different from the normalization of blood glucose control. We assessed the effect of insulin and metformin administration on the wound healing process in rats with streptozotocin-induced diabetes. Read More

Sci Rep 2021 Apr 14;11(1):8129. Epub 2021 Apr 14.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ exposure were studied (n = 6 in each group). Lung pathological changes, tracheal responsiveness to methacholine and ovalbumin (OVA) as well as transforming growth factor beta (TGF-β) and interleukin (IL)-6 level in the lung tissue homogenize as well as TGF-β, IL-6, oxidant and antioxidant levels oxidant and antioxidants were increased in PQ group (p < 0. Read More

Environ Sci Pollut Res Int 2021 Apr 13. Epub 2021 Apr 13.

Chemistry Department, Faculty of Science, Menoufia University, Sheben Elkom, Egypt.

This study evaluated the ameliorative potential of grape seed extract (GSE) against Ehrlich solid tumor (EST)-induced hepatic tissue alterations in mice. The control group was infused with physiological saline. The second group received GSE (50 mg/kg day by day orally) for 2 weeks. Read More

Int J Crit Illn Inj Sci 2020 Oct-Dec;10(4):163-169. Epub 2020 Dec 29.

Deparment of Obstetrics and Gynaecology, Government Medical College, Amritsar, Punjab, India.

Background: Brachial plexus block is popular for upper limb surgeries as it is effective for postoperative analgesia.

Aims: The aim of the study was to compare fentanyl and clonidine as adjuncts to a mixture of local anesthetics in potentiating postoperative analgesia in the supraclavicular block.

Materials And Methods: Sixty patients of the American Society of Anesthesiologist I and II undergoing upper limb surgeries lasting more than 30 min were included and randomly divided into two groups of 30 each. Read More

Toxicol Rep 2021 2;8:793-803. Epub 2021 Apr 2.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

This study is evaluating the effects of ethanol and nicotine exposure during pregnancy and lactation on placenta histology and follicular atresia in the first-generation (f1) mice pups. The experimental groups were 5 groups of NMRI pregnant mice, including: control, vehicle (received normal saline) ethanol (3 g/kg/day, 20 % v/v intraperitoneally), nicotine (1 mg/kg/day, subcutaneously), and ethanol plus nicotine which received both. Pregnant animals in each group were then divided into two groups, one group for examining the placenta that was treated for 18 days and the other group for the ovary of one-day-old (PND1) and fifty-six-day-old (PND56) female offspring who were treated for 42 days (during intrauterine development and lactation). Read More

Basic Clin Neurosci 2020 Nov-Dec;11(6):811-820. Epub 2020 Nov 1.

Department of Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Introduction: MicroRNAs (miRNAs or miRs) are non-coding RNAs. Studies have shown that miRNAs are expressed aberrantly in stroke. The miR1 enhances ischemic damage, and a previous study has demonstrated that reduction of miR1 level has a neuroprotective effect on the Middle Cerebral Artery Occlusion (MCAO). Read More

Int J Med Sci 2021 3;18(9):1910-1920. Epub 2021 Mar 3.

UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.

We investigated the potential of gelatin microspheres (GMs) loaded with platelet-rich plasma (PRP) to enhance their wound healing effect. Platelets from the PRP were immobilized onto GMs to form biomimetic bioreactor GM+PRP. The therapeutic effect of this agent was further investigated on a wound-healing model in rats. Read More

mBio 2021 Apr 13;12(2). Epub 2021 Apr 13.

Department of Microbiology & Molecular Genetics, School of Medicine, University of California Irvine, Irvine, California, USA

Animals that are competent reservoirs of zoonotic pathogens commonly suffer little morbidity from the infections. To investigate mechanisms of this tolerance of infection, we used single-dose lipopolysaccharide (LPS) as an experimental model of inflammation and compared the responses of two rodents: , the white-footed deermouse and reservoir for the agents of Lyme disease and other zoonoses, and the house mouse Four hours after injection with LPS or saline, blood, spleen, and liver samples were collected and subjected to transcriptome sequencing (RNA-seq), metabolomics, and specific reverse transcriptase quantitative PCR (RT-qPCR). Differential expression analysis was at the gene, pathway, and network levels. Read More

J Am Soc Nephrol 2021 Apr 12. Epub 2021 Apr 12.

Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil

Background: SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested the hypothesis that the SGLT2 inhibitor empagliflozin (EMPA) inhibits proximal tubule (PT) NHE3 activity and improves renal salt and water handling.

Methods: Male Wistar rats were subjected to myocardial infarction or sham operation. Read More

BMC Plant Biol 2021 Apr 12;21(1):176. Epub 2021 Apr 12.

School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.

Background: Salinity is a major threat to the agriculture industry due to the negative impact of salinity stress on crop productivity. In the present study, we isolated rhizobacteria and evaluated their capacities to promote crop growth under salt stress conditions.

Results: We isolated rhizospheric bacteria from sand dune flora of Pohang beach, Korea, and screened them for plant growth-promoting (PGP) traits. Read More

Hum Exp Toxicol 2021 Apr 12:9603271211009964. Epub 2021 Apr 12.

Animal Experiments Production and Experimental Research Laboratory, Faculty of Veterinary Medicine, 175651Burdur Mehmet Akif Ersoy University, Burdur, Turkey.

Methotrexate (MTX) is a drug used in the treatment of various types of cancer and inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin (API) is an effective flavonoid with antioxidant and anti-inflammatory properties. The aim of this study was to determine the protective effect of API against MTX-induced liver and kidney toxicity. Read More

J Orthop Trauma 2021 May;35(5):e165-e170

Chemical Engineering Department, Ecole Polytechnique de Montreal, Montreal, QC, Canada.

Objectives: To evaluate if local delivery of boron can accelerate bone healing and examine if the bioactive salt impacts the osteogenic response of bone-derived osteoclasts and osteoblasts by the regulation of the Wnt/β-catenin pathway.

Methods: Bilateral femoral cortical defects were created in 32 skeletally mature C57 mice. On the experimental side, boric acid (8 mg/kg concentration) was injected locally, whereas on the control side, saline was used. Read More

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More