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Pathogenic potential of the surviving Salmonella Enteritidis on strawberries after disinfection treatments based on ultraviolet-C light and peracetic acid.

Int J Food Microbiol 2022 Jan 10;364:109536. Epub 2022 Jan 10.

Universitat de Lleida, Food Technology Department, AGROTECNIO-CERCA Center, Rovira Roure 191, 25198 Lleida, Spain. Electronic address:

Fresh fruits, especially strawberries, are usually consumed raw without any step to ensure their food safety. Salmonella enterica is one of the most important etiologic agents for foodborne diseases throughout the world and its ability to respond to some stress responses makes it even more dangerous. In the present investigation, we study the survival of S. Read More

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January 2022

Lead acetate induces hippocampal pyramidal neuron degeneration in mice via up-regulation of executioner caspase-3, oxido-inflammatory stress expression and decreased BDNF and cholinergic activity: Reversal effects of Gingko biloba supplement.

J Trace Elem Med Biol 2021 Dec 24;71:126919. Epub 2021 Dec 24.

Neurophysiology Unit, Department of Physiology, Faculty of Basic Medical Sciences, PAMO University of Medical Sciences, Port-Harcourt, River State, Nigeria.

Purpose: It has been hypothesized that compounds with strong anti-oxidant activity might mitigate lead-induced neurotoxicity that resulted to neuronal degeneration.Ginkgo biloba supplement (GB-S) is a neuroactive supplement which has been reported to demonstrate neuroprotective effects. In this study, we investigated the reversal effect and the underlying mechanism of GB-S following lead-induced neurotoxicity in mice. Read More

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December 2021

Blocking of VEGF-A is not sufficient to completely revert its long-term effects on the barrier formed by retinal endothelial cells.

Exp Eye Res 2022 Jan 13:108945. Epub 2022 Jan 13.

Department of Ophthalmology, Ulm University Medical Center, Ulm, Germany.

The VEGF-A-induced functional impairment of the barrier formed by retinal endothelial cells (REC) can be prevented and even - at least temporarily - reverted by trapping the growth factor in a complex with a VEGF-binding protein or by inhibiting the activity of the VEGF receptor 2 (VEGFR2). In an approach to emulate the clinically relevant situation of constant exposure to effectors, we investigated (1) whether prolonged exposure to VEGF-A for up to six days results in a different type of disturbance of the barrier formed by immortalized bovine REC (iBREC) and (2) whether alterations of the barrier induced by VEGF-A can indeed be sustainably reverted by subsequent treatment with the VEGF-A-binding proteins ranibizumab or brolucizumab. As a measure of barrier integrity, the cell index (CI) of iBREC cultivated on gold electrodes was monitored continuously. Read More

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January 2022

FLOT (a chemotherapy regimen for gastric/esophagogastric junction cancer): to be treated as a highly emetogenic regimen or a moderately emetogenic one? Comparison of the emetogenic potential of FLOT versus FOLFOX and TAC regimens.

Support Care Cancer 2022 Jan 17. Epub 2022 Jan 17.

Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The current study aimed at investigating the efficacy of aprepitant-containing triple antiemetic regimen in FLOT (fluorouracil + leucovorin + oxaliplatin + docetaxel) recipients as well as the emetogenic potential of FLOT regimen, through comparison of nausea and vomiting rates in a moderately emetogenic chemotherapy, FLOT, and a highly emetogenic chemotherapy recipients.

Study: Patients planned to receive one of FLOT, FOLFOX (fluorouracil + leucovorin + oxaliplatin/moderate-emetic risk), or TAC (docetaxel + doxorubicin + cyclophosphamide/high-emetic risk) regimens were recruited. All patients were treated with the same triple antiemetic regimen containing aprepitant. Read More

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January 2022

[Clinical and social evaluation of depressed patients in a Psychogeriatric Day Hospital program].

An Sist Sanit Navar 2022 Jan 17;0(0). Epub 2022 Jan 17.

Hospital de Día Psicogeriátrico. Gerencia de Salud Mental. Servicio Navarro de Salud-Osasunbidea. Pamplona. España..

Background: The aim of this study was to identify the problems of patients with severe depressive symptoms (GDS>9) according to the HoNOS+65 scale, to evaluate the effectiveness of a partial hospitalization program to reduce severe depressive symptoms, and to identify independent predictors.

Methods: Pre-post study of patients with depression treated at the psychogeriatric Day Hospital (HDPG) of Pamplona (Spain). The scores obtained on the HoNOS+65, MMSE, GDS, BARTHEL, ALSAR, and COTE scales were compared at admission and discharge, and the prognostic factors for no improvement of severe depressive symptoms were determined. Read More

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January 2022

Feasibility and Safety of Ipsilateral Ulnar Access in Cases of Impossibility or Failure of Radial Access for Coronary Angiography or Percutaneous Coronary Intervention.

J Invasive Cardiol 2022 Jan 16. Epub 2022 Jan 16.

Paulo Vinicios Falcão Duarte, Interventional Cardiology Department, Instituto Nacional de Cardiologia, Rua das Laranjeiras, 374, Rio de Janeiro, Brazil 22240-006.

Objectives: To evaluate the feasibility and safety of using the ulnar access in coronary angiography and percutaneous coronary intervention, in the failure or contraindication of ipsilateral radial access.

Methods: We prospectively evaluated, in a quaternary hospital, patients undergoing coronary angiography or percutaneous coronary intervention by transulnar approach, in case of failure or contraindication to the ipsilateral radial access.

Results: Between August 2018 and March 2020, of the 5,916 invasive coronary procedures performed, 2. Read More

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January 2022

Ovarian response to P4-PGF-FSH treatment in Suffolk sheep and P4-PGF-PMSG synchronization in cross-bred ewes, for IVD and ET protocol.

Vet Med Sci 2022 Jan 17. Epub 2022 Jan 17.

Faculty of Veterinary Medicine, Department of Clinics, Reproduction, Iasi University of Life Sciences (IULS), Iasi, Romania.

Background: The success of an embryo transfer protocol in sheep depends on many factors, but the choice of drugs for the desired superovulation as well as the conception rate (CR) are most essential. Reproductive activity in sheep is characterized by a seasonality influenced by several factors such as photoperiod, latitude, temperature, nutrition and breed. Reproductive seasonality and nutritional condition are the main factors that influence embryo production in sheep. Read More

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January 2022

High-intensity interval training along with spirulina algae consumption and caloric restriction ameliorated the Nrf1/Tfam/Mgmt and ATP5A1 pathway in the heart tissue of obese rats.

J Food Biochem 2022 Jan 16:e14061. Epub 2022 Jan 16.

Department of Sports Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.

Nrf1/Tfam/MGMT and ATP5A1 might be a pivotal network in cardiovascular disease-inducing obesity. Therefore, we evaluated eight weeks of exercise, caloric restriction, and spirulina algae consumption on the heart in obese rats. In this study, obese rats were compared with a healthy group. Read More

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January 2022

Hypothalamic expression of GnRH-I and GnIH in the Eurasian tree sparrow over a single long day.

Photochem Photobiol Sci 2022 Jan 17. Epub 2022 Jan 17.

Department of Zoology, North-Eastern Hill University, Shillong, Meghalaya, 793022, India.

Seasonal reproductive cycles of most birds are regulated by photoperiod via neuroendocrine control. The present study aims to investigate the role of a single long day in triggering hypothalamic expressions of GnRH-I and GnIH in the Eurasian tree sparrow (Passer montanus). Sparrows were divided into two groups (n = 24 each) and pre-treated under short days (9L: 15D) for 4 days. Read More

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January 2022

The effect of progesterone administration on the expression of metastasis tumor antigens (MTA1 and MTA3) in placentas of normal and dexamethasone-treated rats.

Mol Biol Rep 2022 Jan 17. Epub 2022 Jan 17.

Department of Physiology, Faculty of Medicine, Kuwait University, Safat, P.O. Box 13060, Kuwait City, Kuwait.

Background: Dexamethasone (DEX) induces intrauterine growth restriction (IUGR) in pregnant rats. IUGR can occur due to apoptosis of trophoblasts, which is believed to be inhibited by progesterone (P4). A group of genes called MTAs play a role in proliferation and apoptosis. Read More

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January 2022

[Arthroscopic augmentation techniques for superior capsule reconstruction].

Oper Orthop Traumatol 2022 Jan 16. Epub 2022 Jan 16.

Abteilung für Orthopädie und Traumatologie, Ordensklinikum Barmherzige Schwestern Linz, Seilerstätte 4, 4010, Linz, Österreich.

Objectives: Reconstruction of the superior capsule for treatment of irreparable supraspinatus tendon tears.

Indications: Irreparable supraspinatus tendon tear; centered humeral head; largely intact cartilage; largely intact transversal "force-couple".

Contraindications: Decentered humeral head; osteoarthritis of the glenohumeral joint/cuff tear arthropathy; irreparable anterosuperior and posterosuperior cuff tears. Read More

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January 2022

Fosfomycin vs Ertapenem for Outpatient Treatment of Complicated Urinary Tract Infections: A Multicenter, Retrospective Cohort Study.

Open Forum Infect Dis 2022 Jan 23;9(1):ofab620. Epub 2021 Dec 23.

Los Angeles County - University of Southern California Medical Center (LAC-USC Medical Center), Los Angeles, California, USA.

Background: We sought to determine the comparative efficacy of fosfomycin vs ertapenem for outpatient treatment of complicated urinary tract infections (cUTIs).

Methods: We conducted a multicenter, retrospective cohort study involving patients with cUTI treated with outpatient oral fosfomycin vs intravenous ertapenem at 3 public hospitals in Los Angeles County between January 2018 and September 2020. The primary outcome was resolution of clinical symptoms 30 days after diagnosis. Read More

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January 2022

Case Report: Successful Management of a Compressive Intraspinal Species Granuloma in a Cat.

Front Vet Sci 2021 3;8:801885. Epub 2022 Jan 3.

Department of Veterinary Clinical Sciences, Veterinary Medical Center, Ohio State University, Columbus, OH, United States.

A 9-year-old, neutered male, domestic shorthair cat from Arizona, was presented for evaluation of a 7-day history of hind limb paraparesis that progressed to paraplegia. There was no history of respiratory abnormalities. Neurologic examination supported localization of a T3-L3 myelopathy. Read More

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January 2022

Microbiota diversity and bacterial load after successful treatment of infection with honey lavage in 4 patients.

Biosci Microbiota Food Health 2022 30;41(1):1-3. Epub 2021 Sep 30.

Department of Gastroenterology and Hepatology, St. Elisabeth-TweeSteden Hospital, Hilvarenbeekseweg 60, Noord-Brabant Tilburg 5022 GC, Netherlands.

In this letter, an experimental therapy in four patients with therapy-resistant infection is described. These four patients were treated with Manuka honey via colon lavage. First, the patients received a three-day fidaxomicin treatment. Read More

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September 2021

A Rare Case of Concomitant Septic Arthritis, Osteomyelitis, and Pyomyositis Caused by Salmonella.

Cureus 2021 Dec 12;13(12):e20365. Epub 2021 Dec 12.

Department of Internal Medicine/Rheumatology, Bronxcare Health System, Bronx, USA.

A common causative organism in osteomyelitis in sickle cell disease is . Septic arthritis and muscle infection due to are much less common. We present a case of a 28-year-old woman with sickle cell disease who presented with left shoulder and elbow pain for two days. Read More

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December 2021

A Complicated Case of COVID-19-Induced Inferolateral Wall Myocardial Infarction Successfully Treated With Streptokinase.

Cureus 2021 Dec 11;13(12):e20348. Epub 2021 Dec 11.

Medicine and Surgery, MS Ramaiah Medical College, Bangalore, IND.

The treatment of myocardial infarction (MI) in coronavirus disease 2019 (COVID-19)-positive patients is both controversial and challenging, particularly in a healthcare setup unable to fulfill COVID-19 protocols. In this report, we describe a case of a COVID-19-positive patient admitted with COVID-19 pneumonia treated symptomatically with a non-rebreathing mask, dexamethasone, remdesivir, and low-molecular-weight heparin (LMWH). On day two of the hospital stay, the patient developed inferolateral wall myocardial infarction (MI) without hemodynamic instability. Read More

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December 2021

Psychometric validation of a patient-reported single-item assessment of 'Good Day Bad Day' in a neurogenic orthostatic hypotension population treated with droxidopa.

J Mark Access Health Policy 2022 10;10(1):2010961. Epub 2022 Jan 10.

Health Economics and Outcomes Research, Lundbeck, Deerfield, Il, USA.

Background: Symptoms of neurogenic orthostatic hypotension (nOH), including lightheadedness/dizziness, presyncope, syncope, and falls, can lead to impaired functional ability and reduced quality of life. Because the severity and frequency of nOH symptoms fluctuate, it may be difficult for patients to accurately quantify the effect of symptoms on their daily lives using available outcome measures. A new single-item instrument, the 'Good Day Bad Day,' was developed, and its psychometric validity was assessed in patients with nOH. Read More

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January 2022

Effect of percutaneous minimally invasive pedicle screw internal fixation in the treatment of thoracolumbar vertebral fractures and its impact on quality of life.

Pak J Med Sci 2022 Jan-Feb;38(1):100-105

Chenyang Jiang, Department of Orthopaedics, Baoding No.1 Hospital, Baoding, Hebei, 071000, P.R. China.

Objectives: To investigate and analyze the effect of percutaneous minimally invasive pedicle screw internal fixation in the treatment of thoracolumbar vertebral fractures and its impact on quality of life.

Methods: Fifty patients with thoracolumbar vertebral fracture admitted to our hospital from January 2015 to December 2018 were selected and divided into two groups according to different treatment regimens. The observation group was treated with minimally invasive percutaneous pedicle screw internal fixation, while the control group was treated with traditional posterior approach open pedicle screw internal fixation. Read More

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February 2021

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function.

Infect Drug Resist 2022 8;15:53-62. Epub 2022 Jan 8.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Purpose: Critically ill patients with preserved or increased renal function have been shown to be at risk of underexposure to meropenem. Although many meropenem population pharmacokinetic (PK) models have been published, there is no large prospective population PK study with rich sampling focusing on patients most at risk of suboptimal pharmacokinetic/pharmacodynamic (PK/PD) target attainment. Therefore, the aim of the present study was to evaluate PK/PD target attainment and to perform a thorough covariate screening using population PK modelling of meropenem in septic patients with preserved or increased renal function. Read More

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January 2022

Ligustrazine protects against chronic hypertensive glaucoma in rats by inhibiting autophagy via the PI3K-Akt/mTOR pathway.

Mol Vis 2021 12;27:725-733. Epub 2021 Dec 12.

Department of Ophthalmology, The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, China.

Purpose: Glaucoma is a leading cause of global irreversible blindness, and characterized by the progressive loss of retinal ganglion cells (RGCs). Ligustrazine (TMP) is a natural product that has shown beneficial effects on various diseases. This study aimed to determine whether ligustrazine produces a therapeutic effect on glaucoma and to investigate its underlying mechanisms. Read More

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December 2021

Effect of Methylphenidate and buspirone-methylphenidate co-administration on biochemical and hematological parameters in rats: Implications for safe and confrontational use.

Pak J Pharm Sci 2021 Nov;34(6):2131-2139

Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan.

Methylphenidate (MPH) is a psychostimulant, beneficial in attention deficit hyperactivity disorder (ADHD). Previously it has been shown that MPH-induced locomotor sensitization could be attenuate by buspirone co administration however the effect of chronic MPH and co-administration of MPH-buspirone on biochemical and hematological parameters are unknown. This study is designed to investigate these parameters after long term administration of MPH, Buspirone and their combination in rats. Read More

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November 2021

Gestational alloimmune liver disease treated with exchange transfusion and intravenous immunoglobulin: A case study.

Transfus Apher Sci 2021 Dec 22:103347. Epub 2021 Dec 22.

Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, South Korea. Electronic address:

Gestational alloimmune liver disease (GALD) is a materno-fetal alloimmune disorder that targets the fetal liver and often causes neonatal liver failure. GALD most commonly presents as neonatal hemochromatosis (NH), which is a severe neonatal liver injury confirmed by extra-hepatic iron accumulation at various sites. With the discovery of the alloimmune mechanism of GALD, exchange transfusion and intravenous immunoglobulin (IVIG) administration are being used as novel treatments. Read More

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December 2021

Therapeutic efficacy of chloroquine for uncomplicated Plasmodium vivax malaria in southeastern and western border areas of Myanmar.

Infection 2022 Jan 16. Epub 2022 Jan 16.

Division of Infectious Diseases and International Medicine, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, FL, 33612, USA.

Background: In the Greater Mekong Subregion of Southeast Asia, Plasmodium vivax malaria is endemic and causes significant morbidity. In this study, the efficacy of chloroquine for treating uncomplicated P. vivax malaria at the eastern and western borders of Myanmar was investigated. Read More

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January 2022

Cytomegalovirus Enteritis Induced by Baricitinib and Tacrolimus: Association or Coincidence?

J Rheumatol 2022 Jan 15. Epub 2022 Jan 15.

Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou; Department of Nephrology, Xiangya Second Hospital, Central South University, Changsha, Hunan, China. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. J. Li, Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China. Email:

We read the recent article by Sugawara et al with great interest. The authors described a 65-year-old patient with rheumatoid arthritis who had been treated with methotrexate for 14 years without any adverse effects, yet within the last 6 months had developed fever and abdominal pain when treated with 2 mg/day of tacrolimus and 4 mg of baricitinib. Read More

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January 2022

Stent retriever versus direct aspiration thrombectomy for acute large vessel occlusion: A meta-analysis including 17,556 patients, from MR CLEAN to present.

Clin Neurol Neurosurg 2022 Jan 10;213:107122. Epub 2022 Jan 10.

Department of Neurosurgery, University of Texas Health and Science Center at San Antonio, San Antonio, TX, United States. Electronic address:

Objective: Stent retriever (SR) and direct aspiration (DA) mechanical thrombectomy (MT) improve clinical outcomes for stroke secondary to large vessel occlusion. The purpose is to perform an updated meta-analysis comparing the two techniques.

Methods: PubMed database was searched for studies between January 1, 2015, and July 5th, 2021 with mechanical thrombectomy to treat acute ischemic stroke. Read More

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January 2022

Resuscitation Using ECPR During In-Hospital Cardiac Arrest (RESCUE-IHCA) Mortality Prediction Score and External Validation.

JACC Cardiovasc Interv 2022 Jan 5. Epub 2022 Jan 5.

Division of Pediatric Critical Care, Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, USA.

Objectives: The aim of this study was to develop and validate a score to accurately predict the probability of death for adult extracorporeal cardiopulmonary resuscitation (ECPR).

Background: ECPR is being increasingly used to treat refractory in-hospital cardiac arrest (IHCA), but survival varies from 20% to 40%.

Methods: Adult patients with extracorporeal membrane oxygenation for IHCA (ECPR) were identified from the American Heart Association GWTG-R (Get With the Guidelines-Resuscitation) registry. Read More

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January 2022

Effects of Bilwa-Lajadi syrup in emesis gravidarum - an exploratory single arm open labeled trial.

J Ayurveda Integr Med 2022 Jan 12:100522. Epub 2022 Jan 12.

Government Ayurveda Hospital, Mudigere, Chikmagalur, 577132, Karnataka, India.

Background: Emesis gravidarum is a common obstetrical problem affecting 50-80% of pregnant women during their first trimester which begins in the morning and frequently continues throughout the day; considered as one of the Vyakta Garbha Lakshana in Ayurveda. If it is not treated effectively in time; it may lead to complications in pregnancy affecting the quality of life and thus the pregnancy outcome.

Objective: To evaluate the clinical effectiveness of Bilwa-Lajadi syrup in emesis gravidarum. Read More

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January 2022

Short-term clinical outcomes of onasemnogene abeparvovec treatment for spinal muscular atrophy.

Brain Dev 2022 Jan 12. Epub 2022 Jan 12.

Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Introduction: Spinal muscular atrophy (SMA) is a degenerative neuromuscular disorder long recognized as the most common genetic cause of infantile mortality described so far. However, the emergence of some innovative therapies, such as nusinersen and onasemnogene abeparvovec (AVXS-101), have made it possible to change the disease course of SMA.

Methods: In this study, five SMA type 1 and one SMA type 2 patients who received AVXS-101 were enrolled (7-24 months of age when administered). Read More

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January 2022

Effects of a single transdermal administration of flunixin meglumine in early postpartum Holstein Friesian dairy cows: Part 1. Inflammatory and metabolic markers, uterine health, and indicators of pain.

J Dairy Sci 2022 Jan 12. Epub 2022 Jan 12.

Ruminant and Swine Clinic, Free University of Berlin, Germany 14163.

The objectives of this study were to assess the effects of a single transdermal administration of flunixin meglumine (FM) in early postpartum Holstein Friesian dairy cows on serum concentrations of inflammatory and metabolic markers, uterine health, and indicators of pain. The hypothesis was that the anti-inflammatory, antipyretic, and analgetic effects of the pharmaceutic agent would reduce systemic inflammation, resulting in improved metabolic and inflammatory profile, diminished incidence of metritis, and reduced expression of pain. A total of 500 cows (153 primiparous, 347 multiparous) from 3 different commercial dairy farms in the northeast of Germany were included in a randomized controlled clinical trial. Read More

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January 2022

Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial.

Lancet Oncol 2022 Jan 13. Epub 2022 Jan 13.

Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Patients with non-small-cell lung cancer (NSCLC) that is resistant to PD-1 and PD-L1 (PD[L]-1)-targeted therapy have poor outcomes. Studies suggest that radiotherapy could enhance antitumour immunity. Therefore, we investigated the potential benefit of PD-L1 (durvalumab) and CTLA-4 (tremelimumab) inhibition alone or combined with radiotherapy. Read More

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January 2022