497,412 results match your criteria treated animals

In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2.

AMB Express 2021 Jul 27;11(1):109. Epub 2021 Jul 27.

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, African Union Organization St. Abbassia, Cairo, 11566, Egypt.

Failure in the treatment of P. aeruginosa, due to its broad spectrum of resistance, has been associated with increased patient mortality. One alternative approach for infection control is quorum quenching which was found to decrease virulence of such pathogen. Read More

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Multigeneric resistance to monepantel on a UK sheep farm.

Vet Parasitol 2019 16;276S:100003. Epub 2019 Feb 16.

Disease Control, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, United Kingdom.

The amino acetonitrile derivative, monepantel, represented the first new broad spectrum anthelmintic to be brought to market for use in sheep for over 25 years when it was introduced in 2009. This study characterised monepantel efficacy, using faecal egg count reduction and controlled efficacy tests, against gastrointestinal nematodes following a report of treatment failure in a UK lowland sheep flock. Twelve lambs were each artificially administered 15,000 infective larvae that had been propagated from lamb faeces collected from the farm of interest. Read More

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February 2019

Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation.

ACS Biomater Sci Eng 2021 Jul 23. Epub 2021 Jul 23.

Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.

Selective permeability of the blood-brain barrier limits effective treatment of neurodegenerative disorders. In the present study, brain-targeted lipid-coated mesoporous silica nanoparticles (MSNs) containing berberine (BBR) were synthesized for the effective treatment of Alzheimer's disease (AD). The study involved synthesis of Mobil Composition of Matter-41 (MCM-41) mesoporous silica nanoparticles (MSNs), BBR loading, and lipid coating of MSNs (MSNs-BBR-L) and and characterization of MSNs-BBR-L. Read More

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Evaluation of lipolysis and toxicological parameters of low-level laser therapy at different wavelengths and doses in the abdominal subcutaneous tissue.

Lasers Med Sci 2021 Jul 23. Epub 2021 Jul 23.

Department of Cosmetics and Aesthetic, Lutheran University of Brazil, Canoas, RS, 92425-900, Brazil.

Investigate the effects of low-level lasers therapy (LLLT) aiming abdominal lipolysis. Female Wistar rats received applications of LLLT directly in the abdominal skin twice a week (5 weeks). Except the control group (n = 5), animals received treatments with red wavelength 660 nm being (I) R3. Read More

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Depression of Pyroptosis by Inhibiting Caspase-1 Activation Improves Neurological Outcomes of Kernicterus Model Rats.

ACS Chem Neurosci 2021 Jul 23. Epub 2021 Jul 23.

Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.

Kernicterus is a severe complication of extreme neonatal hyperbilirubinemia. Prolonged exposure to high-level unconjugated bilirubin (UCB) directly damages brain tissue. Neuroinflammation is believed to contribute to UCB-induced neurotoxicity. Read More

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Vancomycin and daptomycin modulate the innate immune response in a murine model of LPS-induced sepsis.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211031373

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Sepsis is a leading cause of death worldwide, despite the use of multimodal therapies. Common antibiotic regimens are being affected by a rising number of multidrug-resistant pathogens, and new therapeutic approaches are therefore needed. Antibiotics have immunomodulatory properties which appear to be beneficial in the treatment of sepsis. Read More

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Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway.

Mol Med Rep 2021 Sep 23;24(3). Epub 2021 Jul 23.

Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, Heping, Shenyang, Liaoning 110001, P.R. China.

The present study aimed to investigate the protective effects of sacubitril/valsartan (LCZ696) on ventricular remodeling in myocardial infarction (MI) and the effects of the inflammasome‑mediated inflammatory response. First, a rat model was established. Animals were then treated with LCZ696 so that the histopathological changes associated with ventricular remodeling could be investigated. Read More

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September 2021

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates.

Sci Rep 2021 Jul 22;11(1):15043. Epub 2021 Jul 22.

Department of Biomedical Engineering, Columbia University, New York City, NY, 10032, USA.

An emerging approach with potential in improving the treatment of neurodegenerative diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood-brain barrier (BBB) in a non-invasive and localized manner. A large body of pre-clinical work has paved the way for the gradual clinical implementation of FUS-induced BBB opening. Even though the safety profile of FUS treatments in rodents has been extensively studied, the histological and behavioral effects of clinically relevant BBB opening in large animals are relatively understudied. Read More

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First Report of Enterobacter cloacae Causing Bulb Decay on Garlic in China.

Plant Dis 2021 Jul 26. Epub 2021 Jul 26.

Beijing, China;

Enterobacter cloacae is a symbiotic bacterium, which is one of the species in intestinal microbiota in many humans and animals. In some cases, it causes harmful diseases in humans. More and more studies showed that E. Read More

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Angiotensin aldosterone inhibitors improve survival and ameliorate kidney injury induced by sepsis through suppression of inflammation and apoptosis.

Fundam Clin Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt.

Sepsis is an extensive life-threatening illness that occurs due to an abnormal host response which extends through the initial storm of inflammation and oxidative stress and terminates at the late stage of immunosuppression. Among global intensive care units, sepsis induced acute kidney injury is reported with high mortality rate. The purpose of this study was to evaluate the protective effect of the renin angiotensin aldosterone system (RAAS) inhibition on sepsis outcomes. Read More

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[Ginsenoside Rh2 inhibits renal fibrosis and renal cell apoptosis in rats with diabetic nephropathy by downregulating discoid domain receptor 1].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1107-1113

Department of Pharmacy, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an 237005, China.

Objective: To investigate the effect of ginsenoside Rh2 (G-Rh2) on renal fibrosis and cell apoptosis in rats with diabetic nephropathy (DN) and explore its possible mechanism.

Methods: Thirty male SD rats were randomized equally into control group, DN group and ginsenoside Rh2 intervention group. In the latter two groups, rat models of DN were established by intraperitoneal injection of streptozotocin, and the rats in the control group received injection of citrate buffer. Read More

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[2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside alleviates lipopolysaccharide-induced acute lung injury in rats].

J Chen H Liu

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1101-1106

Department of General Practice, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, China.

Objective: To observe the protective effect of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats and explore the underlying mechanism.

Methods: Thirty-six SD rats were randomized equally into 4 groups: the normal control group, ALI model group, and low- and high-dose TSG groups (treated with 50 and 100 mg/kg TSG via intragastric administration, respectively). In all but the normal control group, the rats were subjected to tail vein injection of LPS to induced ALI. Read More

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[Antitumor effects of AZD2014, a dual mTORC1/2 inhibitor, against human hepatocellular carcinoma xenograft in nude mice].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1056-1061

Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To investigate the antitumor effects of AZD2014 (a dual mTORC1/2 inhibitor) against human hepatocellular carcinoma (HCC) xenograft in mice.

Methods: HCCLM3 cells were injected subcutaneously in the right flank of nude mice, and when the tumors were macroscopic, the mice were randomized into 2 groups for daily intraperitoneal injection of AZD2014 (5 mg/kg, =5) or vehicle (5 mL/kg, =5) for 24 days. Tumor growth was assessed using calipers every 4 days and the tumor growth curve was drawn. Read More

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[ formula alleviates liver fibrosis in mice by inhibiting hepatic IDO1 expression and promoting phenotypic maturation of dendritic cells].

C Mo S Xie L Gao Z Lü

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1002-1011

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Objective: To investigate the protective effect of (BGN), a traditional Chinese medicinal formula, against CCl4-induced liver fibrosis in mice and explore the mechanism.

Methods: C57BL/6 mice were randomly divided into control group, liver fibrosis model group, positive control group and the low-, middle-, and high-dose BGN groups (=10). In all but the control group, the mice were subjected to daily intraperitoneal injection of 25% CCl (in olive oil) to induce liver fibrosis and intragastric gavage of corresponding drugs. Read More

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[Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):972-979

Department of Neurology, Guangdong Provincial People's Hospital //Guangdong Neuroscience Institute, Guangzhou 510080, China.

Objective: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-κB (NF-κB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.

Methods: Murine microglial cell line Bv-2 was infected with a lentivirus carrying MIF shRNA for MIF knockdown and then treated with MPP+. The total protein levels of NLRP3, caspase-1, p65 and p65 in the cell nuclei and cytoplasm were detected. Read More

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Effect of Adipose derived mesenchymal stem cells on multiple Organ Injuries in diet-induced obese mice.

Tissue Barriers 2021 Jul 25:1952150. Epub 2021 Jul 25.

Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.

: Obesity is a complex disease involving the accumulation of body fat that can inflict a substantial risk to health due to the potent role it plays in the development of a series of chronic diseases including cardiovascular diseases (CVD), nonalcoholic fatty liver diseases (NAFLD), kidney diseases, diabetes, and some cancers. Despite all efforts made, no therapy has succeeded in reversing the obesity pandemic and its associated diseases. Herein, the aim was to study the effect of adipose-derived mesenchymal stem cells on obesity-induced multi-organ injuries in a diet-induced obese mouse model. Read More

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Green tea catechins in combination with irinotecan attenuates tumorigenesis and treatment-associated toxicity in an inflammation-associated colon cancer mice model.

J Egypt Natl Canc Inst 2021 Jul 26;33(1):17. Epub 2021 Jul 26.

Cell & Molecular Biology Section, Department of Zoology, Rajiv Gandhi University, Rono Hills, Doimukh, Itanagar, Arunachal Pradesh, 791112, India.

Background: Administration of green tea (GT) catechins has been reported to ensue antitumor activity in combination with chemotherapeutic drugs against different cancer types. Irinotecan (IRN) is a highly effective chemotherapeutic drug against various types of cancer including colon cancer along with its analogous dose-limiting side effects viz. diarrhea, neutropenia, leucopenia, and non-alcoholic fatty liver disease (NAFLD) as major toxicities. Read More

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Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model.

Regen Ther 2021 Dec 9;18:182-190. Epub 2021 Jul 9.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Introduction: Idiopathic dilated cardiomyopathy (DCM) is associated with abnormalities in cytoskeletal proteins, mitochondrial ATP transporter, microvasculature, and fibrosis. Mesenchymal stem cells (MSCs) can ameliorate distressed mitochondrial and structural proteins, as well as fibrosis, via the paracrine effect of cytokines. This study aimed to investigate whether the transplantation of adipose tissue-derived MSCs (ADSCs) reverses histological and functional abnormalities in the distressed myocardium of DCM-like hamsters by modulating the expression of adenine nucleotide translocase 1 (ANT-1). Read More

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December 2021

Peri-interventional Triple Therapy With Dabigatran Improves Vasomotion and Promotes Endothelialization in Porcine Coronary Stenting Model.

Front Cardiovasc Med 2021 2;8:690476. Epub 2021 Jul 2.

Department of Cardiology, Medical University of Vienna, Vienna, Austria.

We evaluated the short and long-term effect of peri-interventional dabigatran therapy on vasomotion, endothelialization, and neointimal formation in a porcine coronary artery stenting model. Stenting of coronary arteries induces local inflammation, impairs vasomotion and delays endothelialization. Twenty-eight animals underwent percutaneous coronary intervention (PCI) with drug eluting stents. Read More

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Patellar luxation in Hejazi goats.

Open Vet J 2021 Apr-Jun;11(2):295-300. Epub 2021 Jun 18.

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya.

Background: Patellar luxation (PL) is a common orthopedic affection among farm and pet animals with mostly congenital (environmental and/or genetic) background.

Aim: We report here the first observation of lateral PL in Hejazi goats bred in Libya.

Methods: Five Hejazi goats aged between 4 months and 2 years with severe hind limb lameness were admitted to Al-Sorouh veterinary clinic in Tripoli during the period from 2016 to 2018. Read More

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2018 Survey of factors associated with antimicrobial drug use and stewardship practices in adult cows on conventional California dairies: immediate post-Senate Bill 27 impact.

PeerJ 2021 13;9:e11596. Epub 2021 Jul 13.

Veterinary Medicine Teaching and Research Center, University of California, Davis, Tulare, CA, United States.

Background: Antimicrobial drugs (AMD) are critical for the treatment, control, and prevention of diseases in humans and food-animals. Good AMD stewardship practices and judicious use of AMD are beneficial to the preservation of animal and human health from antimicrobial resistance threat. This study reports on changes in AMD use and stewardship practices on California (CA) dairies, following the implementation of CA Senate Bill 27 (SB 27; codified as Food and Agricultural Code, FAC 14400-14408; here onward referred to as SB 27), by modeling the associations between management practices on CA conventional dairies and seven outcome variables relating to AMD use and stewardship practices following SB 27. Read More

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Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of (Ait). R. Br. (Apocynaceae) in Mice.

Scientifica (Cairo) 2021 1;2021:5551380. Epub 2021 Jul 1.

Department of Pharmacology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.

Background: has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated. Read More

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Linn. Extract Improves Cognitive Deficits in Olfactory Bulbectomized Mice via the Enhancement of Central Cholinergic Systems and VEGF Expression.

Evid Based Complement Alternat Med 2021 30;2021:6627648. Epub 2021 Jun 30.

Center for Supporting Pharmaceutical Education, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan.

This study aimed to clarify the antidementia effects of ethanolic extract of Linn. (OS) and its underlying mechanisms using olfactory bulbectomized (OBX) mice. OBX mice were treated daily with OS or a reference drug, donepezil (DNP). Read More

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Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-/) and the Fatty Acid Metabolizing Enzyme Protein CPT1A by Camel Milk Treatment Counteracts the High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease.

PPAR Res 2021 9;2021:5558731. Epub 2021 Jul 9.

Physiology Department (29), College of Medicine, King Saud University Medical City (KSUMC), King Saud University, PO Box 2925, Riyadh 11461, Saudi Arabia.

Camel milk (CM) has a unique composition rich in antioxidants, trace elements, immunoglobulins, insulin, and insulin-like proteins. Treatment by CM demonstrated protective effects against nonalcoholic fatty liver disease (NAFLD) induced by a high-fat cholesterol-rich diet (HFD-C) in rats. CM dampened the steatosis, inflammation, and ballooning degeneration of the hepatocytes. Read More

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Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats.

Front Pharmacol 2021 8;12:626238. Epub 2021 Jul 8.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-R), Raebareli, India.

We evaluated the neuro-, immuno-, and male reproductive toxicity of zinc oxide nanoparticles (ZnO NPs) alone and in combination with lead acetate. We also studied the therapeutic role of α-lipoic acid postexposure. Lead (10 mg/kg, body weight), ZnO NPs (100 mg/kg, bwt) alone, and their combination were administered orally in Wistar rats for 28 days, followed by the administration of α-lipoic acid (15 mg/kg, bwt) for the next 15 days. Read More

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The Role of Interhemispheric Interactions in Cortical Plasticity.

Front Neurosci 2021 9;15:631328. Epub 2021 Jul 9.

Faculty of Biology, University of Warsaw, Warsaw, Poland.

Despite the fact that there is a growing awareness to the callosal connections between hemispheres the two hemispheres of the brain are commonly treated as independent structures when peripheral or cortical manipulations are applied to one of them. The contralateral hemisphere is often used as a within-animal control of plastic changes induced onto the other side of the brain. This ensures uniform conditions for producing experimental and control data, but it may overlook possible interhemispheric interactions. Read More

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Role of TRPV1 channels on glycogen synthase kinase-3β and oxidative stress in ouabain-induced bipolar disease.

J Recept Signal Transduct Res 2021 Jul 26:1-11. Epub 2021 Jul 26.

Department of Pharmacology, School of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Bipolar disorder (BD) is a multifactorial chronic and refractory disease characterized by manic, depressive, and mixed mood episodes. Although epidemiological, and pathophysiological studies demonstrated a strong correlation between bipolar disorder and oxidative stress, precise etiology is still missing. Recent studies suggested the possible role of transient receptor potential channels (TRP) in the BD but, current knowledge is limited. Read More

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Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling.

Hypertension 2021 Jul 26:HYPERTENSIONAHA12117517. Epub 2021 Jul 26.

Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), Barcelona, Spain (L.C., J.A., C.B.-S., S.V., J.M.-G.).

Pharmacological treatments for preventing abdominal aortic aneurysm (AAA) rupture or slowing aneurysm progression remain a challenge. It is increasingly recognized that sympathetic activity might play a role in the pathogenesis of AAA; however, the impact of this pathway remains unclear. Here, we show that the expression of tyrosine hydroxylase (), dopamine β-hydroxylase (), and the norepinephrine transporter is upregulated in abdominal aorta samples from AAA patients and in the aneurysmal aorta from 2 animal models susceptible to Ang II (angiotensin II)-induced AAA: the apolipoprotein E-deficient (ApoE) model and a transgenic mouse that overexpresses the human nuclear receptor NOR-1 (neuron-derived orphan receptor-1) in the vascular wall (TgNOR-1). Read More

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Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole.

Purinergic Signal 2021 Jul 24. Epub 2021 Jul 24.

Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.

Chagas disease (CD) is caused by the parasite Trypanosoma cruzi. CD affects people worldwide, primarily in tropical areas. The central nervous system (CNS) is an essential site for T. Read More

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Folpet induces mitochondrial dysfunction and ROS-mediated apoptosis in mouse Sertoli cells.

Pestic Biochem Physiol 2021 Aug 12;177:104903. Epub 2021 Jun 12.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Folpet is a phthalimide type of fungicide and has been used to control several crop diseases. Although it has adverse effects on the gastrointestinal tract, its mechanism and toxic effects on testis have not been demonstrated. In the present study, we elucidated the cytotoxic effect of folpet on the mouse Sertoli cell line, TM4. Read More

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