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Occipital Nerve Blockade for the Treatment of Occipital Neuralgia-Like Acute Postcraniotomy Headache: A Retrospective Study.

Pain Res Manag 2021 19;2021:5572121. Epub 2021 Apr 19.

Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Objective: The therapeutic effectiveness and safety of occipital nerve blockade (ONB) on occipital neuralgia- (ON-) like acute postcraniotomy headache (ON-APCH) was evaluated.

Background: Persistent occipital neuralgia is a subclassification of chronic postcraniotomy headache and has been investigated sporadically in previous publications. The long-lasting neuralgic pain significantly impairs postoperative recovery and quality of life. Read More

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Efficacy and Safety of Tripterygium Glycoside in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis Based on the Duration of Medication.

Front Endocrinol (Lausanne) 2021 20;12:656621. Epub 2021 Apr 20.

School of Life and Science, Beijing University of Chinese Medicine, Beijing, China.

Aim: The aim of this study was to assess the clinical efficacy and safety of Tripterygium-derived glycosides (TG) after 3-month and 6-month of treatments of diabetic nephropathy (DN) and to resolve the conflict between medicine guidance and clinical practice for TG application.

Methods: We conducted a systematic review and meta-analysis of randomized controlled trials involving TG application in treating DN. We extensively searched PubMed, Cochrane Library, CNKI, VIP, Wan-Fang, CBM, Chinese Clinical Trial Registry, and WHO International Clinical Trial Registration Platform till November 2020, along with grey literature for diabetes and all other relevant publications to gather eligible studies. Read More

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Influence of Early Enteral Nutrition on Clinical Outcomes in Neurocritical Care Patients With Intracerebral Hemorrhage.

Front Neurol 2021 20;12:665791. Epub 2021 Apr 20.

Department of Neurology, University Hospital Erlangen-Nuremberg, Erlangen, Germany.

Early enteral nutrition (EEN) represents the current standard of care for patients treated in general intensive care units (ICU). Specific nutritional recommendations for patients receiving dedicated neurocritical care are not established. This study investigated associations of EEN with clinical outcomes for patients suffering from intracerebral hemorrhage treated at a neurological ICU (NICU). Read More

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Timing and Spectrum of Neurological Complications After Flow Diverter Implantation for Intracranial Aneurysms.

Front Neurol 2021 20;12:590383. Epub 2021 Apr 20.

Interventional Neuroradiology, Rothschild Foundation Hospital, Paris, France.

The aim of this study was to characterize neurological complications after flow diverter (FD) treatment on a long follow-up cohort and identify predictive factors associated with these complications. This study was conducted on a monocentric cohort of patients treated for intracranial aneurysms by FD. Between September 2008 and July 2018, 413 patients were treated for 514 aneurysms: 18% of the patients presented with at least one neurological complication during a median follow-up of 446 days (IQR 186-1,210). Read More

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Tropical pyomyositis in scrub typhus: a rare association.

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, Kolkata, India.

Tropical pyomyositis manifests as single or multiple abscesses inside skeletal muscles and it has a higher prevalence in immunocompromised patients. Scrub typhus, a zoonotic disease is caused by and the clinical manifestations range from simple febrile illness to organ threatening complications. Here, we present a rare case of an immunocompetent young man diagnosed as tropical pyomyositis in association with scrub typhus. Read More

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Selective transvenous embolization combined with balloon angioplasty of the occluded inferior petrosal sinus for the treatment of cavernous sinus dural arteriovenous fistulas.

Interv Neuroradiol 2021 May 6:15910199211016234. Epub 2021 May 6.

Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.

Background And Purpose: Angioplasty of the dural sinus has rarely been performed for the treatment of cavernous sinus dural arteriovenous fistulas. We evaluated the efficacy of selective transvenous embolization (TVE) combined with balloon angioplasty of the occluded inferior petrosal sinus (IPS) for the treatment of cavernous sinus dural arteriovenous fistulas (CSDAVFs).

Materials And Methods: A total of 8 consecutive patients with CSDAVFs with occlusion of the IPS treated by selective TVE with balloon angioplasty of the IPS from July 2018 to January 2019 were retrospectively reviewed. Read More

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Direct vs Indirect Revascularization in a North American Cohort of Moyamoya Disease.

Neurosurgery 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: In adults with ischemic moyamoya disease (MMD), the efficacy of direct vs indirect revascularization procedures remains a matter of debate.

Objective: To investigate the outcomes of ischemic MMD in a North American cohort treated by direct and indirect revascularizations.

Methods: We retrospectively reviewed medical records of adult patients with MMD with ischemic presentation from 1984 to 2018 at the Brigham and Women's Hospital and Massachusetts General Hospital who underwent either direct or indirect bypasses. Read More

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Subthalamic Nucleus Deep Brain Stimulation Lessens Acquired Dystonia: Report of Two Patients and Systematic Review of Published Cases.

Stereotact Funct Neurosurg 2021 May 6:1-13. Epub 2021 May 6.

Neurology and Functional Neurosurgery Department, Hospital Santa Marcelina, São Paulo, Brazil.

Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficient treatment of primary dystonia. Few studies have reported the effect of STN-DBS on secondary or acquired dystonia.

Methods: We reported 2 patients with acquired dystonia treated by subthalamic DBS and followed up for 24 months, besides providing a systematic review and meta-analysis of published series. Read More

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Metanalysis of alloplastic materials versus autologous fat for injection augmentation pharyngoplasty treatment of velopharyngeal insufficiency.

Int J Pediatr Otorhinolaryngol 2021 Apr 28;146:110738. Epub 2021 Apr 28.

Tufts Medical Center, Boston, MA, USA.

Background: Velopharyngeal insufficiency (VPI) can cause resonance, speech and feeding problems. While reconstructive palatoplasty and surgical pharyngoplasty techniques are the mainstay of treatment for severe VPI, injection augmentation pharyngoplasty offers a minimally invasive approach in patients with mild-to-moderate VPI.

Methods: We conducted a systematic review of the literature available on PubMed and Embase from 1990 to 2019 including studies that addressed VPI, incompetence, or dysfunction managed with injection augmentation. Read More

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Laryngeal cleft: A literature review.

Am J Otolaryngol 2021 Apr 20;42(6):103072. Epub 2021 Apr 20.

Department of Otolaryngology - Head and Neck Surgery, Drexel University College of Medicine, United States of America; Lankenau Institute for Medical Research, United States of America. Electronic address:

Introduction: Laryngeal cleft is a congenital condition in which an opening in the posterior laryngotracheal wall allows food and liquid to pass from the esophageal lumen to the airway and causes aspiration. The severity of a laryngeal cleft is measured using the Benjamin-Inglis system, and can be managed conservatively or with a variety of surgical options With increased awareness, higher suspicion among primary physicians, advanced technology and improved intensive neonatal care services, more babies with laryngeal clefts survive in the modern era. Therefore, the focus has shifted from infant survival to treatment of laryngeal clefts and the challenging, complex medical conditions they create. Read More

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Coil assisted glue embolization to improve safety and accuracy in endovascular management of Vein of Galen patients.

Clin Neurol Neurosurg 2021 Apr 21;205:106652. Epub 2021 Apr 21.

Army Hospital (Referral & Research), Delhi Cantt, New Delhi 110010, India. Electronic address:

Background: Vein of Galen malformation (VOGM) patients present in neonatal age with cardiac failure or significant neurologic consequences. The most established method of treatment has been transarterial embolization with high concentration glue (N-Butyl Cyano Acrylate) which may be difficult to control due to very high flow rates and may migrate to the venous side with undesirable consequences. We describe our experience in four patients in whom initial coil placement in prominent feeding arteries helped inflow reduction thereby facilitating controlled glue injection with a good result and no incidence of non-target embolization. Read More

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Benefits of conservative management of a retained appendicolith after laparoscopic appendectomy: A case series.

Int J Surg Case Rep 2021 Apr 27;82:105925. Epub 2021 Apr 27.

Trauma and Acute Care Surgery Unit, Department of Surgery, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Introduction: Acute appendicitis is a disease with multifactorial etiology and frequently includes lumen obstruction. Appendicoliths can pose a challenge during the appendectomy procedure if not identified.

Methods: This is a prospective case series at our academic institution involving two medically free patients with intra-abdominal abscess formation secondary to an overlooked appendicolith who were treated conservatively with a follow up period of one year for each patient. Read More

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Outcomes of endovenous laser ablation with additional iliac vein stenting of non-thrombotic lesions in patients presenting with active venous ulcers.

J Vasc Surg Venous Lymphat Disord 2021 May 3. Epub 2021 May 3.

Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine; Vascular Center of Shanghai JiaoTong University, Shanghai 200011, China. Electronic address:

Objective: To evaluate the clinical outcomes of superficial and perforator ablation and the impact on wound healing by adding iliac vein stenting of non-thrombotic iliac vein lesions (NIVLs) in patients presenting with active venous ulcers.

Methods And Materials: A retrospective analysis was performed from January 2017 to December 2019, examining patients presenting with venous ulcers who were diagnosed with NIVLs. Patients with> 50% diameter reduction in the iliac vein based on computed tomography venogram underwent transfemoral venography for further confirmation. Read More

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Reconstruction in Women with T4 Breast Cancer after Neoadjuvant Chemotherapy: When Is It Safe?

J Am Coll Surg 2021 Apr 24. Epub 2021 Apr 24.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Background: Despite limited evidence regarding its safety, immediate reconstruction (IR) is increasingly offered to women with T4 breast cancer. We compared outcomes following IR, delayed reconstruction (DR), and no reconstruction (NR) in patients treated with neoadjuvant chemotherapy (NAC) and postmastectomy radiation therapy (PMRT) for T4 disease.

Study Design: We retrospectively identified consecutive women with T4 tumors treated with trimodality therapy from 1/2007-12/2019. Read More

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In silico network pharmacology and in vivo analysis of berberine-related mechanisms against type 2 diabetes mellitus and its complications.

J Ethnopharmacol 2021 May 3:114180. Epub 2021 May 3.

Endocrinology Department, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China. Electronic address:

Ethnopharmacological Relevance: Berberine (BBR), extracted from the traditional medicinal plant Coptis chinensis Franch., has been widely used for the treatment of type 2 diabetes mellitus (T2DM) and its complications.

Aim Of The Study: To determine the potential pharmacological mechanisms underlying BBR therapeutic effect on T2DM and its complications by in silico network pharmacology and experimental in vivo validation. Read More

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Risk stratification of cardiovascular complications using CHADS-VASc and CHADS scores in chronic atherosclerotic cardiovascular disease.

Int J Cardiol 2021 May 3. Epub 2021 May 3.

Cardiology Research Unit, University Hospital Geelong, Barwon Health, Geelong, Australia.

Background The COMPASS (Cardiovascular Outcomes for People Using Anticoagulation Strategies) trial showed that rivaroxaban plus aspirin reduced major adverse cardiovascular events (MACE) in patients with chronic coronary artery disease (CAD) and/or peripheral artery disease (PAD). We explored whether CHADS-VASc or CHADS scores, well-validated tools for assessing risk of thromboembolic events in atrial fibrillation, can identify vascular patients at highest risk of recurrent events who may derive greatest benefits of treatment. Methods Predictive accuracies of the CHADS-VASc and CHADS scores for MACE, were assessed in this analysis of the COMPASS trial. Read More

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Clinical Perspectives of Multiple and Extensively Drug-Resistant Typhoid; result from a tertiary care hospital from Pakistan.

J Infect Dev Ctries 2021 Apr 30;15(4):530-537. Epub 2021 Apr 30.

Department of Medicine, Combined Military Hospital Lahore Medical College, Lahore, Pakistan.

Introduction: Typhoid fever remains a problem in developing countries, including Pakistan. The emergence of multidrug-resistant and, since 2016, of extensively drug-resistant cases is a continuous challenge for health care workers. The COVID-19 pandemic is making management more difficult. Read More

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Platelet aggregometry for hip fracture surgery in patients treated with clopidogrel: a pilot study.

J Clin Monit Comput 2021 May 6. Epub 2021 May 6.

Anesthesia and Intensive Care Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.

Surgery for hip fractures should be performed within 48 h from patient's admission. However, several factors including chronic antiplatelet therapy could delay operation. Among the totality of patients taking clopidogrel, up to 30% are resistant to the drug and have a normal platelets reactivity. Read More

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Transarterial embolization with n-butyl cyanoacrylate for the treatment of active abdominopelvic bleeding in the polytraumatized patient.

CVIR Endovasc 2021 May 6;4(1):39. Epub 2021 May 6.

Division of Interventional Radiology, Department of Radiology, Hematology and Oncology, Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, 14048-090, Brazil.

Purpose: An increasing number of polytraumatized patient presenting with active abdominal pelvic bleeding (APB) have been treated by endovascular selective embolization. However, reports on evaluate the efficacy, safety and complications caused by this technique have been limited. The aim of this study was to assess the safety and efficacy of embolization of APB using N-butyl cyanoacrylate glue (NBCA). Read More

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Impact of ABO blood group on bleeding complications after surgery for acute type A aortic dissection.

Blood Coagul Fibrinolysis 2021 Jun;32(4):253-258

Department of Cardiothoracic Surgery, Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden.

Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD surgery. Read More

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Gender Differences and Mortality Trends After Transcatheter Aortic Valve Implantation: A 10-Year Analysis From a Single Tertiary Center.

J Invasive Cardiol 2021 May 6. Epub 2021 May 6.

Division of Interventional Cardiology of MedStar, Cardiovascular Research Network at MedStar Washington Hospital Center, 110 Irving Street, Suite 4B-1, Washington, D.C., 20010.

Aim: To evaluate gender differences and mortality trends in a population undergoing transcatheter aortic valve implantation (TAVI) and to analyze the correlates to all-cause mortality at follow-up.

Methods: The study comprises a prospective cohort of 592 TAVI patients (53.4% female) treated between 2008 and 2018. Read More

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Prescribing patterns for treating common complications of spinal cord injury.

J Spinal Cord Med 2021 May 6:1-9. Epub 2021 May 6.

Rural Clinical School in Family Medicine, University of New South Wales, Sydney, Australia.

Objective: The purpose of this study was to find the most and least commonly prescribed medications for treating secondary health complications associated with spinal cord injury (SCI); and determine overall polypharmacy rates and risk factors associated with it.

Design: Observational design, cross-sectional analysis.

Setting: Community; Canada. Read More

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Effects of Judet Quadricepsplasty in the Treatment of Post-traumatic Extension Contracture of the Knee.

Orthop Surg 2021 May 6. Epub 2021 May 6.

Department of Orthopaedic Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.

Objective: To investigate the clinical outcomes and the affecting factors of Judet's quadricepsplasty on the stiffness of post-traumatic knee flexion.

Methods: A retrospective survey was analyzed from June 2015 to October 2018. A total of 15 patients (eight males, seven females; mean age, 48. Read More

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Application of Oblique Lateral Interbody Fusion in Treatment of Lumbar Spinal Tuberculosis in Adults.

Orthop Surg 2021 May 6. Epub 2021 May 6.

Department of Orthopaedic Surgery, Zhongshan Hospital Fudan University, Shanghai, China.

Objective: The purpose of the present paper was to evaluate the safety and clinical efficacy of mini-open retroperitoneal oblique lumbar interbody fusion (OLIF) for the treatment of lumbar spinal tuberculosis.

Methods: A total of 115 patients who suffered from lumbar spinal tuberculosis from June 2014 to December 2017 were included in this research. A total of 59 patients underwent OLIF and percutaneous pedicle screw fixation (OLIF group) and 56 patients underwent the anterior-only approach (anterior-only group). Read More

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Short-term outcomes of 59 dogs treated for ilial body fractures with locking or non-locking plates.

Vet Surg 2021 May 6. Epub 2021 May 6.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Objective: To determine the influence of plating systems on the clinical outcomes in dogs treated for ilial fractures.

Design: Retrospective study.

Animals: Fifty-nine dogs (63 hemipelves). Read More

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Transplant-associated thrombotic microangiopathy and immune haematological complications following intestine-containing organ transplantation: experience from over 100 consecutive cases.

Br J Haematol 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Descriptions of passenger lymphocyte syndrome (PLS), immune cytopenias and transplant-associated thrombotic microangiopathy (TA-TMA) after intestine-containing transplants remain scarce. We describe our centre's experience of these complications from 2007 to 2019. Ninety-six patients received 103 transplants. Read More

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Contrast-enhanced voiding urosonography in the assessment of vesical-ureteral reflux: the time has come.

Radiol Med 2021 May 5. Epub 2021 May 5.

Section of Radiological Sciences, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, "G. Martino" Policlinic, Via Consolare Valeria 1, 98100, Messina, Italy.

Vesicoureteral reflux (VUR) is a pathological condition contradistinguished by monolateral or bilateral retrograde flow of urine from the bladder to the ureter and to the kidney. If not properly recognized and treated, VUR can potentially be associated to several complications such as recurrent infections and possible secondary scars with Chronic Kidney Disease (CKD). Furthermore, it represents an important risk factor for nephrovascular hypertension. Read More

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A standardized soft tissue release technique to lower the risk of greater trochanteric fractures for the anterior approach in total hip arthroplasty.

Arch Orthop Trauma Surg 2021 May 5. Epub 2021 May 5.

Hospital for Special Surgery, New York, NY, 10021, USA.

Introduction: The direct anterior approach (DAA) is suggested to accelerate postoperative recovery and decrease the dislocation risk after primary total hip arthroplasty (THA). However, exposure of the femur can be challenging. Insufficient exposure increases the risk for intraoperative femoral fracture. Read More

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Conversion Total Hip Arthroplasty Following Failed Hip Fracture Fixation in a Patient with Factor XI Deficiency: A Case Report.

J Orthop Case Rep 2020 May-Jun;10(3):80-84

Department of Orthopedic Surgery, Albany Medical Center, Albany, New York, USA.

Introduction: Factor XI (FXI) deficiency is a hematologic condition that is rarely encountered by the arthroplasty surgeon. Effective risk assessment and perioperative management are paramount in minimizing the risk of intra- and post-operative bleeding in this patient population. An interdisciplinary approach is crucial in minimizing complications and achieving successful outcomes. Read More

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A First Report on Experience in Managing Infants with Congenital Toxoplasmosis in Ethiopia: Case Reports and a Review of Evaluation and Treatment.

Case Rep Infect Dis 2021 15;2021:9934391. Epub 2021 Apr 15.

Division of Neonatology, Department of Pediatrics and Child Health, Addis Ababa University, Addis Ababa, Ethiopia.

. Congenital toxoplasmosis is a major sequela of untreated primary maternal infection. With or without symptoms, untreated infections eventually lead to multiple neurologic complications. Read More

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