732,529 results match your criteria transport potadpotf


Protein biosensor based on Schottky barrier nanowire field effect transistor.

Talanta 2021 Nov 24;239:123092. Epub 2021 Nov 24.

Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, 660036, Russia.

A top-down nanofabrication approach involving molecular beam epitaxy and electron beam lithography was used to obtain silicon nanowire-based back gate field-effect transistors with Schottky contacts on silicon-on-insulator (SOI) wafers. The resulting device is applied in biomolecular detection based on the changes in the drain-source current (I). In this context, we have explained the physical mechanisms of charge carrier transport in the nanowire using energy band diagrams and numerical 2D simulations in TCAD. Read More

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November 2021

Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I.

J Nutr Biochem 2021 Nov 29:108922. Epub 2021 Nov 29.

Laboratory for Molecular Chemistry of Aquatic Materials, Department of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Mie, Japan.

Diet is a crucial factor for preventing most diseases. Edible plant extracts are known to contain exosome-like nanoparticles, in which food-derived plant microRNAs are included and may serve as a novel functional component in human health. Here, we demonstrated that hvu-MIR168-3p included in the nanoparticles of rice aleurone cells down-regulated the expression of the genes related to mitochondrial electron transport chain complex I in human cells. Read More

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November 2021

Organic contaminants in marine sediments and seawater: A review for drawing environmental diagnostics and searching for informative predictors.

Sci Total Environ 2021 Nov 29:152012. Epub 2021 Nov 29.

Department of Chemistry and CESAM, Universidade de Aveiro, Portugal.

Marine ecosystems represent major sinks for persistent organic pollutants (POPs). Yet, if their regulations are adjusted on regional activity and emissions, POPs are mobile and can persist away from their source. The present review draws an environmental diagnostic of the organic substances studied over the past forty months, which ones accumulates the most, and where. Read More

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November 2021

FT-IR and synchronous fluorescence two-dimensional correlation spectroscopic analysis on the binding properties of mercury onto humic acids as influenced by pH modification and sulfide addition.

Sci Total Environ 2021 Nov 29:152047. Epub 2021 Nov 29.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

Mercuric Hg ion forms strong complexes with dissolved organic matter (DOM) in natural waters. The complexation of Hg by sulfhydryl groups of DOM was regarded as the main mechanism for Hg-DOM interactions, particularly in anoxic sulfur and DOM-rich environments. In the present study, the influences of pH and sulfide addition on the molecular structure of Hg-DOM complexes and the characteristics of Hg binding to DOM were investigated using FT-IR and synchronous fluorescence two-dimensional correlation spectroscopic analysis. Read More

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November 2021

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis.

Lancet Gastroenterol Hepatol 2021 Nov 29. Epub 2021 Nov 29.

INSERM NGERE and Department of Hepatogastroenterology, Nancy University Hospital, Lorraine University, Vandoeuvre-lés-Nancy, France. Electronic address:

Background: There is a growing armamentarium for the treatment of moderate-to-severe ulcerative colitis. We aimed to compare the relative efficacy and safety of biologics and small molecule drugs for the treatment of patients with moderate-to-severe ulcerative colitis.

Methods: In this systematic review and network meta-analysis, we searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials without language restrictions for articles published between Jan 1, 1990, and July 1, 2021. Read More

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November 2021

Impact of the dose quantity used in MV photon optimization on dose distribution, robustness and complexity.

Med Phys 2021 Dec 2. Epub 2021 Dec 2.

Radiation Oncology Department, Institut Català d'Oncologia, Avda. França s/n, Girona, 17007, Spain.

Purpose: Convolution/superposition algorithms used in MV photon radiotherapy model radiation transport in water, yielding dose to water-in-water (D ). Advanced algorithms constitute a step forward, but their dose distributions in terms of dose to medium-in-medium (D ) or dose to water-in-medium (D ) can be problematic when used in plan optimization due to their different dose responses to some atomic composition heterogeneities. Failure to take this into account can lead to undesired overcorrections and thus to unnoticed suboptimal and unrobust plans. Read More

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December 2021

Understanding the intention to use bike-sharing system: A case study in Xi'an, China.

PLoS One 2021 2;16(12):e0258790. Epub 2021 Dec 2.

College of Transportation Engineering, Chang'an University, Xi'an, Shaanxi, China.

Bike-sharing is widely recognized as an eco-friendly mode of transportation and seen as one of the solutions to the problem of air pollution and congestion. With the emphasis on sustainability in transportation, bike-sharing systems is an emerging topic of urban transport and sustainable mobility related research. Existing studies mainly explored the factors affecting individuals' initial intentions to start using a shared bicycle, but few looked at the likelihood that a user would continue using one This study proposed a structural equation model with bike-sharing purchase decision involvement as independent variable, bike-sharing willingness to use as dependent variable, traveler participation and traveler perceived value as intermediary variables by introducing the concepts of purchase decision involvement, customer participation and perceived value in consumer psychology and behavior. Read More

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December 2021

Access to primary care services using public transport in Ōtautahi Christchurch.

N Z Med J 2021 Nov 26;134(1546):59-69. Epub 2021 Nov 26.

Lecturer, Department of Population Health, University of Otago Christchurch.

Aims: Lack of transport is a contributor to poor access to healthcare and missed appointments. This research aimed to understand the accessibility of primary care for patients using public transport in Ōtautahi Christchurch, and to describe spatial and social distribution.

Methods: We measured access to primary care using geospatial analysis based on the time taken to reach the nearest general practice, the number of practices accessible within given time thresholds and the frequency of public transport services. Read More

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November 2021

Why Environmental Biomarkers Work: Transcriptome-Proteome Correlations and Modeling of Multistressor Experiments in the Marine Bacterium .

J Proteome Res 2021 Dec 2. Epub 2021 Dec 2.

Marine and Environmental Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.

Ocean microbial communities are important contributors to the global biogeochemical reactions that sustain life on Earth. The factors controlling these communities are being increasingly explored using metatranscriptomic and metaproteomic environmental biomarkers. Using published proteomes and transcriptomes from the abundant colony-forming cyanobacterium (strain IMS101) grown under varying Fe and/or P limitation in low and high CO, we observed robust correlations of stress-induced proteins and RNAs (i. Read More

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December 2021

Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers.

Biomacromolecules 2021 Dec 2. Epub 2021 Dec 2.

Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, Wroclaw 50-383, Poland.

Fibroblast growth factor receptor 1 (FGFR1) is an integral membrane protein that transmits prolife signals through the plasma membrane. Overexpression of FGFR1 has been reported in various tumor types, and therefore, this receptor constitutes an attractive molecular target for selective anticancer therapies. Here, we present a novel system for generation of intrinsically fluorescent, self-assembling, oligomeric cytotoxic conjugates with high affinity and efficient internalization targeting FGFR1. Read More

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December 2021

Nano-Interlayers Fabricated via Interfacial Azo-Coupling Polymerization: Effect of Pore Properties of Interlayers on Overall Performance of Thin-Film Composite for Nanofiltration.

ACS Appl Mater Interfaces 2021 Dec 2. Epub 2021 Dec 2.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

The supporting layer of nanofiltration membranes is critical to the overall nanofiltration performance. However, conventional supports lack efficient surface porosity, which leads to the limited utilization rate of the polyamide (PA) layer. Herein a double-skin-layer nanofiltration membrane with porous organic polymer nanointerlayers prepared via a two-step interfacial polymerization technique is presented to investigate the effect of the interlayers' pore properties on the performance of the thin-film composite. Read More

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December 2021

Contribution of a ZIP-family protein to manganese uptake and infective endocarditis virulence in Streptococcus sanguinis.

Mol Microbiol 2021 Dec 2. Epub 2021 Dec 2.

Philips Institute for Oral Health Research, Virginia Commonwealth University School of Dentistry, Richmond, Virginia, United States.

Streptococcus sanguinis is an important cause of infective endocarditis. In strain SK36, the ABC-family manganese transporter, SsaACB, is essential for virulence. We have now identified a ZIP-family protein, TmpA, as a secondary manganese transporter. Read More

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December 2021

Critical review on low-temperature Li-ion/metal batteries.

Adv Mater 2021 Dec 2:e2107899. Epub 2021 Dec 2.

State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang University, Hangzhou, 310027, China.

With the highest energy density ever among all sorts of commercialized rechargeable batteries, Li-ion batteries (LIBs) have stimulated the upsurge utilization in 3C devices, electric vehicles, and stationary energy storage systems. However, a high performance of commercial LIBs based on ethylene carbonate electrolytes and graphite anodes can only be achieved at above -20°C, which restricts their applications in harsh environments. In this review, we provided a comprehensive research progress and in-depth understanding of the critical factors leading to the poor low-temperature performance of LIBs, sorted out the distinctive challenges on the anodes, electrolytes, cathodes and electrolyte-electrodes interphases, with a special focus on Li-ions transport mechanism therein. Read More

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December 2021

Biological functions of nuclear-localized insulin receptor (IR) on A549 lung cancers cell.

Endokrynol Pol 2021 Dec 2. Epub 2021 Dec 2.

Harbin Medical University, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, People's Republic of China, 150001 Herbin, China.

Background: Under normal physiological conditions, insulin exhibits a series of important biological functions and roles. However, recent studies have shown that insulin is also closely related to the occurrence and development of lung cancer. However, until now, the cellular properties of insulin/insulin receptor (IR) on lung cancer have not been fully revealed. Read More

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December 2021

Investigating the links between ICTs, passenger transportation, and environmental sustainability.

Environ Sci Pollut Res Int 2021 Dec 2. Epub 2021 Dec 2.

School of Economics, Quaid-i-Azam University, Islamabad, Pakistan.

This paper investigates linkages between ICTs, passenger transportation, and environmental sustainability with regard to a panel dataset of 46 countries over the years 1998-2016. Telephone and internet penetration are employed to measure ICTs, while environmental damages are proxied in terms of three different indicators related to carbon emissions coming from different sources. The empirical methodology employs the 2-step system Generalized Method of Moments (GMM) with the consideration of two empirical specifications: without and with conditioning variables (per capita GDP growth, urbanization, and energy consumption). Read More

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December 2021

Understanding the role of SWEET genes in fruit development and abiotic stress in pomegranate (Punica granatum L.).

Mol Biol Rep 2021 Dec 2. Epub 2021 Dec 2.

National Agri-Food Biotechnology Institute (NABI), Sector 80, SAS Nagar, Mohali, Punjab, 140306, India.

Background: The Sugar Will Eventually Be Exported Transporters (SWEET), consisting of the MtN3 and salvia domain, are sugar transporters having an active role in diverse activities in plants such as pollen nutrition, phloem loading, nectar secretion, reproductive tissue development, and plant-pathogen interaction. The SWEET genes have been characterized only in a few fruit crop species.

Methods And Results: In this study, a total of 15 SWEET genes were identified in the pomegranate (Punica granatum) genome. Read More

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December 2021

Expression of Genes and Proteins of the Sarcoplasmic Reticulum Са-Transport Systems in Cardiomyocytes in Concomitant Coronary Heart Disease and Type 2 Diabetes Mellitus.

Bull Exp Biol Med 2021 Dec 2. Epub 2021 Dec 2.

Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia.

We compared the expression of Са-ATPase (SERCA2a), calsequestrin (CASQ2), ryanodine receptors (RyR2) proteins and their genes (ATP2A2, CASQ2, and RYR2) in coronary heart disease (CHD) patients with and without comorbid type 2 diabetes mellitus. All studies were performed on the right atrial appendages resected during coronary bypass surgeries. Expression of SERCA2a and RyR2 proteins and their ATP2A2 (p=0. Read More

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December 2021

IPSC-Derived Human Neurons with GCaMP6s Expression Allow In Vitro Study of Neurophysiological Responses to Neurochemicals.

Neurochem Res 2021 Dec 2. Epub 2021 Dec 2.

Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovitianov Street, Moscow, Russia, 117997.

The study of human neurons and their interaction with neurochemicals is difficult due to the inability to collect primary biomaterial. However, recent advances in the cultivation of human stem cells, methods for their neuronal differentiation and chimeric fluorescent calcium indicators have allowed the creation of model systems in vitro. In this paper we report on the development of a method to obtain human neurons with the GCaMP6s calcium indicator, based on a human iPSC line with the TetON-NGN2 transgene complex. Read More

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December 2021

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development.

Nanomicro Lett 2021 Dec 2;14(1). Epub 2021 Dec 2.

Nuffield Department of Clinical Neurosciences, New Biochemistry Building, University of Oxford, Oxford, OX1 3QU, UK.

Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. Read More

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December 2021

Computational design of thermoelectric alloys through optimization of transport and dopability.

Mater Horiz 2021 Dec 2. Epub 2021 Dec 2.

Colorado School of Mines, Golden, CO 80401, USA.

Alloying is a common technique to optimize the functional properties of materials for thermoelectrics, photovoltaics, energy storage Designing thermoelectric (TE) alloys is especially challenging because it is a multi-property optimization problem, where the properties that contribute to high TE performance are interdependent. In this work, we develop a computational framework that combines first-principles calculations with alloy and point defect modeling to identify alloy compositions that optimize the electronic, thermal, and defect properties. We apply this framework to design n-type BaSrCdP Zintl thermoelectric alloys. Read More

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December 2021

Inelastic Electron Transport and Ortho-Para Fluctuation of Water Molecule in [email protected] Single Molecule Transistors.

Nano Lett 2021 Dec 2. Epub 2021 Dec 2.

Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Light molecules such as HO are the systems in which we can have access to quantum mechanical information on their constituent atoms. Here, we have investigated electron transport through [email protected] single molecule transistors (SMTs). The [email protected] SMTs exhibit Coulomb stability diagrams that show multiple tunneling-induced excited states below 30 meV. Read More

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December 2021

Comparative Microbial Conversion of Deoxynivalenol and Acetylated Deoxynivalenol in Different Parts of the Chicken Intestine as Detected and Translated to the Situation.

J Agric Food Chem 2021 Dec 2. Epub 2021 Dec 2.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs of P. R. China, 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, P. R. China.

To assess potential differences in the intestinal microbial metabolism of deoxynivalenol (DON) and its acetylated forms 3-Ac-DON and 15-Ac-DON, anaerobic incubations with intestinal contents from chickens were conducted. Quantitative microbiota characterization was obtained by 16S rRNA sequencing. The data showed substantial differences in the level of different toxin conversions by the microbiota from the different intestinal segments. Read More

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December 2021

Y6 Organic Thin-Film Transistors with Electron Mobilities of 2.4 cm V s via Microstructural Tuning.

Adv Sci (Weinh) 2021 Dec 2:e2104977. Epub 2021 Dec 2.

POLYMAT, University of the Basque Country, UPV/EHU, Av. de Tolosa 72, San Sebastián, 20018, Spain.

There is a growing demand to attain organic materials with high electron mobility, μ , as current reliable reported values are significantly lower than those exhibited by their hole mobility counterparts. Here, it is shown that a well-known nonfullerene-acceptor commonly used in organic solar cells, that is, BTP-4F (aka Y6), enables solution-processed organic thin-film transistors (OTFT) with a μ as high as 2.4 cm  V  s . Read More

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December 2021

Achieving Efficient p-Type Organic Thermoelectrics by Modulation of Acceptor Unit in Photovoltaic π-Conjugated Copolymers.

Adv Sci (Weinh) 2021 Dec 2:e2103646. Epub 2021 Dec 2.

Department of Materials Science, Fudan University, Shanghai, 200433, China.

π-Conjugated donor (D)-acceptor (A) copolymers have been extensively studied as organic photovoltaic (OPV) donors yet remain largely unexplored in organic thermoelectrics (OTEs) despite their outstanding mechanical bendability, solution processability and flexible molecular design. Importantly, they feature high Seebeck coefficient (S) that are desirable in room-temperature wearable application scenarios under small temperature gradients. In this work, the authors have systematically investigated a series of D-A semiconducting copolymers possessing various electron-deficient A-units (e. Read More

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December 2021

Shedding Light on DNA-Based Nanoprobes for Live-Cell MicroRNA Imaging.

Small 2021 Dec 2:e2106281. Epub 2021 Dec 2.

Marshall Laboratory of Biomedical Engineering Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Center, Shenzhen University, Guangdong, 518060, P. R. China.

DNA-based nanoprobes integrated with various imaging signals have been employed for fabricating versatile biosensor platforms for the study of intracellular biological process and biomarker detection. The nanoprobes developments also provide opportunities for endogenous microRNA (miRNA) in situ analysis. In this review, the authors are primarily interested in various DNA-based nanoprobes for miRNA biosensors and declare strategies to reveal how to customize the desired nanoplatforms. Read More

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December 2021

Ultrafast and Ultrastable Heteroarchitectured Porous Nanocube Anode Composed of CuS/FeS Embedded in Nitrogen-Doped Carbon for Use in Sodium-Ion Batteries.

Small 2021 Dec 2:e2105310. Epub 2021 Dec 2.

Energy Storage Research Center, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.

The enhancement of the structural stability of conversion-based metal sulfides at high current densities remains a major challenge in realizing the practical application of sodium-ion batteries (SIBs). The instability of metal sulfides is caused by the large volume variation and sluggish reaction kinetics upon sodiation/desodiation. To overcome this, herein, a heterostructured nanocube anode composed of CuS/FeS embedded in nitrogen-doped carbon (CuS/FeS @NC) is synthesized. Read More

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December 2021

Upregulated SLC27A2/FATP2 in differentiated thyroid carcinoma promotes tumor proliferation and migration.

J Clin Lab Anal 2021 Dec 2:e24148. Epub 2021 Dec 2.

Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Differentiated thyroid carcinoma (DTC) accounts for the vast majority of thyroid cancer (TC) cases. The rapidly increasing incidence of TC requires the urgent identification of new diagnostic and therapeutic targets. Solute carrier family 27 member 2 (SLC27A2/FATP2) plays an essential role in lipid biosynthesis and fatty acid transport. Read More

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December 2021

dipeptidyl peptidase IV inhibitory activity and insulinotropic activity of milk and egg white protein digests.

Food Funct 2021 Dec 2. Epub 2021 Dec 2.

Department of Biological Sciences, University of Limerick, Castletroy, Limerick, Ireland.

Dietary proteins are involved in the regulation of glucose homeostasis by different mechanisms. Food protein digestion products are reported to inhibit dipeptidyl peptidase IV (DPP-IV), induce incretin secretion or directly exert an insulinotropic effect in pancreatic β-cells. This study illustrates the DPP-IV inhibitory activity of gastric and intestinal digests of casein, whey and egg white proteins determined , using Gly-Pro-AMC, and using non-differentiated Caco-2 cells. Read More

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December 2021