74,422 results match your criteria transplant recipients


Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival.

Am J Transplant 2021 Sep 22. Epub 2021 Sep 22.

Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Obesity initiates a chronic inflammatory network linked to perioperative complications and increased acute rejection rates in organ transplantation. Bariatric surgery is the most effective treatment of obesity recommended for morbidly obese transplant recipients. Here, we delineated effects of obesity and bariatric surgery on alloimmunity and transplant outcomes in diet-induced obese (DIO)-mice. Read More

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September 2021

Negative immune responses to two-dose mRNA COVID-19 vaccines in renal allograft recipients assessed with simple antibody and interferon gamma release assay cellular monitoring.

Am J Transplant 2021 Sep 22. Epub 2021 Sep 22.

Department of Nephrology, Hospital del Mar, Barcelona, Spain.

Studies are urgently needed to characterize immunogenicity, efficacy, and safety of SARS-CoV-2 mRNA vaccines in kidney transplant (KT) recipients, excluded from major clinical trials. Complex ELISPOT and other cellular response techniques have been applied, but simpler tools are needed. An easy-to-use real-world monitoring of SARS-CoV-2 IgG antibodies against the Spike protein and QuantiFERON SARS-CoV-2 IFNγ release assay (IGRA) were performed at baseline and 28 days after the second dose in KT recipients and controls (dialysis patients and healthy ones). Read More

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September 2021

Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients.

Am J Transplant 2021 Sep 22. Epub 2021 Sep 22.

Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

Kidney transplant recipients (KTRs) are extremely vulnerable to SARS-CoV-2 infection and show an impaired immune response to SARS-CoV-2 vaccination. We analyzed factors related to vaccination efficiency in KTRs. In a multicenter prospective observational study (NCT04743947), IgG antibodies levels against SARS-CoV-2 spike S1 subunit and their neutralization capacity after SARS-CoV-2 vaccination were analyzed in 225 KTRs and compared to 176 controls. Read More

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September 2021

A unique case of Miller Fisher-Guillain-Barré overlap syndrome in a liver transplant recipient.

J Neurovirol 2021 Sep 22. Epub 2021 Sep 22.

Department of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, San Diego, CA, USA.

Guillain-Barré syndrome (GBS) is an ascending demyelinating polyneuropathy often associated with recent infection. Miller Fisher syndrome represents a variant with predominant facial and cranial nerve involvement, although Miller Fisher and Guillain-Barré overlap syndromes can occur. Guillain-Barré spectrum syndromes have been thought to be rare among solid organ transplant recipients. Read More

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September 2021

Is degree of chronic illness management in heart transplant centers associated with better patient survival? Findings from the intercontinental BRIGHT study.

Chronic Illn 2021 Sep 22:17423953211039773. Epub 2021 Sep 22.

Department Public Health, Institute of Nursing Science, 27209University of Basel, Switzerland.

Purpose: To explore the association between the degree of Chronic illness management and survival rates at 1-, 3-, 5-years post heart transplantation.

Methods: Exploratory secondary analysis of a cross-sectional, international study (Building Research Initiative Group study). Latent profile analysis was performed to classify 36 heart transplant centers according to the degree of chronic illness management. Read More

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September 2021

Cancer After Pediatric Kidney Transplantation: A Long-term Single-center Experience in Japan.

Transplant Direct 2021 Apr 22;7(4):e687. Epub 2021 Mar 22.

Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

Background: The cancer incidence, types, and risk factors after pediatric kidney transplantation (KT) have been reported in the United States, Canada, Europe, Australia, and New Zealand. However, no information is available about cancer in pediatric KT recipients in Asian countries.

Methods: Children aged <20 y who underwent initial KT from 1983 to 2016 were analyzed. Read More

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Liver Transplantation for Cholangiocarcinoma: Charting a Path With Lessons Learned From Center Experience.

Transplant Direct 2021 Apr 22;7(4):e686. Epub 2021 Mar 22.

Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN.

Background: While liver transplantation (LT) with neoadjuvant chemoradiation is increasingly utilized for the management of unresectable cholangiocarcinoma (CCA), data on post-LT survival are limited.

Methods: We identified 844 patients who underwent LT (2002-2019) for nonincidental (CCA listing) or incidental (CCA on explant, not at listing) CCA in the Scientific Registry of Transplant Recipients. Kaplan-Meier and multivariable proportional hazards regression methods evaluated the effects of patient characteristics, donor type, transplant era (before/after 2010), and center volume (center-level CCALTs/active year) on the risk of graft failure and patient mortality. Read More

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Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.

Transplant Direct 2021 Apr 22;7(4):e685. Epub 2021 Mar 22.

Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC.

Background: Acute perivascular rejection (AR) is common in lung recipients and increases the risk for chronic lung allograft dysfunction (CLAD). Hyaluronan (HA), an extracellular matrix constituent, accumulates in experimental AR and can act as an innate immune agonist, breaking tolerance and potentiating alloimmunity. We previously demonstrated HA accumulates in CLAD after human-lung transplantation. Read More

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Pretransplant Hepatitis C Virus Treatment Decreases Access to High-quality Livers.

Transplant Direct 2021 Apr 22;7(4):e684. Epub 2021 Mar 22.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Despite the revolutionary role of direct-acting antivirals for hepatitis C virus (HCV), the treatment timing for liver transplant candidates remains controversial. We hypothesize that deferring treatment until after liver transplantation improves access to a larger and higher-quality donor pool without a detrimental impact on post-liver transplantation outcomes.

Methods: This single-center study includes recipients that underwent deceased-donor liver transplant with HCV as the primary indication January 1, 2014, to December 31, 2018. Read More

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Hepatitis B Virus/Hepatitis D Virus-Coinfected Liver Transplant Candidate Receiving Hepatitis B Virus-Deoxyribonucleic Acid-Positive Allograft and Treated With High-Dose Hepatitis B Immune Globulin.

ACG Case Rep J 2021 May 12;8(5):e00582. Epub 2021 May 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Liver transplantation (LT) for patients with hepatitis D virus (HDV) and hepatitis B virus (HBV) coinfection is uncommon in the United States. Previous case reports described poor outcomes when hepatitis B surface antigen (HBsAg)-positive grafts are transplanted in HBV/HDV-coinfected recipients. However, LT from an HBsAg-negative/HBV-deoxyribonucleic acid-positive donor in an HBV/HDV-coinfected recipient has not been reported. Read More

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A Case Series of Extrapulmonary in Liver Transplant Recipients.

ACG Case Rep J 2021 May 14;8(5):e00571. Epub 2021 May 14.

Division of Hepatology, Department of Medicine, Carolinas Medical Center, Charlotte, NC.

Liver transplant recipients are at increased risk of infection because of the immunosuppression required after transplantation. Infection by species increases the morbidity and mortality of liver transplant recipients. The prompt recognition and diagnosis of opportunistic infection is necessary for good outcomes, particularly during periods of increased immunosuppression. Read More

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Beneficial effects of posttransplant dipeptidyl peptidase-4 inhibitor administration after pancreas transplantation to improve β cell function.

Ann Surg Treat Res 2021 Sep 31;101(3):187-196. Epub 2021 Aug 31.

Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels and enhance the function of pancreatic β cells. Yet, it is unknown whether posttransplant administration of DPP4 inhibitors is beneficial for pancreas transplant recipients.

Methods: We thus retrospectively analyzed the records of 312 patients who underwent pancreas transplantation between 2000 and 2018 at Asan Medical Center (Seoul, Korea) and compared the metabolic and survival outcomes according to DPP-4 inhibitor treatment. Read More

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September 2021

Clinical Profile and Outcome of Haemodialysis in Patients With COVID-19 - A Single Centre Experience.

Cureus 2021 Aug 14;13(8):e17170. Epub 2021 Aug 14.

Physical Medicine & Rehabilitation, Employees' State Insurance Corporation (ESIC) Medical College and Hospital, Patna, Patna, IND.

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 disease is the third coronavirus to have emerged in the last 20 years. The COVID-19 infection causes more severe illness in patients with comorbid diseases, especially in patients with diabetes, hypertension and kidney failure. Methods This is a retrospective study using electronic records and laboratory data of adult patients hospitalised at All India Institute of Medical Sciences (AIIMS), Patna between May 1st, 2020 and March 31st, 2021, who were diagnosed with COVID-19 and needed haemodialysis. Read More

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Impact of mother donor, peripheral blood stem cells and measurable residual disease on outcomes after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in children with acute leukaemia.

Bone Marrow Transplant 2021 Sep 21. Epub 2021 Sep 21.

Hospital Infantil Pequeno Príncipe, Curitiba, PR, Brazil.

Haploidentical hematopoietic-cell transplantation using post-transplant cyclophosphamide(Haplo-PTCy) is a feasible procedure in children with haematologic malignancies. However, data of a large series of children with acute leukaemia(AL) in this setting is missing. We analysed 144 AL Haplo-PTCy paediatric recipients; median age was 10 years. Read More

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September 2021

Evaluation of prognostic scores for respiratory syncytial virus infection in a French multicentre cohort of allogeneic haematopoietic stem cell transplantation recipients.

Bone Marrow Transplant 2021 Sep 21. Epub 2021 Sep 21.

Université de Paris, Service de Pneumologie, Hôpital Saint-Louis, AP-HP -, Paris, France.

Haematopoietic stem cell transplantation (HSCT) recipients are at risk for severe respiratory syncytial virus (RSV) infection. Two prognostic scores have been proposed to predict the risk of progression from upper respiratory tract infection (URTI) to lower respiratory tract infection (LRTI) and death. This was a multicentre study of allogeneic HSCT recipients diagnosed with an RSV infection between 2010 and 2019 who were retrospectively stratified by the immunodeficiency scoring index (ISI) and the severe immunodeficiency (SID) score. Read More

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September 2021

[Lung Retransplantation for Cadaveric Lung-transplant Recipients].

Authors:
Masaaki Sato

Kyobu Geka 2021 Sep;74(10):845-849

Department of Thoracic Surgery, The University of Tokyo, Tokyo, Japan.

As the number of lung transplantation is increasing in Japan, retransplantation is also expected to increase, especially for chronic lung allograft dysfunction (CLAD). According to international experience on lung retransplantation, the short and long-term outcomes of retransplantation is inferior to the initial lung transplantation. Thus, indication and surgical options of retransplantation should be carefully and objectively examined. Read More

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September 2021

Facial Transplantation: An Ethical Debate.

Authors:
Simra Azher

J Clin Ethics 2021 ;32(3):256-265

Resident Dentist at the Oral and Maxillofacial Surgery Department, Royal Dental Hospital of Melbourne in Carlton, Victoria, Australia.

With the recent advent of facial transplant (FT) treatment, patients who live with facial disfigurement have a new hope of improved facial aesthetics and quality of life. However, FT has been the subject of intense ethical debate, and there are numerous important ethical considerations surrounding FT that require further in-depth exploration. In the present review, the numerous ethical issues surrounding FT are elucidated, especially the weighty psychosocial impacts of FT, issues surrounding patients' consent, selection and donor matching, and current challenges with postoperative complication management and the facial reconstruction of donors. Read More

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January 2021

Abnormal one-year post-lung transplant spirometry is a significant predictor of increased mortality and chronic lung allograft dysfunction.

J Heart Lung Transplant 2021 Aug 21. Epub 2021 Aug 21.

Lung Transplant Service, Alfred Hospital, Melbourne, Australia; Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia.

Background: The prognostic value of evaluating spirometry at a fixed time point using standardized population reference has not previously been evaluated. Our aim was to assess the association between spirometric phenotype at 12 months (Spiro), survival and incidence of chronic lung allograft dysfunction (CLAD) in bilateral lung transplant recipients.

Methods: We conducted a retrospective cohort study of bilateral lung transplant recipients transplanted between January 2003 and September 2012. Read More

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Access to hepatitis C direct-acting antiviral therapy in hepatitis C-positive donor to hepatitis C-negative recipient solid-organ transplantation in a real-world setting.

Am J Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Background: Emerging data supports expanding the solid organ donor pool with transplantation from hepatitis C virus (HCV)-positive donors into HCV-negative recipients. However, concerns exist regarding the ability to access direct-acting antivirals (DAAs) post-transplant in a real-world setting.

Methods: This single-center, retrospective study evaluated DAA access rates, time to first dose, and patient cost in donor-derived HCV solid-organ transplant recipients utilizing an integrated specialty pharmacy process. Read More

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September 2021

Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation model.

Transpl Immunol 2021 Sep 18:101467. Epub 2021 Sep 18.

Latner Thoracic Surgery Research Laboratories, University Health Network, Canada. Electronic address:

IL-17A is implicated in the pathogenesis of chronic lung allograft dysfunction, which limits survival after lung transplantation. While many cells express the IL-17 receptor A (IL-17RA) which is the main receptor for IL-17A, the cellular targets of IL-17A in development of post-transplant fibrosis are unknown. The purpose of this study was to determine whether IL-17RA expression by donor or recipient structural or bone marrow (BM) cells is required for the development of allograft fibrosis in a mouse intrapulmonary tracheal transplantation (IPTT) model. Read More

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September 2021

Cytomegalovirus infection in kidney transplant patients: Prevalence, risk factors, and impact on outcome - A local multicentre experience.

Transpl Immunol 2021 Sep 18:101473. Epub 2021 Sep 18.

Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon.

Background: CMV infection prevalence in kidney transplant recipients (KTR) is reported to be high in the literature, reaching rates of over 80%.

Objectives: The primary endpoints were the evaluation of the prevalence, the risks factors, and the effects of CMV infection on graft function and survival, as well as patient survival at three years after kidney transplantation.

Material And Methods: We retrospectively reviewed the medical records of 288 kidney transplant patients operated in three Lebanese transplant centers between 1998 and 2017 with three years of follow-up. Read More

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September 2021

The SARS-CoV-2 neutralizing capacity of kidney transplant recipients four weeks after receiving a second dose of the BNT162b2 vaccine.

Kidney Int 2021 Sep 18. Epub 2021 Sep 18.

Department of Clinical Microbiology, Odense University Hospital and Research Unit for Clinical Microbiology, University of Southern Denmark, Odense, Denmark.

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September 2021

Airway cilia recovery post lung transplantation.

Immun Inflamm Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Respiratory and Sleep Medicine,, Victorian Diagnostic Service for PCD, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.

Background: Normally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation period is associated with airway infection, which we hypothesize may be caused by impaired cilia function. Read More

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September 2021

Impact of allogeneic stem cell transplantation comorbidity indexes after haplotransplant using post-transplant cyclophosphamide.

Cancer Med 2021 Sep 21. Epub 2021 Sep 21.

Hematology Department, Nantes University Hospital, Nantes, France.

Background: Three different scoring systems have been developed to assess pre-transplant comorbidity in allogeneic hematopoietic stem cell transplantation (Allo-HSCT): the Hematopoietic Cell Transplantation-Specific Comorbidity Index, the Comorbidity/Age index, and the Augmented Comorbidity/Age index. All were devised to predict overall survival (OS) and disease-free survival (DFS) survivals and non-relapse mortality (NRM) in patients receiving HLA-matched Allo-HSCT, but their performance has scarcely been studied in the haploidentical Allo-HSCT setting with post-transplant cyclophosphamide, a procedure in constant expansion worldwide.

Methods: To address this issue, their impact on survivals and NRM was examined in a cohort of 223 patients treated with haploidentical Allo-HSCT in four different centers. Read More

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September 2021

Long term follow-up of SARS-CoV-2 recovered renal transplant recipients: A single-centre experience from India.

Transpl Infect Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, India.

Introduction: Follow-up studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in kidney transplant recipients (KTR) are scarcely reported.

Methods: We studied 142 hospitalized KTR for a median (interquartile range) follow-up of 9(8-11) months who recovered from SARS-CoV-2 during May 2020 to Dec 2020.The outcomes were to assess persistent symptoms post-discharge; EuroQoL visual analogue score (EQ-VAS); EuroQoL 5-dimension score (E5-QD-5L) score and modified medical research Dyspnea score (mMRC) at 1-month, 3-month and beyond 6 months. Read More

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September 2021

The Effects of Donor-Specific Antibody Characteristics on Cardiac Allograft Vasculopathy.

Clin Transplant 2021 Sep 21:e14483. Epub 2021 Sep 21.

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Cardiac allograft vasculopathy (CAV) causes late graft dysfunction and post-transplant mortality. Currently, the effects of different donor-specific antibodies (DSA) on the severity of CAV remain unclear.

Method: We evaluated 526 adult heart transplant recipients at a single center between January 2010 and August 2015. Read More

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September 2021

Transplantation of a Severely Traumatized Liver During the COVID-19 Pandemic: A Case Report and Review of the Literature.

Exp Clin Transplant 2021 Sep 20. Epub 2021 Sep 20.

From the Department of General Surgery and Liver Transplantation Service, San Camillo Forlanini, Italian National Institute for the Infectious Diseases "L. Spallanzani," Rome, Italy.

Shortages of grafts for liver transplant remain a persistent problem. The use of lacerated livers for liver transplant can add an option for extended criteria donations, especially during the COVID-19 pandemic. We present the case of a successful liver transplant performed using a high-grade lacerated liver previously treated with superselective arterial embolization and packing for bleeding control. Read More

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September 2021

Organ Procurement From Poisoned Patients: A 14-Year Survey in 2 Academic Centers.

Exp Clin Transplant 2021 Sep 20. Epub 2021 Sep 20.

From the School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Organ transplant from poisoned donors is an issue that has received much attention, especially over the past decade. Unfortunately, there are still opponents to this issue who emphasize that toxins and drugs affect the body's organs and do not consider organs from poisoned donors appropriate for transplantation.

Materials And Methods: Cases of brain death due to poisoning were collected from 2 academic centers in Tehran, Iran during a period from 2006 to 2020. Read More

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September 2021

COVID-19 Pneumonia and Intensive Care Treatment of a Lung Transplant Recipient.

Exp Clin Transplant 2021 Sep 20. Epub 2021 Sep 20.

From the Department of Intensive Care Unit, Ankara City Hospital, Ankara, Turkey.

In the COVID-19 pandemic presently affecting the whole world, solid-organ transplant recipients under immunosuppressive therapy are at higher risk than the general population. COVID-19 infection primarily affects the lungs, and so the risk is further increased in lung transplant recipients. The course of COVID-19 in lung transplant recipients is unclear. Read More

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September 2021

Influence of donor and recipient hepatitis B virus infection on long-term outcomes after kidney transplantation.

Clin Transplant 2021 Sep 21:e14466. Epub 2021 Sep 21.

Center for Transplantation Sciences, and Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.

The demand for transplantable kidneys continues to outstrip supply, and the risk of donor-derived infection limits utilization. The effect of donor or recipient HBV status, defined by surface antigen (HBsAg) positivity, on long-term survival outcomes of kidney transplant (KT) is unknown. We conducted a retrospective cohort study based on Organ Procurement and Transplantation Network (OPTN) data from 2000 to 2019. Read More

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September 2021