911,218 results match your criteria transplant


[KDIGO 2021 guideline glomerulonephritis - focus on ANCA-associated vasculitides and anti-glomerular basement membrane glomerulonephritis].

Dtsch Med Wochenschr 2021 Nov 26;146(23):1552-1558. Epub 2021 Nov 26.

Medizinische Klinik und Poliklinik IV, Nephrologisches Zentrum, LMU Klinikum, Campus Großhadern.

In 2021 new KDIGO (Kidney Disease: Improving Global Outcomes) guidelines for the management of glomerular diseases were published.For ANCA-associated glomerulonephritis the new recommendations comprise a more rapid steroid taper during induction treatment with cyclophosphamide or rituximab, the advice against routine use of plasma exchange, the choice of drug for and duration of maintenance treatment in accordance with predictors of relapse. A kidney transplant should be performed after at least 6 months of remission irrespective of the ANCA titer in ANCA-associated disease, and 6 months after absence of anti-GBM-antibodies in anti-GBM-disease. Read More

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November 2021

Public health risks associated with methadone in Iran: A systematic review and meta-analysis.

Int J Drug Policy 2021 Nov 23;100:103529. Epub 2021 Nov 23.

Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: There has been a marked growth in methadone maintenance treatment (MMT) in Iran in the past two decades with positive health outcomes. We conducted a systematic review of studies on the prevalence of non-prescribed methadone use, methadone use disorder, and methadone-related poisoning and mortality in Iran.

Methods: We searched International and Iranian databases up to May 2020 and contacted relevant experts. Read More

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November 2021

Evaluation of computer-aided diagnosis in breast ultrasonography: Improvement in diagnostic performance of inexperienced radiologists.

Clin Imaging 2021 Nov 22;82:150-155. Epub 2021 Nov 22.

Division of Breast imaging IEO; European institute of Oncology, IRCCS, Via Ripamonti 435, Milan Italy.

Purpose: To evaluate if a computer-aided diagnosis (CAD) system on ultrasound (US) can improve the diagnostic performance of inexperienced radiologists.

Methods: We collected ultrasound images of 256 breast lesions taken between March and May 2020. We asked two experienced and two inexperienced radiologists to retrospectively review the US features of each breast lesion according to the Breast Imaging Reporting and Data System (BI-RADS) categories. Read More

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November 2021

Infective endocarditis following heart transplantation: A systematic review.

Transplant Rev (Orlando) 2021 Nov 6;36(1):100672. Epub 2021 Nov 6.

Division of Infectious Disease, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

Purpose: Infective endocarditis (IE) is a rare but potentially fatal complication following heart transplantation (HTx). There is a lack of literature regarding the patterns and clinical course of IE development following HTx. We sought to pool the existing data in regards to defining characteristics, management options, and outcomes of IE following HTx. Read More

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November 2021

Preemptive approach against toxoplasmosis in allogeneic hematopoietic cell transplantation. Still far away from experience in CMV. Commentary on: toxoplasmosis after allogeneic hematopoietic cell transplantation: experience using a PCR-guided pre-emptive approach.

Clin Microbiol Infect 2021 Nov 23. Epub 2021 Nov 23.

Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense, Madrid.

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November 2021

How to Adapt an Intestinal Microbiota Transplantation program to reduce the risk of invasive multidrug-resistant infection.

Clin Microbiol Infect 2021 Nov 23. Epub 2021 Nov 23.

Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.

Background: Vulnerable patients with intestinal colonisation of multidrug-resistant organisms (MDROs) are recognised to be at increased risk of invasive MDRO driven infection. Intestinal Microbiota Transplantation (IMT aka FMT) is the transfer of healthy screened donor stool to an affected recipient, and recent interest has focused on its impact on the reduction of invasive MDRO infection.

Objectives: To describe 'How to' establish a clinical IMT pathway for patients at risk of MDRO invasive infection, with special considerations for optimising administration and assessment of endpoints. Read More

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November 2021

Next- Generation Sequencing Is An Effective Method For Diagnosing Patients With Different Forms Of Monogenic Diabetes.

Diabetes Res Clin Pract 2021 Nov 23:109154. Epub 2021 Nov 23.

Department of Clinical Genetics, Medical University of Lodz, Lodz, Poland.

Aim: Monogenic diabetes (MD) represents 5-7% of antibody-negative diabetes cases and is a heterogeneous group of disorders.

Methods: We used targeted next-generation sequencing (NGS) on Illumina NextSeq 550 platform involving the SureSelect assay to perform genetic and clinical characteristics of a study group of 684 individuals, including 542 patients referred from 12 Polish Diabetes Centers with suspected MD diagnosed between December 2016 and December 2019 and their 142 family members (FM).

Results: In 198 probands (36. Read More

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November 2021

Differences and mechanism of dynamic changes of Cd activity regulated by polymorphous sulfur in paddy soil.

Chemosphere 2021 Nov 23:133055. Epub 2021 Nov 23.

Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin, 300191, China; Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin, 300191, China. Electronic address:

Sulfur (S) can decrease the bioavailability of Cd in paddy soil, and therefore reduce Cd uptake by rice. However, the dynamic influence mechanism of different forms of sulfur on the bioavailability of cadmium in soil has not been systematically studied. In this study, we used Diffusive gradients in thin films (DGT) technology and soil pore water sampling technology to investigate the effects of different types of S application on the bioavailability of Cd. Read More

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November 2021

A New Potential Strategy for Acute Non-Alcoholic Steatohepatitis (NASH).

Am J Case Rep 2021 Nov 26;22:e932961. Epub 2021 Nov 26.

Research Department, Texas A&M-affiliated DeTar Family Medicine Residency Program, Victoria, TX, USA.

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States, and 25% of patients with NAFLD progress to non-alcoholic steatohepatitis (NASH). NAFLD is predicted to be the most common indication for liver transplantation by 2030. Despite associated high morbidity and mortality, there is currently no approved therapy for NASH. Read More

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November 2021

The new era of Liver Transplantation for Cholangiocarcinoma - no longer just a one man show.

Liver Transpl 2021 Nov 26. Epub 2021 Nov 26.

Department of Medicine, University of Chicago Medicine, Chicago, IL, USA.

Liver transplantation (LT) has emerged as a novel therapy for patients with cholangiocarcinoma (CCA) who were previously deemed unresectable. While initial data showed poor survival after LT alone, neoadjuvant chemoradiotherapy with LT showed great promise. This became the basis for the Mayo protocol which has rightfully been the standard of care for selecting and managing patients with hilar cholangiocarcinoma (hCCA) for liver transplantation for the past two decades . Read More

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November 2021

Burnout among Transplant Hepatologists in the United States.

Liver Transpl 2021 Nov 26. Epub 2021 Nov 26.

Division of Digestive Diseases, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.

Background & Aims: Burnout among transplant hepatologists has not been well-characterized. The goal of this study was to describe the prevalence and predictors of burnout among practicing transplant hepatologists in the United States.

Methods: We designed a 69-item survey, including the Maslach Burnout Inventory - Human Services Survey (MBI-HSS) and questions on provider demographics, practice characteristics, and psychological factors. Read More

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November 2021

The Tsunami of COVID-19 Infection Among Kidney Transplant Recipients: A Single-Center Study from Iran.

J Epidemiol Glob Health 2021 Nov 26. Epub 2021 Nov 26.

Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Although most evidence supports the fact that kidney transplant (KT) recipients are at significant risk of morbidity and mortality, risk factors of accruing COVID-19 in this population have remained poorly defined.

Methods: All KT recipients who had been transplanted in Sina Hospital and were actively followed between March 1996 and January 2021 were enrolled in a retrospective manner. The demographic characteristics, immunosuppressive treatment before KT, and death were gathered by calling patients with a designed questionnaire. Read More

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November 2021

The innate immune system in human kidney inflammaging.

J Nephrol 2021 Nov 26. Epub 2021 Nov 26.

Unit of Nephrology, Dialysis, Transplantation, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.

Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Read More

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November 2021

An expanded-access clinical study of thiotepa (DSP-1958) high-dose chemotherapy before autologous hematopoietic stem cell transplantation in patients with malignant lymphoma.

Int J Hematol 2021 Nov 26. Epub 2021 Nov 26.

Department of Hematology, Kawasaki Medical School, Kurashiki, Japan.

Thiotepa, an antineoplastic ethylenimine alkylating agent that can penetrate the central nervous system, was recently approved in Japan as high-dose chemotherapy prior to autologous hematopoietic stem cell transplantation (HSCT) for patients with malignant lymphoma. To further evaluate the safety and efficacy of thiotepa, a multicenter, open-label, non-comparative, expanded access program was undertaken in Japan, including a larger population of Asian patients with malignant lymphoma. Intravenous thiotepa (200 mg/m/day) was administered over 2 h on days -4 and -3 before scheduled HSCT, plus intravenous busulfan (0. Read More

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November 2021

Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide.

Int J Hematol 2021 Nov 26. Epub 2021 Nov 26.

Department of Pediatric Bone Marrow Transplantation Unit, MedicalPark Antalya Hospital, Antalya, Turkey.

EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. Read More

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November 2021

REGγ drives Lgr5 stem cells to potentiate radiation induced intestinal regeneration.

Sci China Life Sci 2021 Nov 19. Epub 2021 Nov 19.

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, 200241, China.

Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), a marker of intestinal stem cells (ISCs), is considered to play key roles in tissue homoeostasis and regeneration after acute radiation injury. However, the activation of Lgr5 by integrated signaling pathways upon radiation remains poorly understood. Here, we show that irradiation of mice with whole-body depletion or conditional ablation of REGγ in Lgr5 stem cell impairs proliferation of intestinal crypts, delaying regeneration of intestine epithelial cells. Read More

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November 2021

Efficacy and safety of nivolumab combined with brentuximab vedotin after nivolumab monotherapy failure in patients with relapsed and refractory classic Hodgkin lymphoma.

Int J Clin Oncol 2021 Nov 26. Epub 2021 Nov 26.

RM Gorbacheva Research Institute, Pavlov University, 6-8 L'va Tolstogo, 197022, St. Petersburg, Russia.

Objectives: Therapy of patients with relapsed and refractory classic Hodgkin lymphoma (r/r cHL) after PD-1 inhibitors failure remains an unresolved issue. The aim of this study was to evaluate the efficacy and safety of the combination of nivolumab with brentuximab vedotin (Nivo + BV) after nivolumab monotherapy failure.

Methods: This study retrospectively analyzed 21 patients with r/r cHL who were treated with the combination of Nivo + BV after Nivo failure. Read More

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November 2021

Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial.

Ann Intensive Care 2021 Nov 26;11(1):161. Epub 2021 Nov 26.

Department of Cardiovascular Medicine, Institute for Pharmacological Research Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.

Background: The role of intravenous immunoglobulins (IVIG) during sepsis is controversial, as different trials on IVIG have observed inconsistent survival benefits. We aimed to elucidate the possible association and clinical significance between circulating levels of immunoglobulins.

Methods: In a subset of 956 patients with severe sepsis and septic shock of the multicentre, open-label RCT ALBIOS, venous blood samples were serially collected 1, 2, and 7 days after enrolment (or at ICU discharge, whichever came first). Read More

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November 2021

Impact of the explanting surgeon's impression of donor arteriosclerosis on outcome of kidney transplantations from donors aged ≥65 years.

Langenbecks Arch Surg 2021 Nov 26. Epub 2021 Nov 26.

Department of Nephrology, Klinikum Stuttgart - Katharinenhospital, Kriegsbergstrasse 60, 70174, Stuttgart, Germany.

Purpose: Careful donor selection is important for kidney transplantations (KT) from suboptimal donors aged ≥65 years. Several tools such as histopathological assessment of preimplant biopsies have been shown to predict allograft survival and can be applied for selection. Whether the explanting surgeon's appraisal is associated with outcomes of KTs from suboptimal donors is unknown. Read More

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November 2021

[Two severe cases of disseminated cutaneous nontuberculous mycobacteriosis due to Mycobacterium haemophilum].

Z Rheumatol 2021 Nov 26. Epub 2021 Nov 26.

Abteilung Rheumatologie, Klinische Immunologie und Osteologie - Standort Wannsee, Immanuel Krankenhaus Berlin - Klinik für Innere Medizin, Berlin, Deutschland.

Mycobacterium haemophilum is a rare pathogen belonging to the group of slowly growing nontuberculous mycobacteria (NTM) that can cause infections, especially in immunocompromised patients. Detection by culturing is difficult because M. haemophilum only grows under special cultivation conditions. Read More

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November 2021

Regulatory effects of N-3 PUFAs on pancreatic β-cells and insulin-sensitive tissues.

Curr Drug Metab 2021 Nov 25. Epub 2021 Nov 25.

Key Laboratory of Transplant Engineering and Immunology, NHFPC; Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.

The N-3 polyunsaturated fatty acids (PUFAs) have a wide range of health benefits, including anti-inflammatory effects, improvements in lipids metabolism and promoting insulin secretion, as well as reduction of cancer risk. Numerous studies support that N-3 PUFAs have the potentials to improve many metabolic diseases, such as diabetes, nonalcoholic fatty liver disease and obesity, which are attributable to N-3 PUFAs mediated enhancement of insulin secretion by pancreatic β-cells and improvements in insulin sensitivity and metabolic disorders in peripheral insulin-sensitive tissues such as liver, muscles, and adipose tissue. In this review, we summarized the up-to-date clinical and basic studies on the regulatory effects and molecular mechanisms of N-3 PUFAs mediated benefits on pancreatic β-cells, adipose tissue, liver, and muscles in the context of glucose and/or lipid metabolic disorders. Read More

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November 2021

High-grade blunt traumatic rupture of kidney transplant: is conservative management an option?

Ann R Coll Surg Engl 2021 Nov 26. Epub 2021 Nov 26.

Guy's and St Thomas' NHS Foundation Trust, UK.

Road traffic accidents are the most common cause of blunt native kidney injuries. Transplanted kidneys are more exposed to such injuries due to the common positioning in the iliac fossa compared with the relatively protected position of the native kidneys. The small number of cases identified in the literature describe grade II and III transplant kidney injuries that were treated surgically. Read More

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November 2021

Acute corneal graft rejection after anti-severe acute respiratory syndrome-coronavirus-2 vaccination: A report of four cases.

Eur J Ophthalmol 2021 Nov 26:11206721211064033. Epub 2021 Nov 26.

98022Ophthalmica Eye Institute, Thessaloniki, Greece.

Purpose: This study intends to add to previous reports on acute corneal graft rejection following anti-severe acute respiratory syndrome-coronavirus-2 vaccination, providing data to corroborate a possible causative relationship between anti-COVID-19 immunization and corneal graft rejection, regardless of vaccine or graft type.

Methods And Results: This report describes 4 cases of acute-onset rejection as early as 5 days following the first dose of anti-severe acute respiratory syndrome-coronavirus-2 vaccine types not yet referred for corneal allograft. Patients were individually given the Moderna messenger RNA-1273 COVID-19 vaccine (2 patients) and the AstraZeneca COVID-19 vaccine, Vaxzevria, AZD1222 (2 patients). Read More

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November 2021

High Levels of Donor-derived Cell-Free DNA in a Case of Graft-Versus-Host-Disease Following Liver Transplantation.

Am J Transplant 2021 Nov 26. Epub 2021 Nov 26.

Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, USA.

The diagnosis of graft-versus-host-disease (GVHD) after solid organ transplantation is made difficult by its variable clinical presentation and lack of sensitive and specific biomarkers to evaluate the immune state of transplant recipients. Emerging noninvasive diagnostic techniques like the quantification of donor-derived cell-free DNA (dd-cfDNA) for surveillance may improve the current standard-of-care. Herein, we report the use of this methodology in a patient with GVHD and corresponding levels of dd-cfDNA without any evidence of graft injury. Read More

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November 2021

Splenic auto-transplantation after splenectomy for trauma: evaluation of a new technique.

ANZ J Surg 2021 Nov 25. Epub 2021 Nov 25.

General Surgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Splenic autotransplantation is a promising method to recover splenic functions after traumatic splenectomy. However, it is associated with several postoperative complications, such as subphrenic abscess, intestinal obstruction and torsion of the omentum with necrosis of the implanted splenic tissues. Therefore, the aim of this study is to evaluate a new splenic autotransplantation technique that could overcome those complications. Read More

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November 2021

Changes in circumferential strain can differentiate pediatric heart transplant recipients with and without graft rejection.

Pediatr Transplant 2021 Nov 25:e14195. Epub 2021 Nov 25.

Division of Cardiology, Department of Pediatrics, Medical University of South Carolina Children's Hospital, Charleston, South Carolina, USA.

Background: Routine surveillance protocols rely heavily on endomyocardial biopsy (EMB) for detection of rejection in pediatric heart transplant recipients. More sensitive echocardiographic tools to assess rejection may help limit the number of EMBs. This study compared changes in left ventricular (LV) strain in patients who had rejection versus those who did not. Read More

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November 2021

Risk factors and outcomes of BK viremia among deceased donor kidney transplant recipients based on donor characteristics.

Transpl Infect Dis 2021 Nov 25. Epub 2021 Nov 25.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Introduction: BK polyomavirus (BKV) is a common infection among kidney transplant recipients (KTR). Risk factors and outcomes based on donor characteristics remain largely unknown.

Methods: In this study, we aimed to analyze the impact of donor factors through a paired kidney analysis. Read More

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November 2021

The effects of mannuronic acid on IL-1β, IL-17A, STAT1 and STAT3 gene expression and TLR2 and TLR4 molecules in multiple sclerosis.

J Clin Pharmacol 2021 Nov 25. Epub 2021 Nov 25.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Multiple sclerosis (MS) is a chronic neurologic disease defined by inflammation and demyelination of the central nervous system (CNS) comes with variable degrees of axonal and neuronal damage. The efficacy of β-D-Mannuronic acid (M2000) as a novel drug with immunosuppressive properties, patented (PCT/EP2017/067920), has been shown in experimental model of MS. In this study, the effects of M2000 on IL-1β, IL-17A, STAT1 and STAT3 gene expression and TLR2 and TLR4 molecules in secondary progressive MS (SPMS) patients have been evaluated. Read More

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November 2021

The characteristics of patients with macrovascular invasion in hepatocellular carcinoma: when East meets West.

Langenbecks Arch Surg 2021 Nov 25. Epub 2021 Nov 25.

Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.

Purpose: To evaluate the prevalence and extension of macrovascular invasion (MaVI) in a large cohort of hepatocellular carcinoma (HCC) patients and analyze the association between MaVI and overall survival (OS).

Methods: From 2011 to 2018, 2540 patients with newly diagnosed HCC who were managed in our institution were enrolled in this retrospective study. Tumor invasion of the intrahepatic branches of the portal or hepatic veins was defined as peripheral MaVI. Read More

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November 2021

Pancreatic adenocarcinoma in liver transplant recipients: a case series.

Ann Pancreat Cancer 2021 Oct 30;4. Epub 2021 Oct 30.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Malignancy is one of the known leading causes of death among long-term liver transplantation (LT) survivors. Pancreatic cancer has an incidence of 7.6/100,000 in North America and constitutes a diagnostic challenge post-LT. Read More

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October 2021