645,063 results match your criteria translation initiation


Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose.

J Surg Res 2021 May 11;266:125-141. Epub 2021 May 11.

Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan; Department of Surgery, Feinberg School of Medicine/Northwestern University, Chicago, Illinois. Electronic address:

Objective: Valproic acid (VPA) treatment improves survival in animal models of injuries on doses higher than those allowed by Food and Drug Administration (FDA). We investigated the proteomic alterations induced by a single high-dose (140mg/kg) of VPA (VPA140) compared to the FDA-approved dose of 30mg/kg (VPA30) in healthy humans. We also describe the proteomic and transcriptomic changes induced by VPA140 in an injured patient. Read More

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In-vivo kinematic assessment of alloplastic temporomandibular joint replacements by means of helical axis: A cohort study with historical control.

J Biomech 2021 May 5;122:110494. Epub 2021 May 5.

Clinic of Masticatory Disorders, Center of Dental Medicine, University of Zurich, Switzerland. Electronic address:

Alloplastic total temporomandibular joint replacement (TJR) is a surgical procedure used to restore normal mandibular function when conservative therapies fail. The instantaneous helical axis (HA), is a mathematical model used to visualize globally rigid body kinematics. It can be applied to mandibular motion for quantification of movement patterns and irregularities. Read More

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Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation.

Bioorg Med Chem Lett 2021 May 12:128106. Epub 2021 May 12.

School of Pharmaceutical Science, University of South China, Hengyang 421001, China; School of Pharmacy, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address:

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthesis of marine natural product Chrysamide B, it and series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure-activity relationships were conducted. Read More

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Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies.

Int J Pharm 2021 May 12:120707. Epub 2021 May 12.

Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland. Electronic address:

Age-related eye disorders are chronic diseases that affect millions of people worldwide. They cause visual impairment and, in some cases, irreversible blindness. Drug targeting to the retina is still a challenge due to the difficulties with drug distribution, crossing eye barriers, and reaching intraocular tissues in an effective therapeutic concentration. Read More

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Extracellular vesicles for the treatment of central nervous system diseases.

Adv Drug Deliv Rev 2021 May 12. Epub 2021 May 12.

Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université Catholique de Louvain, UCLouvain, 1200 Brussels, Belgium. Electronic address:

The interest in extracellular vesicles (EVs) increased during the last decade. It is now established that these vesicles play a role in the pathogenesis of central nervous system diseases (CNS), which explains why they are studied as biomarkers in these pathologies. On the other hand, EVs can also present therapeutic properties, often similar to their parent cells, as observed with mesenchymal stem cell-derived EVs. Read More

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Unconventional anxiety pharmacology in zebrafish: drugs beyond traditional anxiogenic and anxiolytic spectra.

Pharmacol Biochem Behav 2021 May 12:173205. Epub 2021 May 12.

Ural Federal University, Ekaterinburg, Russia; School of Pharmacy, Southwest University, Chongqing, China. Electronic address:

Anxiety is the most prevalent brain disorder and a common cause of human disability. Animal models are critical for understanding anxiety pathogenesis and its pharmacotherapy. The zebrafish (Danio rerio) is increasingly utilized as a powerful model organism in anxiety research and anxiolytic drug screening. Read More

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Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice.

Physiol Rep 2021 May;9(9):e14853

Department of Anesthesiology & Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, USA.

Previously, we demonstrated that global knockout (KO) of the gene encoding myelin protein zero-like 3 (Mpzl3) results in reduced body weight and adiposity, increased energy expenditure, and reduced hepatic lipid synthesis in mice. These mice also exhibit cyclic and progressive alopecia which may contribute to the observed hypermetabolic phenotype. The goal of the current study was to determine if acute and peripherally restricted knockdown of Mpzl3 could ameliorate the negative metabolic effects of exposure to a high-fat and sucrose, energy-dense (HED) diet similar to what was observed in global Mpzl3 KO mice in the absence of a skin phenotype. Read More

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Current and emerging pharmacological targets for medical expulsive therapy.

Basic Clin Pharmacol Toxicol 2021 May 15. Epub 2021 May 15.

Centre for Urology Research, Faculty of Health Science & Medicine, Bond University, Bond, QLD, 4229, Australia.

The primary goals of medical expulsive therapy are to increase the rate of stone expulsion along the ureter to avoid ureteral obstruction and reduce ureteral colic, and thus avoid the need for surgical and more invasive interventions. This review focuses on the findings from in vivo and in vitro animal and human studies that have investigated the pharmacological mechanisms controlling ureteral motility and their translation to current and potentially new clinically used drugs for increasing rate of stone expulsion along the ureter. The complicated contractility profile of the ureter, which alters with age, tissue segment region, orientation, and species, contributes to the difficulty of interpreting studies on ureteral pharmacology, which translates to the complexity of discovering ideal drug targets for medical expulsive therapy. Read More

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Factor Xa inhibitors: critical considerations for clinical development and testing.

Authors:
Richard C Becker

J Thromb Thrombolysis 2021 May 15. Epub 2021 May 15.

University of Cincinnati Heart, Lung and Vascular Institute, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.

The selection of factor (F) X and its activated protease FXa for targeted inhibition to prevent and treat thrombotic conditions is based on an understanding of coagulation biochemistry, sequential steps that occur on tissue factor bearing cells and the interface of coagulation proteins, platelets, mononuclear cells and the nuclear constituents of inflammatory cells. The goal for developing direct oral FXa inhibitors was to achieve rapid, selective, predictable, safe and effective anticoagulation across a broad group of patients expected to derive benefit. The history and development in patient care are exemplars of knowledge, translation and collaboration between the public and private sectors. Read More

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Psychometric Properties of the Chinese Version of the Sarcopenia and Quality of Life, a Quality of Life Questionnaire Specific for Sarcopenia.

Calcif Tissue Int 2021 May 15. Epub 2021 May 15.

Chemistry, National University of Singapore, No. 21, Lower Kent Ridge Road, Singapore, 119077, Singapore.

A quality of life questionnaire specific to sarcopenia (SarQoL®) was successfully developed. There is a huge demand for translation and validation in Chinese. The aim of this study was to translate the SarQoL® into Chinese and investigate its psychometric properties. Read More

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Translational research in pediatric contrast-enhanced ultrasound.

Pediatr Radiol 2021 May 15. Epub 2021 May 15.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

The role of contrast-enhanced ultrasound (CEUS) imaging is being widely explored by various groups for its use in the pediatric population. Clinical implementation of new diagnostic or therapeutic techniques requires extensive and meticulous preclinical testing and evaluation. The impact of CEUS will be determined in part by the extent to which studies are oriented specifically toward a pediatric population. Read More

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Self-Case Report of Oral and Skin Lesions Associated with Positivity of COVID-19.

J Cosmet Dermatol 2021 May 15. Epub 2021 May 15.

Department of Prosthetic Dentistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

We would like to present, according to the CARE guidelines, a case report of a surgeon who had been repeatedly exposed to coronavirus disease (COVID-19) patients and developed oral and skin lesions before typical respiratory symptoms of COVID-19 . Read More

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A practice-based model to guide nursing science and improve the health and well-being of patients and caregivers.

J Clin Nurs 2021 May 15. Epub 2021 May 15.

Nursing Research Division, Mayo Clinic, Rochester, MN, USA.

Aims And Objectives: The purpose of this paper is to describe a model to guide nursing science in a clinical practice-based setting. Exemplars are provided to highlight the application of this nursing research model, which can be applied to other clinical settings that aim to fill evidence gaps in the literature.

Background: Nurse scientists are well positioned to develop new knowledge aimed at identifying global health solutions to multiple disparities. Read More

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Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins.

FASEB J 2021 Jun;35(6):e21640

Swansea University Medical School, Swansea University, Swansea, UK.

Certain species of pathogenic bacteria damage tissues by secreting cholesterol-dependent cytolysins, which form pores in the plasma membranes of animal cells. However, reducing cholesterol protects cells against these cytolysins. As the first committed step of cholesterol biosynthesis is catalyzed by squalene synthase, we explored whether inhibiting this enzyme protected cells against cholesterol-dependent cytolysins. Read More

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Electroporation-based Therapy for Brain Tumors: A Review.

J Biomech Eng 2021 May 15. Epub 2021 May 15.

Energy-based Tumor Ablation Laboratory, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, China.

Electroporation-based therapy (EBT), as a high-voltage-pulse technology has been prevalent with favorable clinical outcomes in the treatment of various solid tumors. The aim of this review paper is to promote the clinical translation of EBT for brain tumors. First, we briefly introduced the mechanism of pore formation in a cell membrane activated by external electric fields using a single cell model. Read More

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Decellularization protocol-dependent DAMPs in rat uterus scaffolds differentially affect the immune response after transplantation.

J Tissue Eng Regen Med 2021 May 14. Epub 2021 May 14.

Laboratory for Transplantation and Regenerative Medicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30, Sweden.

Scaffolds derived from decellularized tissue possess many advantages for bioengineering applications, including for novel infertility treatments. However, the decellularization process results in allogenic-independent damage associated molecular patterns (DAMPs). This field is poorly studied, in particular for uterus bioengineering applications. Read More

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Reconstruction of the glutamate decarboxylase system in Lactococcus lactis for biosynthesis of food-grade γ-aminobutyric acid.

Appl Microbiol Biotechnol 2021 May 15. Epub 2021 May 15.

School of Biotechnology, Jiangnan University, Wuxi, 214122, China.

Gamma-aminobutyric acid (GABA), an important bioactive compound, is synthesized through the decarboxylation of L-glutamate (L-Glu) by glutamate decarboxylase (GAD). The use of lactic acid bacteria (LAB) as catalysts opens interesting avenues for the biosynthesis of food-grade GABA. However, a key obstacle involved in the improvement of GABA production is how to resolve the discrepancy of optimal pH between the intracellular GAD activity and cell growth. Read More

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Context-specific action of macrolide antibiotics on the eukaryotic ribosome.

Nat Commun 2021 May 14;12(1):2803. Epub 2021 May 14.

Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.

Macrolide antibiotics bind in the nascent peptide exit tunnel of the bacterial ribosome and prevent polymerization of specific amino acid sequences, selectively inhibiting translation of a subset of proteins. Because preventing translation of individual proteins could be beneficial for the treatment of human diseases, we asked whether macrolides, if bound to the eukaryotic ribosome, would retain their context- and protein-specific action. By introducing a single mutation in rRNA, we rendered yeast Saccharomyces cerevisiae cells sensitive to macrolides. Read More

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Inclisiran: A Novel Agent for Lowering Apolipoprotein B-Containing Lipoproteins.

J Cardiovasc Pharmacol 2021 May 10. Epub 2021 May 10.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health & Science University, Portland, OR, USA.

Abstract: Hypercholesterolemia is a leading cause of cardiovascular morbidity and mortality. Accordingly, efforts to lower apolipoprotein B-containing lipoproteins in plasma are the centerpiece of strategies for cardiovascular prevention and treatment in primary and secondary management. Despite the importance of this endeavor, many patients do not achieve appropriate low density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) goals, even among those who have experienced atherosclerotic cardiovascular disease (ASCVD). Read More

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Translation and Cultural Adaptation of the Ages and Stages Questionnaires (ASQ) Worldwide: A Scoping Review.

J Dev Behav Pediatr 2021 May 12. Epub 2021 May 12.

Department of Psychoeducation, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada; Department of Pediarics, Clinica Alemana-Facultad de Medicina Universidad del Desarrollo, Santiago, Chile.

Objective: This scoping review aims to provide a data mapping and narrative synthesis of the available peer-reviewed scientific literature on the translation and cultural adaptation processes relative to the Ages and Stages Questionnaires (ASQ) as reported by the authors. It also seeks to paint an overall portrait of the implementation of the translated and culturally adapted ASQ worldwide.

Methods: Articles published between 1995 and May 11, 2018, were identified via systematic searches of peer-reviewed literature carried out using CINAHL, Scopus, MEDLINE, Education Source, PsycINFO, and ERIC. Read More

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Creating a Resident Research Track in Synergy with the Rehabilitation Medicine Scientist Training Program.

Am J Phys Med Rehabil 2021 May 13. Epub 2021 May 13.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 Department of Physical Medicine and Rehabilitation, Mayo Clinic, Minneapolis, MN, 55403.

Abstract: Physician scientists play an important role in the translation of research findings to patient care; however, their training faces numerous challenges. Residency research track programs represent an opportunity to facilitate the training of future physician scientists in Physical Medicine and Rehabilitation (PM&R), although optimal program organization and long-term outcomes remain unknown. The Rehabilitation Medicine Scientist Training Program (RMSTP) is a National Institutes of Health (NIH) funded program aimed at addressing the shortage of physician researchers in the field of PM&R by providing instruction, mentorship, and networking opportunities for a successful research career. Read More

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How, why and under what circumstances does a quality improvement collaborative build knowledge and skills in clinicians working with people with dementia? A realist informed process evaluation.

BMJ Open Qual 2021 May;10(2)

College of Medicine and Public Health, Flinders University, Flinders University, Adelaide, South Australia, Australia.

In increasingly constrained health and aged care services, strategies are needed to improve quality and translate evidence into practice. In dementia care, recent failures in quality and safety have led the WHO to prioritise the translation of known evidence into practice. While quality improvement collaboratives have been widely used in healthcare, there are few examples in dementia care. Read More

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Prevalence of winter migration to warmer destinations among Ontarians ("snowbirds") and patterns of their use of health care services: a population-based analysis.

CMAJ Open 2021 Apr-Jun;9(2):E491-E499. Epub 2021 May 14.

ICES Western (Shariff, Dixon, Garg, Clemens); Arthur Labatt Family School of Nursing (Shariff), Western University; Lawson Health Research Institute (Shariff, Garg, Clemens), London, Ont.; ICES Central (Paterson), Toronto, Ont.; Department of Family Medicine (Paterson), McMaster University, Hamilton, Ont.; Institute of Health Policy, Management and Evaluation (Paterson), University of Toronto, Toronto, Ont.; Department of Epidemiology and Biostatistics (Dixon, Garg), Western University, London, Ont.; Department of Mathematics and Statistics (Dixon), University of Guelph, Guelph, Ont.; Department of Medicine (Garg, Clemens), Western University; St. Joseph's Health Care London (Clemens), London, Ont.

Background: Older Canadians frequently migrate to warmer destinations for the winter season (snowbirds). Our aim was to examine the prevalence of migration to warmer destinations among Ontarians, and to compare the characteristics and use of health care services of snowbirds to those of older Ontarians who did not migrate for the winter.

Methods: We conducted a population-based analysis using health administrative databases from Ontario. Read More

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Translation of oncology multidisciplinary team meeting (MDM) recommendations into clinical practice.

BMC Health Serv Res 2021 May 14;21(1):461. Epub 2021 May 14.

South Western Sydney Clinical School, University of NSW, Liverpool, NSW, Australia.

Background: Multidisciplinary team meeting (MDM) processes differ according to clinical setting and tumour site. This can impact on decision making. This study aimed to evaluate the translation of MDM recommendations into clinical practice across solid tumour MDMs at an academic centre. Read More

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Replicable Quasi-Three-Dimensional Plasmonic Nanoantennas for Infrared Bandpass Filtering.

ACS Appl Mater Interfaces 2021 May 14. Epub 2021 May 14.

School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.

Quasi-three-dimensionally designed metal-dielectric hybrid nanoantennas have provided a unique capability to control light at the nanoscale beyond the diffraction limit, which has enabled powerful optical manipulation techniques. However, the fabrication of these nanoantennas has largely relied on the use of nanolithography techniques that are time- and cost-consuming, impeding their application in wide-ranging use. Herein, we report a versatile methodology enabling the repetitive replication of these nanoantennas from their silicon molds with tailored optical features for infrared bandpass filtering. Read More

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Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review.

Pharmacol Res 2021 May 11:105666. Epub 2021 May 11.

School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia. Electronic address:

Benzyl isothiocyanate (BITC) is one of the common isothiocyanates found in cruciferous vegetables such as broccoli, cabbage or watercress. Preclinical studies report of its effectiveness in the prevention and treatment against several cancers. This review aims to report and discuss findings on anticancer activities of BITC and its modes of action against 14 types of cancer. Read More

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Facilitators to referrals to CDC's National Diabetes Prevention Program in primary care practices and pharmacies: DocStyles 2016-2017.

Prev Med 2021 May 11:106614. Epub 2021 May 11.

Centers for Disease Control and Prevention, Division of Diabetes Translation, 4770 Buford Hwy, Mail Stop S107-3, Atlanta, GA 30341, USA. Electronic address:

Despite evidence of the effectiveness of behavioral change interventions for type 2 diabetes prevention, health care provider referrals to organizations offering the National Diabetes Prevention Program (National DPP) lifestyle change program (LCP) remain suboptimal. This study examined facilitators of LCP referrals among primary care providers and pharmacists (providers). We analyzed data on 1956 providers from 2016 to 2017 DocStyles web-based surveys. Read More

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Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1.

J Biol Chem 2021 May 11:100772. Epub 2021 May 11.

Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC) - CONICET and Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. Electronic address:

TRIM7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1, the autoglucosyltransferase that initiates glycogen biosynthesis. A growing body of evidence indicates that TRIM7 plays an important role in cancer development, viral pathogenesis, and atherosclerosis, and thus represents a potential therapeutic target. TRIM family proteins share a multidomain architecture with a conserved N-terminal tripartite motif (TRIM) and a variable C-terminal domain. Read More

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Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis.

Cell Host Microbe 2021 May 7. Epub 2021 May 7.

Institute for Glycomics, Griffith University Gold Coast Campus, Southport 4215, Australia. Electronic address:

Babesia spp. are tick-transmitted intra-erythrocytic protozoan parasites that infect humans and animals, causing a flu-like illness and hemolytic anemia. There is currently no human vaccine available. Read More

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Long-term Pre-Clinical Evaluation of an Injectable Chitosan Nanocellulose Hydrogel with Encapsulated Adipose-Derived Stem Cells in an Ovine Model for IVD Regeneration.

J Tissue Eng Regen Med 2021 May 14. Epub 2021 May 14.

University of Leipzig, Translational Centre for Regenerative Medicine, Leipzig, Germany.

The potential therapeutic benefit of adipose-derived stem cells (ASCs) encapsulated in an injectable hydrogel for stimulating intervertebral disc (IVD) regeneration has been assessed by a number of translational and preclinical studies. However, previous work has been primarily limited to small animal models and short-term outcomes of only a few weeks. Long-term studies in representative large animal models are crucial for translation into clinical success, especially for permanent stabilization of major defects such as disc herniation. Read More

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