Toxicol Lett 2021 Jun 3;344:11-17. Epub 2021 Mar 3.
School of Medicine, Sun Yat-Sen University, Guangzhou, 518000, China; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, China; International Joint Laboratoryof Novel Anti-Dementia Drugs of Guangzhou, Guangzhou, China. Electronic address:
Acrolein is a universal contaminant with high nucleophilicity in environment and also an endogenous product from lipid peroxidation or polyamine metabolism. Acrolein can react with nucleophilic amino acids, such as cysteines, lysines and histidines via Michael addition. Also, Schiff base products can be formed between acrolein and free amine of lysines. Read More